Joana Margarida Verdasca Jorge

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Overview

Joana Margarida Verdasca Jorge is a PhD student at the Doctoral Programme in Health Sciences of the Faculty of Medicine of University of Coimbra, holding a PhD scholarship funded by FCT. She has a master's degree in Biochemistry (2014) and a degree in Biology (2011) both in Faculty of Sciences and Technology, University of Coimbra. She is a researcher in Coimbra Institute for Clinical and Biomedical Research (iCBR) - Group of Environment Genetics and Oncobiology (CIMAGO) of FMUC and Centre for Innovative Biomedicine and Biotechnology Consortium (CIBB). She is a member of several societies, namely the European Association for Cancer Research (EACR), European Hematology Association (EHA) and Portuguese Association for Cancer Research (ASPIC). Joana Jorge published 22 journal articles (4 as the first author), 3 book chapters, and over 70 abstracts in international and national journals (h-index 9 and 264 citations). She presented more than 170 works in scientific meetings (127 poster presentations and 43 oral communications). She received 17 awards/distinctions. She is also a Invited Assistant at the FMUC in Applied Molecular Biology and collaborates in Ph.D. and MSc courses. She co-supervised 4 MSc students (1 ongoing) and provides laboratory support for students' investigation projects or in investigation curricular units.

Affiliation

Laboratory of Oncobiology and Hematology (LOH), University Clinic of Hematology, Faculty of Medicine (FMUC), University of Coimbra

Publications

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Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.

Unveiling the antitumor mechanism of 7a-acetoxy-6ß-hydroxyroyleanone from Plectranthus hadiensis in glioblastoma

Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Massenzio, Francesca; Spigarelli, Renato; Ribeiro-Rodrigues, Teresa; et al, Journal of Ethnopharmacology. 335. 2024. http://dx.doi.org/10.1016/j.jep.2024.118689 . 10.1016/j.jep.2024.118689 . Journal of Ethnopharmacology

Batimastat Induces Cytotoxic and Cytostatic Effects in In Vitro Models of Hematological Tumors

Alves, Raquel; Pires, Ana; Jorge, Joana; Balça-Silva, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela, International Journal of Molecular Sciences. 8. 25. 2024. http://dx.doi.org/10.3390/ijms25084554 . 10.3390/ijms25084554 . International Journal of Molecular Sciences

In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation

Marto, Carlos Miguel; Laranjo, Mafalda; Gonçalves, Ana Cristina; Paula, Anabela; Jorge, Joana; Caetano-Oliveira, Rui; Sousa, Maria Inês; et al, Pharmaceutics. 2. 16. 2024. http://dx.doi.org/10.3390/pharmaceutics16020207 . 10.3390/pharmaceutics16020207 . Pharmaceutics

AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

Lapa, Beatriz Santos; Costa, Maria Inês; Figueiredo, Diana; Jorge, Joana; Alves, Raquel; Monteiro, Ana Raquel; Serambeque, Beatriz; et al, International Journal of Molecular Sciences. 20. 24. 2023. http://dx.doi.org/10.3390/ijms242015331 . 10.3390/ijms242015331 . International Journal of Molecular Sciences

Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study

Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Teixeira-Veríssimo, Manuel; Andrade, José Paulo; Dourado, Marília, International Journal of Molecular Sciences. 13. 24. 2023. http://dx.doi.org/10.3390/ijms241310723 . 10.3390/ijms241310723 . International Journal of Molecular Sciences

Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies

Jorge, Joana; Neves, Joana; Alves, Raquel; Geraldes, Catarina; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela, International Journal of Molecular Sciences. 11. 24. 2023. http://dx.doi.org/10.3390/ijms24119167 . 10.3390/ijms24119167 . International Journal of Molecular Sciences

Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe Dementia

Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Teixeira-Veríssimo, Manuel; Dourado, Marília; Andrade, José Paulo, Biomedicines. 2. 11. 2023. http://dx.doi.org/10.3390/biomedicines11020380 . 10.3390/biomedicines11020380 . Biomedicines

Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines

Alves, Raquel; Santos, Diogo; Jorge, Joana; Gonçalves, Ana Cristina; Catarino, Steve; Girão, Henrique; Melo, Joana Barbosa; Sarmento-Ribeiro, Ana Bela, Molecules. 3. 28. 2023. http://dx.doi.org/10.3390/molecules28031210 . 10.3390/molecules28031210 . Molecules

Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells

Costa, Maria Inês; Santos Lapa, Beatriz; Jorge, Joana; Alves, Raquel; Carreira, Isabel Marques; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana Cristina, International Journal of Molecular Sciences. 5. 23. 2022. http://dx.doi.org/10.3390/ijms23052567 . 10.3390/ijms23052567 . published International Journal of Molecular Sciences

Combination of Elacridar with Imatinib Modulates Resistance Associated with Drug Efflux Transporters in Chronic Myeloid Leukemia

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Almeida, António M.; Sarmento-Ribeiro, Ana Bela, Biomedicines. 5. 10. 2022. http://dx.doi.org/10.3390/biomedicines10051158 . 10.3390/biomedicines10051158 . Biomedicines

Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Ribeiro, André B.; Tenreiro, Rita; Coucelo, Margarida; et al, International Journal of Molecular Sciences. 17. 23. 2022. http://dx.doi.org/10.3390/ijms23179815 . 10.3390/ijms23179815 . International Journal of Molecular Sciences

Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Jorge, Joana; Magalhães, Nisa; Alves, Raquel; Lapa, Beatriz; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela, Biomedicines. 9. 10. 2022. http://dx.doi.org/10.3390/biomedicines10092207 . 10.3390/biomedicines10092207 . Biomedicines

Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway

Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Díaz-Lanza, Ana María; Manadas, Bruno; Efferth, Thomas; Rijo, Patrícia; Cabral, Célia, Frontiers in Pharmacology. 13. 2022. http://dx.doi.org/10.3389/fphar.2022.1006832 . 10.3389/fphar.2022.1006832 . Frontiers in Pharmacology

Impact of cancer metabolism on therapy resistance – Clinical implications

Jorge, Joana, Drug Resistance Updates. 100797 - 100797. 2021. http://dx.doi.org/10.1016/j.drup.2021.100797 . 10.1016/j.drup.2021.100797 . Drug Resistance Updates

Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients

Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Jorge, Joana; Marques, Bárbara; Paiva, Artur; Oliveiros, Bárbara; et al, Frontiers in Cell and Developmental Biology. 9. 2021. http://dx.doi.org/10.3389/fcell.2021.701328 . 10.3389/fcell.2021.701328 . Frontiers in Cell and Developmental Biology

Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro

Fonseca, Élisa; Marques, Carla Cruz; Pimenta, Jorge; Jorge, Joana; Baptista, Maria Conceição; Gonçalves, Ana Cristina; Pereira, Rosa M. L. N., Animals. 7. 11. 2021. http://dx.doi.org/10.3390/ani11072048 . 10.3390/ani11072048 . Animals

Can peripheral blood provide good DNA methylation biomarkers in myelodysplastic syndrome?

Jorge, Joana; Gonçalves, Ana Cristina; Cortesão, Emília; Pires, Ana Cláudia; Alves, Raquel; Geraldes, Catarina; Pereira, Amélia; et al, Journal of Molecular and Clinical Medicine. 1. 4. 2021. http://dx.doi.org/10.31083/j.jmcm.2021.01.015 . 10.31083/j.jmcm.2021.01.015 . Journal of Molecular and Clinical Medicine

Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring

Martins, Ivana; Ribeiro, Ilda Patrícia; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Melo, Joana Barbosa; Carreira, Isabel Marques, Genes. 3. 12. 2021. http://dx.doi.org/10.3390/genes12030349 . 10.3390/genes12030349 . published Genes

Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines

Jorge, Joana; Petronilho, Sara; Alves, Raquel; Coucelo, Margarida; Gonçalves, Ana Cristina; Nascimento Costa, José Manuel; Sarmento-Ribeiro, Ana Bela, Investigational New Drugs. 369 - 377. 2. 38. 2020. http://dx.doi.org/10.1007/s10637-019-00796-2 . 10.1007/s10637-019-00796-2 . Investigational New Drugs

Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target

Lapa, Beatriz; Gonçalves, Ana Cristina; Jorge, Joana; Alves, Raquel; Pires, Ana Salomé; Abrantes, Ana Margarida; Coucelo, Margarida; et al, Medical Oncology. 8. 37. 2020. http://dx.doi.org/10.1007/s12032-020-01394-6 . 10.1007/s12032-020-01394-6 . Medical Oncology

miR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells

Magalhães, Mariana; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Carvalho, Rui; Figueiras, Ana; Santos, Ana Cláudia; Veiga, Francisco, Drug Delivery and Translational Research. 2020. http://dx.doi.org/10.1007/s13346-020-00768-7 . 10.1007/s13346-020-00768-7 . Drug Delivery and Translational Research

All projects

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Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.

2022/01

HemaCirc: CircRNAs as an innovative tool in hematological neoplasms

CIMAGO 08/22

Researcher

Coimbra Institute for Clinical and Biomedical Research (iCBR) – Group of Environment, Genetics and Oncobiology (CIMAGO) - Faculty of Medicine, University of Coimbra

2022/01

The role of platelets in diagnosis, prognosis and therapeutic monitoring in diffuse large B-cell lymphoma

CIMAGO 06/22

Researcher

Coimbra Institute for Clinical and Biomedical Research (iCBR) – Group of Environment, Genetics and Oncobiology (CIMAGO) - Faculty of Medicine, University of Coimbra

2022/01

Evaluation of molecular mechanisms of resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma

CIMAGO 05/22

Researcher

Coimbra Institute for Clinical and Biomedical Research (iCBR) – Group of Environment, Genetics and Oncobiology (CIMAGO) - Faculty of Medicine, University of Coimbra

2022/01

Synthetic lethality in acute myeloid leukemia – Role of DNA damage response

CIMAGO 04/22

Researcher

Coimbra Institute for Clinical and Biomedical Research (iCBR) – Group of Environment, Genetics and Oncobiology (CIMAGO) - Faculty of Medicine, University of Coimbra

2021/02

Clinical relevance of platelets as non-invasive biomarkers in diffuse large B-cell lymphoma - A pilot study

NRC-LPCC/CIMAGO 2020,

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2020/01/01 - 2023/12/31

Clinical relevance of platelets in mature B cell neoplasms: Role as non-invasive biomarkers and therapeutic delivery systems

SFRH/BD/145531/2019

PhD Student Fellow

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2018/01/01 -

Identification of new response markers to Bortezomib and Lenalidomide in patients with multiple myeloma - The role of NF-kB and NRF2/KEAP1

Project 04/18

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2018/01/01 -

NRF2-KEAP1 axis as a new potential prognostic biomarker in chronic lymphocytic leukemia

Project 03/18

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2016/01/01 - 2018

The role of microRNAs for chronic myeloid leukemia therapeutic selection

Project FMUC-BST-2016-2014

Researcher

Banco Santander Totta; Universidade de Coimbra Faculdade de Medicina

Funders: Banco Santander Totta; Universidade de Coimbra Faculdade de Medicina

2016/01/01 -

Epigenetic in Chronic Lymphocytic Leukemia B - Impact in prognosis and therapy

Project FMUC-BST-2016-2020

Researcher

Banco Santander Totta; Universidade de Coimbra Faculdade de Medicina

Funders: Banco Santander Totta; Universidade de Coimbra Faculdade de Medicina

2015/01/01 - 2015/12/31

Modulação redox em neoplasias hematológicas - O NRF2 como novo marcador e alvo terapêutico

LPCC-NRC/CIMAGO 2015

Master Student Fellow

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2014/01/01 - 2018

The role of MicroRNAs for therapeutic selection in BCR-ABL+ Leukemias

Project 10/14

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012/01/01 - 2014/12/31

Caracterização Clínica e Molecular da Síndrome Mielodisplásica - Implicações no Prognóstico e Terapêutica

Project 24/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012/01/01 -

Characterization of Cellular and Molecular mechanisms involved in Sensitivity and Resistance to BCR-ABL targeted therapies in Chronic Myelogenous Leukemia

Project 18/12

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

Funders: Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

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