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Information about journal articles, updated at 24-11-2024, from platform CIÊNCIAVITAE.

In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation

Marto, Carlos Miguel; Laranjo, Mafalda; Gonçalves AC; Paula, Anabela; Jorge, Joana; Caetano-Oliveira, Rui; Sousa, Maria Inês; et al, Pharmaceutics. 2. 16. 2024. http://dx.doi.org/10.3390/pharmaceutics16020207 . 10.3390/pharmaceutics16020207 . published Pharmaceutics

Practical Management of Disease-related Manifestations and Drug Toxicities in Patients with Multiple Myeloma

Geraldes, C; Roque, A; Sarmento-Ribeiro, AB; Neves, M; Ionita, A; Gerivaz, R; Tomé, A; et al, Front. Oncol. (Sec. Hematologic Malignancies). 14. 2024. published Front. Oncol. (Sec. Hematologic Malignancies)

Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe Dementia

Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Teixeira-Veríssimo, Manuel; Dourado, Marília; Andrade, José Paulo, Biomedicines. 2. 11. 2023. http://dx.doi.org/10.3390/biomedicines11020380 . 10.3390/biomedicines11020380 . Biomedicines

Zinc: From Biological Functions to Therapeutic Potential

Costa, Maria Inês; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana Cristina, International Journal of Molecular Sciences. 5. 24. 2023. http://dx.doi.org/10.3390/ijms24054822 . 10.3390/ijms24054822 . International Journal of Molecular Sciences

AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

Beatriz Lapa; Maria Inês Costa; Diana Figueiredo; Joana Jorge; Raquel Alves; Ana Raquel Monteiro; Beatriz Serambeque; et al, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/20/15331 . 10.3390/ijms242015331 . International Journal of Molecular Sciences

Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines

Alves, Raquel; Santos, Diogo; Jorge, Joana; Gonçalves, Ana Cristina; Catarino, Steve; Girão, Henrique; Melo, Joana Barbosa; Sarmento-Ribeiro, AB, Molecules. 3. 28. 2023. http://dx.doi.org/10.3390/molecules28031210 . 10.3390/molecules28031210 . Molecules

Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma Múltiplo

João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; et al, Acta Médica Portuguesa. 517 - 526. 7-8. 36. 2023. http://dx.doi.org/10.20344/amp.19037 . 10.20344/amp.19037 . published Acta Médica Portuguesa

Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies

Jorge, Joana; Neves, Joana; Alves, Raquel; Geraldes, Catarina; Gonçalves, Ana Cristina; Sarmento-Ribeiro, AB, International Journal of Molecular Sciences. 11. 24. 2023. http://dx.doi.org/10.3390/ijms24119167 . 10.3390/ijms24119167 . International Journal of Molecular Sciences

Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study

Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, AB; Teixeira-Veríssimo, Manuel; Andrade, José Paulo; Dourado, Marília, International Journal of Molecular Sciences. 13. 24. 2023. http://dx.doi.org/10.3390/ijms241310723 . 10.3390/ijms241310723 . International Journal of Molecular Sciences

Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells

Costa, Maria Inês; Lapa, Beatriz Santos; Jorge, Joana; Alves, Raquel; Carreira, Isabel Marques; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana Cristina, International Journal of Molecular Sciences. 5. 23. 2022. http://dx.doi.org/10.3390/ijms23052567 . 10.3390/ijms23052567 . International Journal of Molecular Sciences

Cold Atmospheric Plasma Apoptotic and Oxidative Effects on MCF7 and HCC1806 Human Breast Cancer Cells

Almeida-Ferreira, Catarina; Silva-Teixeira, Rafael; Gonçalves, Ana Cristina; Marto, Carlos Miguel; Sarmento-Ribeiro, Ana Bela; Caramelo, Francisco; Botelho, Maria Filomena; Laranjo, Mafalda, International Journal of Molecular Sciences. 3. 23. 2022. http://dx.doi.org/10.3390/ijms23031698 . 10.3390/ijms23031698 . International Journal of Molecular Sciences

Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Jorge, Joana; Magalhães, Nisa; Alves, Raquel; Lapa, Beatriz; Gonçalves, Ana Cristina; Sarmento-Ribeiro, AB, Biomedicines. 9. 10. 2022. http://dx.doi.org/10.3390/biomedicines10092207 . 10.3390/biomedicines10092207 . Biomedicines

Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Ribeiro, André B.; Tenreiro, Rita; Coucelo, Margarida; et al, International Journal of Molecular Sciences. 17. 23. 2022. http://dx.doi.org/10.3390/ijms23179815 . 10.3390/ijms23179815 . International Journal of Molecular Sciences

Apoptosis and (in) Pain—Potential Clinical Implications

Ribeiro, Hugo; Sarmento-Ribeiro, AB; Andrade, José Paulo; Dourado, Marília, Biomedicines. 6. 10. 2022. http://dx.doi.org/10.3390/biomedicines10061255 . 10.3390/biomedicines10061255 . Biomedicines

Combination of Elacridar with Imatinib Modulates Resistance Associated with Drug Efflux Transporters in Chronic Myeloid Leukemia

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Almeida, António M.; Sarmento-Ribeiro, AB, Biomedicines. 5. 10. 2022. http://dx.doi.org/10.3390/biomedicines10051158 . 10.3390/biomedicines10051158 . Biomedicines

Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring

Martins, Ivana; Ribeiro, Ilda Patrícia; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Melo, Joana Barbosa; Carreira, Isabel Marques, Genes. 3. 12. 2021. http://dx.doi.org/10.3390/genes12030349 . 10.3390/genes12030349 . published Genes

A Combined Antitumor Strategy Mediated by a New Targeted Nanosystem to Hepatocellular Carcinoma

Farinha, Dina; Migawa, Michael; Sarmento-Ribeiro, Ana Bela; Faneca, Henrique, International Journal of Nanomedicine. 3385 - 3405. Volume 16. 2021. http://dx.doi.org/10.2147/ijn.s302288 . 10.2147/ijn.s302288 . published International Journal of Nanomedicine

Genomic characterisation of multiple myeloma: study of a Portuguese cohort

Couto Oliveira, Alexandra; Ribeiro, Ilda Patrícia; Pires, Luís Miguel; Gonçalves, Ana Cristina; Paiva, Artur; Geraldes, Catarina; Roque, Adriana; et al, Journal of Clinical Pathology. jclinpath - 2020. 2021. http://dx.doi.org/10.1136/jclinpath-2020-207204 . 10.1136/jclinpath-2020-207204 . published Journal of Clinical Pathology

Plasma activated media and direct exposition can selectively ablate retinoblastoma cells

Silva-Teixeira, Rafael; Laranjo, Mafalda; Lopes, Beatriz; Almeida-Ferreira, Catarina; Gonçalves, Ana Cristina; Rodrigues, Tiago; Matafome, Paulo; et al, Free Radical Biology and Medicine. 302 - 313. 171. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2021.05.027 . 10.1016/j.freeradbiomed.2021.05.027 . in press Free Radical Biology and Medicine

Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients

Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Jorge, Joana; Marques, Bárbara; Paiva, Artur; Oliveiros, Bárbara; et al, Frontiers in Cell and Developmental Biology. 9. 2021. http://dx.doi.org/10.3389/fcell.2021.701328 . 10.3389/fcell.2021.701328 . accepted Frontiers in Cell and Developmental Biology

Can peripheral blood provide good DNA methylation biomarkers in myelodysplastic syndrome?

Jorge, Joana; Gonçalves, Ana Cristina; Cortesão, Emília; Pires, Ana Cláudia; Alves, Raquel; Geraldes, Catarina; Pereira, Amélia; et al, Journal of Molecular and Clinical Medicine. 1. 4. 2021. http://dx.doi.org/10.31083/j.jmcm.2021.01.015 . 10.31083/j.jmcm.2021.01.015 . published Journal of Molecular and Clinical Medicine

Bone marrow follicular-like T cells in monoclonal gammopathies

Silva, Ana; Silva, Sandra; Silva, Isabel; Santos, Susana; Laranjeira, Paula; Geraldes, Catarina; Silva, Helena; et al, Cytometry Part B: Clinical Cytometry. 70 - 72. 1. 102. 2021. http://dx.doi.org/10.1002/cyto.b.22029 . 10.1002/cyto.b.22029 . Cytometry Part B: Clinical Cytometry

Accessing the Cytotoxicity and Cell Response to Biomaterials

Paula, Anabela Baptista; Laranjo, Mafalda; Coelho, Ana Sofia; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Ferreira, Manuel Marques; et al, Journal of Visualized Experiments. 173. 2021. http://dx.doi.org/10.3791/61512 . 10.3791/61512 . Journal of Visualized Experiments

The Hydropathy Index of the HCDR3 Region of the B-Cell Receptor Identifies Two Subgroups of IGHV-Mutated Chronic Lymphocytic Leukemia Patients With Distinct Outcome

Rodríguez-Caballero, Arancha; Fuentes Herrero, Blanca; Oliva Ariza, Guillermo; Criado, Ignacio; Alcoceba, Miguel; Prieto, Carlos; Pérez Caro, María; et al, Frontiers in Oncology. 11. 2021. http://dx.doi.org/10.3389/fonc.2021.723722 . 10.3389/fonc.2021.723722 . Frontiers in Oncology

Hypoxia as a driver of resistance to immunotherapy

Kopecka, Joanna; Salaroglio, Iris C.; Perez-Ruiz, Elizabeth; Sarmento-Ribeiro, Ana Bela; Saponara, Simona; De Las Rivas, Javier; Riganti, Chiara, Drug Resistance Updates. 59. 2021. http://dx.doi.org/10.1016/j.drup.2021.100787 . 10.1016/j.drup.2021.100787 . Drug Resistance Updates

Impact of cancer metabolism on therapy resistance – Clinical implications

Gonçalves, Ana Cristina; Richiardone, Elena; Jorge, Joana; Polónia, Bárbara; Xavier, Cristina P.R.; Salaroglio, Iris Chiara; Riganti, Chiara; et al, Drug Resistance Updates. 59. 2021. http://dx.doi.org/10.1016/j.drup.2021.100797 . 10.1016/j.drup.2021.100797 . Drug Resistance Updates

DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome—Relevance as Complementary Prognostic Biomarkers

Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Marques, Bárbara; Oliveiros, Bárbara; Pereira, Amélia; Nascimento Costa, José Manuel; et al, Cancers. 13. 13. 2021. http://dx.doi.org/10.3390/cancers13133138 . 10.3390/cancers13133138 . Cancers

Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance

Alves, Raquel; Gonçalves, Ana Cristina; Rutella, Sergio; Almeida, António M.; De Las Rivas, Javier; Trougakos, Ioannis P.; Sarmento Ribeiro, Ana Bela, Cancers. 19. 13. 2021. http://dx.doi.org/10.3390/cancers13194820 . 10.3390/cancers13194820 . Cancers

Genomic characterisation of multiple myeloma: study of a Portuguese cohort

Couto Oliveira, Alexandra; Ribeiro, Ilda Patrícia; Pires, Luís Miguel; Gonçalves, Ana Cristina; Paiva, Artur; Geraldes, Catarina; Roque, Adriana; et al, Journal of Clinical Pathology. 422 - 425. 6. 75. 2021. http://dx.doi.org/10.1136/jclinpath-2020-207204 . 10.1136/jclinpath-2020-207204 . Journal of Clinical Pathology

Bone marrow follicular-like T cells in monoclonal gammopathies

Silva, Ana; Silva, Sandra; Silva, Isabel; Santos, Susana; Laranjeira, Paula; Geraldes, Catarina; Silva, Helena; et al, Cytometry Part B: Clinical Cytometry. 70 - 72. 1. 102. 2021. http://dx.doi.org/10.1002/cyto.b.22029 . 10.1002/cyto.b.22029 . Cytometry Part B: Clinical Cytometry

Effects of Adper™ Scotchbond™ 1 XT, Clearfil™ SE Bond 2 and Scotchbond™ Universal in Odontoblasts

Miguel Cardoso; Ana Coelho; Carlos Miguel Marto; Ana Cristina Gonçalves; Anabela Paula; Ana Bela Sarmento Ribeiro; Manuel Marques Ferreira; et al, Materials. 6435 - 6435. 21. 14. 2021. https://doi.org/10.3390/ma14216435 . 10.3390/ma14216435 . Materials

Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-a

Alves, Raquel; McArdle, Stephanie E. B.; Vadakekolathu, Jayakumar; Gonçalves, Ana Cristina; Freitas-Tavares, Paulo; Pereira, Amélia; Almeida, Antonio M.; Sarmento-Ribeiro, Ana Bela; Rutella, Sergio, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-019-02194-x . 10.1186/s12967-019-02194-x . published Journal of Translational Medicine

Cytotoxic Effects of Zoom® Whitening Product in Human Fibroblasts

Marto, Carlos Miguel; Laranjo, Mafalda; Paula, Anabela; Coelho, Ana Sofia; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana Cristina; et al, Materials. 7. 13. 2020. http://dx.doi.org/10.3390/ma13071491 . 10.3390/ma13071491 . Materials

GuttaFlow® Bioseal Cytotoxicity Assessment: In Vitro Study

Ferreira, Inês; Laranjo, Mafalda; Marto, Carlos Miguel; Casalta-Lopes, João; Serambeque, Beatriz; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; et al, Molecules. 18. 25. 2020. http://dx.doi.org/10.3390/molecules25184297 . 10.3390/molecules25184297 . published Molecules

Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target

Lapa, Beatriz; Gonçalves, Ana Cristina; Jorge, Joana; Alves, Raquel; Pires, Ana Salomé; Abrantes, Ana Margarida; Coucelo, Margarida; et al, Medical Oncology. 8. 37. 2020. http://dx.doi.org/10.1007/s12032-020-01394-6 . 10.1007/s12032-020-01394-6 . published Medical Oncology

Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer

Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A.M.; Brites, Gonçalo; Nascimento, Bruno F.O.; Brito, Ana F.; Casalta-Lopes, João; et al, European Journal of Medicinal Chemistry. 200. 2020. http://dx.doi.org/10.1016/j.ejmech.2020.112468 . 10.1016/j.ejmech.2020.112468 . published European Journal of Medicinal Chemistry

miR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells

Magalhães, Mariana; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Carvalho, Rui; Figueiras, Ana; Santos, Ana Cláudia; Veiga, Francisco, Drug Delivery and Translational Research. 1367 - 1380. 5. 10. 2020. http://dx.doi.org/10.1007/s13346-020-00768-7 . 10.1007/s13346-020-00768-7 . published Drug Delivery and Translational Research

Iodine-131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma

Brito, Ana; Abrantes, Ana; Teixo, Ricardo; Pires, Ana; Ribeiro, Ana; Ferreira, Rafael; Fernandes, Alexandra; et al, International Journal of Oncology. 2020. http://dx.doi.org/10.3892/ijo.2020.4957 . 10.3892/ijo.2020.4957 . published International Journal of Oncology

Cancer immunotherapy resistance based on immune checkpoints inhibitors: Targets, biomarkers, and remedies

Pérez-Ruiz, Elisabeth; Melero, Ignacio; Kopecka, Joanna; Sarmento-Ribeiro, Ana Bela; García-Aranda, Marilina; De Las Rivas, Javier, Drug Resistance Updates. 53. 2020. http://dx.doi.org/10.1016/j.drup.2020.100718 . 10.1016/j.drup.2020.100718 . published Drug Resistance Updates

Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw

Paulo, Siri; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Santos, Kathleen; Gonçalves, Ana C.; Paula, Anabela Baptista; et al, Materials. 11. 12. 2019. http://dx.doi.org/10.3390/ma12111840 . 10.3390/ma12111840 . published Materials

MicroRNA signature refine response prediction in CML

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Marques, Gilberto; Luís, Dino; Ribeiro, André B.; Freitas-Tavares, Paulo; et al, Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-46132-9 . 10.1038/s41598-019-46132-9 . published Scientific Reports

Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Alves, Joana; Alves da Silva, António; Freitas-Tavares, Paulo; Nascimento Costa, José M.; Almeida, António M.; Sarmento-Ribeiro, Ana B., Medical Oncology. 3. 36. 2019. http://dx.doi.org/10.1007/s12032-019-1253-5 . 10.1007/s12032-019-1253-5 . published Medical Oncology

CD43 and CD49d from the B-Cell Chronic Lymphoproliferative Disorders Diagnostic Panel Are Useful to Detect Erythroid Dysplasia

Oliveira, Melissa; Laranjeira, Paula; Fortuna, Manuela; Bártolo, Rui; Ribeiro, André; Santos, Mónica; Cortesão, Emília; et al, Cytometry Part B: Clinical Cytometry. 417 - 425. 5. 96. 2019. http://dx.doi.org/10.1002/cyto.b.21792 . 10.1002/cyto.b.21792 . published Cytometry Part B: Clinical Cytometry

Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines

Jorge, Joana; Petronilho, Sara; Alves, Raquel; Coucelo, Margarida; Gonçalves, Ana Cristina; Nascimento Costa, José Manuel; Sarmento-Ribeiro, Ana Bela, Investigational New Drugs. 369 - 377. 2. 38. 2019. http://dx.doi.org/10.1007/s10637-019-00796-2 . 10.1007/s10637-019-00796-2 . published Investigational New Drugs

Cellular and molecular mechanisms of glioblastoma malignancy: Implications in resistance and therapeutic strategies

Balça-Silva, Joana; Matias, Diana; Carmo, Anália do; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moura-Neto, Vivaldo, Seminars in Cancer Biology. 130 - 141. 58. 2019. http://dx.doi.org/10.1016/j.semcancer.2018.09.007 . 10.1016/j.semcancer.2018.09.007 . published Seminars in Cancer Biology

The multi-factorial nature of clinical multidrug resistance in cancer

Assaraf, Yehuda G.; Brozovic, Anamaria; Gonçalves, Ana Cristina; Jurkovicova, Dana; Line, Aija; Machuqueiro, Miguel; Saponara, Simona; et al, Drug Resistance Updates. 46. 2019. http://dx.doi.org/10.1016/j.drup.2019.100645 . 10.1016/j.drup.2019.100645 . published Drug Resistance Updates

The emergence of drug resistance to targeted cancer therapies: Clinical evidence

Sarmento-Ribeiro, Ana Bela; Scorilas, Andreas; Gonçalves, Ana Cristina; Efferth, Thomas; Trougakos, Ioannis P., Drug Resistance Updates. 47. 2019. http://dx.doi.org/10.1016/j.drup.2019.100646 . 10.1016/j.drup.2019.100646 . published Drug Resistance Updates

Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast Activity

Paula, Anabela; Laranjo, Mafalda; Marto, Carlos Miguel; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; et al, Materials. 7. 12. 2019. http://dx.doi.org/10.3390/ma12071184 . 10.3390/ma12071184 . published Materials

Multiple myeloma in elderly patients—a Portuguese multicentric real-life study

João, Cristina; Bergantim, Rui; Neves, Manuel; Chacim, Sérgio; Afonso, Celina; Barradas, João; Bernardo, Manuela; et al, Annals of Hematology. 1689 - 1701. 7. 98. 2019. http://dx.doi.org/10.1007/s00277-019-03640-y . 10.1007/s00277-019-03640-y . published Annals of Hematology

Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity

Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno, Experimental Cell Research. 68 - 77. 1. 370. 2018. http://dx.doi.org/10.1016/j.yexcr.2018.06.005 . 10.1016/j.yexcr.2018.06.005 . published Experimental Cell Research

Venous thromboembolism risk associated with ABO, F11 and FGG loci

Manco, Licínio; Silva, Catarina; Fidalgo, Teresa; Martinho, Patrícia; Sarmento, Ana B.; Ribeiro, M. Letícia, Blood Coagulation & Fibrinolysis. 528 - 532. 6. 29. 2018. http://dx.doi.org/10.1097/mbc.0000000000000753 . 10.1097/mbc.0000000000000753 . published Blood Coagulation & Fibrinolysis

Quantification and phenotypic characterization of peripheral blood Vd1¿+¿T cells in chronic lymphocytic leukemia and monoclonal B cell lymphocytosis

Simões, Catarina; Silva, Isabel; Carvalho, Anabela; Silva, Sandra; Santos, Susana; Marques, Gilberto; Ribeiro, André; et al, Cytometry Part B: Clinical Cytometry. 164 - 168. 2. 96. 2018. http://dx.doi.org/10.1002/cyto.b.21645 . 10.1002/cyto.b.21645 . published Cytometry Part B: Clinical Cytometry

Clonal shifts in MDS – from SF3B1 to EZH2

Barbosa Ribeiro, André; Coucelo, Margarida; Tenreiro, Rita; Simões, Ana Teresa; Marques, Gilberto; Ribeiro, Letícia; Cortesão, Emília; Sarmento-Ribeiro, Ana Bela, Leukemia & Lymphoma. 2994 - 2997. 12. 59. 2018. http://dx.doi.org/10.1080/10428194.2018.1443452 . 10.1080/10428194.2018.1443452 . published Leukemia & Lymphoma

Epithelial-mesenchymal transition and microRNAs: Challenges and future perspectives in oral cancer

Domingues, Cátia Sofia da Costa; Serambeque, Beatriz Prazeres; Laranjo Cândido, Mafalda Sofia; Marto, Carlos Miguel Machado; Veiga, Francisco José de Baptista; Sarmento Antunes Cruz Ribeiro, Ana Bela; Figueiras, Ana Rita Ramalho; Botelho, Maria Filomena Roque; Dourado, Marília de Assunção Rodrigues Ferre, Head & Neck. 2304 - 2313. 10. 40. 2018. http://dx.doi.org/10.1002/hed.25381 . 10.1002/hed.25381 . published Head & Neck

Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins

Pereira, Nelson A.M.; Laranjo, Mafalda; Pina, João; Oliveira, Andreia S.R.; Ferreira, João Dias; Sánchez-Sánchez, Carles; Casalta-Lopes, João; et al, European Journal of Medicinal Chemistry. 395 - 408. 146. 2018. http://dx.doi.org/10.1016/j.ejmech.2017.12.093 . 10.1016/j.ejmech.2017.12.093 . published European Journal of Medicinal Chemistry

TISSULAR GROWTH FACTORS PROFILE AFTER TEDUGLUTIDE ADMINISTRATION ON AN ANIMAL MODEL OF INTESTINAL ANASTOMOSIS; PERFIL TISULAR DE FACTORES DE CRECIMIENTO POST-ADMINISTRACIÓN DE TEDUGLUTIDE EN UN MODELO ANIMAL DE ANASTOMOSIS INTESTINAL

Costa, Beatriz Pinto; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Alves, Raquel; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco, Nutrición Hospitalaria. 2018. http://dx.doi.org/10.20960/nh.1326 . 10.20960/nh.1326 . published Nutrición Hospitalaria

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells

Encarnação, João Crispim; Pires, Ana Salomé; Amaral, Renata Alexandra; Gonçalves, Telmo José; Laranjo, Mafalda; Casalta-Lopes, João Eduardo; Gonçalves, Ana Cristina; et al, The Journal of Nutritional Biochemistry. 183 - 192. 56. 2018. http://dx.doi.org/10.1016/j.jnutbio.2018.02.018 . 10.1016/j.jnutbio.2018.02.018 . published The Journal of Nutritional Biochemistry

Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth

Pires, Ana S.; Marques, Cláudia R.; Encarnação, João C.; Abrantes, Ana M.; Marques, Inês A.; Laranjo, Mafalda; Oliveira, Rui; et al, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00911 . 10.3389/fphys.2018.00911 . published Frontiers in Physiology

Effects of resistance exercise on endothelial progenitor cell mobilization in women

Ribeiro, Fernando; Ribeiro, Ilda P.; Gonçalves, Ana C.; Alves, Alberto J.; Melo, Elsa; Fernandes, Raquel; Costa, Rui; et al, Scientific Reports. 1. 7. 2017. http://dx.doi.org/10.1038/s41598-017-18156-6 . 10.1038/s41598-017-18156-6 . published Scientific Reports

Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis

Costa, Beatriz P.; Gonçalves, Ana C.; Abrantes, Ana M.; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana B.; Botelho, Maria Filomena; Castro-Sousa, Francisco, Journal of Surgical Research. 87 - 98. 216. 2017. http://dx.doi.org/10.1016/j.jss.2017.04.022 . 10.1016/j.jss.2017.04.022 . published Journal of Surgical Research

Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration

Costa, Beatriz P.; Gonçalves, Ana C.; Abrantes, Ana M.; Alves, Raquel; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana B.; Botelho, M. Filomena; Castro-Sousa, Francisco, Journal of Investigative Surgery. 243 - 252. 3. 31. 2017. http://dx.doi.org/10.1080/08941939.2017.1294217 . 10.1080/08941939.2017.1294217 . published Journal of Investigative Surgery

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

Costa, Beatriz Pinto da; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco, Acta Cirurgica Brasileira. 648 - 661. 8. 32. 2017. http://dx.doi.org/10.1590/s0102-865020170080000007 . 10.1590/s0102-865020170080000007 . published Acta Cirurgica Brasileira

Effects of teduglutide on histological parameters of intestinal anastomotic healing

Costa, Beatriz P.; Cipriano, Maria A.; Gonçalves, Ana C.; Abrantes, Ana M.; Matafome, Paulo; Seiça, Raquel; Sarmento-Ribeiro, Ana B.; Botelho, M. Filomena; Castro-Sousa, Francisco, European Surgery. 218 - 227. 5. 49. 2017. http://dx.doi.org/10.1007/s10353-017-0478-9 . 10.1007/s10353-017-0478-9 . published European Surgery

Glioblastoma entities express subtle differences in molecular composition and response to treatment

Balça-Silva, Joana; Matias, Diana; Do Carmo, Anália; Dubois, Luiz Gustavo; Gonçalves, Ana Cristina; Girão, Henrique; Silva Canedo, Nathalie Henriques; et al, Oncology Reports. 1341 - 1352. 3. 38. 2017. http://dx.doi.org/10.3892/or.2017.5799 . 10.3892/or.2017.5799 . published Oncology Reports

The Expression of Connexins and SOX2 Reflects the Plasticity of Glioma Stem-Like Cells

Balça-Silva, Joana; Matias, Diana; Dubois, Luiz Gustavo; Carneiro, Brenno; do Carmo, Anália; Girão, Henrique; Ferreira, Fernanda; et al, Translational Oncology. 555 - 569. 4. 10. 2017. http://dx.doi.org/10.1016/j.tranon.2017.04.005 . 10.1016/j.tranon.2017.04.005 . published Translational Oncology

Dual treatment with shikonin and temozolomide reduces glioblastoma tumor growth, migration and glial-to-mesenchymal transition

Matias, Diana; Balça-Silva, Joana; Dubois, Luiz Gustavo; Pontes, Bruno; Ferrer, Valéria Pereira; Rosário, Luciane; do Carmo, Anália; et al, Cellular Oncology. 247 - 261. 3. 40. 2017. http://dx.doi.org/10.1007/s13402-017-0320-1 . 10.1007/s13402-017-0320-1 . published Cellular Oncology

Single Shot Irradiation and Molecular Effects on a Diffuse Large B Cell Lymphoma Cell Line

Mendes, Fernando; Domingues, Cátia; Schugk, Susann; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Sales, Tiago; Teixo, Ricardo; et al, Journal of Cancer Research and Treatment. 9 - 16. 1. 4. 2016. published Journal of Cancer Research and Treatment

Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications

Geraldes, Catarina; Gonçalves, Ana Cristina; Cortesão, Emília; Pereira, Marta Isabel; Roque, Adriana; Paiva, Artur; Ribeiro, Letícia; Nascimento-Costa, José Manuel; Sarmento-Ribeiro, Ana Bela, Clinical Lymphoma Myeloma and Leukemia. 713 - 720.e2. 12. 16. 2016. http://dx.doi.org/10.1016/j.clml.2016.08.016 . 10.1016/j.clml.2016.08.016 . published Clinical Lymphoma Myeloma and Leukemia

Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability

Carrapita, Jorge; Abrantes, Ana Margarida; Campelos, Sofia; Gonçalves, Ana Cristina; Cardoso, Dulce; Sarmento-Ribeiro, Ana Bela; Rocha, Clara; et al, Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep34731 . 10.1038/srep34731 . published Scientific Reports

The role of immune system exhaustion on cancer cell escape and anti-tumor immune induction after irradiation

Mendes, Fernando; Domingues, Cátia; Rodrigues-Santos, Paulo; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Estrela, Jéssica; Encarnação, João; et al, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 168 - 175. 2. 1865. 2016. http://dx.doi.org/10.1016/j.bbcan.2016.02.002 . 10.1016/j.bbcan.2016.02.002 . published Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile

Pires, Ana Salomé; Marques, Cláudia Raquel; Encarnação, João Carlos; Abrantes, Ana Margarida; Mamede, Ana Catarina; Laranjo, Mafalda; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena, European Journal of Cell Biology. 208 - 218. 6-7. 95. 2016. http://dx.doi.org/10.1016/j.ejcb.2016.04.001 . 10.1016/j.ejcb.2016.04.001 . published European Journal of Cell Biology

Hyperresistinemia and metabolic dysregulation: a risky crosstalk in obese breast cancer

Crisóstomo, Joana; Matafome, Paulo; Santos-Silva, Daniela; Gomes, Ana L.; Gomes, Manuel; Patrício, Miguel; Letra, Liliana; et al, Endocrine. 433 - 442. 2. 53. 2016. http://dx.doi.org/10.1007/s12020-016-0893-x . 10.1007/s12020-016-0893-x . published Endocrine

Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis

Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Cortesão, Emília; Carda, José Pedro; Branco, Claudia C.; Oliveiros, Bárbara; et al, Molecular Carcinogenesis. 130 - 148. 1. 56. 2016. http://dx.doi.org/10.1002/mc.22478 . 10.1002/mc.22478 . published Molecular Carcinogenesis

New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin

Brito, Ana Filipa; Ribeiro, Marina; Abrantes, Ana Margarida; Mamede, Ana Catarina; Laranjo, Mafalda; Casalta-Lopes, João Eduardo; Gonçalves, Ana Cristina; et al, Nutrition and Cancer. 250 - 266. 2. 68. 2016. http://dx.doi.org/10.1080/01635581.2016.1145245 . 10.1080/01635581.2016.1145245 . published Nutrition and Cancer

Chemical characterization and cytotoxic potential of an ellagitannin-enriched fraction from Fragaria vesca leaves

Liberal, Joana; Costa, Gustavo; Carmo, Anália; Vitorino, Rui; Marques, Carla; Domingues, Maria Rosário; Domingues, Pedro; et al, Arabian Journal of Chemistry. 3652 - 3666. 8. 12. 2015. http://dx.doi.org/10.1016/j.arabjc.2015.11.014 . 10.1016/j.arabjc.2015.11.014 . published Arabian Journal of Chemistry

Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma

Mamede, A. C.; Guerra, S.; Laranjo, M.; Carvalho, M. J.; Oliveira, R. C.; Gonçalves, A. C.; Alves, R.; et al, Medical Oncology. 12. 32. 2015. http://dx.doi.org/10.1007/s12032-015-0702-z . 10.1007/s12032-015-0702-z . published Medical Oncology

Effects of X-radiation on lung cancer cells: the interplay between oxidative stress and P53 levels

Mendes, Fernando; Sales, Tiago; Domingues, Cátia; Schugk, Susann; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Teixo, Ricardo; et al, Medical Oncology. 12. 32. 2015. http://dx.doi.org/10.1007/s12032-015-0712-x . 10.1007/s12032-015-0712-x . published Medical Oncology

Fluorine-18 Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma: Correlation with Glucose Transporters and p53 Expression

Brito, Ana F.; Abrantes, Ana M.; Ribeiro, Marina; Oliveira, Rui; Casalta-Lopes, João; Gonçalves, Ana C.; Sarmento-Ribeiro, Ana B.; Tralhão, José G.; Botelho, Maria F., Journal of Clinical and Experimental Hepatology. 183 - 189. 3. 5. 2015. http://dx.doi.org/10.1016/j.jceh.2015.05.003 . 10.1016/j.jceh.2015.05.003 . published Journal of Clinical and Experimental Hepatology

Influence of P53 on the radiotherapy response of hepatocellular carcinoma

Gomes, Ana R.; Abrantes, Ana M.; Brito, Ana F.; Laranjo, Mafalda; Casalta-Lopes, João E.; Gonçalves, Ana C.; Sarmento-Ribeiro, Ana B.; Botelho, Maria F.; Tralhão, José G., Clinical and Molecular Hepatology. 3. 21. 2015. http://dx.doi.org/10.3350/cmh.2015.21.3.257 . 10.3350/cmh.2015.21.3.257 . published Clinical and Molecular Hepatology

L744,832 and Everolimus Induce Cytotoxic and Cytostatic Effects in Non-Hodgkin Lymphoma Cells

Mendes, José; Gonçalves, Ana Cristina; Alves, Raquel; Jorge, Joana; Pires, Ana; Ribeiro, Ana; Sarmento-Ribeiro, Ana Bela, Pathology & Oncology Research. 301 - 309. 2. 22. 2015. http://dx.doi.org/10.1007/s12253-015-9998-4 . 10.1007/s12253-015-9998-4 . published Pathology & Oncology Research

The importance of radiotherapy on diffuse large B cell lymphoma treatment: a current review

Mendes, Fernando; Domingues, Cátia; Teixo, Ricardo; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Nobre-Gois, Inês; Jacobetty, Miguel; et al, Cancer and Metastasis Reviews. 511 - 525. 3. 34. 2015. http://dx.doi.org/10.1007/s10555-015-9581-1 . 10.1007/s10555-015-9581-1 . published Cancer and Metastasis Reviews

Oxidative stress and mitochondrial dysfunction play a role in myelodysplastic syndrome development, diagnosis, and prognosis: A pilot study

Gonçalves, A. C.; Cortesão, E.; Oliveiros, B.; Alves, V.; Espadana, A. I.; Rito, L.; Magalhães, E.; et al, Free Radical Research. 1081 - 1094. 9. 49. 2015. http://dx.doi.org/10.3109/10715762.2015.1035268 . 10.3109/10715762.2015.1035268 . published Free Radical Research

Oxidative stress levels are correlated with P15 and P16 gene promoter methylation in myelodysplastic syndrome patients

Gonçalves, Ana Cristina; Cortesão, Emília; Oliveiros, Barbara; Alves, Vera; Espadana, Ana Isabel; Rito, Luís; Magalhães, Emília; et al, Clinical and Experimental Medicine. 333 - 343. 3. 16. 2015. http://dx.doi.org/10.1007/s10238-015-0357-2 . 10.1007/s10238-015-0357-2 . published Clinical and Experimental Medicine

Eritropoietina Sérica como Marcador Prognóstico em Síndrome Mielodisplásica

Cortesão, Emília; Tenreiro, Rita; Ramos, Sofia; Pereira, Marta; César, Paula; Carda, José P.; Gomes, Marília; et al, Acta Médica Portuguesa. 720 - 725. 6. 28. 2015. http://dx.doi.org/10.20344/amp.6518 . 10.20344/amp.6518 . published Acta Médica Portuguesa

Drug transporters play a key role in the complex process of Imatinib resistance in vitro

Alves, Raquel; Fonseca, Ana Raquel; Gonçalves, Ana C.; Ferreira-Teixeira, Margarida; Lima, Joana; Abrantes, Ana M.; Alves, Vera; et al, Leukemia Research. 355 - 360. 3. 39. 2015. http://dx.doi.org/10.1016/j.leukres.2014.12.008 . 10.1016/j.leukres.2014.12.008 . published Leukemia Research

Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cells

Pereira, Nelson A.M.; Laranjo, Mafalda; Pineiro, Marta; Serra, Arménio C.; Santos, Kathleen; Teixo, Ricardo; Abrantes, Ana Margarida; et al, European Journal of Medicinal Chemistry. 374 - 380. 103. 2015. http://dx.doi.org/10.1016/j.ejmech.2015.08.059 . 10.1016/j.ejmech.2015.08.059 . published European Journal of Medicinal Chemistry

Lung cancer: the immune system and radiation

Mendes, F.; Antunes, C.; Abrantes, A. M.; Gonçalves, A. C.; Nobre-Gois, I.; Sarmento, A. B.; Botelho, M. F.; Rosa, M. S., British Journal of Biomedical Science. 78 - 84. 2. 72. 2015. http://dx.doi.org/10.1080/09674845.2015.11666801 . 10.1080/09674845.2015.11666801 . published British Journal of Biomedical Science

Tamoxifen in combination with temozolomide induce a synergistic inhibition of PKC-pan in GBM cell lines

Balça-Silva, Joana; Matias, Diana; do Carmo, Anália; Girão, Henrique; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste, Biochimica et Biophysica Acta (BBA) - General Subjects. 722 - 732. 4. 1850. 2015. http://dx.doi.org/10.1016/j.bbagen.2014.12.022 . 10.1016/j.bbagen.2014.12.022 . Biochimica et Biophysica Acta (BBA) - General Subjects

Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles

Santos, Kathleen; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana F.; Gonçalves, Cristina; Sarmento Ribeiro, Ana Bela; Botelho, M. Filomena; et al, European Journal of Medicinal Chemistry. 273 - 281. 79. 2014. http://dx.doi.org/10.1016/j.ejmech.2014.04.008 . 10.1016/j.ejmech.2014.04.008 . published European Journal of Medicinal Chemistry

Gamapatias Monoclonais de Significado Indeterminado: Critérios de Diagnóstico e Acompanhamento Clínico

Parreira, Joana; Lúcio, Paulo; João, Cristina; Macedo, Ana; Sarmento, Ana Bela; Geraldes, Catarina; Gonçalves, Cristina; Esteves, Graça, Acta Médica Portuguesa. 661 - 664. 5. 27. 2014. http://dx.doi.org/10.20344/amp.5411 . 10.20344/amp.5411 . published Acta Médica Portuguesa

Beyond the Limits of Oxygen: Effects of Hypoxia in a Hormone-Independent Prostate Cancer Cell Line

Mamede, A. C.; Abrantes, A. M.; Pedrosa, L.; Casalta-Lopes, J. E.; Pires, A. S.; Teixo, R. J.; Gonçalves, A. C.; et al, ISRN Oncology. 1 - 8. 2013. 2013. http://dx.doi.org/10.1155/2013/918207 . 10.1155/2013/918207 . published ISRN Oncology

Study of hepatocellular function in the murine model following hepatic artery selective clamping

Tralhão, José Guilherme; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Hoti, Emir; Laranjo, Mafalda; Martins, Ricardo; Oliveiros, Bárbara; et al, Acta Cirurgica Brasileira. 657 - 663. 9. 28. 2013. http://dx.doi.org/10.1590/s0102-86502013000900006 . 10.1590/s0102-86502013000900006 . published Acta Cirurgica Brasileira

Selenium Compounds Induced ROS-Dependent Apoptosis in Myelodysplasia Cells

Gonçalves, Ana Cristina; Barbosa-Ribeiro, André; Alves, Vera; Silva, Teresa; Sarmento-Ribeiro, Ana Bela, Biological Trace Element Research. 440 - 447. 3. 154. 2013. http://dx.doi.org/10.1007/s12011-013-9749-x . 10.1007/s12011-013-9749-x . published Biological Trace Element Research

Oxidative stress mediates apoptotic effects of ascorbate and dehydroascorbate in human Myelodysplasia cells in vitro

Gonçalves, Ana Cristina; Alves, Vera; Silva, Teresa; Carvalho, Cristina; Oliveira, Catarina Resende de; Sarmento-Ribeiro, Ana Bela, Toxicology in Vitro. 1542 - 1549. 5. 27. 2013. http://dx.doi.org/10.1016/j.tiv.2013.03.009 . 10.1016/j.tiv.2013.03.009 . published Toxicology in Vitro

Polycyclic Aromatic Hydrocarbons May Contribute for Prostate Cancer Progression

Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana; Mota-Pinto, Anabela, Journal of Cancer Therapy. 37 - 46. 04. 04. 2013. http://dx.doi.org/10.4236/jct.2013.44a005 . 10.4236/jct.2013.44a005 . published Journal of Cancer Therapy

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

Laranjo, Mafalda; Serra, Arménio C.; Abrantes, Margarida; Piñeiro, Marta; Gonçalves, Ana C.; Casalta-Lopes, João; Carvalho, Lina; et al, Photodiagnosis and Photodynamic Therapy. 51 - 61. 1. 10. 2013. http://dx.doi.org/10.1016/j.pdpdt.2012.05.003 . 10.1016/j.pdpdt.2012.05.003 . published Photodiagnosis and Photodynamic Therapy

Acção anti-cancerígena da quercetina no Carcinoma Hepatocelular: O papel do GLUT-1

Brito, AF; Ribeiro, M; Abrantes, AM; Gonçalves, AC; Sarmento-Ribeiro, AB; Tralhão, JG; Botelho, MF, Revista Portuguesa de Cirurgia. 23 - 30. 25. 2013. published Revista Portuguesa de Cirurgia

Microenvironment influence on human colon adenocarcinoma phenotypes and matrix metalloproteinase-2, p53 and ß-catenin tumor expressions from identical monoclonal cell tumor in the orthotopic model in athymic nude rats

Priolli, Denise Gonçalves; Abrantes, Ana Margarida; Neves, Silvia; Gonçalves, Ana Cristina; Lopes, Camila Oliveira; Martinez, Natalia Peres; Cardinalli, Izilda Aparecida; Sarmento Ribeiro, Ana Bela; Botelho, Maria Filomena, Scandinavian Journal of Gastroenterology. 309 - 316. 3. 49. 2013. http://dx.doi.org/10.3109/00365521.2013.869350 . 10.3109/00365521.2013.869350 . published Scandinavian Journal of Gastroenterology

Farnesyltransferase Inhibitors: Molecular Evidence of Therapeutic Efficacy in Acute Lymphoblastic Leukemia Through Cyclin D1 Inhibition

Costa, Carlos; Casalta-Lopes, João; Andrade, Carlos; Moreira, Diana; Oliveira, Ana; Gonçalves, Ana Cristina; Alves, Vera; et al, Anticancer Research. 831 - 838. 3. 32. 2012. published Anticancer Research

Effect of miR-34b Overexpression on the Radiosensitivity of Non-small Cell Lung Cancer Cell Lines

Balça-Silva, Joana; Neves, Sílvia; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Casalta-Lopes, João; Botelho, Maria Filomena; Sarmento-Ribeiro, AB; Silva, Henriqueta, Anticancer Research. 1603 - 1609. 5. 32. 2012. published Anticancer Research

Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells

Serra, Arménio C.; Rocha Gonsalves, António M. d'A.; Laranjo, Mafalda; Abrantes, Ana M.; Gonçalves, Ana C.; Sarmento-Ribeiro, Ana B.; Botelho, M. Filomena, European Journal of Medicinal Chemistry. 398 - 402. 53. 2012. http://dx.doi.org/10.1016/j.ejmech.2012.04.003 . 10.1016/j.ejmech.2012.04.003 . published European Journal of Medicinal Chemistry

Apoptosis Deregulation Influences Chemoresistance to Azaguanine in Human Leukemic Cell Lines

Sarmento-Ribeiro, A. B.; Dourado, M.; Paiva, A.; Freitas, A.; Silva, T.; Regateiro, F.; Oliveira, C. R., Cancer Investigation. 331 - 342. 5. 30. 2012. http://dx.doi.org/10.3109/07357907.2012.659925 . 10.3109/07357907.2012.659925 . published Cancer Investigation

A possible role for oxidation stress in lymphoid leukaemias and therapeutic failure

Sarmento-Ribeiro, Ana Bela; Proença, Maria T.; Sousa, Isabel; Pereira, Amélia; Guedes, Fátima; Teixeira, Adriana; Oliveira, Catarina R., Leukemia Research. 1041 - 1048. 8. 36. 2012. http://dx.doi.org/10.1016/j.leukres.2012.03.015 . 10.1016/j.leukres.2012.03.015 . published Leukemia Research

Oxidative stress adaptation in aggressive prostate cancer may be counteracted by the reduction of glutathione reductase

Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana, FEBS Open Bio. 119 - 128. 1. 2. 2012. http://dx.doi.org/10.1016/j.fob.2012.05.001 . 10.1016/j.fob.2012.05.001 . published FEBS Open Bio

Hepatocellular Carcinoma and Chemotherapy: The Role of p53

Brito, A.F.; Abrantes, A.M.; Pinto-Costa, C.; Gomes, A.R.; Mamede, A.C.; Casalta-Lopes, J.; Gonçalves, A.C.; et al, Chemotherapy. 381 - 386. 5. 58. 2012. http://dx.doi.org/10.1159/000343656 . 10.1159/000343656 . published Chemotherapy

Tumour Hypoxia and Technetium Tracers: In Vivo Studies

M. Abrantes, A.; Serra, E.; Goncalves, C.; Oliveiros, B.; Laranjo, M.; B. Sarmento-Ribeiro, A.; Rocha-Gonsalves, A.; F. Botelho, M., Current Radiopharmaceuticalse. 99 - 105. 2. 5. 2012. http://dx.doi.org/10.2174/1874471011205020099 . 10.2174/1874471011205020099 . published Current Radiopharmaceuticalse

Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): In Vitro and In Vivo Studies

Mamede, Ana Catarina; Pires, Ana Salomé; Abrantes, Ana Margarida; Tavares, Sónia Dorilde; Gonçalves, Ana Cristina; Casalta-Lopes, João Eduardo; Sarmento-Ribeiro, Ana Bela; Maia, Jorge Manuel; Botelho, Maria Filomena, Nutrition and Cancer. 1049 - 1057. 7. 64. 2012. http://dx.doi.org/10.1080/01635581.2012.713539 . 10.1080/01635581.2012.713539 . published Nutrition and Cancer

Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate cancer cell line

Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, Anabela, Biochemical and Biophysical Research Communications. 713 - 719. 4. 408. 2011. http://dx.doi.org/10.1016/j.bbrc.2011.04.109 . 10.1016/j.bbrc.2011.04.109 . published Biochemical and Biophysical Research Communications

Efflux Pumps Modulation in Colorectal Adenocarcinoma Cell Lines: The Role of Nuclear Medicine

Casalta-Lopes, João; Abrantes, Ana Margarida; Laranjo, Mafalda; Rio, Joana; Gonçalves, Ana Cristina; Oliveiros, Bárbara; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena, Journal of Cancer Therapy. 408 - 417. 03. 02. 2011. http://dx.doi.org/10.4236/jct.2011.23056 . 10.4236/jct.2011.23056 . published Journal of Cancer Therapy

Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells

Abrantes, Ana Margarida; Serra, Maria Elisa Silva; Gonçalves, Ana Cristina; Rio, Joana; Oliveiros, Bárbara; Laranjo, Mafalda; Rocha-Gonsalves, António Manuel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena, Nuclear Medicine and Biology. 125 - 132. 2. 37. 2010. http://dx.doi.org/10.1016/j.nucmedbio.2009.11.001 . 10.1016/j.nucmedbio.2009.11.001 . published Nuclear Medicine and Biology

Development of an Analytical Methodology for Simultaneous Determination of Vincristine and Doxorubicin in Pharmaceutical Preparations for Oncology by HPLC--UV

Rodrigues, A. S.; Lopes, A. R.; Leao, A.; Couceiro, A.; Ribeiro, A. B. S.; Ramos, F.; da Silveira, M. I. N.; de Oliveira, C. R., Journal of Chromatographic Science. 387 - 391. 5. 47. 2009. http://dx.doi.org/10.1093/chromsci/47.5.387 . 10.1093/chromsci/47.5.387 . published Journal of Chromatographic Science

Modelos experimentais em oncologia: O contributo da cultura de células para o conhecimento da biologia do cancro

Cruz, Mariana; Enes, Margarida; Pereira, Marta; Dourado, Marília; Sarmento Ribeiro, Ana Bela; Ribeiro, Ana Bela Sarmento, Revista Portuguesa de Pneumologia (English Edition). 669 - 682. 4. 15. 2009. http://dx.doi.org/10.1016/s2173-5115(09)70140-x . 10.1016/s2173-5115(09)70140-x . published Revista Portuguesa de Pneumologia (English Edition)

Estudo experimental do impacto da clampagem selectiva da veia porta na função hepatocelular

Tralhão, J Guilherme; Abrantes, Ana Margarida; Gonçalves, Ana Cristina; Carvalho, César; Portela, Ivan; Laranjo, Mafalda; Oliveiros, Bárbara; et al, Revista Portuguesa de Cirurgia Cardio-Torácica e Vascular. 171 - 176. 3. 16. 2009. published Revista Portuguesa de Cirurgia Cardio-Torácica e Vascular

Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer

Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N., Cytometry Part A. 1165 - 1172. 12. 73A. 2008. http://dx.doi.org/10.1002/cyto.a.20634 . 10.1002/cyto.a.20634 . published Cytometry Part A

Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington’s disease patients

Almeida, Sandra; Sarmento-Ribeiro, Ana Bela; Januário, Cristina; Rego, A Cristina; Oliveira, Catarina R, Biochemical and Biophysical Research Communications. 599 - 603. 4. 374. 2008. http://dx.doi.org/10.1016/j.bbrc.2008.07.009 . 10.1016/j.bbrc.2008.07.009 . published Biochemical and Biophysical Research Communications

CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture

Dourado, Marília; Sarmento, Ana Bela; Pereira, Sofia Vale; Alves, Vera; Silva, Teresa; Pinto, Anabela Mota; Rosa, Manuel Santos, Pathophysiology. 3 - 10. 1. 14. 2007. http://dx.doi.org/10.1016/j.pathophys.2006.09.003 . 10.1016/j.pathophys.2006.09.003 . published Pathophysiology

Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Preliminary Study

Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Pascoal, Rui; Rabaça, Carlos; Valido, Frederico; Mota-Pinto, Anabela; Sarmento-Ribeiro, AB, European Meeting of the Society for Free Radical Research, In Free Radical Research. 51 - 54. 2007. published European Meeting of the Society for Free Radical Research, In Free Radical Research

Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: Mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy

Neves, Sílvia S.; Sarmento-Ribeiro, Ana B.; Simões, Sérgio P.; Pedroso de Lima, Maria C., Biochimica et Biophysica Acta (BBA) - Biomembranes. 1703 - 1712. 11. 1758. 2006. http://dx.doi.org/10.1016/j.bbamem.2006.08.021 . 10.1016/j.bbamem.2006.08.021 . published Biochimica et Biophysica Acta (BBA) - Biomembranes

Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)

Dourado, Marília; Bento, Joana; Mesquita, Luís; Marques, Alcide; Vale-Pereira, Sofia; Ribeiro, Ana Bela Sarmento; Pinto, Anabela Mota, Revista Portuguesa de Pneumologia. 111 - 133. 2. 11. 2005. http://dx.doi.org/10.1016/s0873-2159(15)30495-5 . 10.1016/s0873-2159(15)30495-5 . published Revista Portuguesa de Pneumologia

Partition of Dopamine Antagonists into Synthetic Lipid Bilayers: the Effect of Membrane Structure and Composition

SARMENTO, ANA BELA; LIMA, M. C. PEDROSO; OLIVEJRA, C. R., Journal of Pharmacy and Pharmacology. 601 - 605. 7. 45. 1993. http://dx.doi.org/10.1111/j.2042-7158.1993.tb05660.x . 10.1111/j.2042-7158.1993.tb05660.x . published Journal of Pharmacy and Pharmacology

All projects

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Information of exclusive responsibility of the researcher 24-11-2024 , from platform CIÊNCIAVITAE.

2024

Relevance of NF-kB and NRF2/KEAP1 pathways as biomarkers of drug response in patients with Multiple Myeloma

LPCC/GSK

Researcher

Funders: Liga Portuguesa Contra o Cancro; GlaxoSmithKline Produtos Farmacêuticos Lda

2023

Relevância clínica das plaquetas como biomarcadores não invasivos no Mieloma Múltiplo - Um estudo piloto

APCL 2023

Principal investigator

Associação Portuguesa Contra a Leucemia; Sociedade Portuguesa de Hematologia; Amgen Biofarmaceutica Lda

Funders: Associação Portuguesa Contra a Leucemia; Sociedade Portuguesa de Hematologia; Amgen Biofarmaceutica Lda

2023

Clinical Relevance of non-invasive biomarkers in bone and soft tissue tumors

NRC-LPCC/CIMAGO 2023

Researcher

Funders: Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2023

Circular RNAs in hematological neoplasms: Potentialbiomarker from diagnosis to therapy

NRC-LPCC/CIMAGO 2023

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2022

HemaCirc: CircRNAs as an innovative tool in hematological neoplasms

CIMAGO 08/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022 -

The role of platelets in diagnosis, prognosis and therapeutic monitoring in diffuse large B-cell lymphoma

CIMAGO 06/22

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022 -

The role of platelets in diagnosis, prognosis and therapeutic monitoring in diffuse large B-cell lymphoma

CIMAGO 06/22

Principal investigator

2022 -

Evaluation of molecular mechanisms of resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma

CIMAGO 05/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022 -

Synthetic lethality in acute myeloid leukemia – Role of DNA damage response

CIMAGO 04/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2021/02 -

Clinical relevance of platelets as non-invasive biomarkers in diffuse large B-cell lymphoma - A pilot study

NRC-LPCC/CIMAGO 2020,

Supervisor

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2021/02 -

Clinical implications of DNA damage repair in acute myeloid leukemia.

SPH02/22

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Universidade de Coimbra; Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra; Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019 -

Molecular characterization and Clinical Relevance of the crosstalk between the NRF2/KEAP1 axis and Erythropoietin in Hematopoietic Stem Cell - Clinical Relevance in Myelodysplastic Syndromes

02/19

Principal investigator

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro; Sociedade Portuguesa de Hematologia

2019 - 2021

Red Transfronteriza de Innovation en Diagnóstico Precoz de Leucemia para envejecimiento saludable IDIAL-NET

POCTEP 2308

Researcher

2018 -

Characterization and Clinical Relevance of the NRF2/KEAP1 axis in the Hematopoietic Stem Cell of Myelodysplastic Syndromes

08/18

Researcher

Sociedade Portuguesa de Hematologia

2018 - 2022

Development of an innovative nanosystem to mediate a combined and multi-target therapeutic strategy to hepatocellular carcinoma

PTDC/BTM-MAT/30916/2017

Researcher

Fundação para a Ciência e a Tecnologia

2018 -

The NRF2-KEAP1 axis as a potential prognostic biomarker and therapeutic target in chronic lymphocytic leukemia.

03/18

Supervisor

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia; Sociedade Portuguesa de Hematologia

2018 - 2020

New diagnostic and therapeutic tools against multidrug resistant tumors - COST action

CA17104

Researcher

2018 -

Identification of new response markers to Bortezomib and Lenalidomide treatment in patients with multiple myeloma - The role of NF-kB and NRF2/KEAP1

04/18

Supervisor

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2016 - 2018

Epigenetic in Chronic Lymphocytic Leukemia B – Impact in prognosis and therapy.

FMUC-BST-2016-220

Researcher

Universidade de Coimbra Faculdade de Medicina

2015 - 2016

Modulação redox em neoplasias hematológicas – O NRF2 com novo marcador e alvo terapêutico

LPCC-CIMAGO 2015

Supervisor

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2015 - 2016

Role of Wingless and Hedgehog signaling pathways in pediatric B acute lymphoblastic leukemia as new prognostic markers and therapeutic targets

LPCC-2015

Supervisor

Liga Portuguesa Contra o Cancro; Pfizer Portugal

2015 - 2017

The role of Hedgehog signaling pathway in pediatric B acute lymphoblastic leukemia as a new prognostic marker and therapeutic target

GAI/2015

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2015 - 2016

Local anesthetics as a new therapeutic approach in oral squamous cell carcinoma - An in vitro study

GAI-2015

Researcher

Universidade de Coimbra Faculdade de Medicina

2014 - 2019

The role of microRNAs for chronic myeloid leukemia therapeutic selection

FMUC-BST-2016-214

Principal investigator

Universidade de Coimbra Faculdade de Medicina; Banco Santander Totta; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2013 - 2015

Aging, Stress And Chronic Diseases: From Mechanisms to Therapeutics

CENTRO-07-ST24-FEDER-002006

Researcher

2012/04/01 - 2015/09/30

Pathways of adipose tissue dysfunction: a route for obesity- related cancer

PTDC/SAU-MET/121133/2010

Universidade de Coimbra; Universidade de Coimbra Faculdade de Medicina; Unidade Local de Saúde de Coimbra EPE; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2012 - 2013

The cross-talk between oxidative stress and epigenetics – A possible route in myeloid leukaemia

GAI-2012

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2012 - 2018

Characterization of Cellular and Molecular mechanisms involved in Sensitivity and Resistance to BCR-ABL targeted therapies in Chronic Myelogenous Leukemia

18/12

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012 - 2014

MicroRNAs profile expression in hepatocellular carcinoma – Potencial prognostic and therapeutic value

11/12

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012 - 2016

Modulação redox em neoplasias hematológicas – O NRF2 com novo marcador e alvo terapêutico

10/12

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2011 - 2012

Strategic Project -LA 1

PEst-C/SAU/LA0001/2011

Researcher

2011/04/04 - 2014/10/02

Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors

PTDC/QUI-QUI/111891/2009

Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra; Universidade de Coimbra Faculdade de Medicina; Fundação para a Ciência e a Tecnologia

Funders: Fundação para a Ciência e a Tecnologia

2009 - 2016

Caracterização clínica e molecular da síndrome mielodisplásica – papel da apoptose e dos microRNAs no prognóstico e terapêutica

24/09

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2015

Cancro da cavidade oral – Estudo experimental do microambiente tumoral e novos alvos terapêuticos

26/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2016

Avaliação de Novos Marcadores Moleculares no Cancro Colorectal

25/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2015

Alterações celulares e moleculares no Mieloma Múltiplo – Implicações clínicas e terapêuticas

23/09

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2013

Molecular and Epigenetic Mechanisms Involved in Hepatocarcinoma – The Potential Prognostic Value And Therapeutic Targeted Approach

96560

Researcher

Fundação Calouste Gulbenkian

2009 - 2011

Síndrome metabólica e cancro da mama: implicações no prognóstico e terapêutica

21/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2016

Avaliação da relação entre o stress oxidativo e modulação epigenética em neoplasias hematológicas - Papel da variabilidade genética/epigenética no risco de desenvolver neoplasias hematológicas e/ou resistência ao tratamento

22/09

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2008 - 2010

Apo2L/TRAIL as a new therapeutic approach in cancer

02/08

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2007 - 2009

O papel do metabolismo energético no desenvolvimento do cancro

26/07

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2007 - 2008

Protocolo ES(H)AP - etopósido, metilprednisolona, citarabina e cisplatina - Estabilidade físico-química e biológica in vitro

01/07

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2007 - 2009

Nutrição e alterações epigenéticas na síndrome mielodisplásica – implicações prognósticas e terapêuticas

07/07

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2007 - 2009

Implementation of a new methodology for prostate cancer diagnosis and prognosis

01/07

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2006 - 2007

Epigenetic Modulation – A new therapeutic approach in hematological neoplasias

GAI-2006

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2006 - 2010

Molecular and genetic targets involved in prostate cancer susceptibility – The influence of oxidative stress and cigarette smoke

03/06

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2006 - 2008

Development of a cellular system for the study of Cr(VI)-induced lung carcinogenesis

16/06

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2006 - 2008

Novas abordagens terapêuticas no cancro da boca - O papel dos inibidores da tirosina cinase e do proteasoma

06/07

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2005 - 2007

Mitochondrial dysfunction in prostate cancer

14/05

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2005 - 2006

Cell signalling and cancer – The role of farnesyl transferase inhibitors in leukemia

GAI-2005

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2005 - 2006

Evaluation of Ubiquitin proteasome system in patients with Chronic Lymphocytic Leukaemias – Bortezomib as a potential therapeutic approach

JC-2005

Principal investigator

Janssen-Cilag Farmacêutica Lda

2005 - 2007

Protein Kinase inhibitors – Molecular and cellular mechanisms of drug resistance to Enzastaurin (LY317615) – a study in cell culture

LILLY 2005

Principal investigator

Lilly Portugal Produtos Farmacêuticos Lda

2004 - 2006

Apoptosis and Hemato-oncological Diseases – TRAIL/Apo2L as a Potential Therapeutics Approach

01/04

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2004 - 2005

Ubiquitin/proteasome System in Hematological Neoplasia – The Proteasome Inhibitors of as Potential Therapeutic Approach

03/04

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2004 - 2005

Apopptosis and new anticarcinogenic agents – The therapeutic potential of TRAIL/Apo2L

GAI-2004

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2004 - 2006

Molecular Alterations in Prostate Cancer – Evaluation of Chromosomal Alterations and Resistance to Apoptosis

02/04

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2002 - 2003

Role of nitric oxide in limphomagenesis – Relation with resistance to chemotherapy

01/02

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2002 - 2003

Proteasome inhibitors and its use in chemotherapy resistance – A Study in leukemic cells in culture

GAI-19/02

Principal investigator

Universidade de Coimbra Faculdade de Medicina

2002 - 2003

DPPIV/CD26 and Cytotoxicity Induced by Anticancer Drugs

IPG-FMUC

Researcher

Universidade de Coimbra Faculdade de Medicina

2002 - 2004

Role of mitochondria in cell death observed in Huntington’s Disease

GAI-2002

Researcher

Universidade de Coimbra Faculdade de Medicina

1997 - 1998

Influence of oxidative stress and membrane alterations in leukemia pathogenesis and in resistance to chemotherapy.

136/97

Principal investigator

1996 - 2000

Phenotypic alterations of the tumor cell and its involvement in resistance to anti-neoplasic drugs

PRODEP

Principal investigator

1990 - 1992

Retina oxidative stress. Involvement in aging and diabetes

JNICT 90/92

Researcher

1989 - 1991

Partition of Dopamine Antagonists into Synthetic Lipid Bilayers - The Effect of Membrane Structure and Composition

JNICT nº87583

Researcher

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