Publications
Information about journal articles, updated at 02-02-2025, from platform CIÊNCIAVITAE.
The potential of exosomes as a new therapeutic strategy for glioblastoma
Cunha Silva, Leonor; Branco, Francisco; Cunha, Joana; Vitorino, Carla; Gomes, Célia; Carrascal, Mylène A.; Falcão, Amílcar; Miguel Neves, Bruno; Teresa Cruz, Maria, European Journal of Pharmaceutics and Biopharmaceutics. 203. 2024. https://doi.org/10.1016/j.ejpb.2024.114460 . 10.1016/j.ejpb.2024.114460 . published European Journal of Pharmaceutics and Biopharmaceutics
ENPP1 induces blood-brain barrier dysfunction and promotes brain metastasis formation in HER2-positive breast cancer
Gomes, Célia; Tomatis, Francesca; Ferreira, Hugo R S; Almeida, Sara F F; Ciputra, Edward; Sereno, José; Almeida, Rui; et al, Neuro-Oncology. 1 - 17. 2024. http://dx.doi.org/10.1093/neuonc/noae169 . 10.1093/neuonc/noae169 . accepted Neuro-Oncology
Nerve growth factor inducible (<scp>VGF</scp>) is a secreted mediator for metastatic breast cancer tropism to the brain
Carvalho, Rita; Santos, Liliana; Conde, Inês; Leitão, Ricardo; Ferreira, Hugo RS; Gomes, Célia; Silva, Ana Paula; et al, The Journal of Pathology. 132 - 147. 2. 264. 2024. https://doi.org/10.1002/path.6319 . 10.1002/path.6319 . published The Journal of Pathology
Brain metastasis: An insight into novel molecular targets for theranostic approaches
Santos, Liliana; Moreira, João Nuno; Abrunhosa, Antero; Gomes, Célia, Critical Reviews in Oncology/Hematology. 198. 2024. http://dx.doi.org/10.1016/j.critrevonc.2024.104377 . 10.1016/j.critrevonc.2024.104377 . Critical Reviews in Oncology/Hematology
Self-Renewal and Pluripotency in Osteosarcoma Stem Cells’ Chemoresistance: Notch, Hedgehog, and Wnt/ß-Catenin Interplay with Embryonic Markers
Martins-Neves, Sara R.; Sampaio-Ribeiro, Gabriela; Gomes, Célia M. F., International Journal of Molecular Sciences. 9. 24. 2023. https://doi.org/10.3390/ijms24098401 . 10.3390/ijms24098401 . published International Journal of Molecular Sciences
Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
Almeida, Sara F.F.; Santos, Liliana; Sampaio-Ribeiro, Gabriela; Ferreira, Hugo R.S.; Lima, Nuno; Caetano, Rui; Abreu, Mónica; et al, Journal of Experimental & Clinical Cancer Research. 1. 42. 2023. http://dx.doi.org/10.1186/s13046-023-02886-9 . 10.1186/s13046-023-02886-9 . Journal of Experimental & Clinical Cancer Research
Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy
Mateus, Daniela; Sebastião, Ana I.; Frasco, Manuela F.; Carrascal, Mylène A.; Falcão, Amílcar; Gomes, Célia M.; Neves, Bruno; Sales, Maria G. F.; Cruz, Maria T., Small. 46. 19. 2023. https://doi.org/10.1002/smll.202303940 . 10.1002/smll.202303940 . Small
Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3
Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al, Molecular Therapy. 1275 - 1292. 5. 31. 2023. http://dx.doi.org/10.1016/j.ymthe.2023.04.001 . 10.1016/j.ymthe.2023.04.001 . Molecular Therapy
Chemoresistance-Related Stem Cell Signaling in Osteosarcoma and Its Plausible Contribution to Poor Therapeutic Response: A Discussion That Still Matters
Martins-Neves, Sara R.; Sampaio-Ribeiro, Gabriela; Gomes, Célia M. F., International Journal of Molecular Sciences. 19. 23. 2022. https://doi.org/10.3390/ijms231911416 . 10.3390/ijms231911416 . published International Journal of Molecular Sciences
Osteosarcoma-Derived Exosomes as Potential PET Imaging Nanocarriers for Lung Metastasis
Almeida, Sara F.F.; Fonseca, Alexandra; Sereno, José; Ferreira, Hugo R. S.; Lapo-Pais, Mariana; Martins-Marques, Tânia; Rodrigues, Teresa; et al, Small. 49. 18. 2022. http://dx.doi.org/10.1002/smll.202203999 . 10.1002/smll.202203999 . Small
A selective p53 activator and anticancer agent to improve colorectal cancer therapy
Ramos, Helena; Soares, Maria I.L.; Silva, Joana; Raimundo, Liliana; Calheiros, Juliana; Gomes, Célia; Reis, Flávio; et al, Cell Reports. 2. 35. 2021. http://dx.doi.org/10.1016/j.celrep.2021.108982 . 10.1016/j.celrep.2021.108982 . Cell Reports
Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance
Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; et al, Cancers. 7. 13. 2021. http://dx.doi.org/10.3390/cancers13071648 . 10.3390/cancers13071648 . Cancers
In-Depth Analysis of the Impact of Different Serum-Free Media on the Production of Clinical Grade Dendritic Cells for Cancer Immunotherapy
Calmeiro, João; Mendes, Luís; Duarte, Iola F.; Leitão, Catarina; Tavares, Adriana R.; Ferreira, Daniel Alexandre; Gomes, Célia; et al, Frontiers in Immunology. 11. 2021. http://dx.doi.org/10.3389/fimmu.2020.593363 . 10.3389/fimmu.2020.593363 . Frontiers in Immunology
Exosomes as new therapeutic vectors for pancreatic cancer treatment
Oliveira, Constança; Calmeiro, João; Carrascal, Mylène A.; Falcão, Amílcar; Gomes, Célia; Miguel Neves, Bruno; Teresa Cruz, Maria, European Journal of Pharmaceutics and Biopharmaceutics. 4 - 14. 161. 2021. http://dx.doi.org/10.1016/j.ejpb.2021.02.002 . 10.1016/j.ejpb.2021.02.002 . European Journal of Pharmaceutics and Biopharmaceutics
Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies
Hrynchak, Ivanna; Santos, Liliana; Falcão, Amílcar; Gomes, Célia M.; Abrunhosa, Antero J., International Journal of Molecular Sciences. 19. 22. 2021. https://doi.org/10.3390/ijms221910745 . 10.3390/ijms221910745 . published International Journal of Molecular Sciences
Pharmacological Combination of Nivolumab with Dendritic Cell Vaccines in Cancer Immunotherapy: an Overview.
Calmeiro J; Carrascal MA; Tavares AR; Ferreira DA; Gomes C; Cruz MT; Falcão A; Neves BM, Pharmacological research. 2020. http://europepmc.org/abstract/med/33212291 . 10.1016/j.phrs.2020.105309 . Pharmacological research
In Vivo Tracking of Extracellular Vesicles by Nuclear Imaging: Advances in Radiolabeling Strategies
Almeida, Sara; Santos, Liliana; Falcão, Amílcar; Gomes, Célia; Abrunhosa, Antero, International Journal of Molecular Sciences. 24. 21. 2020. http://dx.doi.org/10.3390/ijms21249443 . 10.3390/ijms21249443 . International Journal of Molecular Sciences
Dendritic Cell Vaccines for Cancer Immunotherapy: The Role of Human Conventional Type 1 Dendritic Cells
Calmeiro, João; Carrascal, Mylène A.; Tavares, Adriana Ramos; Ferreira, Daniel Alexandre; Gomes, Célia; Falcão, Amílcar; Cruz, Maria Teresa; Neves, Bruno Miguel, Pharmaceutics. 2. 12. 2020. http://dx.doi.org/10.3390/pharmaceutics12020158 . 10.3390/pharmaceutics12020158 . Pharmaceutics
Biomaterial-based platforms for in situ dendritic cell programming and their use in antitumor immunotherapy.
Calmeiro J; Carrascal M; Gomes C; Falcão A; Cruz MT; Neves BM, Journal for immunotherapy of cancer. 238 - 249. 7(1). 4. 2019. http://europepmc.org/abstract/med/31484548 . 10.1186/s40425-019-0716-8 . published Journal for immunotherapy of cancer
The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration.
Henriques-Antunes H; Cardoso RMS; Zonari A; Correia J; Leal EC; Jiménez-Balsa A; Lino MM; et al, ACS nano. 2019. http://europepmc.org/abstract/med/31390518 . 10.1021/acsnano.9b00376 . ACS nano
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Gomes S; Bosco B; Loureiro JB; Ramos H; Raimundo L; Soares J; Nazareth N; et al, Cancers. 2019. http://europepmc.org/abstract/med/31405179 . 10.3390/cancers11081151 . Cancers
The interplay between glioblastoma and microglia cells leads to endothelial cell monolayer dysfunction via the interleukin-6-induced JAK2/STAT3 pathway
Couto, Marina; Coelho-Santos, Vanessa; Santos, Liliana; Fontes-Ribeiro, Carlos; Silva, Ana Paula; Gomes, Célia M. F., Journal of Cellular Physiology. 19750 - 19760. 11. 234. 2019. http://dx.doi.org/10.1002/jcp.28575 . 10.1002/jcp.28575 . published Journal of Cellular Physiology
Development of a novel dendritic cell-based immunotherapy targeting cancer stem cells
Calmeiro, Joao; Carrascal, Mylene; Mendes, Luis; Duarte, Iola F.; Gomes, Celia; Serra, Joao; Falcao, Amilcar; Cruz, Maria Teresa; Neves, Bruno Miguel, Journal of Clinical Oncology. 2019. https://publons.com/wos-op/publon/21604203/ . 10.1200/JCO.2019.37.15_SUPPL.E14009 . Journal of Clinical Oncology
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease
Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al, Molecular Therapy. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS . 10.1016/j.ymthe.2018.07.007 . Molecular Therapy
IWR-1, a tankyrase inhibitor, attenuates Wnt/ß-catenin signaling in cancer stem-like cells and inhibits in vivo the growth of a subcutaneous human osteosarcoma xenograft
Martins-Neves, Sara R.; Paiva-Oliveira, Daniela I.; Fontes-Ribeiro, Carlos; Bovée, Judith V.M.G.; Cleton-Jansen, Anne-Marie; Gomes, Célia M.F., Cancer Letters. 1 - 15. 414. 2018. http://dx.doi.org/10.1016/j.canlet.2017.11.004 . 10.1016/j.canlet.2017.11.004 . Cancer Letters
Discovery of a small-molecule protein kinase Cd-selective activator with promising application in colon cancer therapy.
Bessa C; Soares J; Raimundo L; Loureiro JB; Gomes C; Reis F; Soares ML; et al, Cell death & disease. 2018. http://europepmc.org/abstract/med/29348560 . 10.1038/s41419-017-0154-9 . Cell death & disease
Therapy-induced enrichment of cancer stem-like cells in solid human tumors: Where do we stand?
Sara R. Martins-Neves; Anne-Marie Cleton-Jansen; Célia M.F. Gomes, Pharmacological Research. 193 - 204. 137. 2018. https://doi.org/10.1016/j.phrs.2018.10.011 . 10.1016/j.phrs.2018.10.011 . Pharmacological Research
Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats.
Coelho-Santos V; Cardoso FL; Magalhães A; Ferreira-Teixeira M; Leitão RA; Gomes C; Rito M; et al, European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2018. http://europepmc.org/abstract/med/30554860 . 10.1016/j.euroneuro.2018.12.007 . European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells
Rodrigues, C.F.D.; Serrano, E.; Patrício, M.I.; Val, M.M.; Albuquerque, P.; Fonseca, J.; Gomes, C.M.F.; et al, Scientific Reports. 1. 8. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050990420&partnerID=MN8TOARS . 10.1038/s41598-018-29947-w . Scientific Reports
Impact of different GMP media in the production of dendritic cells for next-generation cancer immunotherapy: Functional and metabolic characterization
Calmeiro, J.; Carrascal, M.; Gomes, C.; Falcão, A.; Serra, J.; Cruz, M.T.; Neves, B., Annals of Oncology. 29. 2018. http://dx.doi.org/10.1093/annonc/mdy485.010 . 10.1093/annonc/mdy485.010 . published Annals of Oncology
Repeated mesenchymal stromal cells treatment sustainably alleviates Machado-Joseph disease/spinocerebellar ataxia type-3
Gomes, Célia, Human Gene Therapy. A1 - A169. 12. 29. 2018. http://dx.doi.org/10.1089/hum.2018.29077.abstracts . 10.1089/hum.2018.29077.abstracts . published Human Gene Therapy
DIMP53-1: A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties.
Soares J; Espadinha M; Raimundo L; Ramos H; Gomes AS; Gomes S; Loureiro JB; et al, 2017. http://europepmc.org/abstract/med/28296148 . 10.1002/1878-0261.12051 .
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells
Ferreira-Teixeira, M.; Parada, B.; Paiva-Oliveira, D.; Alves, V.; Sousa, V.; Chijioke, O.; Münz, C.; et al, European Urology Supplements. e1683 - e1684. 3. 16. 2017. http://dx.doi.org/10.1016/s1569-9056(17)31016-3 . 10.1016/s1569-9056(17)31016-3 . European Urology Supplements
Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells
Paiva-Oliveira, Daniela I.; Martins-Neves, Sara R.; Abrunhosa, Antero J.; Fontes-Ribeiro, Carlos; Gomes, Célia M. F., Cancer Chemotherapy and Pharmacology. 49 - 63. 1. 81. 2017. http://dx.doi.org/10.1007/s00280-017-3467-6 . 10.1007/s00280-017-3467-6 . Cancer Chemotherapy and Pharmacology
Dendritic cell-based immunotherapy: a basic review and recent advances
Constantino, João; Gomes, Célia; Falcão, Amílcar; Neves, Bruno Miguel; Cruz, Maria Teresa, Immunologic Research. 798 - 810. 4. 65. 2017. http://dx.doi.org/10.1007/s12026-017-8931-1 . 10.1007/s12026-017-8931-1 . Immunologic Research
Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells
Liberal, Joana; Carmo, Anália; Gomes, Célia; Cruz, Maria Teresa; Batista, Maria Teresa, Investigational New Drugs. 671 - 681. 6. 35. 2017. http://dx.doi.org/10.1007/s10637-017-0483-7 . 10.1007/s10637-017-0483-7 . Investigational New Drugs
Deconstructing cancer stem cells: IL-6, G-CSF and Activin-A as mediators of stroma-orchestrated epithelial cells' dedifferentiation
Rodrigues, Carlos F.; Serrano, Eurico; Cunha, Marco; Patricio, Maria I.; Val, Mariana; Fonseca, Joao; Gomes, Celia; et al, Cancer Research. 2017. https://publons.com/wos-op/publon/29056170/ . 10.1158/1538-7445.AM2017-1915 . Cancer Research
Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles
Conceição, M.; Mendonça, L.; Nóbrega, C.; Gomes, C.; Costa, P.; Hirai, H.; Moreira, J.N.; et al, Data in Brief. 700 - 705. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956617357&partnerID=MN8TOARS . 10.1016/j.dib.2016.01.017 . Data in Brief
Presence of Cx43 in extracellular vesicles reduces the cardiotoxicity of the anti-tumour therapeutic approach with doxorubicin.
Martins-Marques T; Pinho MJ; Zuzarte M; Oliveira C; Pereira P; Sluijter JP; Gomes C; Girao H, 2016. http://europepmc.org/abstract/med/27702427 . 10.3402/jev.v5.32538 .
Mitochondria-Targeted Photodynamic Therapy with a Galactodendritic Chlorin to Enhance Cell Death in Resistant Bladder Cancer Cells.
Pereira PM; Silva S; Bispo M; Zuzarte M; Gomes C; Girão H; Cavaleiro JA; et al, 2016. http://europepmc.org/abstract/med/27750007 . 10.1021/acs.bioconjchem.6b00519 .
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule
Soares, J.; Raimundo, L.; Pereira, N.A.L.; Monteiro, Â; Gomes, S.; Bessa, C.; Pereira, C.; et al, Oncotarget. 4326 - 4343. 4. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957991161&partnerID=MN8TOARS . 10.18632/oncotarget.6775 . Oncotarget
Phthalocyanine Labels for Near-Infrared Fluorescence Imaging of Solid Tumors.
Lobo AC; Silva AD; Tomé VA; Pinto SM; Silva EF; Calvete MJ; Gomes CM; Pereira MM; Arnaut LG, 2016. http://europepmc.org/abstract/med/27070884 . 10.1021/acs.jmedchem.6b00054 .
Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
Conceição M; Mendonça L; Nóbrega C; Gomes C; Costa P; Hirai H; Moreira JN; et al, 2016. http://europepmc.org/abstract/med/26757259 . 10.1016/j.biomaterials.2015.12.021 .
The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin.
Pereira PM; Silva S; Ramalho JS; Gomes CM; Girão H; Cavaleiro JA; Ribeiro CA; Tomé JP; Fernandes R, 2016. http://europepmc.org/abstract/med/27718388 .
Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells.
Ferreira-Teixeira M; Paiva-Oliveira D; Parada B; Alves V; Sousa V; Chijioke O; Münz C; et al, 2016. http://europepmc.org/abstract/med/27769244 . 10.1186/s12916-016-0715-2 .
Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles.
Conceição M; Mendonça L; Nóbrega C; Gomes C; Costa P; Hirai H; Moreira JN; et al, 2016. http://europepmc.org/abstract/PMC/PMC4773411 .
The role of galectin-1 in in vitro and in vivo photodynamic therapy with a galactodendritic porphyrin
Pereira, P.M.R.; Silva, S.; Ramalho, J.S.; Gomes, C.M.; Girão, H.; Cavaleiro, J.A.S.; Ribeiro, C.A.F.; Tomé, J.P.C.; Fernandes, R., European Journal of Cancer. 60 - 69. 68. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84990857207&partnerID=MN8TOARS . 10.1016/j.ejca.2016.08.018 . European Journal of Cancer
Sensitizing osteosarcoma stem cells to doxorubicin-induced apoptosis through retention of doxorubicin and modulation of apoptotic-related proteins
Gonçalves, C.; Martins-Neves, S.R.; Paiva-Oliveira, D.; Oliveira, V.E.B.; Fontes-Ribeiro, C.; Gomes, C.M.F., Life Sciences. 47 - 56. 130. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84927731861&partnerID=MN8TOARS . 10.1016/j.lfs.2015.03.009 . Life Sciences
Functional and molecular characterization of cancer stem-like cells in bladder cancer: A potential signature for muscle-invasive tumors
Ferreira-Teixeira, M.; Parada, B.; Rodrigues-Santos, P.; Alves, V.; Ramalho, J.S.; Caramelo, F.; Sousa, V.; Reis, F.; Gomes, C.M., Oncotarget. 36185 - 36201. 34. 6. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946866394&partnerID=MN8TOARS . 10.18632/oncotarget.5517 . Oncotarget
Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives.
Constantino J; Gomes C; Falcão A; Cruz MT; Neves BM, 2015. http://europepmc.org/abstract/med/26297944 . 10.1016/j.trsl.2015.07.008 .
Osteosarcoma Stem Cells Have Active Wnt/ß-Catenin and Overexpress SOX2 and KLF4.
Martins-Neves SR; Corver WE; Paiva-Oliveira DI; van den Akker BE; Briaire-de-Bruijn IH; Bovée JV; Gomes CM; Cleton-Jansen AM, 2015. http://europepmc.org/abstract/med/26332365 . 10.1002/jcp.25179 .
Chemotherapy induces stemness in osteosarcoma cells through activation of Wnt/ß-catenin signaling.
Martins-Neves SR; Paiva-Oliveira DI; Wijers-Koster PM; Abrunhosa AJ; Fontes-Ribeiro C; Bovée JV; Cleton-Jansen AM; Gomes CM, 2015. http://europepmc.org/abstract/med/26577806 . 10.1016/j.canlet.2015.11.013 .
Synthesis of a new <sup>18</sup>F labeled porphyrin for potential application in positron emission tomography. in vivo imaging and cellular uptake
Simões, A.V.C.; Pinto, S.M.A.; Calvete, M.J.F.; Gomes, C.M.F.; Ferreira, N.C.; Castelo-Branco, M.; Llop, J.; Pereira, M.M.; Abrunhosa, A.J., RSC Advances. 99540 - 99546. 120. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948415914&partnerID=MN8TOARS . 10.1039/c5ra16103g . RSC Advances
Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate.
Capelôa T; Caramelo F; Fontes-Ribeiro C; Gomes C; Silva AP, 2014. http://europepmc.org/abstract/med/24652521 . 10.1007/s12640-014-9464-1 .
Erratum to: Role of Methamphetamine on Glioblastoma Cytotoxicity Induced by Doxorubicin and Methotrexate.
Capelôa T; Caramelo F; Fontes-Ribeiro C; Gomes C; Silva AP, 2014. http://europepmc.org/abstract/med/24788666 . 10.1007/s12640-014-9471-2 .
The dual role of mesenchymal stem cells in tumor progression.
Gomes CM, 2013. http://europepmc.org/abstract/med/23680129 . 10.1186/scrt189 .
Diamond Based Biosensors: Surface-Fluid Interaction Issues
Neto, M.A.; Gomes, C.M.F.; Silva, E.L.; Fernandes, A.J.S.; Oliveira, F.J.; Silva, R.F., Procedia Chemistry. 117 - 124. 6. 2012. http://dx.doi.org/10.1016/j.proche.2012.10.137 . 10.1016/j.proche.2012.10.137 . Procedia Chemistry
Cationic lipophilic radiotracers for functional imaging of multidrug resistance
Gomes, C.M.F., Current Radiopharmaceuticals. 113 - 123. 2. 5. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857132048&partnerID=MN8TOARS . 10.2174/1874471011205020113 . Current Radiopharmaceuticals
Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line.
Martins-Neves SR; Lopes ÁO; do Carmo A; Paiva AA; Simões PC; Abrunhosa AJ; Gomes CM, 2012. http://europepmc.org/abstract/med/22475227 . 10.1186/1471-2407-12-139 .
Molecular imaging with SPECT and PET in exploratory investigational new drug studies
Gomes, C.M.F.; Abrunhosa, A.J.; Pauwels, E.K.J., Drugs of the Future. 69 - 77. 1. 36. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952981021&partnerID=MN8TOARS . 10.1358/dof.2011.036.01.1507257 . Drugs of the Future
Visualization of deep lung lymphatic network using radioliposomes
Botelho, M.F.; de Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E., Revista Portuguesa de Pneumologia. 124 - 130. 3. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054973162&partnerID=MN8TOARS . 10.1016/j.rppneu.2011.03.003 . Revista Portuguesa de Pneumologia
Molecular imaging with SPECT as a tool for drug development
Gomes, C.M.; Abrunhosa, A.J.; Ramos, P.; Pauwels, E.K.J., Advanced Drug Delivery Reviews. 547 - 554. 7. 63. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955445971&partnerID=MN8TOARS . 10.1016/j.addr.2010.09.015 . Advanced Drug Delivery Reviews
Cytotoxicity evaluation of boron-doped diamond surfaces obtained by the HFCVD technique in osteoblast-like cells
Neto, M.A.; Silva, E.L.; Gomes, C.M.F.; Fernandes, A.J.S.; Oliveira, F.J.; Silva, R.F., European Cells and Materials. 186 - 186. SUPPL.3. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860905328&partnerID=MN8TOARS . European Cells and Materials
Indentification of cancer stem-like cells in osteosarcoma and their implications in response to chemotherapy.
Lopes ÁO; Neves SR; do Carmo A; Paiva AA; Botelho M; Gomes CM, 2010. http://europepmc.org/abstract/PMC/PMC3255039 .
Osteosarcoma contains a subpopulation of cancer stem-like cells that are highly resistant to radiotherapy.
Neves SR; Lopes AO; do Carmo A; Abrunhosa AJ; Simões PC; Paiva AA; Botelho MF; Gomes CM, 2010. http://europepmc.org/abstract/PMC/PMC3255038 .
Nanoradioliposomes molecularly modulated to study the lung deep lymphatics drainage.
Botelho MF; Marques MA; Gomes C; da Silva AM; Bairos V; Santos Rosa MA; Abrunhosa AP; de Lima JJ, 2010. http://europepmc.org/abstract/med/25965698 . 10.1016/S0873-2159(15)30083-0 .
Nanoradioliposomes molecularly modulated to study the lung deep lymphatic drainage,Nanorradiolipossomas modulados molecularmente para estudar a drenagem linfática pulmonar profunda
Gomes, Célia; Botelho, M.F.R.R.; Marques, M.A.T.; Gomes, C.M.F.; da Silva, A.M.F.; Bairos, V.A.A.F.; Rosa, M.A. de M.S.; Abrunhosa, A.P.; de Lima, J.J.P., Revista Portuguesa de Pneumologia. 261 - 293. 2. 15. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650327279&partnerID=MN8TOARS . 10.1016/S0873-2159(15)30131-8 . Revista Portuguesa de Pneumologia
P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: A comparative study using [<sup>99m</sup>Tc]sestamibi and [<sup>99m</sup>Tc]tetrofosmin
Gomes, C.M.F.; Abrunhosa, A.J.; Pauwels, E.K.J.; Botelho, M.F., Cancer Biotherapy and Radiopharmaceuticals. 215 - 227. 2. 24. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249094896&partnerID=MN8TOARS . 10.1089/cbr.2008.0539 . Cancer Biotherapy and Radiopharmaceuticals
Multidrug resistance in cancer: Its mechanism and its modulation
Pauwels, E.K.J.; Erba, P.; Mariani, G.; Gomes, C.M.F., Drug News & Perspectives. 6. 20. 2007. http://dx.doi.org/10.1358/dnp.2007.20.6.1141496 . 10.1358/dnp.2007.20.6.1141496 . Drug News & Perspectives
Functional imaging of multidrug resistance in an orthotopic model of osteosarcoma using <sup>99m</sup>Tc-sestamibi
Gomes, C.M.F.; Welling, M.; Que, I.; Henriquez, N.V.; Van Der Pluijm, G.; Romeo, S.; Abrunhosa, A.J.; et al, European Journal of Nuclear Medicine and Molecular Imaging. 1793 - 1803. 11. 34. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348958961&partnerID=MN8TOARS . 10.1007/s00259-007-0480-8 . European Journal of Nuclear Medicine and Molecular Imaging
Multidrug resistance mediated by ABC transporters in osteosarcoma cell lines: mRNA analysis and functional radiotracer studies
Gomes, C.M.F.; van Paassen, H.; Romeo, S.; Welling, M.M.; Feitsma, R.I.J.; Abrunhosa, A.J.; Botelho, M.F.; et al, Nuclear Medicine and Biology. 831 - 840. 7. 33. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749426881&partnerID=MN8TOARS . 10.1016/j.nucmedbio.2006.07.011 . Nuclear Medicine and Biology
Comparison of the predicted in vivo behaviour of the Sn(II)-APDDMP complex and the results as studied in a rodent model
Zeevaart, J.R.; Jansen, D.R.; Filomena Botelho, M.; Abrunhosa, A.; Gomes, C.; Metello, L.; Kolar, Z.I.; et al, Journal of Inorganic Biochemistry. 1521 - 1530. 9. 98. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444319191&partnerID=MN8TOARS . 10.1016/j.jinorgbio.2004.06.004 . Journal of Inorganic Biochemistry
Visualising deep lung lymphatic drainage with radioliposomes.
Botelho MF; Gomes CM; de Lima JJ, 2003. http://europepmc.org/abstract/med/12750850 . 10.1007/s00259-003-1179-0 .
Pulmonary arterial-venous shunts: A method for detection and quantification
Botelho, M.F.; Couceiro, M.; Gomes, C.M.; De Lima, J.J.P., Physica Medica. 35 - 37. SUPPL. 4. 17. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035572747&partnerID=MN8TOARS . Physica Medica
5 74 out of 74 Publications
All projects
Information of exclusive responsibility of the researcher 02-02-2025 , from platform CIÊNCIAVITAE.
2024/01/01 - 2025/12/31
Preventing Brain Metastasis in HER2-positive Breast Cancer
Principal investigator
Universidade de Coimbra Faculdade de Medicina; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra
Funders: Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
2024/01/01 - 2025/04/28
[64Cu/67Cu]Radiolabeled Exosomes as a Theranostic Tool for Lung Metastasis
1695913505_7qUJw
Co-Principal Investigator (Co-PI)
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde
Funders: European Organization for Nuclear Research
2022/01/23
Multifunctional cell membrane-camouflaged polymeric micelles for combination therapy of colorectal cancer
PTDC/NAN-MAT/1431/2021
Researcher
Universidade de Coimbra Faculdade de Farmácia
Funders: Fundação para a Ciência e a Tecnologia
2022/01/02
Inibição da via da adenosina - uma nova abordagem para potenciar a imunoterapia no cancro da bexiga avançado
03/22
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Liga Portuguesa Contra o Cancro; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
2021/03/29 - 2025/03/28
Radiolabeled EXosomes - a nanotheranostic tool for lung micrometastasis in osteosarcoma
PTDC/BTM-SAL/4451/2020
Principal investigator
Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Centro Hospitalar e Universitário de Coimbra EPE; Universidade de Coimbra Faculdade de Medicina; Universidade do Porto Instituto de Investigação e Inovação em Saúde
Funders: Fundação para a Ciência e a Tecnologia
2020 -
IDIAL_NET – Rede de Inovação Tranfronteiriça no Diagnóstico Precoce da Leucemia e da Promoção do Envelhecimento Saudável
0639_IDIALNET_3_E
Researcher
Universidade de Coimbra Faculdade de Medicina; Administração Regional de Saúde do Centro IP
Funders: Interreg VA España-Portugal - Fundo Europeu de Desenvolvimento Regional
2020 -
In-beam Time-of-Flight Positron Emission Tomography guided proton radiation therapy.
45904
Researcher
Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde
Funders: UT Austin-Portugal Program
2020/07 - 2021/06
Exosome-based Imaging Tool for Diagnosis of Lung Micrometastasis in Osteosarcoma.
Lions Portugal/2020
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Liga Portuguesa Contra o Cancro
2019 - 2020
Uma nova abordagem para potenciar a imunoterapia no cancro da bexiga avançado – a inibição da via da adenosina
Associação Portuguesa de Urologia 2019
Researcher
Universidade de Coimbra Faculdade de Medicina
Funders: Associação Portuguesa de Urologia
2019 - 2020
Uma nova abordagem para potenciar a imunoterapia no cancro da bexiga avançado – a inibição da via da adenosina
APU 2019
Funders: Associação Portuguesa de Urologia
2019/03/15 -
BRAIN METastaseS: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment
PTDC/MED-ONC/30625/2017
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular; Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2018 - 2019
Combining chemotherapy with immune checkpoint blockade: harnessing synergies for the treatment of muscle-invasive bladder cancer
09/18
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Liga Portuguesa Contra o Cancro Núcleo Regional do Centro
2018/01 - 2020/12
ImmunoDCs@CancerStemCells: Imunoterapia celular direcionada para a eliminação de células estaminais cancerígenas
SII&DT 33532 ImunnoDSs@CancerStemCells
Researcher
Universidade de Coimbra
Funders: Agência Nacional de Inovação, S.A. PT2020-SII&DT – Copromoção; COMPETE 2020 - Portugal 2020 - Fundo Europeu de Desenvolvimento Regional
2017/01 - 2019/12
Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde
Funders: Fundação para a Ciência e Tecnologia
2017/01/01 - 2021/03/31
Estaminalidade das células do cancro: um desafio e uma oportunidade para avançar no tratamento em Oncologia
SAICTPAC/0022/2015
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Instituto Nacional de Engenharia Biomédica; Fundação Calouste Gulbenkian; Universidade de Coimbra; Universidade do Porto Instituto de Patologia e Imunologia Molecular
Funders: Fundação para a Ciência e a Tecnologia
2016/04/01 - 2019/04/01
Targeting p53 family proteins: on the route to new anticancer agents
PTDC/DTP-FTO/1981/2014
Universidade do Minho; Universidade de Coimbra; Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT
Funders: Fundação para a Ciência e a Tecnologia
2015 - 2017
UpCells - Cell Therapy pilot laboratory
Centro-ICT-2013-05
Researcher
Universidade de Coimbra; Grupo Tecnimede
Funders: PT2020 –Sistemas de Incentivos à Investigação e Desenvolvimento Tecnológico
2014 - 2015
Generation of a novel dendritic cell-based vaccine against glioblastoma
Principal investigator
Funders: inovC - Programa Operacional Reginal do Centro
2013/05/01 - 2015/09/30
Cancer stem cells and tumor progression: from molecular mechanisms to clinical consequences
PTDC/BBB-BQB/2450/2012
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2013 - 2015
From moleculas to man: novel diagnostic imaging tools in neurological and psychiatric disorders.
PEst-C/SAU/UI3282/2013
Researcher
Universidade de Coimbra Faculdade de Medicina
Funders: QREN ; N/A
2013 - 2014
Natural Killer-cell based immunotherapy targeting human bladder cancer stem cells.
FreitasGomes04.01.13
Funders: Universidade de Coimbra Faculdade de Medicina
2013 - 2015
NK cell-based adoptive therapy targeting human bladder cancer stem cells: impact on tumor progression using a humanized orthotopic animal model
PEP II0119
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Astellas European Foundation; Universidade de Coimbra Faculdade de Medicina
2012 - 2013
O papel das células estaminais cancerígenas na iniciação e progressão do cancro da bexiga.
Refª14/12
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
2011/01/01 - 2012/12/31
Projecto Estratégico - UI 3282 - 2011-2012
PEst-C/SAU/UI3282/2011
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2009 - 2010
Células cancerígenas estaminais e resistência à quimioterapia no osteossarcoma.
CIMAGO 16/09
Principal investigator
Universidade de Coimbra Faculdade de Medicina
Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
2009 - 2012
Tumorigenese como um modelo fisiológico para a degradação do HIF-1alpha pela autofagia mediada por chaperones
PTDC/SAU-ORG/113542/2009
Researcher
Universidade de Coimbra Faculdade de Medicina
Funders: Fundação para a Ciência e a Tecnologia
2004 - 2005
Avaliação molecular e funcional do desenvolvimento de resistência a citostáticos (MDR) em tumores pulmonares de pequenas células
CIMAGO 05/04
PhD Student Fellow
Universidade de Coimbra Faculdade de Medicina
Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia
2001 - 2003
Gated acquisition of xenon-133 gammagraphy to obtain regional data of the breathing tree in impulse oscillometry.
POCTI/CBO/39284/2001
Master Student Fellow
Universidade de Coimbra Faculdade de Medicina
Funders: Fundação para a Ciência e a Tecnologia
1995 - 1997
Carriers for medical imaging and drug cancer associated with lung lymphatics
2/2.1/SAU/1305/95
Research Technician Fellow
Universidade de Coimbra Faculdade de Medicina
Funders: Fundação para a Ciência e a Tecnologia
5 29 out of 29 projects
We use cookies to improve your visit to our website.