Understanding genetic predisposition to disease and knowledge of lifestyle modifications that change the potential for disease is necessary to make informed choices. This multidisciplinary line promotes and disseminates fundamental, translational and clinical scientific research having as main vectors the interaction environment-individual in developmental disorders, aging-related chronic diseases, and cancer. Using in vitro and in vivo biological systems, the approach is transversal from the cellular and molecular mechanisms to new biomarkers and therapeutic targets, allowing an effective personalized medicine. We aim to understand the impact of genetic/epigenetic factors and environmental/microenvironment exposures on health and on the susceptibility and course of the conditions investigated. An important focus is to study genotypes, transcripts, methylation markers, proteins and metabolites together with environmental risk factors and clinical information as powerful tools to understand the human variability and networks underlying diseases.
This multidisciplinary approach includes study of human genome variability, identification of new biomarkers, essential for disease risk and outcome prediction and to identify new therapeutic targets translating into clinical research. We integrate complex information from multiple data sources generating a usable output to support prevention, diagnostic, prognostic, and interventions. To accomplish these goals, our multidisciplinary group has researchers with strong expertise in basic, translational and clinical investigation and bioinformatics. Furthermore, we work in close contact with institutions involved in developmental and genetic disorders and cancer diagnosis and treatment, such as CHUC, IPO Coimbra and Centro Académico Clínico. Our scientific background and technology platforms are collaboratively used by other members of the Metabolism, Aging and Disease line, as well as others.
Red Transfronteriza de Innovación en Diagnóstico Precoz de Leucemia para un envejecimiento saludable – IDIAL-NET Portugal e Espanha - Interreg-POCTEP, 2019/2021).
New diagnostic and therapeutic tools against multidrug resistant tumors - COST action CA17104, COST, 2018/2022.
ONCONET SUDOE - Reseau Europeen de Recherche translationnelle et d'Innovation en oncologie. Ref. SOE1/P1/F0082. INTERREG SUDOE.
BrainHealth2020: Early Detection, Neuromodulation and Advanced Therapies to Brain Disorders. Reference: SAICT 000008 BrainHealth 2020.
MED4Youth - Mediterranean enriched diet for tackling youth obesity. PRIMA. FCT.
International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches (SPRINT). COST Action CA17116, COST, 2018-2022.