Mitochondria are critical organelles for cell physiology and survival. Mitochondria are the cell energy powerplants, producing most of the chemical energy for cell metabolism, and playing an important role in cell death and quality control processes. Since mitochondria are active players in cellular redox and calcium homeostasis, as well as in intermediate metabolism, our general objective is to provide insights into the role of mitochondria in cellular metabolism, redox signaling and stress responses associated with chemical toxicology, cancer, cardiovascular and hepatic diseases, osteoporosis, aging-related diseases, and stem cell differentiation. Another objective of our group is to develop interventions to specifically target mitochondria in the context of drug discovery.
The group has distinct objectives in four research lines:
“FOIE GRAS”, H2020-MSCA-ITN-2016, Proposal 722619, 2017-2020 (European Commission)
“mtFOIE GRAS”, H2020-MSCA-RISE-2016, Proposal 734719, 2017-2020 (European Commission)
"Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis" PTDC/BTM-ORG/0055/2021; Universidade de Coimbra Centro de Neurociências e Biologia Celular. Funders: Fundação para a Ciência e a Tecnologia
"Development and validation of innovative screening methods for mitochondrial health modulators" PTDC/BTM-SAL/29297/2017; Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra; Funders: Fundação para a Ciência e a Tecnologia
"Mit.OnOff : Malfunctions of the energy factory / Avarias na fábrica de energia" fbr_oc2_01_universidade de coimbra; Universidade de Coimbra; Universitetet i Bergen; Funders: EEA Grants Portugal