Pedro P. Cunha

Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses

David Bargiela; Pedro P. Cunha; Pedro Veliça; Iosifina P. Foskolou; Laura Barbieri; Helene Rundqvist; Randall S. Johnson, Frontiers in Immunology. 13. 2022. http://dx.doi.org/10.3389/fimmu.2022.837669 . 10.3389/fimmu.2022.837669 . Frontiers in Immunology

Infiltration of tumors is regulated by T cell-intrinsic nitric oxide synthesis

Pedro P. Cunha; David Bargiela; Eleanor Minogue; Lena C.M. Krause; Laura Barbieri; Carolin Brombach; Milos Gojkovic; et al, Cancer Immunology Research. 2022. https://doi.org/10.1158/2326-6066.CIR-22-0387 . 10.1158/2326-6066.CIR-22-0387 . Cancer Immunology Research

The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

Foskolou, I. P.; Cunha, P. P.; Minogue, E.; Nicolet, B.; Guislain, A.; Jorgensen, C.; Zandhuis, N. D.; et al, BioRxiv. 2022. https://publons.com/wos-op/publon/58339254/ . 10.1101/2022.08.18.504372 . BioRxiv

Lactate regulation of activation in CD8+ T cells

Barbieri, L.; Velica, P.; Gameiro, P. A.; Cunha, P. P.; Foskolou, I. P.; Bargiela, D.; Rundqvist, H.; Johnson, Randall S., BioRxiv. 2021. https://publons.com/wos-op/publon/58339252/ . 10.1101/2021.12.14.472728 . BioRxiv

Differentiation of glioblastoma stem cells promoted by miR-128 or miR-302a overexpression enhances senescence-associated cytotoxicity of axitinib

Cardoso, A.M.; Morais, C.M.; Pena, F.; Marante, T.; Cunha, P.P.; Jurado, A.S.; Pedroso de Lima, M.C., Human Molecular Genetics. 160 - 171. 3-4. 30. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106069155&partnerID=MN8TOARS . 10.1093/hmg/ddab011 . Human Molecular Genetics

Modified hypoxia-inducible factor expression in CD8^þ T cells increases antitumor efficacy

Veliça, P.; Cunha, P.P.; Vojnovic, N.; Foskolou, I.P.; Bargiela, D.; Gojkovic, M.; Rundqvist, H.; Johnson, R.S., Cancer Immunology Research. 401 - 414. 4. 9. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104428121&partnerID=MN8TOARS . 10.1158/2326-6066.CIR-20-0561 . Cancer Immunology Research

Oxygen regulation of TET enzymes

Matuleviciute, R.; Cunha, P.P.; Johnson, R.S.; Foskolou, I.P., FEBS Journal. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099991597&partnerID=MN8TOARS . 10.1111/febs.15695 . FEBS Journal

Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation

Gojkovic, M.; Cunha, P.P.; Darmasaputra, G.S.; Barbieri, L.; Rundqvist, H.; Veliça, P.; Johnson, R.S., Frontiers in Immunology. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107036662&partnerID=MN8TOARS . 10.3389/fimmu.2021.633586 . Frontiers in Immunology

miRNA-31 Improves Cognition and Abolishes Amyloid-ß Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer’s Disease

Cunha, Pedro, Molecular Therapy - Nucleic Acids. 2020. http://dx.doi.org/10.1016/j.omtn.2020.01.010 . 10.1016/j.omtn.2020.01.010 . Molecular Therapy - Nucleic Acids

The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome

Iosifina P. Foskolou; Laura Barbieri; Aude Vernet; David Bargiela; Pedro P. Cunha; Pedro Velica; Eunyeong Suh; et al, Blood Advances. 2020. https://doi.org/10.1182/bloodadvances.2020002309 . 10.1182/bloodadvances.2020002309 . Blood Advances

Glucosylceramide synthase silencing combined with the receptor tyrosine kinase inhibitor axitinib as a new multimodal strategy for glioblastoma

Catarina M Morais; Pedro P Cunha; Tânia Melo; Ana M Cardoso; Pedro Domingues; M Rosário Domingues; Maria C Pedroso de Lima; Amália S Jurado, Human Molecular Genetics. 2019. https://doi.org/10.1093/hmg/ddz152 . 10.1093/hmg/ddz152 . Human Molecular Genetics

Acylation of the S4<inf>13</inf>-PV cell-penetrating peptide as a means of enhancing its capacity to mediate nucleic acid delivery: Relevance of peptide/lipid interactions

Morais, C.M.; Cardoso, A.M.; Cunha, P.P.; Aguiar, L.; Vale, N.; Lage, E.; Pinheiro, M.; et al, Biochimica et Biophysica Acta - Biomembranes. 2619 - 2634. 12. 1860. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054439165&partnerID=MN8TOARS . 10.1016/j.bbamem.2018.10.002 . Biochimica et Biophysica Acta - Biomembranes

High-throughput screening uncovers miRNAs enhancing glioblastoma cell susceptibility to tyrosine kinase inhibitors

Pedro P Cunha; Pedro M Costa; Catarina M Morais; Inês R Lopes; Ana M Cardoso; Ana L Cardoso; Miguel Mano; Amália S Jurado; Maria C Pedroso de Lima, Human Molecular Genetics. 4375 - 4387. 22. 26. 2017. https://doi.org/10.1093/hmg/ddx323 . 10.1093/hmg/ddx323 . Human Molecular Genetics

MicroRNA modulation renders glioblastoma cells sensitive to chemotherapy

Cunha, P. P.; Costa, P.; Costa, R.; Custodia, C.; Branco, R.; Morais, C. M.; Cardoso, A. M.; et al, European Journal of Clinical Investigation. 2015. https://publons.com/wos-op/publon/11264927/ . European Journal of Clinical Investigation

MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma

Cunha, Pedro, Journal of Controlled Release . 2015. http://www.sciencedirect.com/science/article/pii/S0168365915002205 . http://dx.doi.org/10.1016/j.jconrel.2015.04.002 . Journal of Controlled Release