The MitoXT platform is designed to analyse the toxicity and safety of different classes of compounds using in situ mitochondrial function as a highly reliable and accurate biosensor. This toxicological testing provides certified analysis of mitochondrial function based on the Seahorse XFe96 extracellular flux analyser platform complemented by other assays that provide a complete picture of mitochondrial metabolism at the cellular level. In addition, the MitoXT platform has provided support to research groups or industry to validate the use of specific molecules or biological extracts as cellular or mitochondrial protectors to counteract oxidative stress or other stress agonists, paving the way for their therapeutic application. The MitoXT platform allows the characterisation of mitochondrial function in cells of different origins, including patients suffering from
different metabolic diseases (including mitochondrial diseases) or animal models.
