Overview
Project Summary
Rett syndrome is a rare neurodevelopmental disorder caused by mutations in the MECP2 gene. Recently, Prof. Tongiorgi’s lab identified from a panel of FDA-approved drugs 13 compounds able to rescue aberrant neuronal morphology in cultured hippocampal RTT neurons. In this project, we aim at testing in vivo the effects of compounds D4 and D5 in rescuing emotional dysregulation using the Mecp2 mutant animals, a mouse model of Rett.
Main Goals
Aim 1: Test the effects of coumpounds D4 and D5 is rescuing anxiety, depressive-like and fear memory alterations in the Mecp2-mutant mice.
Coordination
External Team
Prof. Enrico Tongiorgi, University of Trieste, Italy
Dr. Carmen Agustín-Pavón, University of Valencia, Spain
Partners
Funding
Project Details
Project Code
ProRETT Ricerca
Approval Date
2023-12-26
Start Date
2024-05-01
End Date
2025-04-30
Total Cost
20000,0€
