The role of platelets in diagnosis, prognosis, and therapeutic monitoring in diffuse large b-cell lymphoma

Overview

Project Summary

Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous B-cell neoplasm that represents the most common aggressive non-Hodgkin's lymphoma in adults. The European Society for Medical Oncology (ESMO) recommends post-treatment follow-up, but the current diagnosis is made through lymph node biopsy, an invasive procedure that poses challenges. New non-invasive methods, including liquid biopsies, are promising for detecting tumour biomarkers. Tumour-educated platelets (TEPs) present an alternative source of tumour material with clinical potential, as they exhibit altered function and RNA profiles that can distinguish cancer patients with high accuracy.

Main Goals

The main objective of this project is to develop an RNA signature based on TEPs as an alternative non-invasive method for the diagnosis, prognosis and monitoring of patients with DLBCL.

Project Details