Mitocôndria
Microbioma
Imunidade Inata
Doenças Neurodegenerativas
Doenças Neuropsiquiátricas
O eixo intestino-cérebro na etiologia das doenças neurodegenerativas e neuropsiquiátricas
Sinalização da imunidade inata neuronal pela mitocôndria
O impacto da imunidade intestinal no cérebro
ASYN como uma proteína bacteriostática
miRNAs e ccf-mtDNA como novos mediadores do eixo intestino-cérebro
Vivemos num mundo onde se acumulam vários factores ambientais que favorecem o desenvolvimento de doenças neurodegenerativas e neuropsiquiátricas crónicas. Uma área de investigação de ponta envolve o eixo intestino-cérebro (GAin), no qual a comunicação bidirecional entre os sistemas nervoso entérico e central através do nervo vago se estende também às vias endócrinas, humorais, metabólicas e imunitárias. Investigações recentes indicam que um regulador-chave deste eixo é o microbiota intestinal, em particular a sua composição e metabolitos. Os principais objectivos do grupo GAin são a) validar um novo paradigma para a etiologia de doenças neurodegenerativas e neuropsiquiátricas na interface intestino-cérebro; b) estudar como mitocôndrias disfuncionais levam a respostas imunes desreguladas e qual o impacto no sistema nervoso central, tendo em conta a sua origem microbiana e os ecos de eventuais confrontos entre os seus antepassados evolutivos, as mitocôndrias; c) explorar como as células imunes intestinais se alteram após transplantes de microbioma e infecções bacterianas em ratinhos, e o seu impacto na função e desenvolvimento cerebral; d) elucidar o papel de proteínas como a ASYN, que são caraterísticas de doenças neurodegenerativas e e) compreender como os microRNAs (miRNAs) e o ADN mitocondrial livre de células circulantes (ccf-mtDNA) regulam a expressão genética, servindo como moléculas sinalizadoras ao longo do eixo intestino-cérebro e como potenciais biomarcadores para a deteção precoce e monitorização da progressão da disfunção do eixo intestino-cérebro em doenças neurodegenerativas e inflamatórias intestinais. Para atingir os nossos objectivos, são utilizados modelos como linhas celulares, ratinhos e tecido humano, bem como diferentes técnicas (citometria de fluxo, IHC/ICC, Seahorse, comportamento e outras) para compreender e caraterizar os mecanismos celulares e moleculares subjacentes às alterações cerebrais e para fornecer bases científicas para futuros estudos em humanos. O nosso grupo integra investigadores com formações complementares, tais como neurobiólogos, bioquímicos, farmacêuticos e neurologistas, permitindo uma perspetiva integrada mais aprofundada das questões científicas. Estamos também empenhados na formação de jovens estudantes altamente motivados, maioritariamente ao nível do doutoramento.
Informação sobre artigos em revista, actualizada a 26-01-2025, a partir da plataforma CIÊNCIAVITAE.
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2023. Gut. 73 - 89. 1. 72. 2023. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut
The neuromicrobiology of Parkinson’s disease: A unifying theory
Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, 2021. Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation
The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease
Cardoso, Sandra M.; Empadinhas, Nuno, 2018. Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .
Bacterial extracellular vesicles at the interface of gut microbiota and immunity
Cardoso, Sandra M.; Melo-Marques I; Empadinhas, Nuno, 2024. Gut Microbes. 16. 2024. in press Gut Microbes
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .
The mitochondrial cascade hypothesis for parkinson's disease
Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics
Functional mitochondria are required for amyloid beta-mediated neurotoxicity.
Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gut-first Parkinson’s disease is encoded by gut dysbiome
Muñoz-Pinto MFª; Pereira-Santos AR, 2024. Molecular Neurodegeneration. 1. 19. 2024. https://doi.org/10.1186/s13024-024-00766-0 . 10.1186/s13024-024-00766-0 . Molecular Neurodegeneration
5 11 de 11 Publicações em destaque
Informação sobre artigos em revista, actualizada a 26-01-2025, a partir da plataforma CIÊNCIAVITAE.
Exploiting the potential of rivastigmine-melatonin derivatives as multitarget metal-modulating drugs for neurodegenerative diseases
Dias I, 2025. Journal of Inorganic Biochemistry. 262. 2025. https://doi.org/10.1016/j.jinorgbio.2024.112734 . 10.1016/j.jinorgbio.2024.112734 . Journal of Inorganic Biochemistry
Gut-first Parkinson’s disease is encoded by gut dysbiome
Muñoz-Pinto MFª; Pereira-Santos AR, 2024. Molecular Neurodegeneration. 1. 19. 2024. https://doi.org/10.1186/s13024-024-00766-0 . 10.1186/s13024-024-00766-0 . Molecular Neurodegeneration
Nocardia cyriacigeorgica elicits gut disturbances in a leaky gut model of colitis, but not the harmful cascade leading to gut-first Parkinson’s Disease
Magalhães JD, 2024. International Journal of Molecular Sciences. 2024. https://doi.org/10.3390/ijms25063423 . 10.3390/ijms25063423 . International Journal of Molecular Sciences
Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease
Magalhães, João Duarte; Candeias, Emanuel; Melo-Marques, Inês; Abreu, António E.; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra Morais; Empadinhas, Nuno, 2024. International Journal of Molecular Sciences. 6. 25. 2024. http://dx.doi.org/10.3390/ijms25063423 . 10.3390/ijms25063423 . International Journal of Molecular Sciences
Neuronal control of microglia through the mitochondria
Pereira-Santos, A.R.; Candeias, Emanuel; Magalhães, J.D.; Empadinhas, Nuno; Esteves, A. Raquel; Cardoso, Sandra M., 2024. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2024. http://dx.doi.org/10.1016/j.bbadis.2024.167167 . 10.1016/j.bbadis.2024.167167 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Bacterial extracellular vesicles at the interface of gut microbiota and immunity
Cardoso, Sandra M.; Melo-Marques I; Empadinhas, Nuno, 2024. Gut Microbes. 16. 2024. in press Gut Microbes
The gut-brain axis in Alzheimer’s and Parkinson’s diseases: The catalytic role of mitochondria
Candeias E, 2024. Journal of Alzheimer's Disease. 413 - 429. 2. 100. 2024. https://doi.org/10.3233/jad-240524 . 10.3233/jad-240524 . Journal of Alzheimer's Disease
Gut-first Parkinson’s disease is encoded by gut dysbiome
Munoz-Pinto, Mário F.; Candeias, Emanuel; Melo-Marques, Inês; Esteves, A. Raquel; Maranha, Ana; Magalhães, João D.; Carneiro, Diogo Reis; et al, 2024. Molecular Neurodegeneration. 1. 19. 2024. http://dx.doi.org/10.1186/s13024-024-00766-0 . 10.1186/s13024-024-00766-0 . Molecular Neurodegeneration
Impact of Nutrition on Gut Microbiota: Implication to Parkinson’s Disease
Sobral, Joana; Esteves, Ana Raquel; Nuno Empadinhas; Sandra Morais Cardoso, 2024. Nutrition Reviews. 2024. Manuscript ID NUTR-REV-085-NR-02-2024 . accepted Nutrition Reviews
Neuronal control of microglia through the mitochondria
Pereira-Santos AR, 2024. BBA-Molecular Basis of Disease . 2024. accepted BBA-Molecular Basis of Disease
New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease
Leo Bon; Angelika Banas; Inês Dias; Inês Melo-Marques; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2024. Pharmaceutics. 2024. https://doi.org/10.3390/pharmaceutics16020281 . 10.3390/pharmaceutics16020281 . Pharmaceutics
The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease
Magalhães, João D.; Esteves, Ana Raquel; Candeias, Emanuel; Silva, Diana F.; Empadinhas, Nuno; Cardoso, Sandra Morais, 2023. International Journal of Molecular Sciences. 5. 24. 2023. http://dx.doi.org/10.3390/ijms24054339 . 10.3390/ijms24054339 . International Journal of Molecular Sciences
The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson's Disease
Guedes, Beatriz F. S.; Cardoso, Sandra Morais; Esteves, Ana Raquel, 2023. Biomedicines. 5. 11. 2023. http://dx.doi.org/10.3390/biomedicines11051349 . 10.3390/biomedicines11051349 . Biomedicines
Mitochondrial signaling on innate immunity activation in Parkinson disease
João D. Magalhães; Sandra Morais Cardoso, 2023. Current Opinion in Neurobiology. 2023. https://doi.org/10.1016/j.conb.2022.102664 . 10.1016/j.conb.2022.102664 . Current Opinion in Neurobiology
The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson’s Disease
Beatriz F. S. Guedes; Sandra Morais Cardoso; Ana Raquel Esteves, 2023. Biomedicines. 2023. https://doi.org/10.3390/biomedicines11051349 . 10.3390/biomedicines11051349 . Biomedicines
Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson’s disease
D. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Silva, Diana F.; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, 2023. Cellular and Molecular Life Sciences. 6. 80. 2023. http://dx.doi.org/10.1007/s00018-023-04819-3 . 10.1007/s00018-023-04819-3 . Cellular and Molecular Life Sciences
Parkinson's Disease: A Multisystem Disorder
Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, 2023. Neuroscience Bulletin. 113 - 124. 1. 39. 2023. http://dx.doi.org/10.1007/s12264-022-00934-6 . 10.1007/s12264-022-00934-6 . published Neuroscience Bulletin
LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease
A. Raquel Esteves; Diana F. Silva; Diogo Banha; Emanuel Candeias; Beatriz Guedes; Sandra M. Cardoso, 2023. Redox Biology. 2023. https://doi.org/10.1016/j.redox.2023.102714 . 10.1016/j.redox.2023.102714 . Redox Biology
LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease
Esteves, A. Raquel; Silva, Diana F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M., 2023. Redox Biology. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102714 . 10.1016/j.redox.2023.102714 . Redox Biology
Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson’s disease
João D. Magalhães; Emanuel Candeias; Inês Melo-Marques; Diana F. Silva; A. Raquel Esteves; Nuno Empadinhas; Sandra Morais Cardoso, 2023. Cellular and Molecular Life Sciences. 2023. https://doi.org/10.1007/s00018-023-04819-3 . 10.1007/s00018-023-04819-3 . Cellular and Molecular Life Sciences
Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease
Daniela Marinho; Ildete Luísa Ferreira; Ricardo Lorenzoni; Sandra M. Cardoso; Isabel Santana; A. Cristina Rego, 2023. Aging Cell. 2023. https://doi.org/10.1111/acel.13895 . 10.1111/acel.13895 . Aging Cell
Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases
David Vicente-Zurdo; Leonardo Brunetti; Luca Piemontese; Beatriz Guedes; Sandra M. Cardoso; Daniel Chavarria; Fernanda Borges; et al, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24098312 . 10.3390/ijms24098312 . International Journal of Molecular Sciences
The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease
João D. Magalhães; Ana Raquel Esteves; Emanuel Candeias; Diana F. Silva; Nuno Empadinhas; Sandra Morais Cardoso; João Duarte Magalhães, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24054339 . 10.3390/ijms24054339 . accepted International Journal of Molecular Sciences
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2023. Gut. 73 - 89. 1. 72. 2023. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut
Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel, 2022. Antioxidants. 11. 11. 2022. http://dx.doi.org/10.3390/antiox11112141 . 10.3390/antiox11112141 . Antioxidants
Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation
Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel, 2022. Antioxidants. 11. 11. 2022. http://dx.doi.org/10.3390/antiox11112141 . 10.3390/antiox11112141 . published Antioxidants
Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease
David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al, 2022. Biomedicines. 2022. https://doi.org/10.3390/biomedicines10071510 . 10.3390/biomedicines10071510 . Biomedicines
Parkinson's Disease: A Multisystem Disorder
Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, 2022. Neuroscience Bulletin. 2022. http://dx.doi.org/10.1007/s12264-022-00934-6 . 10.1007/s12264-022-00934-6 . Neuroscience Bulletin
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.
Cardoso SM, 2021. Biomolecules. 2021. https://europepmc.org/articles/PMC7830597 . 10.3390/biom11010111 . Biomolecules
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Cardoso SM, 2021. Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, 2021. Gut. gutjnl - 2021. 2021. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . Gut
Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease
Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., 2021. Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines
Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
João Duarte Magalhães; Lígia Fão; Rita Vilaça; Sandra Morais Cardoso; Ana Cristina Rego, 2021. Biomedicines. 2021. https://doi.org/10.3390/biomedicines9111625 . 10.3390/biomedicines9111625 . Biomedicines
The neuromicrobiology of Parkinson’s disease: A unifying theory
Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, 2021. Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews
The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease
Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno, 2021. Antioxidants & Redox Signaling. 694 - 711. 8. 34. 2021. http://dx.doi.org/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling
Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
Esteves, A. R.; Cardoso, S. M., 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-70174-z . 10.1038/s41598-020-70174-z . accepted Scientific Reports
THE MITORIBOSOME: A WORLD OF OPPORTUNITIES FOR MITOCHONDRIAL DYSFUNCTION TOWARD PARKINSON’S DISEASE
Gonçalves, A Mafalda; Pereira-Santos, A Raquel; Esteves, A. Raquel; Cardoso, Sandra Morais; Empadinhas, Nuno, 2020. Antioxidants & Redox Signaling. 2020. http://dx.doi.org/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . Journal of Neuroinflammation
Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients
Esteves, A. R.; Cardoso, S. M., 2020. Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-70174-z . 10.1038/s41598-020-70174-z . Scientific Reports
Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease
Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2020. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry
Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration
Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno, 2020. Frontiers in Aging Neuroscience. 12. 2020. http://dx.doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . Frontiers in Aging Neuroscience
Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization
Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, 2020. Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., 2020. Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation
Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease
Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al, 2020. Molecules. 4. 25. 2020. http://dx.doi.org/10.3390/molecules25040985 . 10.3390/molecules25040985 . Molecules
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology
Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology
Esteves, Ana; Andreia Palma; Rui Gomes; Daniel Santos; Diana Silva; Sandra Morais Cardoso, 2019. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019. published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Is Alzheimer’s disease an inflammasomopathy?
Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, 2019. Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews
The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease
Esteves, A. Raquel; Filipe, Filipa; Magalhães, João D.; Silva, Diana F.; Cardoso, Sandra M., 2019. Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos, 2019. Molecules. 2019. http://www.mdpi.com/1420-3049/24/3/587 . 10.3390/molecules24030587 . Molecules
The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease
A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso, 2019. Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. https://doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology
The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease
Cardoso, Sandra M.; Empadinhas, Nuno, 2018. Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology
Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.
Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA, 2018. Journal of inorganic biochemistry. 2018. http://europepmc.org/abstract/med/29182921 . 10.1016/j.jinorgbio.2017.11.015 . Journal of inorganic biochemistry
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry
Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy
Hiremathad, Asha; Chand, Karam; Tolayan, Lori; Rajeshwari; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2018. Journal of Inorganic Biochemistry. 82 - 96. 179. 2018. http://dx.doi.org/10.1016/j.jinorgbio.2017.11.015 . 10.1016/j.jinorgbio.2017.11.015 . Journal of Inorganic Biochemistry
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease
Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2018. European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry
Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.
2018. Molecular neurobiology. 2018. http://europepmc.org/abstract/med/28168426 . 10.1007/s12035-017-0420-y . Molecular neurobiology
Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug
Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, 2018. Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics
Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols
Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R., 2018. Neurotoxicity Research. 410 - 420. 2. 35. 2018. http://dx.doi.org/10.1007/s12640-018-9966-3 . 10.1007/s12640-018-9966-3 . Neurotoxicity Research
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease
Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, 2018. European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry
Effects of mild running on substantia nigra during early neurodegeneration.
Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al, 2017. Journal of sports sciences. 2017. http://europepmc.org/abstract/med/28895489 . 10.1080/02640414.2017.1378494 . Journal of sports sciences
Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease
Esteves, Ana R.; Arduíno, Daniela M.; Silva, Diana F.; Viana, Sofia D.; Pereira, Frederico C.; Cardoso, Sandra M., 2017. Molecular Neurobiology. 1440 - 1462. 2. 55. 2017. http://dx.doi.org/10.1007/s12035-017-0420-y . 10.1007/s12035-017-0420-y . Molecular Neurobiology
Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.
Cardoso SM, 2017. 2017. http://europepmc.org/abstract/med/27311773 .
Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates
Sandra Morais Cardoso, 2016. RSC Advances . 2016. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation . published RSC Advances
New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.
Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA, 2016. 2016. http://europepmc.org/abstract/med/26256122 . 10.1111/cbdd.12633 .
LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking
Esteves, A. Raquel; Cardoso, Sandra M., 2016. The Neuroscientist. 16 - 26. 1. 23. 2016. http://dx.doi.org/10.1177/1073858415616558 . 10.1177/1073858415616558 . The Neuroscientist
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al, 2016. 2016. http://europepmc.org/abstract/med/26799652 . 10.1080/15548627.2015.1100356 .
LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.
Esteves AR; Cardoso SM, 2016. 2016. http://europepmc.org/abstract/med/26740081 .
Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology
Silva, D. F.; Esteves, A. R.; Oliveira, C. R.; Cardoso, S. M., 2016. Molecular Neurobiology. 4021 - 4040. 6. 54. 2016. http://dx.doi.org/10.1007/s12035-016-9951-x . 10.1007/s12035-016-9951-x . Molecular Neurobiology
Special focus on autophagy.
Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25844484 . 10.1089/dna.2015.1501 .
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.
Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .
Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates
Sandra Morais Cardoso, 2015. Medicinal Chemical Communications. 2015. https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract . published Medicinal Chemical Communications
Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum
Sandra Morais Cardoso; Fonseca AC, 2015. Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.428 . 10.14800/ttnd.428 . Therapeutic Targets for Neurological Diseases
The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer’s disease
Fonseca, Ana Catarina R.G.; Resende, Rosa; Cardoso, Sandra M.; Pereira, Cláudia F., 2015. Endoplasmic Reticulum Stress in Diseases. 1. 2. 2015. http://dx.doi.org/10.1515/ersc-2015-0005 . 10.1515/ersc-2015-0005 . Endoplasmic Reticulum Stress in Diseases
LRRK2 a pivotal player in mitochondrial dynamics and lysosomal clustering: highlights to sporadic Parkinson’s disease
Ana Raquel Fernandes Esteves, 2015. Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.629 . 10.14800/ttnd.629 . published Therapeutic Targets for Neurological Diseases
The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.
Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M., 2014. Experimental Neurology. 206 - 216. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology
Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells
Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS . 10.1016/j.bbamcr.2014.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
Esteves, A. Raquel; Swerdlow, Russell H.; Cardoso, Sandra M., 2014. Experimental Neurology. 206 - 216. 261. 2014. http://dx.doi.org/10.1016/j.expneurol.2014.05.025 . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology
The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson’s Disease
Santos, Daniel; Esteves, A. Raquel; Silva, Diana F.; Januário, Cristina; Cardoso, Sandra M., 2014. Molecular Neurobiology. 573 - 586. 1. 52. 2014. http://dx.doi.org/10.1007/s12035-014-8893-4 . 10.1007/s12035-014-8893-4 . Molecular Neurobiology
The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm
Esteves, A. R.; G-Fernandes, M.; Santos, D.; Januário, C.; Cardoso, S. M., 2014. Molecular Neurobiology. 1804 - 1820. 3. 52. 2014. http://dx.doi.org/10.1007/s12035-014-8980-6 . 10.1007/s12035-014-8980-6 . Molecular Neurobiology
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells
Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., 2014. Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology
The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease
Esteves, A.R.; Gozes, I.; Cardoso, S.M., 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, 2014. Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease
Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2013. Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research
Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines
Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al, 2013. Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS . 10.1093/hmg/ddt247 . Human Molecular Genetics
Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells
Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., 2013. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease
Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., 2013. Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease
Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., 2013. Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry
Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2013. Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy
Multifunctional iron-chelators with protective roles against neurodegenerative diseases
Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A., 2013. Dalton Transactions. 6058 - 6073. 17. 42. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS . 10.1039/c3dt50406a . Dalton Transactions
Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease
Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2013. Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research
Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2013. Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy
Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?
Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., 2012. Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology
Guidelines for the use and interpretation of assays for monitoring autophagy
Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, 2012. Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy
Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?
Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., 2012. Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology
Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a
Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., 2012. Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease
Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease
Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., 2012. Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics
Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions
Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2012. Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging
Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease
Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., 2012. Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases
Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic
Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2012. Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics
Mitochondrial dynamics and neuronal fate in Parkinson's disease
Santos, D.; Cardoso, S.M., 2012. Mitochondrion. 428 - 437. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS . 10.1016/j.mito.2012.05.002 . Mitochondrion
Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD
Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease
Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases
Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., 2011. Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design
Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease
Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors
Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A., 2011. Journal of Enzyme Inhibition and Medicinal Chemistry. 485 - 497. 4. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS . 10.3109/14756366.2010.529806 . Journal of Enzyme Inhibition and Medicinal Chemistry
Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway
Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2011. Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease
Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease
Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2011. Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research
Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease
Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2011. Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research
Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway
Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., 2011. Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease
SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization
Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, 2011. Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell
The mitochondrial cascade hypothesis for parkinson's disease
Cardoso, S.M., 2011. Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design
Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases
Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., 2011. Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design
Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease
Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD
Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., 2011. Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease
Cross-talk between mitochondria and proteasome in Parkinson’s disease pathogenesis
Branco, Diogo Martins, 2010. Frontiers in Aging Neuroscience. 2010. http://dx.doi.org/10.3389/fnagi.2010.00017 . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience
Microtubule depolymerization potentiates alpha-synuclein oligomerization
Esteves, A. Raquel, 2010. Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience
Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer
Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, 2010. Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry
Mitochondrial-dependent apoptosis in Huntington's disease human cybrids
Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, 2010. Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology
Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2010. Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease
Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis
Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R., 2010. Frontiers in Aging Neuroscience. MAY. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience
ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria
Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2010. Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease
Microtubule depolymerization potentiates alpha-synuclein oligomerization
Esteves, A. Raquel, 2010. Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience
Polymorphic variation in cytochrome oxidase subunit genes
Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, 2010. Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease
Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2010. Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer
Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, 2010. Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry
Polymorphic Variation in Cytochrome Oxidase Subunit Genes
Lu, Jianghua; Wang, Kaixuan; Rodova, Mariana; Esteves, Raquel; Berry, Diana; E, Lezi; Crafter, Adam; et al, 2010. Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://dx.doi.org/10.3233/jad-2010-100123 . 10.3233/jad-2010-100123 . Journal of Alzheimer's Disease
Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2010. CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets
Polymorphic variation in cytochrome oxidase subunit genes
Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, 2010. Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease
Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., 2010. CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets
Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease
Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., 2010. Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells
Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports
Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2009. Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling
Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids
Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2009. Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling
ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells
Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., 2009. BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., 2009. Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International
Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease
Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., 2009. Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International
Mitochondria as a therapeutic target in Alzheimer's disease and diabetes
Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., 2009. CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets
Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells
Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research
Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease
Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine
Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background
Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Mitochondrion. 219 - 228. 3. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS . 10.1016/j.mito.2008.03.004 . Mitochondrion
Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells
Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research
Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126
Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., 2008. Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry
Mitochondrial function in Parkinson’s disease cybrids containing an nt2 neuron-like nuclear background
Esteves, A. Raquel F.; Domingues, A. Filipa; Ferreira, I. Luísa; Januário, Cristina; Swerdlow, Russell H.; Oliveira, Catarina R.; Cardoso, Sandra M., 2008. Mitochondrion. 219 - 228. 3. 8. 2008. http://dx.doi.org/10.1016/j.mito.2008.03.004 . 10.1016/j.mito.2008.03.004 . Mitochondrion
New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs
Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A., 2008. Frontiers in Bioscience. 6763 - 6774. 17. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS . Frontiers in Bioscience
Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease
Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., 2008. Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine
Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine
Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., 2006. Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research
The key role of mitochondria in Alzheimer's disease
Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., 2006. Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease
Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity
Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., 2005. Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research
Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies
Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.; Moreira, P.; Cardoso, S.; Oliveira, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders
The role of calcineurin in amyloid-ß-peptides-mediated cell death
Cardoso, S.M.; Oliveira, C.R., 2005. Brain Research. 1 - 7. 1-2. 1050. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS . 10.1016/j.brainres.2005.04.078 . Brain Research
Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies
Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C., 2005. Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders
Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity
Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R., 2004. Journal of Neurochemistry. 1417 - 1426. 6. 89. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02438.x . Journal of Neurochemistry
Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells
Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., 2004. Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International
Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease
Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende; Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., 2004. Journal of Molecular Neuroscience. 097 - 104. 1-2. 23. 2004. http://dx.doi.org/10.1385/jmn:23:1-2:097 . 10.1385/jmn:23:1-2:097 . Journal of Molecular Neuroscience
Cytochrome c oxidase is decreased in Alzheimer's disease platelets
Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R., 2004. Neurobiology of Aging. 105 - 110. 1. 25. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS . 10.1016/S0197-4580(03)00033-2 . Neurobiology of Aging
Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides
Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 967 - 973. 9. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS . 10.1080/10715760310001595757 . Free Radical Research
Glutathione cycle impairment mediates Aß-induced cell toxicity
Cardoso, S.M.; Oliveira, C.R., 2003. Free Radical Research. 241 - 250. 3. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS . 10.1080/1071576021000041023 . Free Radical Research
Induction of cytocrome c-mediated apoptosis by amyloid beta 25-35 requires functional mitochondria
Sandra M Cardoso, 2002. Brain Research. 2002. Brain Research
Functional mitochondria are required for amyloid beta-mediated neurotoxicity.
Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., 2001. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mitochondrial function is differentially affected upon oxidative stress
Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1999. Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine
The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes
Cardoso, S.M.; Pereira, C.; Oliveira, C.R., 1998. Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications
Contribuição para o estudo do metabolismo da amiodarona: variação da concentração do iodo em diferentes orgãos dos ratinhos, após administração intraperitonial do fármaco.
Cardoso SM, 1994. Coimbra Médica. 15. 1994. Coimbra Médica
5 165 de 165 Publicações
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O Eixo Intestino-Sistema Imune-Cérebro na Doença de Parkinson
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Microbiome-miRNAs axis in Parkinson’s disease: involvement of mitochondria mediated inflammatory response
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O papel dos mecanismos de controlo de qualidade da perda de homeostasia proteica em doenças neurodegenerativas associadas à idade
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Prémio Santa Casa Neurociências Mantero Belard, Santa Casa da Misericórdia de Lisboa
Prémio Janssen Neuroscience, Janssen Pharmaceutics
Distinção com Medalha de Prata de reconhecimento em Investigação Científica pelo Ministro da Saúde português
Prémio Pfizer de Investigação Básica
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