Publications
Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.
Activation of Laminin ¿2 by Helicobacter pylori Promotes Invasion and Survival of Gastric Cancer Cells With E-Cadherin Defects
Rui M Ferreira; Joana Figueiredo; Ines Pinto-Ribeiro; Irene Gullo; Dionyssios N Sgouras; Laura Carreto; Patricia Castro; et al, The Journal of Infectious Diseases. 2226 - 2237. 226. 2022. https://academic.oup.com/jid/article/226/12/2226/6731086 . 10.1093/infdis/jiac397 . The Journal of Infectious Diseases
The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
Francisco, Stephany; Martinho, Vera; Ferreira, Margarida; Reis, Andreia; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A. S., International Journal of Molecular Sciences. 6. 23. 2022. http://dx.doi.org/10.3390/ijms23063232 . 10.3390/ijms23063232 . International Journal of Molecular Sciences
Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations
Marçalo, Rui; Neto, Sonya; Pinheiro, Miguel; Rodrigues, Ana J.; Sousa, Nuno; Santos, Manuel A. S.; Simão, Paula; et al, PLOS ONE. 2. 17. 2022. http://dx.doi.org/10.1371/journal.pone.0264009 . 10.1371/journal.pone.0264009 . PLOS ONE
Upregulation of tRNA-Ser-AGA-2-1 Promotes Malignant Behavior in Normal Bronchial Cells
Santos, Mafalda; Fidalgo, Ana; Varanda, Ana Sofia; Soares, Ana Raquel; Almeida, Gabriela M.; Martins, Diana; Mendes, Nuno; Oliveira, Carla; Santos, Manuel A. S., Frontiers in Molecular Biosciences. 9. 2022. http://dx.doi.org/10.3389/fmolb.2022.809985 . 10.3389/fmolb.2022.809985 . Frontiers in Molecular Biosciences
All you need to know about sperm RNAs
Santiago, Joana; Silva, Joana V; Howl, John; Santos, Manuel A S; Fardilha, Margarida, Human Reproduction Update. 67 - 91. 1. 28. 2021. http://dx.doi.org/10.1093/humupd/dmab034 . 10.1093/humupd/dmab034 . Human Reproduction Update
Protein Aggregation Patterns Inform about Breast Cancer Response to Antiestrogens and Reveal the RNA Ligase RTCB as Mediator of Acquired Tamoxifen Resistance
Direito, Inês; Monteiro, Liliana; Melo, Tânia; Figueira, Daniela; Lobo, João; Enes, Vera; Moura, Gabriela; et al, Cancers. 13. 13. 2021. http://dx.doi.org/10.3390/cancers13133195 . 10.3390/cancers13133195 . Cancers
The role of non-standard translation in Candida albicans pathogenesis
Bezerra, Ana Rita; Oliveira, Carla; Correia, Inês; Guimarães, Ana Rita; Sousa, Gonçalo; Carvalho, Maria João; Moura, Gabriela; Santos, Manuel A S, FEMS Yeast Research. 4. 21. 2021. http://dx.doi.org/10.1093/femsyr/foab032 . 10.1093/femsyr/foab032 . FEMS Yeast Research
tRNAs as a Driving Force of Genome Evolution in Yeast
Guimarães, Ana Rita; Correia, Inês; Sousa, Inês; Oliveira, Carla; Moura, Gabriela; Bezerra, Ana Rita; Santos, Manuel A. S., Frontiers in Microbiology. 12. 2021. http://dx.doi.org/10.3389/fmicb.2021.634004 . 10.3389/fmicb.2021.634004 . Frontiers in Microbiology
The role of micropeptides in biology
Vitorino, Rui; Guedes, Sofia; Amado, Francisco; Santos, Manuel; Akimitsu, Nobuyoshi, Cellular and Molecular Life Sciences. 3285 - 3298. 7. 78. 2021. http://dx.doi.org/10.1007/s00018-020-03740-3 . 10.1007/s00018-020-03740-3 . Cellular and Molecular Life Sciences
Association of positive and negative life events with cognitive performance and psychological status in late life: A cross-sectional study in Northern Portugal
Castanho, T.C.; Santos, N.C.; Meleiro-Neves, C.; Neto, S.; Moura, G.R.; Santos, M.A.; Cruz, A.R.; et al, Aging Brain. 1. 2021. http://dx.doi.org/10.1016/j.nbas.2021.100020 . 10.1016/j.nbas.2021.100020 . Aging Brain
Fighting Bisphenol A-Induced Male Infertility: The Power of Antioxidants
Santiago, Joana; Silva, Joana V.; Santos, Manuel A. S.; Fardilha, Margarida, Antioxidants. 2. 10. 2021. http://dx.doi.org/10.3390/antiox10020289 . 10.3390/antiox10020289 . Antioxidants
Integration of segmented regression analysis with weighted gene correlation network analysis identifies genes whose expression is remodeled throughout physiological aging in mouse tissues
Ferreira, Margarida; Francisco, Stephany; Soares, Ana R.; Nobre, Ana; Pinheiro, Miguel; Reis, Andreia; Neto, Sonya; et al, Aging. 18150 - 18190. 14. 13. 2021. http://dx.doi.org/10.18632/aging.203379 . 10.18632/aging.203379 . Aging
tRNA-modifying enzyme mutations induce codon-specific mistranslation and protein aggregation in yeast
Tavares, Joana F; Davis, Nick K.; Poim, Ana; Reis, Andreia; Kellner, Stefanie; Sousa, Inês; Soares, Ana R.; et al, RNA Biology. 563 - 575. 4. 18. 2020. http://dx.doi.org/10.1080/15476286.2020.1819671 . 10.1080/15476286.2020.1819671 . RNA Biology
Does proteostasis get lost in translation? Implications for protein aggregation across the lifespan
Francisco, Stephany; Ferreira, Margarida; Moura, Gabriela; Soares, Ana Raquel; Santos, Manuel A.S., Ageing Research Reviews. 62. 2020. http://dx.doi.org/10.1016/j.arr.2020.101119 . 10.1016/j.arr.2020.101119 . Ageing Research Reviews
Emerging Roles of tRNAs in RNA Virus Infections
Nunes, Alexandre; Ribeiro, Diana Roberta; Marques, Mariana; Santos, Manuel A.S.; Ribeiro, Daniela; Soares, Ana Raquel, Trends in Biochemical Sciences. 794 - 805. 9. 45. 2020. http://dx.doi.org/10.1016/j.tibs.2020.05.007 . 10.1016/j.tibs.2020.05.007 . Trends in Biochemical Sciences
Human cells adapt to translational errors by modulating protein synthesis rate and protein turnover
Varanda, Ana Sofia; Santos, Mafalda; Soares, Ana Raquel; Vitorino, Rui; Oliveira, Patrícia; Oliveira, Carla; Santos, Manuel, RNA Biology. 135 - 149. 1. 17. 2020. http://dx.doi.org/10.1080/15476286.2019.1670039 . 10.1080/15476286.2019.1670039 . RNA Biology
De novo sequencing of proteins by mass spectrometry
Vitorino, Rui; Guedes, Sofia; Trindade, Fabio; Correia, Inês; Moura, Gabriela; Carvalho, Paulo; Santos, Manuel A. S.; Amado, Francisco, Expert Review of Proteomics. 595 - 607. 7-8. 17. 2020. http://dx.doi.org/10.1080/14789450.2020.1831387 . 10.1080/14789450.2020.1831387 . Expert Review of Proteomics
tRNA Deregulation and Its Consequences in Cancer
Santos, Mafalda; Fidalgo, Ana; Varanda, A. Sofia; Oliveira, Carla; Santos, Manuel, Trends in Molecular Medicine. 853 - 865. 10. 25. 2019. http://dx.doi.org/10.1016/j.molmed.2019.05.011 . 10.1016/j.molmed.2019.05.011 . published Trends in Molecular Medicine
MicroRNA-186-5p controls GluA2 surface expression and synaptic scaling in hippocampal neurons
Silva, Mariline M.; Rodrigues, Beatriz; Fernandes, Joana; Santos, Sandra D.; Carreto, Laura; Santos, Manuel; Pinheiro, Paulo; Carvalho, Ana Luísa, Proceedings of the National Academy of Sciences. 5727 - 5736. 12. 116. 2019. http://dx.doi.org/10.1073/pnas.1900338116 . 10.1073/pnas.1900338116 . published Proceedings of the National Academy of Sciences
One year of exercise training promotes distinct adaptations in right and left ventricle of female Sprague-Dawley rats
Nogueira-Ferreira, Rita; Ferreira, Rita; Padrão, Ana Isabel; Oliveira, Paula; Santos, Manuel; Kavazis, Andreas N.; Vitorino, Rui; Moreira-Gonçalves, Daniel, Journal of Physiology and Biochemistry. 561 - 572. 4. 75. 2019. http://dx.doi.org/10.1007/s13105-019-00705-4 . 10.1007/s13105-019-00705-4 . Journal of Physiology and Biochemistry
Human cells adapt to translational errors by modulating protein synthesis rate and protein turnover
Varanda, Ana Sofia; Santos, Mafalda; Soares, Ana R.; Vitorino, Rui; Oliveira, Patrícia; Oliveira, Carla; Santos, Manuel A. S., RNA Biology. 135 - 149. 1. 17. 2019. http://dx.doi.org/10.1080/15476286.2019.1670039 . 10.1080/15476286.2019.1670039 . RNA Biology
Human cells adapt to translational errors by modulating protein synthesis rate and protein turnover
Varanda, Ana Sofia; Santos, Mafalda; Soares, Ana R.; Vitorino, Rui; Oliveira, Patrícia; Oliveira, Carla; Santos, Manuel A. S., RNA Biology. 135 - 149. 1. 17. 2019. http://dx.doi.org/10.1080/15476286.2019.1670039 . 10.1080/15476286.2019.1670039 . RNA Biology
Impact of tRNA modifications and tRNA-modifying enzymes on proteostasis and human disease
Pereira, M.; Francisco, S.; Varanda, A.S.; Santos, M.; Santos, M.A.S.; Soares, A.R., International Journal of Molecular Sciences. 12. 19. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057211964&partnerID=MN8TOARS . 10.3390/ijms19123738 . International Journal of Molecular Sciences
Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2a dephosphorylation by the GADD34/PP1c complex
Perego, Jessica; Mendes, A; Bourbon, Clarisse; Camosseto, Voahirana; Combes, Alexis; Liu, Hong; Manh, Thien-Phong Vu; et al, Science Signaling. 514. 11. 2018. http://dx.doi.org/10.1126/scisignal.aam8104 . 10.1126/scisignal.aam8104 . published Science Signaling
Plasmodium apicoplast tyrosyl-tRNA synthetase recognizes an unusual, simplified identity set in cognate tRNATyr
Cela, Marta; Paulus, Caroline; Santos, Manuel; Moura, Gabriela; Frugier, Magali; Rudinger-Thirion, Joëlle, PLOS ONE. 12. 13. 2018. http://dx.doi.org/10.1371/journal.pone.0209805 . 10.1371/journal.pone.0209805 . published PLOS ONE
A Fluorescence-Based Sensor Assay that Monitors General Protein Aggregation in Human Cells
Pereira, M.; Tomé, D.; Domingues, A.S.; Varanda, A.S.; Paulo, C.; Santos, M.A.S.; Soares, A.R., Biotechnology Journal. 4. 13. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043346932&partnerID=MN8TOARS . 10.1002/biot.201700676 . Biotechnology Journal
Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast
Araújo, A.R.D.; Melo, T.; Maciel, E.A.; Pereira, C.; Morais, C.M.; Santinha, D.R.; Tavares, J.F.; et al, PLoS ONE. 8. 13. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85052640327&partnerID=MN8TOARS . 10.1371/journal.pone.0202402 . PLoS ONE
Proteomics Analysis for Amino Acid Misincorporation Detection: Mini Review
Tavares, Joana; Santos, Filipe Assis; Santos, Manuel, Journal of Proteomics & Bioinformatics. 45 - 50. 2. 11. 2018. http://dx.doi.org/10.4172/jpb.1000464 . 10.4172/jpb.1000464 . published Journal of Proteomics & Bioinformatics
Codon misreading tRNAs promote tumor growth in mice
Santos, M.; Pereira, P.M.; Varanda, A.S.; Carvalho, J.; Azevedo, M.; Mateus, D.D.; Mendes, N.; et al, RNA Biology. 773 - 786. 6. 15. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048065304&partnerID=MN8TOARS . 10.1080/15476286.2018.1454244 . RNA Biology
Saccharomyces cerevisiae as a Model to Confirm the Ability of FTIR to Evaluate the Presence of Protein Aggregates
Magalhães, S.; Graça, Ana; Tavares, Joana; Santos, Manuel; Delgadillo, Ivonne; Nunes, Alexandra, Spectral Analysis Review. 1 - 11. 01. 06. 2017. http://dx.doi.org/10.4236/sar.2018.61001 . 10.4236/sar.2018.61001 . published Spectral Analysis Review
Discovery and function of transfer RNA-derived fragments and their role in disease
Soares, Ana Raquel; Santos, Manuel, Wiley Interdisciplinary Reviews: RNA. 5. 8. 2017. http://dx.doi.org/10.1002/wrna.1423 . 10.1002/wrna.1423 . published Wiley Interdisciplinary Reviews: RNA
Phenotypic heterogeneity promotes adaptive evolution
Bódi, Zoltán; Farkas, Zoltán; Nevozhay, Dmitry; Kalapis, Dorottya; Lázár, Viktória; Csörgo, Bálint; Nyerges, Ákos; et al, PLOS Biology. 6. 15. 2017. http://dx.doi.org/10.1371/journal.pbio.1002607 . 10.1371/journal.pbio.1002607 . published PLOS Biology
Protein synthesis inhibition and GADD34 control IFN-ß heterogeneous expression in response to dsRNA
Dalet, Alexandre; Argüello, Rafael J; Combes, Alexis; Spinelli, Lionel; Jaeger, Sebastien; Fallet, Mathieu; Vu Manh, Thien-Phong; et al, The EMBO Journal. 761 - 782. 6. 36. 2017. http://dx.doi.org/10.15252/embj.201695000 . 10.15252/embj.201695000 . published The EMBO Journal
The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons
Leal, Graciano; Comprido, Diogo; de Luca, Pasqualino; Morais, Eduardo; Rodrigues, Luís; Mele, Miranda; Santos, Ana R.; et al, eneuro. 6. 4. 2017. http://dx.doi.org/10.1523/eneuro.0268-17.2017 . 10.1523/eneuro.0268-17.2017 . published eneuro
Adaptive mistranslation accelerates the evolution of fluconazole resistance and induces major genomic and gene expression alterations in Candida albicans
Weil, T.; Santamaría, R.; Lee, W.; Rung, J.; Tocci, N.; Abbey, D.; Bezerra, A.R.; et al, mSphere. 4. 2. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040978047&partnerID=MN8TOARS . 10.1128/mSphere.00167-17 . published mSphere
Erratum : mRNA secondary structure optimization using a correlated stem-loop prediction (Nucleic Acids Research (2013) 41:6 (e73) DOI: 10.1093/nar/gks1473)
Gaspar, P.; Moura, G.; Santos, M.A.S.; Oliveira, J.L., Nucleic Acids Research. 5490 - 5490. 11. 44. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976435942&partnerID=MN8TOARS . 10.1093/nar/gkw127 . Nucleic Acids Research
Erratum: EuGene: Maximizing synthetic gene design for heterologous expression (Bioinformatics (2012) 28: 20 (2683-2684))
Gaspar, P.; Luís Oliveira, J.; Frommlet, J.; Santos, M.A.S.; Moura, G., Bioinformatics. 1120 - 1120. 7. 32. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964432672&partnerID=MN8TOARS . 10.1093/bioinformatics/btw063 . Bioinformatics
The Fungus Candida albicans Tolerates Ambiguity at Multiple Codons
Simões, João; Bezerra, Ana R.; Moura, Gabriela; Araújo, Hugo; Gut, Ivo; Bayes, Mónica; Santos, Manuel, Frontiers in Microbiology. 7. 2016. http://dx.doi.org/10.3389/fmicb.2016.00401 . 10.3389/fmicb.2016.00401 . published Frontiers in Microbiology
Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host withSaccharomyces cerevisiae
Rizzetto, Lisa; Ifrim, Daniela C.; Moretti, Silvia; Tocci, Noemi; Cheng, Shih-Chin; Quintin, Jessica; Renga, Giorgia; et al, Journal of Biological Chemistry. 7961 - 7972. 15. 291. 2016. http://dx.doi.org/10.1074/jbc.m115.699645 . 10.1074/jbc.m115.699645 . published Journal of Biological Chemistry
Comparison of the compatible solute pool of two slightly halophilic planctomycetes species, Gimesia maris and Rubinisphaera brasiliensis
Ferreira, Catarina; Soares, Ana Raquel; Lamosa, Pedro; Santos, Manuel; da Costa, Milton S., Extremophiles. 811 - 820. 6. 20. 2016. http://dx.doi.org/10.1007/s00792-016-0868-0 . 10.1007/s00792-016-0868-0 . published Extremophiles
Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways
Costa, Angela M.; Ferreira, Rui M.; Pinto-Ribeiro, Ines; Sougleri, Ioanna S.; Oliveira, Maria J.; Carreto, Laura; Santos, Manuel; et al, Journal of Infectious Diseases. 1767 - 1776. 11. 213. 2016. http://dx.doi.org/10.1093/infdis/jiw031 . 10.1093/infdis/jiw031 . published Journal of Infectious Diseases
Non-Standard Genetic Codes Define New Concepts for Protein Engineering
Bezerra, Ana; Guimarães, Ana; Santos, Manuel, Life. 1610 - 1628. 4. 5. 2015. http://dx.doi.org/10.3390/life5041610 . 10.3390/life5041610 . published Life
Intrastrain genomic and phenotypic variability of the commercialSaccharomyces cerevisiaestrain Zymaflore VL1 reveals microevolutionary adaptation to vineyard environments
Franco-Duarte, Ricardo; Bigey, Frédéric; Carreto, Laura; Mendes, Inês; Dequin, Sylvie; Santos, Manuel; Pais, Célia; Schuller, Dorit, FEMS Yeast Research. 6. 15. 2015. http://dx.doi.org/10.1093/femsyr/fov063 . 10.1093/femsyr/fov063 . published FEMS Yeast Research
Conserved and highly expressed tRNA derived fragments in zebrafish
Soares, Ana Raquel; Fernandes, Noémia; Reverendo, Marisa; Araújo, Hugo Rafael; Oliveira, José Luís; Moura, Gabriela; Santos, Manuel, BMC Molecular Biology. 1. 16. 2015. http://dx.doi.org/10.1186/s12867-015-0050-8 . 10.1186/s12867-015-0050-8 . published BMC Molecular Biology
RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4
Terawaki, Seigo; Camosseto, Voahirana; Prete, Francesca; Wenger, Till; Papadopoulos, Alexia; Rondeau, Christiane; Combes, Alexis; et al, The Journal of Cell Biology. 1133 - 1152. 7. 210. 2015. http://dx.doi.org/10.1083/jcb.201501059 . 10.1083/jcb.201501059 . published The Journal of Cell Biology
Improving the accuracy of recombinant protein production through integration of bioinformatics, statistical and mass spectrometry methodologies
Ragionieri, Lapo; Vitorino, Rui; Frommlet, Joerg; Oliveira, José L.; Gaspar, Paulo; Ribas de Pouplana, Lluís; Santos, Manuel; Moura, Gabriela, The FEBS Journal. 769 - 787. 4. 282. 2015. http://dx.doi.org/10.1111/febs.13181 . 10.1111/febs.13181 . published The FEBS Journal
Erratum: Species-Specific Codon Context Rules Unveil Non-Neutrality Effects of Synonymous Mutations (PLoS ONE (2011) 6:10 (e26817))
Moura, G.R.; Pinheiro, M.; Freitas, A.; Oliveira, J.L.; Frommlet, J.C.; Carreto, L.; Soares, A.R.; Bezerra, A.R.; Santos, M.A.S., PLoS ONE. 12. 10. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956899012&partnerID=MN8TOARS . 10.1371/journal.pone.0145593 . PLoS ONE
Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover
Kalapis, Dorottya; Bezerra, Ana R.; Farkas, Zoltán; Horvath, Peter; Bódi, Zoltán; Daraba, Andreea; Szamecz, Béla; et al, PLOS Biology. 11. 13. 2015. http://dx.doi.org/10.1371/journal.pbio.1002291 . 10.1371/journal.pbio.1002291 . published PLOS Biology
Yap1 mediates tolerance to cobalt toxicity in the yeast Saccharomyces cerevisiae
Pimentel, Catarina; Caetano, Soraia M.; Menezes, Regina; Figueira, Inês; Santos, Claudia N.; Ferreira, Ricardo B.; Santos, Manuel; Rodrigues-Pousada, Claudina, Biochimica et Biophysica Acta (BBA) - General Subjects. 1977 - 1986. 6. 1840. 2014. http://dx.doi.org/10.1016/j.bbagen.2014.01.032 . 10.1016/j.bbagen.2014.01.032 . published Biochimica et Biophysica Acta (BBA) - General Subjects
Protein mistranslation: friend or foe?
Ribas de Pouplana, Liuís; Santos, Manuel; Zhu, Jun-Hao; Farabaugh, Philip J.; Javid, Babak, Trends in Biochemical Sciences. 355 - 362. 8. 39. 2014. http://dx.doi.org/10.1016/j.tibs.2014.06.002 . 10.1016/j.tibs.2014.06.002 . published Trends in Biochemical Sciences
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels and cAMP-Dependent Modulation of Exocytosis in Cultured Rat Lactotrophs
Calejo, A. I.; Jorga evski, J.; Rituper, B.; Gu ek, A.; Pereira, P. M.; Santos, Manuel; Potokar, M.; et al, Journal of Neuroscience. 15638 - 15647. 47. 34. 2014. http://dx.doi.org/10.1523/jneurosci.5290-13.2014 . 10.1523/jneurosci.5290-13.2014 . published Journal of Neuroscience
Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA
Bordeira-Carriço, Renata; Ferreira, Daniel; Mateus, Denisa D; Pinheiro, Hugo; Pêgo, Ana Paula; Santos, Manuel; Oliveira, Carla, European Journal of Human Genetics. 1085 - 1092. 9. 22. 2014. http://dx.doi.org/10.1038/ejhg.2013.292 . 10.1038/ejhg.2013.292 . published European Journal of Human Genetics
Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3
Vieira, M.; Fernandes, J.; Carreto, L.; Anuncibay-Soto, B.; Santos, Manuel; Han, J.; Fernández-López, A.; et al, Neurobiology of Disease. 26 - 36. 68. 2014. http://dx.doi.org/10.1016/j.nbd.2014.04.002 . 10.1016/j.nbd.2014.04.002 . published Neurobiology of Disease
High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin
Bernardes, Nuno; Ribeiro, Ana Sofia; Abreu, Sofia; Vieira, André F.; Carreto, Laura; Santos, Manuel; Seruca, Raquel; Paredes, Joana; Fialho, Arsenio M., The International Journal of Biochemistry & Cell Biology. 1 - 9. 50. 2014. http://dx.doi.org/10.1016/j.biocel.2014.01.023 . 10.1016/j.biocel.2014.01.023 . published The International Journal of Biochemistry & Cell Biology
TRNA mutations that affect decoding fidelity deregulate development and the proteostasis network in zebrafish
Reverendo, M.; Soares, A.R.; Pereira, P.M.; Carreto, L.; Ferreira, V.; Gatti, E.; Pierre, P.; Moura, G.R.; Santos, M.A., RNA Biology. 1199 - 1213. 9. 11. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921709623&partnerID=MN8TOARS . 10.4161/rna.32199 . RNA Biology
In vitro ischemia triggers a transcriptional response to down-regulate synaptic proteins in hippocampal neurons
Fernandes, J.; Vieira, M.; Carreto, L.; Santos, M.A.S.; Duarte, C.B.; Carvalho, A.L.; Santos, A.E., PLoS ONE. 6. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903512303&partnerID=MN8TOARS . 10.1371/journal.pone.0099958 . PLoS ONE
Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications
Calejo, Ana I.; Reverendo, Marisa; Silva, Virgília S.; Pereira, Patrícia M.; Santos, Manuel; Zorec, Robert; Gonçalves, Paula P., Molecular Biology Reports. 297 - 307. 1. 41. 2013. http://dx.doi.org/10.1007/s11033-013-2862-2 . 10.1007/s11033-013-2862-2 . published Molecular Biology Reports
Selective Inhibition of an Apicoplastic Aminoacyl-tRNA Synthetase from Plasmodium falciparum
Hoen, Rob; Novoa, Eva Maria; López, Alba; Camacho, Noelia; Cubells, Laia; Vieira, Pedro; Santos, Manuel; et al, ChemBioChem. 499 - 509. 4. 14. 2013. http://dx.doi.org/10.1002/cbic.201200620 . 10.1002/cbic.201200620 . published ChemBioChem
mRNA secondary structure optimization using a correlated stem–loop prediction
Gaspar, Paulo; Moura, Gabriela; Santos, Manuel; Oliveira, José Luís, Nucleic Acids Research. e73 - e73. 6. 41. 2013. http://dx.doi.org/10.1093/nar/gks1473 . 10.1093/nar/gks1473 . published Nucleic Acids Research
Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification
Bezerra, A.R.; Simões, J.; Lee, W.; Rung, J.; Weil, T.; Gut, I.G.; Gut, M.; et al, Proceedings of the National Academy of Sciences of the United States of America. 11079 - 11084. 27. 110. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879727622&partnerID=MN8TOARS . 10.1073/pnas.1302094110 . Proceedings of the National Academy of Sciences of the United States of America
Heterologous Expression and Purification of ? Galactosidase Protein Using Affinity Chromatography
Alam, M. Z.; Ragionieri, L.; Santos, Manuel; Iqbal, A., Journal of Scientific Research. 499 - 513. 3. 5. 2013. http://dx.doi.org/10.3329/jsr.v5i3.13820 . 10.3329/jsr.v5i3.13820 . published Journal of Scientific Research
Molecular reconstruction of a fungal genetic code alteration
Mateus, D.D.; Paredes, J.A.; Español, Y.; De Pouplana, L.R.; Moura, G.R.; Santos, M.A.S., RNA Biology. 961 - 973. 6. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879488664&partnerID=MN8TOARS . 10.4161/rna.24683 . RNA Biology
Candida albicans CUG mistranslation is a mechanism to create cell surface variation
Miranda, I.; Silva-Dias, A.; Rocha, R.; Teixeira-Santos, R.; Coelho, C.; Gonçalves, T.; Santos, M.A.S.; et al, mBio. 4. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883429281&partnerID=MN8TOARS . 10.1128/mBio.00285-13 . published mBio
Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid
Silva, A.; Sampaio-Marques, B.; Fernandes, Â.; Carreto, L.; Rodrigues, F.; Holcik, M.; Santos, M.A.S.; Ludovico, P., PLoS ONE. 8. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881561857&partnerID=MN8TOARS . 10.1371/journal.pone.0071294 . PLoS ONE
P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model
Ribeiro, A.S.; Sousa, B.; Carreto, L.; Mendes, N.; Nobre, A.R.; Ricardo, S.; Albergaria, A.; et al, Journal of Pathology. 705 - 718. 5. 229. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875054847&partnerID=MN8TOARS . 10.1002/path.4143 . Journal of Pathology
Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays
Quintela, T.; Gonçalves, I.; Carreto, L.C.; Santos, M.A.S.; Marcelino, H.; Patriarca, F.M.; Santos, C.R.A., PLoS ONE. 4. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876025530&partnerID=MN8TOARS . 10.1371/journal.pone.0060199 . PLoS ONE
EuGene: maximizing synthetic gene design for heterologous expression
Gaspar, P.; Oliveira, J. L.; Frommlet, J.; Santos, Manuel; Moura, Gabriela, Bioinformatics. 2683 - 2684. 20. 28. 2012. http://dx.doi.org/10.1093/bioinformatics/bts465 . 10.1093/bioinformatics/bts465 . published Bioinformatics
Cancer syndromes and therapy by stop-codon readthrough
Bordeira-Carriço, Renata; Pêgo, Ana Paula; Santos, Manuel; Oliveira, Carla, Trends in Molecular Medicine. 667 - 678. 11. 18. 2012. http://dx.doi.org/10.1016/j.molmed.2012.09.004 . 10.1016/j.molmed.2012.09.004 . published Trends in Molecular Medicine
An integrative approach for codon repeats evolutionary analyses
Lousado, José Paulo; Oliveira, José Luis; Moura, Gabriela; Santos, Manuel; Lousado, J.P.; Oliveira, J.L.; Moura, G.; Santos, M.A.S., International Journal of Data Mining and Bioinformatics. 369 - 381. 4. 6. 2012. http://dx.doi.org/10.1504/ijdmb.2012.049294 . 10.1504/ijdmb.2012.049294 . published International Journal of Data Mining and Bioinformatics
Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast
Paredes, João A; Carreto, Laura; Simões, João; Bezerra, Ana R; Gomes, Ana C; Santamaria, Rodrigo; Kapushesky, Misha; Moura, Gabriela; Santos, Manuel, BMC Biology. 1. 10. 2012. http://dx.doi.org/10.1186/1741-7007-10-55 . 10.1186/1741-7007-10-55 . published BMC Biology
Lack of microRNA-101 causes E-cadherin functional deregulation through EZH2 up-regulation in intestinal gastric cancer
Carvalho, J.; Van Grieken, N.C.; Pereira, P.M.; Sousa, S.; Tijssen, M.; Buffart, T.E.; Diosdado, B.; et al, Journal of Pathology. 31 - 44. 1. 228. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864749110&partnerID=MN8TOARS . 10.1002/path.4032 . Journal of Pathology
Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos
Soares, A.R.; Reverendo, M.; Pereira, P.M.; Nivelles, O.; Pendeville, H.; Bezerra, A.R.; Moura, G.R.; Struman, I.; Santos, M.A.S., PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862690378&partnerID=MN8TOARS . 10.1371/journal.pone.0039417 . PLoS ONE
Genetic diversity and population structure of saccharomyces cerevisiae strains isolated from different grape varieties and winemaking regions
Schuller, D.; Cardoso, F.; Sousa, S.; Gomes, P.; Gomes, A.C.; Santos, M.A.S.; Casal, M., PLoS ONE. 2. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857676912&partnerID=MN8TOARS . 10.1371/journal.pone.0032507 . PLoS ONE
Ethanol Exposure Induces Upregulation of Specific MicroRNAs in Zebrafish Embryos
Soares, Ana Raquel; Pereira, Patrícia M.; Ferreira, Violeta; Reverendo, Marisa; Simões, João; Bezerra, Ana Rita; Moura, Gabriela; Santos, Manuel, Toxicological Sciences. 18 - 28. 1. 127. 2012. http://dx.doi.org/10.1093/toxsci/kfs068 . 10.1093/toxsci/kfs068 . published Toxicological Sciences
The genetic code of the fungal CTG clade
Santos, Manuel; Gomes, Ana C.; Santos, Maria C.; Carreto, Laura C.; Moura, Gabriela, Comptes Rendus Biologies. 607 - 611. 8-9. 334. 2011. http://dx.doi.org/10.1016/j.crvi.2011.05.008 . 10.1016/j.crvi.2011.05.008 . published Comptes Rendus Biologies
Differential gene expression analysis in Enchytraeus albidus exposed to natural and chemical stressors at different exposure periods
Novais, Sara C.; Howcroft, Clara F.; Carreto, Laura; Pereira, Patrícia M.; Santos, Manuel; De Coen, Wim; Soares, Amadeu M. V. M.; Amorim, Mónica J. B., Ecotoxicology. 213 - 224. 1. 21. 2011. http://dx.doi.org/10.1007/s10646-011-0780-4 . 10.1007/s10646-011-0780-4 . published Ecotoxicology
Genotyping of Saccharomyces cerevisiae strains by interdelta sequence typing using automated microfluidics
Franco-Duarte, Ricardo; Mendes, Inês; Gomes, Ana Catarina; Santos, Manuel; de Sousa, Bruno; Schuller, Dorit, Electrophoresis. 1447 - 1455. 12. 32. 2011. http://dx.doi.org/10.1002/elps.201000640 . 10.1002/elps.201000640 . published Electrophoresis
Purification, crystallization and preliminary X-ray diffraction analysis of the seryl-tRNA synthetase from Candida albicans
Rocha, R.; Barbosa Pereira, P.J.; Santos, M.A.S.; MacEdo-Ribeiro, S.; Rocha, Rita; Barbosa Pereira, Pedro José; Santos, Manuel; Macedo-Ribeiro, Sandra, Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 153 - 156. 1. 67. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651065708&partnerID=MN8TOARS . 10.1107/S1744309110048542 . published Acta Crystallographica Section F: Structural Biology and Crystallization Communications
Protein translation in Plasmodium parasites
Jackson, Katherine E.; Habib, Saman; Frugier, Magali; Hoen, Rob; Khan, Sameena; Pham, James S.; Pouplana, Lluís Ribas de; et al, Trends in Parasitology. 467 - 476. 10. 27. 2011. http://dx.doi.org/10.1016/j.pt.2011.05.005 . 10.1016/j.pt.2011.05.005 . published Trends in Parasitology
Systems biology of infectious diseases: a focus on fungal infections
Santamaría, Rodrigo; Rizzetto, Lisa; Bromley, Michael; Zelante, Teresa; Lee, Wanseon; Cavalieri, Duccio; Romani, Luigina; et al, Immunobiology. 1212 - 1227. 11. 216. 2011. http://dx.doi.org/10.1016/j.imbio.2011.08.004 . 10.1016/j.imbio.2011.08.004 . published Immunobiology
Improving the performance of the iterative signature algorithm for the identification of relevant patterns
Freitas, A.; Afreixo, V.; Pinheiro, M.; Oliveira, J. L.; Moura, Gabriela; Santos, Manuel, Statistical Analysis and Data Mining. 71 - 83. 1. 4. 2011. http://dx.doi.org/10.1002/sam.10104 . 10.1002/sam.10104 . published Statistical Analysis and Data Mining
Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains
Carreto, L.; Eiriz, M.F.; Domingues, I.; Schuller, D.; Moura, G.R.; Santos, M.A.S., BMC Genomics. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954600765&partnerID=MN8TOARS . 10.1186/1471-2164-12-201 . BMC Genomics
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen
Rocha, R.; Pereira, P.J.B.; Santos, M.A.S.; Macedo-Ribeiro, S., Proceedings of the National Academy of Sciences of the United States of America. 14091 - 14096. 34. 108. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052182956&partnerID=MN8TOARS . 10.1073/pnas.1102835108 . Proceedings of the National Academy of Sciences of the United States of America
Transfer RNA's latest port of call
Santos, M.A.S.; Orellana, O.; Ibba, M., RNA Biology. 517 - 520. 5. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649374380&partnerID=MN8TOARS . 10.4161/rna.7.5.13213 . RNA Biology
Microrna expression variability in human cervical tissues
Pereira, P.M.; Marques, J.P.; Soares, A.R.; Carreto, L.; Santos, M.A.S., PLoS ONE. 7. 5. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955615260&partnerID=MN8TOARS . 10.1371/journal.pone.0011780 . PLoS ONE
Development of the genetic code: Insights from a fungal codon reassignment
Moura, G.R.; Paredes, J.A.; Santos, M.A.S., FEBS Letters. 334 - 341. 2. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549136142&partnerID=MN8TOARS . 10.1016/j.febslet.2009.11.066 . FEBS Letters
Low Complexity Regions behave as tRNA sponges to help co-translational folding of plasmodial proteins
Frugier, M.; Bour, T.; Ayach, M.; Santos, M.A.S.; Rudinger-Thirion, J.; Théobald-Dietrich, A.; Pizzi, E., FEBS Letters. 448 - 454. 2. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549152207&partnerID=MN8TOARS . 10.1016/j.febslet.2009.11.004 . FEBS Letters
Transfer RNA
Ibba, M.; Santos, M.A.S., FEBS Letters. 2. 584. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-71549115416&partnerID=MN8TOARS . 10.1016/j.febslet.2009.11.080 . FEBS Letters
Parallel DNA pyrosequencing unveils new zebrafish microRNAs
Soares, A.R.; Pereira, P.M.; Santos, B.; Egas, C.; Gomes, A.C.; Arrais, J.; Oliveira, J.L.; Moura, G.R.; Santos, M.A.S., BMC Genomics. 10. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65949098165&partnerID=MN8TOARS . 10.1186/1471-2164-10-195 . BMC Genomics
The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation
Silva, R.M.; Duarte, I.C.N.; Paredes, J.A.; Lima-Costa, T.; Perrot, M.; Boucherie, H.; Goodfellow, B.J.; et al, PLoS ONE. 4. 4. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65449173889&partnerID=MN8TOARS . 10.1371/journal.pone.0005212 . PLoS ONE
MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
Ceppi, M.; Pereira, A.M.; Dunand-Sauthier, I.; Barras, E.; Reith, W.; Santos, M.A.; Pierre, P., Proceedings of the National Academy of Sciences of the United States of America. 2735 - 2740. 8. 106. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-62449173209&partnerID=MN8TOARS . 10.1073/pnas.0811073106 . Proceedings of the National Academy of Sciences of the United States of America
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Butler, Geraldine; Rasmussen, Matthew D.; Lin, Michael F.; Santos, Manuel; Sakthikumar, Sharadha; Munro, Carol A.; Rheinbay, Esther; et al, Nature. 657 - 662. 7247. 459. 2009. http://dx.doi.org/10.1038/nature08064 . 10.1038/nature08064 . published Nature
Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity
Moura, Gabriela; Carreto, Laura C; Santos, Manuel, Current Opinion in Microbiology. 631 - 637. 6. 12. 2009. http://dx.doi.org/10.1016/j.mib.2009.09.004 . 10.1016/j.mib.2009.09.004 . published Current Opinion in Microbiology
Surfactants as microbicides and contraceptive agents: A systematic In Vitro study
Vieira, O.V.; Hartmann, D.O.; Cardoso, C.M.P.; Oberdoerfer, D.; Baptista, M.; Santos, M.A.S.; Almeida, L.; Ramalho-Santos, J.; Vaz, W.L.C., PLoS ONE. 8. 3. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51449104764&partnerID=MN8TOARS . 10.1371/journal.pone.0002913 . PLoS ONE
Comparative genomics of wild type yeast strains unveils important genome diversity
Carreto, L.; Eiriz, M.F.; Gomes, A.C.; Pereira, P.M.; Schuller, D.; Santos, M.A.S., BMC Genomics. 9. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-57049101718&partnerID=MN8TOARS . 10.1186/1471-2164-9-524 . BMC Genomics
A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans
Gomes, A.C.; Miranda, I.; Silva, R.M.; Moura, G.R.; Thomas, B.; Akoulitchev, A.; Santos, M.A.S.; et al, Genome Biology. 10. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149086991&partnerID=MN8TOARS . 10.1186/gb-2007-8-10-r206 . Genome Biology
GeneBrowser: an approach for integration and functional classification of genomic data
Santos, Manuel; Arrais, Joel; Santos, Bruno; Fernandes, João; Carreto, Laura; Oliveira, José Luis, Journal of Integrative Bioinformatics. 3. 4. 2007. http://dx.doi.org/10.1515/jib-2007-82 . https://doi.org/10.1515/jib-2007-82 . published Journal of Integrative Bioinformatics
Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure
Moura, G.; Pinheiro, M.; Arrais, J.; Gomes, A.C.; Carreto, L.; Freitas, A.; Oliveira, J.L.; Santos, M.A.S., PLoS ONE. 9. 2. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-39449087192&partnerID=MN8TOARS . 10.1371/journal.pone.0000847 . PLoS ONE
Codon-triplet context unveils unique features of the Candida albicans protein coding genome
Moura, G.R.; Lousado, J.P.; Pinheiro, M.; Carreto, L.; Silva, R.M.; Oliveira, J.L.; Santos, M.A.S., BMC Genomics. 8. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149103111&partnerID=MN8TOARS . 10.1186/1471-2164-8-444 . BMC Genomics
Yeast proteome map (update 2006)
Perrot, Michel; Guieysse-Peugeot, Anne-Laure; Massoni, Aurélie; Espagne, Christelle; Claverol, Stéphane; Silva, Raquel Monteiro; Jenö, Paul; et al, PROTEOMICS. 1117 - 1120. 7. 7. 2007. http://dx.doi.org/10.1002/pmic.200600952 . 10.1002/pmic.200600952 . published PROTEOMICS
Critical roles for a genetic code alteration in the evolution of the genus Candida
Silva, Raquel M; Paredes, João A; Moura, Gabriela; Manadas, Bruno; Lima-Costa, Tatiana; Rocha, Rita; Miranda, Isabel; et al, The EMBO Journal. 4555 - 4565. 21. 26. 2007. http://dx.doi.org/10.1038/sj.emboj.7601876 . 10.1038/sj.emboj.7601876 . published The EMBO Journal
On the molecular mechanism of the evolution of genetic code alterations
Gomes, A.C.; Costa, T.; Carreto, L.; Santos, M.A.S., Molecular Biology. 564 - 569. 4. 40. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747090648&partnerID=MN8TOARS . 10.1134/S002689330604008X . Molecular Biology
Evolution of the genetic code in yeasts
Miranda, I.; Silva, R.; Santos, M.A.S., Yeast. 203 - 213. 3. 23. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645126396&partnerID=MN8TOARS . 10.1002/yea.1350 . Yeast
On the molecular mechanism of the evolution of genetic code alterations
Gomes, A. C.; Costa, T.; Carreto, L.; Santos, Manuel, Molecular Biology. 564 - 569. 4. 40. 2006. http://dx.doi.org/10.1134/s002689330604008x . 10.1134/s002689330604008x . published Molecular Biology
The molecular mechanism of evolution of changes in the genetic code
Gomes, A.C.; Costa, T.; Carreto, L.; Santos, M.A., Molekuliarnaia biologiia.. 634 - 639. 4. 40. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749060498&partnerID=MN8TOARS . Molekuliarnaia biologiia.
Comparative context analysis of codon pairs on an ORFeome scale.
Moura, G.; Pinheiro, M.; Silva, R.; Miranda, I.; Afreixo, V.; Dias, G.; Freitas, A.; Oliveira, J.L.; Santos, M.A., Genome biology. 3. 6. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644889434&partnerID=MN8TOARS . Genome biology
Molecular investigation in 20 patients with mitochondrial cytopathies
Nogueira, C.; Santos, Manuel; Vilarinho, L., Nascer e Crescer. 277 - 285. 4. 14. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645302108&partnerID=MN8TOARS . published Nascer e Crescer
Association between genetic symbols
Afreixo, V.; Pinheiro, M.; Oliveira, J.L.; Moura, Gabriela; Santos, Manuel; Freitas, A., Cadernos de Matemática. 1 - 25. 4. 2004. published Cadernos de Matemática
A Gene from the Mesophilic Bacterium Dehalococcoides ethenogenes Encodes a Novel Mannosylglycerate Synthase
Empadinhas, N.; Albuquerque, L.; Costa, J.; Zinder, S. H.; Santos, Manuel; Santos, H.; da Costa, M. S.; et al, Journal of Bacteriology. 4075 - 4084. 13. 186. 2004. http://dx.doi.org/10.1128/jb.186.13.4075-4084.2004 . 10.1128/jb.186.13.4075-4084.2004 . published Journal of Bacteriology
Yeast as a model organism for studying the evolution of nonstandard genetic codes
Silva, R. M.; Miranda, Isabel; Moura, Gabriela; Santos, Manuel, Briefings in Functional Genomics and Proteomics. 35 - 46. 1. 3. 2004. http://dx.doi.org/10.1093/bfgp/3.1.35 . 10.1093/bfgp/3.1.35 . published Briefings in Functional Genomics and Proteomics
Driving change: the evolution of alternative genetic codes
Santos, Manuel; Moura, Gabriela; Massey, Steven E; Tuite, Mick F, Trends in Genetics. 95 - 102. 2. 20. 2004. http://dx.doi.org/10.1016/j.tig.2003.12.009 . 10.1016/j.tig.2003.12.009 . published Trends in Genetics
Sistema bioinformático para análise do mecanismo molecular de descodificação da informação genética
Pinheiro, M.; Dias, G.; Afreixo, V.; Valente, A.; Moura, Gabriela; Santos, Manuel; Oliveira, J.L., 88 - 96. 4. 2003. published
Comparative Evolutionary Genomics Unveils the Molecular Mechanism of Reassignment of the CTG Codon in Candida spp.
Massey, S. E.; Moura, Gabriela; Beltrão, P.; Almeida, R.; Garey1, J. R.; Tuite, M.F.; Santos, Manuel, Genome Research. 544 - 557. 4. 13. 2003. http://dx.doi.org/10.1101/gr.811003 . 10.1101/gr.811003 . published Genome Research
Stop codon decoding in Candida albicans: from non-standard back to standard
Moura, Gabriela; Miranda, Isabel; Cheesman, Caroline; Tuite, Mick F.; Santos, Manuel, Yeast. 727 - 733. 9. 19. 2002. http://dx.doi.org/10.1002/yea.874 . 10.1002/yea.874 . published Yeast
Genómica Funcional em Aveiro
Santos, J.M.; Silva, R.M.; Domingues, P.; Amado, F.; Santos, Manuel, 13 - 18. 68. 2001. published
Seryl-tRNA synthetase is not responsible for the evolution of CUG codon reassignment in Candida albicans
O'Sullivan, Justin M.; Mihr, Marian J.; Santos, Manuel; Tuite, Mick F.; O'Sullivan, J.M.; Mihr, M.J.; Santos, M.A.S.; Tuite, M.F., Yeast. 313 - 322. 4. 18. 2001. http://dx.doi.org/10.1002/1097-0061(20010315)18:4<313::aid-yea673>3.0.co;2-7 . 10.1002/1097-0061(20010315)18:4<313::aid-yea673>3.0.co;2-7 . published Yeast
The Candida albicans gene encoding the cytoplasmic leucyl-tRNA synthetase: Implications for the evolution of CUG codon reassignment
O'Sullivan, J.M.; Mihr, M.J.; Santos, M.A.S.; Tuite, M.F.; O'Sullivan, Justin M.; Mihr, Marian J.; Santos, Manuel; Tuite, Mick F., Gene. 133 - 140. 1. 275. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035812289&partnerID=MN8TOARS . 10.1016/S0378-1119(01)00632-1 . published Gene
Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp.
Santos, Manuel; Cheesman, Caroline; Costa, Vitor; Moradas-Ferreira, Pedro; Tuite, Mick F., Molecular Microbiology. 937 - 947. 3. 31. 1999. http://dx.doi.org/10.1046/j.1365-2958.1999.01233.x . 10.1046/j.1365-2958.1999.01233.x . published Molecular Microbiology
The Candida albicans CUG-decoding ser-tRNA has an atypical anticodon stem-loop structure
Perreau, Victoria M; Keith, Gerard; Holmes, W.Mike; Przykorska, Anna; Santos, Manuel; Tuite, Mick F, Journal of Molecular Biology. 1039 - 1053. 5. 293. 1999. http://dx.doi.org/10.1006/jmbi.1999.3209 . 10.1006/jmbi.1999.3209 . published Journal of Molecular Biology
The non-standard genetic code of Candida spp.: an evolving genetic code or a novel mechanism for adaptation?
Santos, Manuel; Ueda, Takuya; Watanabe, Kimitsuna; Tuite, Mick F., Molecular Microbiology. 423 - 431. 3. 26. 1997. http://dx.doi.org/10.1046/j.1365-2958.1997.5891961.x . 10.1046/j.1365-2958.1997.5891961.x . published Molecular Microbiology
Beta, a novel repetitive DNA element associated with tRNA genes in the pathogenic yeast Candida albicans
Perreau, Victoria M.; Santos, Manuel; Tuite, Mick F., Molecular Microbiology. 229 - 236. 02. 25. 1997. http://dx.doi.org/10.1046/j.1365-2958.1997.4521816.x . 10.1046/j.1365-2958.1997.4521816.x . published Molecular Microbiology
Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans
Santos, M.A.S.; Perreau, V.M.; Tuite, M.F.; Santos, Manuel; Perreau, V. M.; Tuite, M. F., EMBO Journal. 5060 - 5068. 18. 15. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029816377&partnerID=MN8TOARS . 10.1002/j.1460-2075.1996.tb00886.x . published EMBO Journal
Codon reassignment in Candida species: An evolutionary conundrum
Tuite, M.F.; Santos, M.A.S.; Santos, Manuel, Biochimie. 993 - 999. 11-12. 78. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030437176&partnerID=MN8TOARS . 10.1016/S0300-9084(97)86722-3 . published Biochimie
The CUG codon is decoded in vivo as serine and not leucine in Candida albicans
Santos, Manuel; Tuite, Mick F., Nucleic Acids Research. 1481 - 1486. 9. 23. 1995. http://dx.doi.org/10.1093/nar/23.9.1481 . 10.1093/nar/23.9.1481 . published Nucleic Acids Research
Transfer RNA profiling: A new method for the identification of pathogenic Candida species
Santos, M.A.S.; El-Adlouni, C.; Cox, A.D.; Luz, J.M.; Keith, G.; Tuite, M.F., Yeast. 625 - 636. 5. 10. 1994. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028237559&partnerID=MN8TOARS . 10.1002/yea.320100507 . Yeast
New insights into mRNA decoding — implications for heterologous protein synthesis
Santos, Manuel; Tuite, Mick F., Trends in Biotechnology. 500 - 505. 12. 11. 1993. http://dx.doi.org/10.1016/0167-7799(93)90028-8 . 10.1016/0167-7799(93)90028-8 . published Trends in Biotechnology
Non-standard translational events in Candida albicans mediated by an unusual seryl-tRNA with a 5'-CAG-3' (leucine) anticodon.
Santos, Manuel; Keith, G.; Tuite, M.F., The EMBO Journal. 607 - 616. 2. 12. 1993. http://dx.doi.org/10.1002/j.1460-2075.1993.tb05693.x . 10.1002/j.1460-2075.1993.tb05693.x . published The EMBO Journal
Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm<sup>5</sup>Um) in the wobble position of the anticodon of tRNA<sup>Leu</sup> (U*AA) from brewer's yeast
Glasser, A.-L.; El Adlouni, C.; Keith, G.; Sochacka, E.; Malkiewicz, A.; Santos, M.; Tuite, M.F.; et al, FEBS Letters. 381 - 385. 3. 314. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026677843&partnerID=MN8TOARS . 10.1016/0014-5793(92)81510-S . published FEBS Letters
Candida albicans and three other Candida species contain an elongation factor structurally and functionally analogous to elongation factor 3
Colthurst, David R.; Santos, Manuel; Grant, Chris M.; Tuite, Mick F., FEMS Microbiology Letters. 45 - 50. 1. 80. 1991. http://dx.doi.org/10.1111/j.1574-6968.1991.tb04634.x . 10.1111/j.1574-6968.1991.tb04634.x . published FEMS Microbiology Letters
Efficient translation of the UAG termination codon in Candida species
Santos, M.; Colthurst, D.R.; Wills, N.; McLaughlin, C.S.; Tuite, M.F.; Santos, Manuel; Colthurst, D. R.; McLaughlin, C. S.; Tuite, M. F., Current Genetics. 487 - 491. 6. 17. 1990. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025335761&partnerID=MN8TOARS . 10.1007/BF00313076 . published Current Genetics
Numerical Taxonomy of Thermus Isolates from Hot Springs in Portugal
Santos, Manuel; Williams, Ralph A.D.; Da Costa, Milton S.; Santos, M.A.; Williams, R.A.D.; Da Costa, M.S., Systematic and Applied Microbiology. 310 - 315. 3. 12. 1989. http://dx.doi.org/10.1016/s0723-2020(89)80079-7 . 10.1016/s0723-2020(89)80079-7 . published Systematic and Applied Microbiology
5 131 out of 131 Publications
All projects
Information of exclusive responsibility of the researcher 03-11-2024 , from platform CIÊNCIAVITAE.
2018 - 2020
Medicina de Sistemas das doenças cardiovasculares, neurodegenerativas e musculo-esqueléticas - MEDISIS
CENTRO-01-0246-FEDER-000018
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro
2018/07/01 - 2021/06/30
Identificação e quantificação dos erros da biossíntese de proteínas à escala proteómica
PTDC/BIA-MIB/31238/2017
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2017 - 2020/12/31
Programa de Ações Conjuntas (PAC) : Redes sináticas e abordagens compreensivas de medicina personalizada em doenças neurocomportamentais ao longo da vida – MEDPERSYST
POCI-01-0145-FEDER-016428-PAC
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2017 - 2022
The Discoveries Centre for Regenerative and Precision Medicine – European Union Horizon 2020-Widespread-2016-2017
739572
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: European Union
2017/06/01 - 2020/05/30
Laboratório Nacional de Sequenciação e Análise de Genomas
PINFRA/22184/2016
Principal investigator
Universidade de Aveiro
Funders: Fundação para a Ciência e a Tecnologia
2017 - 2020/12/31
Programas Integrados de IC&DT. Projeto Protein aggregation across the lifespan – pAGE
CENTRO-45-2015-01-SAICT
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro
2016/06/01 - 2019/05/31
A Biologia das modificações do RNA
PTDC/BEX-BCM/2121/2014
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2015 - 2019
Instituto de Biomedicina de Aveiro – iBiMED
UID/BIM/04501/2013
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2013/04/01 - 2016/03/31
Consequences of reciprocal control of mistranslation during antifungal immunity
FCT-ANR/IMI-ANR/0041/2012
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2010/05/02 - 2013/10/31
Functional genomics of ribosomal infidelity phenotypes associated to human diseases
PTDC/SAU-GMG/098850/2008
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2010/06/01 - 2013/11/30
Reversion of a genetic code alteration in the human pathogen Candida albicans
PTDC/BIA-MIC/099826/2008
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2009/11/01 - 2012/10/31
SYBARIS – Finding biomarkers of anti-microbial drug resistance via a systems biology analysis of fungal pathogen interactions with the human immune system
SYBARIS/HEALTH-F3-2009-242220
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: European Union
2009/01/01 - 2011/06/30
Targetting protein synthesis in the apicoplast and cytoplasm of Plasmodium
MEPHITIS-FP7-HEALTH-2009-223024
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: European Union
2009/01/01 - 2011/12/31
Implementation of a national facility for DNA microarrays: phase II
PTDC/BIA-BCM/64745/2006
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2005/09/01 - 2009/02/28
mRNA mistranslation in Biological processes
RGP0045/2005-C
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Human Frontier Science Program
2005 - 2008
Impacto do erro de descodificação do mRNA na degeneração e evolução celular
POCTI/SAL-MMO/55476/2004
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2005 - 2008
Estrutura tridimensional dos factores da tradução que medeiam uma alteração ao código genético em Candida albicans
POCTI/BIA-PRO/55472/2004
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2005 - 2008
Estudo molecular do mecanismo de virulência de Candida albicans
POCI/SAU-IMI/61591/2004
Principal investigator
Universidade do Porto
Funders: Fundação para a Ciência e a Tecnologia
2005 - 2008
Estudo molecular do mecanismo de virulência de Candida albicans
POCI/SAU-IMI/61598/2004
Principal investigator
Universidade do Porto Faculdade de Medicina
Funders: Fundação para a Ciência e a Tecnologia
2005 - 2007
Rede Nacional de Genómica Funcional
CONC-REEQ/737/BIO/2005
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2005 - 2008
Estudo da morfogénese e reprodução sexuada induzida por uma alteração ao código genético em Candida albicans
POCTI/BIA-MIC/55466/2004
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2002 - 2005
Developing a DNA chip for diagnostics of infectious diseases
CTS 12
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Instituto de Investigação da UA - diagnósticos
2002 - 2005
Developing new tools for genome analysis
POCTI/BME/39030/2001
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2002 - 2005
Developing new tools for genome analysis
POCTI/BME/39030/2001
Funders: Fundação para a Ciência e a Tecnologia
2001 - 2005
Screening for new Candida albicans virulence factors associated with morphogenesis using proteomics methodologies
POCTI/2000/ESP/32942/99
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2001 - 2004
Molecular and structural study of the identity of a novel ser-tRNACAG which mediates a genetic code change in Candida albicans.
POCTI/BME/32938/2000
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
2001 - 2002
Acções Integradas Luso-Espanholas
Acção Nº E-45/01
Principal investigator
2001 - 2001
Molecular characterization of non-standard translation in the human pathogen Candida albicans.
POCTI/SAU/14123/2001
Principal investigator
Universidade de Aveiro
Funders: Fundação para a Ciência e a Tecnologia
1999 - 2001
The role of a genetic code alteration in the evolution of novel phenotypes in Candida albicans
POCTI/BIA/11139/2002
Principal investigator
Universidade de Aveiro Instituto de Biomedicina
Funders: Fundação para a Ciência e a Tecnologia
1999 - 2000
Biologia em Rede para as Escolas e a Comunidade
BIOREDE/POSI
Principal investigator
Universidade de Aveiro
Funders: Programa Aveiro Cidade Digital
1998 - 2001
Molecular study of the evolutionary pathway of reassignment of the CUG codon in Candida albicans
96/G08693
Principal investigator
Universidade de Kent
Funders: Biotechnology and Biological Sciences Research Council
1995 - 1999
Structural and functional analysis of a novel seryl-tRNACAG from the human pathogen Candida albicans
045548/Z/JRS/SH
Principal investigator
Universidade de Kent
Funders: Wellcome Trust
1995 - 1999
Structural and functional analysis of a novel seryl-tRNACAG from the human pathogen Candida albicans
045548/Z/JRS/SH
Funders: Wellcome Trust
5 33 out of 33 projects
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