Reprogramação Celular
Epigenética
Células Estaminal Hematopoiética
Célula Dendrítica
Imunoterapia
Indução de Tipos Celulares para a Medicina Regenerativa: Programação dos Tipos Celulares do Sangue
Programação, Reprogramação e Biologia do Desenvolvimento
Desenvolvimento de Novas Terapias
O objetivo do nosso laboratório é compreender os determinantes moleculares subjacentes à reprogramação celular e à especificação hematopoiética. Nos seres humanos, os múltiplos estados celulares diferenciados são normalmente estáveis e herdados através da divisão celular. Em determinadas condições, o destino das células pode, no entanto, ser modificado ou invertido. A reprogramação celular pode ser obtida experimentalmente de diferentes formas, incluindo a transferência nuclear, a fusão celular ou a expressão de factores de transcrição. A capacidade emergente de reprogramar diretamente células somáticas em tipos de células hematopoiéticas desejadas está a abrir caminhos para a descoberta de novas terapias para doenças imunitárias e do sangue. A nossa abordagem centra-se nas células estaminais hematopoiéticas (HSCs), pelo seu notável potencial regenerativo, e nas células dendríticas (DCs), como mediadores-chave da imunidade.
Objetivos:
A nossa investigação aumentará a compreensão dos determinantes intrínsecos subjacentes à especificação do desenvolvimento de células hematopoiéticas progenitoras e efectoras. Este conhecimento pode permitir a recriação destas identidades celulares únicas a partir de qualquer célula humana. Em última análise, acreditamos que a nossa investigação contribuirá para a regeneração hematopoiética personalizada através da utilização de HSCs humanas programadas para o transplante de células específicas do doente. Além disso, a reprogramação das CD permite-nos desenvolver novas formas de modular a resposta imunitária. Isto representa uma oportunidade única para fundir o campo da reprogramação celular e da imunoterapia do cancro e pode resultar no desenvolvimento de novas e poderosas terapêuticas para o cancro e outras doenças resultantes de um sistema imunitário disfuncional.
Informação sobre artigos em revista, actualizada a 03-11-2024, a partir da plataforma CIÊNCIAVITAE.
High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells
Diana Pádua; Paula Figueira; Mariana Pinto; André Filipe Maia; Joana Peixoto; Raquel T. Lima; António Pombinho; et al, 2023. Cancers. 15. 2023. 10.3390/cancers15174406 . Cancers
GATA2 mitotic bookmarking is required for definitive haematopoiesis
Rita Silvério-Alves; Ilia Kurochkin; Anna Rydström; Camila Vazquez Echegaray; Jakob Haider; Matthew Nicholls; Christina Rode; et al, 2023. Nature Communications. 4645. 14. 2023. https://www.nature.com/articles/s41467-023-40391-x . 10.1038/s41467-023-40391-x . Nature Communications
Restoring tumor immunogenicity with dendritic cell reprogramming
Olga Zimmermannova; Alexandra G. Ferreira; Ervin Ascic; Marta Velasco Santiago; Ilia Kurochkin; Morten Hansen; Özcan Met; et al, 2023. Science Immunology. 85. 8. 2023. 10.1126/sciimmunol.add4817 . Science Immunology
Reprogramming Cancer Cells to Antigen-presenting Cells
Alexandra G Ferreira; Olga Zimmermannova; Ilia Kurochkin; Ervin Ascic; Fritiof Åkerström; Pereira, Carlos-Filipe, 2023. Bio-Protocol. 2023. Bio-Protocol
Orchestrating an immune response to cancer with cellular reprogramming
Olga Zimmermannova; Alexandra Gabriela Ferreira ; Pereira, Carlos-Filipe, 2023. Genes & Immunity. 2023. Genes & Immunity
Reprogramming Stars #10: Modeling Cancer with Cellular Reprogramming - An Interview with Dr. Dung-Fang Lee
Lee, D.-F.; Pereira, C.-F., 2023. Cellular Reprogramming. 2 - 6. 1. 25. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85148250551&partnerID=MN8TOARS . 10.1089/cell.2023.29081.dfl . Cellular Reprogramming
Reprogramming Stars #5: Regeneration, a Natural Reprogramming Process—An Interview with Dr. Nicholas Leigh
Leigh, Nicholas D.; Pereira, Carlos-Filipe, 2022. Cellular Reprogramming. 2 - 8. 1. 24. 2022. http://dx.doi.org/10.1089/cell.2022.29055.nl . 10.1089/cell.2022.29055.nl . Cellular Reprogramming
Reprogramming Stars #6: A Venture Based in Cellular Reprogramming-An Interview with Dr. Cristiana Pires
Pires, C.F.; Pereira, C.-F., 2022. Cellular Reprogramming. 57 - 62. 2. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127473849&partnerID=MN8TOARS . 10.1089/cell.2022.29061.cp . Cellular Reprogramming
Reprogramming Stars #8: A Synthetic Biology Approach to Cellular Reprogramming - An Interview with Dr. Katie Galloway
Galloway, K.E.; Pereira, C.-F., 2022. Cellular Reprogramming. 151 - 162. 4. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136909415&partnerID=MN8TOARS . 10.1089/cell.2022.29068.kg . Cellular Reprogramming
Reprogramming Stars #9: Spacing Out Cellular Reprogramming - An Interview with Dr. Valentina Fossati
Fossati, V.; Pereira, C.-F., 2022. Cellular Reprogramming. 107. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584650&partnerID=MN8TOARS . 10.1089/cell.2022.29074.vf . Cellular Reprogramming
Call for Special Issue Papers: Cellular Reprogramming 25th Anniversary Deadline for Manuscript Submission: April 30, 2023
Pereira, C.-F., 2022. Cellular reprogramming. 315 - 316. 6. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584647&partnerID=MN8TOARS . 10.1089/cell.2022.29073.cfp . Cellular reprogramming
Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells
Rosa, F.F.; Pires, C.F.; Kurochkin, I.; Halitzki, E.; Zahan, T.; Arh, N.; Zimmermannová, O.; et al, 2022. Science immunology. eabg5539 - eabg5539. 69. 7. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125875360&partnerID=MN8TOARS . 10.1126/sciimmunol.abg5539 . Science immunology
Reprogramming Stars #7: Dynamic Pluripotent Stem Cell States and Their Applications-An Interview with Dr. Jun Wu
Wu, J.; Pereira, C.-F.; Lu, Y.R., 2022. Cellular Reprogramming. 105 - 110. 3. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85132269580&partnerID=MN8TOARS . 10.1089/cell.2022.29064.jc . Cellular Reprogramming
Reprogramming Stars #4: A Reprogramming Approach for Parkinson's Disease—An Interview with Dr. Malin Parmar
Parmar, Malin; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 319 - 325. 6. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29049.mp . 10.1089/cell.2021.29049.mp . Cellular Reprogramming
Ontogenic Shifts in Cellular Fate are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells
Pereira, Carlos-Filipe, 2021. Cell Reports. 2021. in press Cell Reports
Reprogramming Stars #1: Genome Programming Through the Cell Cycle—An Interview with Dr. Tomomi Tsubouchi
Tsubouchi, Tomomi; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 153 - 157. 3. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29039.tt . 10.1089/cell.2021.29039.tt . Cellular Reprogramming
Reprogramming Stars #2: Reprogramming Towards Neural Lineages—An Interview with Dr. Henrik Ahlenius
Ahlenius, Henrik; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 200 - 205. 4. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29044.ha . 10.1089/cell.2021.29044.ha . Cellular Reprogramming
Reprogramming Stars #3: Mechanisms of iPSC Reprogramming—An Interview with Dr. Keisuke Kaji
Kaji, Keisuke; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 264 - 269. 5. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29046.kk . 10.1089/cell.2021.29046.kk . Cellular Reprogramming
Cell Fate Reprogramming in the Era of Cancer Immunotherapy
Zimmermannova, Olga; Caiado, Inês; Ferreira, Alexandra G.; Pereira, Carlos-Filipe, 2021. Frontiers in Immunology. 12. 2021. http://dx.doi.org/10.3389/fimmu.2021.714822 . 10.3389/fimmu.2021.714822 . Frontiers in Immunology
Reprogramming, The Journal
Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 2021. http://dx.doi.org/10.1089/cell.2021.0036 . 10.1089/cell.2021.0036 . Cellular Reprogramming
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia, 2021. Current Oncology. 56 - 67. 1. 29. 2021. http://dx.doi.org/10.3390/curroncol29010005 . 10.3390/curroncol29010005 . Current Oncology
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, 2020. Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers
Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors
Rosa, Fábio; Pires, Cristiana; Zimmermannova, Olga; Pereira, Carlos-Filipe, 2020. BIO-PROTOCOL. 10. 10. 2020. http://dx.doi.org/10.21769/bioprotoc.3619 . 10.21769/bioprotoc.3619 . BIO-PROTOCOL
Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease
Ulmert, Isabel; Henriques-Oliveira, Luís; Pereira, Carlos-Filipe; Lahl, Katharina, 2020. Immunology. 303 - 313. 4. 161. 2020. http://dx.doi.org/10.1111/imm.13249 . 10.1111/imm.13249 . Immunology
Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture
Daniel, M.G.; Sachs, D.; Bernitz, J.M.; Fstkchyan, Y.; Rapp, K.; Satija, N.; Law, K.; et al, 2019. FEBS Letters. 3266 - 3287. 23. 593. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074051202&partnerID=MN8TOARS . 10.1002/1873-3468.13621 . FEBS Letters
Understanding and Modulating Immunity With Cell Reprogramming
Pires, C.F.; Rosa, F.F.; Kurochkin, I.; Pereira, C.-F., 2019. Frontiers in Immunology. 10. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077260284&partnerID=MN8TOARS . 10.3389/fimmu.2019.02809 . Frontiers in Immunology
Is immunotherapy the holy grail for pancreatic cancer?
Andersson, R.; Pereira, C.-F.; Bauden, M.; Ansari, D., 2019. Immunotherapy. 1435 - 1438. 17. 11. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076450369&partnerID=MN8TOARS . 10.2217/imt-2019-0164 . Immunotherapy
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Silvério-Alves, R.; Gomes, A.M.; Kurochkin, I.; Moore, K.A.; Pereira, C.-F., 2019. Journal of visualized experiments : JoVE. 153. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075191300&partnerID=MN8TOARS . 10.3791/60112 . Journal of visualized experiments : JoVE
Direct reprogramming of fibroblasts into antigen-presenting dendritic cells
Rosa, Fabio F.; Pires, Cristiana F.; Kurochkin, Ilia; Ferreira, Alexandra G.; Gomes, Andreia M.; Palma, Luis G.; Shaiv, Kritika; et al, 2018. Science Immunology. 30. 3. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452571800002&KeyUID=WOS:000452571800002 . 10.1126/sciimmunol.aau4292 . Science Immunology
Ihor R. Lemischka (1953-2017)
Ivanova, Natalia; Pereira, Carlos-Filipe; Lee, Dung-Fang, 2018. Cell Stem Cell. 16 - +. 1. 22. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419306500008&KeyUID=WOS:000419306500008 . 10.1016/j.stem.2017.12.015 . Cell Stem Cell
Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Gomes, Andreia M.; Kurochkin, Ilia; Chang, Betty; Daniel, Michael; Law, Kenneth; Satija, Namita; Lachmann, Alexander; et al, 2018. Cell Reports. 2821 - +. 10. 25. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452894600018&KeyUID=WOS:000452894600018 . 10.1016/j.celrep.2018.11.032 . Cell Reports
INDUCTION OF HEMOGENIC REPROGRAMMING IN HUMAN FIBROBLASTS
Gomes, A.; Pereira, C. -F.; Chang, B.; Kurochkin, I.; Daniel, M.; Law, K.; Satija, N.; et al, 2017. Haematologica. 102. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000404127006340&KeyUID=WOS:000404127006340 . Haematologica
Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate
Freire, A.G.; Waghray, A.; Soares-da-Silva, F.; Resende, T.P.; Lee, D.-F.; Pereira, C.-F.; Nascimento, D.S.; Lemischka, I.R.; Pinto-do-Ó, P., 2017. Stem Cell Reports. 136 - 148. 1. 9. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021126795&partnerID=MN8TOARS . 10.1016/j.stemcr.2017.05.025 . Stem Cell Reports
High-throughput identification of small molecules that affect human embryonic vascular development
Vazão, H.; Rosa, S.; Barata, T.; Costa, R.; Pitrez, P.R.; Honório, I.; De Vries, M.R.; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. E3022 - E3031. 15. 114. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035214278&partnerID=MN8TOARS . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America
MECHANISMS UNDERLYING HUMAN HEMOGENIC REPROGRAMMING
Gomes, Andreia; Pereira, Carlos-Filipe; Papatsenko, Dmitri; Moore, Kateri Ann; Lemischka, Ihor, 2016. Experimental Hematology. S75 - S76. 9. 44. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600129&KeyUID=WOS:000382184600129 . 10.1016/j.exphem.2016.06.144 . Experimental Hematology
The stem cell niche finds its true north
Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira, 2016. Development. 2877 - 2881. 16. 143. 2016. https://doi.org/10.1242/dev.140095 . 10.1242/dev.140095 . Development
ZERO FOOTPRINT INDUCTION OF HUMAN HEMOGENESIS TO STUDY PATHOLOGIC DEVELOPMENTAL HEMATOPOIESIS IN FANCONI ANEMIA
Daniel, Michael; Fstkchyan, Yesai; Gomes, Andreia; Pereira, Carlos-Filipe; Lemischka, Ihor; Moore, Kateri Ann, 2016. Experimental Hematology. S65 - S65. 9. 44. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600098&KeyUID=WOS:000382184600098 . 10.1016/j.exphem.2016.06.112 . Experimental Hematology
Reprogramming mouse embryonic fibroblasts with transcription factors to induce a hemogenic program
Daniel, M.G.; Pereira, C.-F.; Bernitz, J.M.; Lemischka, I.R.; Moore, K., 2016. Journal of Visualized Experiments. 118. 2016. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015946426&partnerID=MN8TOARS . 10.3791/54372 . Journal of Visualized Experiments
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells
Pereira, C.-F.; Chang, B.; Gomes, A.; Bernitz, J.; Papatsenko, D.; Niu, X.; Swiers, G.; et al, 2016. Developmental Cell. 525 - 539. 5. 36. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959312876&partnerID=MN8TOARS . 10.1016/j.devcel.2016.02.011 . Developmental Cell
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm
Waghray, A.; Saiz, N.; Jayaprakash, A.D.; Freire, A.G.; Papatsenko, D.; Pereira, C.-F.; Lee, D.-F.; et al, 2015. Stem Cell Reports. 97 - 110. 1. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937523983&partnerID=MN8TOARS . 10.1016/j.stemcr.2015.05.009 . Stem Cell Reports
Making a Hematopoietic Stem Cell.
Daniel MG; Pereira CF; Lemischka IR; Moore KA, 2015. 2015. http://europepmc.org/abstract/med/26526106 . 10.1016/j.tcb.2015.10.002 .
DIRECT CONVERSION FROM MOUSE FIBROBLASTS INFORMS THE IDENTIFICATION OF HEMOGENIC PRECURSOR CELLS IN VIVO
Pereira, Carlos-Filipe; Chang, Betty; Niu, Xiaohong; Gomes, Andreia; Swiers, Gemma; Azzoni, Emanuele; Schaniel, Christoph; et al, 2014. Experimental Hematology. S55 - S55. 8. 42. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340344300196&KeyUID=WOS:000340344300196 . Experimental Hematology
"There will be blood" from fibroblasts
Pereira, C.-F.; Lemischka, I.R.; Moore, K., 2014. Cell Cycle. 335 - 336. 3. 13. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896884486&partnerID=MN8TOARS . 10.4161/cc.27507 . Cell Cycle
'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells
Pereira, C.-F.; Lemischka, I.R.; Moore, K., 2014. EMBO Journal. 1511 - 1513. 14. 33. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904561142&partnerID=MN8TOARS . 10.15252/embj.201488980 . EMBO Journal
Induction of a hemogenic program in mouse fibroblasts.
Pereira, Carlos-Filipe; Chang, Betty; Qiu, Jiajing; Niu, Xiaohong; Papatsenko, Dmitri; Hendry, Caroline E; Clark, Neil R; et al, 2013. Cell stem cell. 205 - 18. 2. 13. 2013. 10.1016/j.stem.2013.05.024 . Cell stem cell
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
Fidalgo, Miguel; Faiola, Francesco; Pereira, Carlos-Filipe; Ding, Junjun; Saunders, Arven; Gingold, Julian; Schaniel, Christoph; et al, 2012. Proceedings of the National Academy of Sciences of the United States of America. 16202 - 16207. 40. 109. 2012. 10.1073/pnas.1208533109 . Proceedings of the National Academy of Sciences of the United States of America
Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; Carvajal-Vergara, Xonia; Mulero-Navarro, Sonia; Pereira, Carlos F.; Gingold, Julian; et al, 2012. Cell Stem Cell. 179 - 194. 2. 11. 2012. 10.1016/j.stem.2012.05.020 . Cell Stem Cell
Using heterokaryons to understand pluripotency and reprogramming
Piccolo, Francesco M.; Pereira, Carlos F.; Cantone, Irene; Brown, Karen; Tsubouchi, Tomomi; Soza-Ried, Jorge; Merkenschlager, Matthias; Fisher, Amanda G., 2011. Philosophical Transactions of the Royal Society B-Biological Sciences. 2260 - 2265. 1575. 366. 2011. 10.1098/rstb.2011.0004 . Philosophical Transactions of the Royal Society B-Biological Sciences
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
Kanhere, Aditi; Viiri, Keijo; Araujo, Carla C.; Rasaiyaah, Jane; Bouwman, Russell D.; Whyte, Warren A.; Pereira, C. Filipe; et al, 2010. Molecular Cell. 675 - 688. 5. 38. 2010. 10.1016/j.molcel.2010.03.019 . Molecular Cell
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Pereira, Carlos F.; Piccolo, Francesco M.; Tsubouchi, Tomomi; Sauer, Stephan; Ryan, Natalie K.; Bruno, Ludovica; Landeira, David; et al, 2010. Cell Stem Cell. 547 - 556. 6. 6. 2010. 10.1016/j.stem.2010.04.013 . Cell Stem Cell
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
Landeira, David; Sauer, Stephan; Poot, Raymond; Dvorkina, Maria; Mazzarella, Luca; Jorgensen, Helle F.; Pereira, C. Filipe; et al, 2010. Nature Cell Biology. 618 - U214. 6. 12. 2010. 10.1038/ncb2065 . Nature Cell Biology
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Schnetz, M.P.; Handoko, L.; Akhtar-Zaidi, B.; Bartels, C.F.; Pereira, C.F.; Fisher, A.G.; Adams, D.J.; et al, 2010. PLoS genetics. 7. 6. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952538205&partnerID=MN8TOARS . PLoS genetics
Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo
Santos, Joana; Pereira, C. Filipe; Di-Gregorio, Aida; Spruce, Thomas; Alder, Olivia; Rodriguez, Tristan; Azuara, Veronique; Merkenschlager, Matthias; Fisher, Amanda G., 2010. Epigenetics & Chromatin. 3. 2010. 10.1186/1756-8935-3-1 . Epigenetics & Chromatin
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression
Savarese, Fabio; Davila, Amparo; Nechanitzky, Robert; De La Rosa-Velazquez, Inti; Pereira, Carlos F.; Engelke, Rudolf; Takahashi, Keiko; et al, 2009. Genes & Development. 2625 - 2638. 22. 23. 2009. 10.1101/gad.1815709 . Genes & Development
Heterokaryon-based reprogramming for pluripotency
Pereira, C.F.; Fisher, A.G., 2009. Current Protocols in Stem Cell Biology. SUPPL. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65149087887&partnerID=MN8TOARS . 10.1002/9780470151808.sc04b01s9 . Current Protocols in Stem Cell Biology
Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8(+) T Cell Differentiation
Correia, Margareta P.; Cardoso, Elsa M.; Pereira, Carlos F.; Neves, Rui; Uhrberg, Markus; Arosa, Fernando A., 2009. Journal of Immunology. 6149 - 6159. 10. 182. 2009. 10.4049/jimmunol.0802470 . Journal of Immunology
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, Ana; Rashid, Sheikh T.; Acosta, Juan Carlos; Li, SiDe; Pereira, Carlos F.; Geti, Imbisaat; Pinho, Sandra; et al, 2009. Genes & Development. 2134 - 2139. 18. 23. 2009. 10.1101/gad.1811609 . Genes & Development
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells
Jorgensen, Helle F.; Terry, Anna; Beretta, Chiara; Pereira, C. Filipe; Leleu, Marion; Chen, Zhou-Feng; Kelly, Claire; Merkenschlager, Matthias; Fisher, Amanda G., 2009. Development. 715 - 721. 5. 136. 2009. 10.1242/dev.028548 . Development
Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2
Pereira, Carlos F.; Terranova, Remi; Ryan, Natalie K.; Santos, Joana; Morris, Kelly J.; Cui, Wei; Merkenschlager, Matthias; Fisher, Amanda G., 2008. Plos Genetics. 9. 4. 2008. 10.1371/journal.pgen.1000170 . Plos Genetics
Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2
Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M., 2008. Journal of Immunology. 988 - 997. 2. 180. 2008. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252290000036&KeyUID=WOS:000252290000036 . 10.4049/jimmunol.180.2.988 . Journal of Immunology
Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming
Terranova, R.; Pereira, C. F.; Du Roure, C.; Merkenschlager, M.; Fisher, A. G., 2006. Journal of Cell Science. 2065 - 2072. 10. 119. 2006. 10.1242/jcs.02945 . Journal of Cell Science
Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading
Cabrita, M.; Pereira, C. F.; Rodrigues, P.; Cardoso, E. M.; Arosa, F. A., 2005. Febs Journal. 152 - 165. 1. 272. 2005. 10.1111/j.1432-1033.2004.04387.x . Febs Journal
Red blood cells as modulators of T cell growth and survival
Arosa, F. A.; Pereira, C. F.; Fonseca, A. M., 2004. Current Pharmaceutical Design. 191 - 201. 2. 10. 2004. 10.2174/1381612043453432 . Current Pharmaceutical Design
Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress
Fonseca, A.M.; Pereira, C.F.; Porto, G.; Arosa, F.A., 2003. Free Radical Biology and Medicine. 1404 - 1416. 11. 35. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875071&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2003.08.011 . Free Radical Biology and Medicine
Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds
Fonseca, A. M.; Pereira, C. F.; Porto, G.; Arosa, F. A.; Fonseca, A.M.; Pereira, C.F.; Arosa, F.A., 2003. Cellular Immunology. 17 - 28. 1. 224. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142169441&partnerID=MN8TOARS . 10.1016/s0008-8749(03)00170-9 . Cellular Immunology
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Reprogramação de células em células hemogénicas e/ou células estaminais hematopoiéticas
Métodos para reprogramar células estaminais ou células diferenciadas em células hemogénicas e/ou células estaminais hematopoiéticas através da expressão de factores de transcrição num vetor policistrónico. Tratamento ou diagnóstico de doenças do sangue, cancro (especialmente tumores hematológicos) ou doenças infecciosas.
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