Overview

Ana Cristina Gonçalves, Ph.D., is an Assistant Professor at the Faculty of Medicine, University of Coimbra. She received her Microbial Biology and Genetic degree (BSc) in 2004 at the Faculty of Sciences of the University of Lisbon (FCUL). Then, at FMUC, she obtained a Clinical Nutrition Master's degree (MSc) in 2009 and a Ph.D. in Health Sciences in 2016. She is a researcher at Coimbra Institute for Clinical and Biomedical Research (iCBR) - Group of Environment Genetics and Oncobiology (CIMAGO) of FMUC and Centre for Innovative Biomedicine and Biotechnology Consortium (CIBB). She is a member of several societies, namely the European Association for Cancer Research (EACR), Portuguese Association for Cancer Research (ASPIC), and Portuguese Hematology Society (SPH), and a member of various COST Actions. Ana Cristina is a member of the Editorial Board/Advisory Review Board of Translational Oncology, Cancer Treatment and Research Communications, International Journal of Molecular Sciences (Molecular Oncology section), and Experimental and Therapeutic Medicine. Ana Cristina regularly serves as a reviewer in several Q1 journals. She teaches Molecular and Cellular Biology, Nutritional Biology, Scientific Writing and Communication, and Applied Molecular Biology at FMUC. She has supervised 27 Master Thesis (2 ongoing) and 4 Ph.D. (ongoing) and participated in more than 27 Investigation Projects. Currently, Ana Cristina Gonçalves' research is focusing on: molecular and cellular mechanisms involved in cancer; new biomarkers in susceptibility, diagnosis, prognosis, and therapy response; DNA damage in cancer; and circadian rhythms in cancer. She has published more than 95 full articles (PubMed list of articles: https://www.ncbi.nlm.nih.gov/myncbi/18c-ANcfLW55i/bibliography/public/; H-index=23, i10-index=57, citations=1806; Scopus 02/2024), >285 abstracts in international and national journals with peer review, 7 Book Chapters, and received 40 prizes and awards. Ana Cristina frequently engages in outreach activities, namely the European Researchers Night and other activities targeted at the general society.

Publications

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Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.

In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation

Marto, Carlos Miguel; Laranjo, Mafalda; Gonçalves AC; Paula, Anabela; Jorge, Joana; Caetano-Oliveira, Rui; Sousa, Maria Inês; et al, Pharmaceutics. 2. 16. 2024. http://dx.doi.org/10.3390/pharmaceutics16020207 . 10.3390/pharmaceutics16020207 . published Pharmaceutics

Zinc: From Biological Functions to Therapeutic Potential

Costa, Maria Inês; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana Cristina, International Journal of Molecular Sciences. 5. 24. 2023. http://dx.doi.org/10.3390/ijms24054822 . 10.3390/ijms24054822 . International Journal of Molecular Sciences

AZD-7648, a DNA-PK Inhibitor, Induces DNA Damage, Apoptosis, and Cell Cycle Arrest in Chronic and Acute Myeloid Leukemia Cells

Beatriz Lapa; Maria Inês Costa; Diana Figueiredo; Joana Jorge; Raquel Alves; Ana Raquel Monteiro; Beatriz Serambeque; et al, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/20/15331 . 10.3390/ijms242015331 . International Journal of Molecular Sciences

Anti-Algics in the Therapeutic Response of Breast and Urological Cancers

Ana Catarina Matos; João Lorigo; Inês Alexandra Marques; Ana Margarida Abrantes; Matilde Jóia-Gomes; Pedro Sa-Couto; Ana Cristina Gonçalves; et al, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010468 . 10.3390/ijms25010468 . International Journal of Molecular Sciences

Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies

Jorge, Joana; Neves, Joana; Alves, Raquel; Geraldes, Catarina; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela, International Journal of Molecular Sciences. 11. 24. 2023. http://dx.doi.org/10.3390/ijms24119167 . 10.3390/ijms24119167 . International Journal of Molecular Sciences

Maximal Exercise Improves the Levels of Endothelial Progenitor Cells in Heart Failure Patients

Cavalcante, Suiane; Viamonte, Sofia; Cadilha, Rui S.; Ribeiro, Ilda P.; Gonçalves, Ana Cristina; Sousa-Venâncio, João; Gouveia, Marisol; et al, Current Issues in Molecular Biology. 1950 - 1960. 3. 45. 2023. http://dx.doi.org/10.3390/cimb45030125 . 10.3390/cimb45030125 . Current Issues in Molecular Biology

Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiproliferative Effect on Glioblastoma Cells

Marques, Mário Pedro; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Gonçalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; et al, Pharmaceutics. 2. 15. 2023. http://dx.doi.org/10.3390/pharmaceutics15020341 . 10.3390/pharmaceutics15020341 . Pharmaceutics

Platelet Membrane Proteins as Pain Biomarkers in Patients with Severe Dementia

Ribeiro, Hugo; Alves, Raquel; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Teixeira-Veríssimo, Manuel; Dourado, Marília; Andrade, José Paulo, Biomedicines. 2. 11. 2023. http://dx.doi.org/10.3390/biomedicines11020380 . 10.3390/biomedicines11020380 . Biomedicines

Alvespimycin Inhibits Heat Shock Protein 90 and Overcomes Imatinib Resistance in Chronic Myeloid Leukemia Cell Lines

Alves, Raquel; Santos, Diogo; Jorge, Joana; Gonçalves, Ana Cristina; Catarino, Steve; Girão, Henrique; Melo, Joana Barbosa; Sarmento-Ribeiro, Ana Bela, Molecules. 3. 28. 2023. http://dx.doi.org/10.3390/molecules28031210 . 10.3390/molecules28031210 . Molecules

Reduced Levels of Circulating Endothelial Cells and Endothelial Progenitor Cells in Patients with Heart Failure with Reduced Ejection Fraction

Lopes, José; Teixeira, Manuel; Cavalcante, Suiane; Gouveia, Marisol; Duarte, Ana; Ferreira, Miriam; Simões, Maria I.; et al, Archives of Medical Research. 2022. http://dx.doi.org/10.1016/j.arcmed.2022.02.001 . 10.1016/j.arcmed.2022.02.001 . Archives of Medical Research

Genetic Variants of ABC and SLC Transporter Genes and Chronic Myeloid Leukaemia: Impact on Susceptibility and Prognosis

Alves, Raquel; Gonçalves AC; Jorge, Joana; Marques, Gilberto; Ribeiro, André B.; Tenreiro, Rita; Coucelo, Margarida; et al, International Journal of Molecular Sciences. 17. 23. 2022. http://dx.doi.org/10.3390/ijms23179815 . 10.3390/ijms23179815 . International Journal of Molecular Sciences

Antitumor Effect of Brusatol in Acute Lymphoblastic Leukemia Models Is Triggered by Reactive Oxygen Species Accumulation

Jorge, Joana; Magalhães, Nisa; Alves, Raquel; Lapa, Beatriz; Gonçalves AC; Sarmento-Ribeiro, Ana Bela, Biomedicines. 9. 10. 2022. http://dx.doi.org/10.3390/biomedicines10092207 . 10.3390/biomedicines10092207 . Biomedicines

Cold Atmospheric Plasma Apoptotic and Oxidative Effects on MCF7 and HCC1806 Human Breast Cancer Cells

Almeida-Ferreira, Catarina; Silva-Teixeira, Rafael; Gonçalves, Ana Cristina; Marto, Carlos Miguel; Sarmento-Ribeiro, Ana Bela; Caramelo, Francisco; Botelho, Maria Filomena; Laranjo, Mafalda, International Journal of Molecular Sciences. 3. 23. 2022. http://dx.doi.org/10.3390/ijms23031698 . 10.3390/ijms23031698 . International Journal of Molecular Sciences

DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities

Dana Jurkovicova; Christiana M. Neophytou; Ana Cipak Gašparovic; Ana Cristina Gonçalves, International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232314672 . 10.3390/ijms232314672 . International Journal of Molecular Sciences

Zinc Prevents DNA Damage in Normal Cells but Shows Genotoxic and Cytotoxic Effects in Acute Myeloid Leukemia Cells

Costa, Maria Inês; Lapa, Beatriz Santos; Jorge, Joana; Alves, Raquel; Carreira, Isabel Marques; Sarmento-Ribeiro, Ana Bela; Gonçalves, Ana Cristina, International Journal of Molecular Sciences. 5. 23. 2022. http://dx.doi.org/10.3390/ijms23052567 . 10.3390/ijms23052567 . International Journal of Molecular Sciences

Oxidative stress and high-density lipoprotein cholesterol: Cause or consequence?

Gonçalves, Ana Cristina, Revista Portuguesa de Cardiologia. 841 - 842. 10. 41. 2022. http://dx.doi.org/10.1016/j.repc.2022.06.006 . 10.1016/j.repc.2022.06.006 . Revista Portuguesa de Cardiologia

Insights into the anticancer activity of chiral alkylidene-ß-lactams and alkylidene-¿-lactams: Synthesis and biological investigation

Alves, Américo J.S.; Alves, Nuno G.; Laranjo, Mafalda; Gomes, Clara S.B.; Cristina Gonçalves, Ana; Bela Sarmento-Ribeiro, Ana; Filomena Botelho, M.; Pinho e Melo, Teresa M.V.D., Bioorganic & Medicinal Chemistry. 63. 2022. http://dx.doi.org/10.1016/j.bmc.2022.116738 . 10.1016/j.bmc.2022.116738 . Bioorganic & Medicinal Chemistry

Combination of Elacridar with Imatinib Modulates Resistance Associated with Drug Efflux Transporters in Chronic Myeloid Leukemia

Alves, Raquel; Gonçalves, Ana Cristina; Jorge, Joana; Almeida, António M.; Sarmento-Ribeiro, Ana Bela, Biomedicines. 5. 10. 2022. http://dx.doi.org/10.3390/biomedicines10051158 . 10.3390/biomedicines10051158 . Biomedicines

Endothelial Progenitor Cell Response to Acute Multicomponent Exercise Sessions with Different Durations

Cavalcante, Suiane; Teixeira, Manuel; Duarte, Ana; Ferreira, Miriam; Simões, Maria I.; Conceição, Maria; Costa, Mariana; et al, Biology. 4. 11. 2022. http://dx.doi.org/10.3390/biology11040572 . 10.3390/biology11040572 . Biology

Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway

Magalhães, Mariana; Domínguez-Martín, Eva María; Jorge, Joana; Gonçalves, Ana Cristina; Díaz-Lanza, Ana María; Manadas, Bruno; Efferth, Thomas; Rijo, Patrícia; Cabral, Célia, Frontiers in Pharmacology. 13. 2022. http://dx.doi.org/10.3389/fphar.2022.1006832 . 10.3389/fphar.2022.1006832 . Frontiers in Pharmacology

Effects of Adper™ Scotchbond™ 1 XT, Clearfil™ SE Bond 2 and Scotchbond™ Universal in Odontoblasts

Miguel Cardoso; Ana Coelho; Carlos Miguel Marto; Ana Cristina Gonçalves; Anabela Paula; Ana Bela Sarmento Ribeiro; Manuel Marques Ferreira; et al, Materials. 2021. https://doi.org/10.3390/ma14216435 . 10.3390/ma14216435 . Materials

Impact of cancer metabolism on therapy resistance – Clinical implications

Drug Resistance Updates. 100797 - 100797. 59. 2021. http://dx.doi.org/10.1016/j.drup.2021.100797 . 10.1016/j.drup.2021.100797 . Drug Resistance Updates

Cold Atmospheric Plasma, a Novel Approach against Bladder Cancer, with Higher Sensitivity for the High-Grade Cell Line

Tavares-da-Silva, Edgar; Pereira, Eurico; Pires, Ana S.; Neves, Ana R.; Braz-Guilherme, Catarina; Marques, Inês A.; Abrantes, Ana M.; et al, Biology. 1. 10. 2021. http://dx.doi.org/10.3390/biology10010041 . 10.3390/biology10010041 . Biology

Genomic characterisation of multiple myeloma: study of a Portuguese cohort

Couto Oliveira, Alexandra; Ribeiro, Ilda Patrícia; Pires, Luís Miguel; Gonçalves, Ana Cristina; Paiva, Artur; Geraldes, Catarina; Roque, Adriana; et al, Journal of Clinical Pathology. jclinpath - 2020. 2021. http://dx.doi.org/10.1136/jclinpath-2020-207204 . 10.1136/jclinpath-2020-207204 . Journal of Clinical Pathology

Accessing the Cytotoxicity and Cell Response to Biomaterials

Paula, A.B.; Laranjo, M.; Coelho, A.S.; Abrantes, A.M.; Gonçalves, A.C.; Sarmento-Ribeiro, A.B.; Ferreira, M.M.; et al, Journal of visualized experiments : JoVE. 173. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85112589311&partnerID=MN8TOARS . 10.3791/61512 . Journal of visualized experiments : JoVE

Design, synthesis, and antitumor activity evaluation of steroidal oximes

Gomes, A.R.; Pires, A.S.; Abrantes, A.M.; Gonçalves, A.C.; Costa, S.C.; Varela, C.L.; Silva, E.T.; Botelho, M.F.; Roleira, F.M.F., Bioorganic and Medicinal Chemistry. 46. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113611303&partnerID=MN8TOARS . 10.1016/j.bmc.2021.116360 . Bioorganic and Medicinal Chemistry

Plasma activated media and direct exposition can selectively ablate retinoblastoma cells

Silva Teixeira, R; Laranjo, M; Lopes, B; Almeida Ferreira, C; Goncalves, AC; Rodrigues, T; Matafome, P; et al, FREE RADICAL BIOLOGY AND MEDICINE. 2021. 10.1016/j.freeradbiomed.2021.05.027 . FREE RADICAL BIOLOGY AND MEDICINE

Liquid Biopsies: Applications for Cancer Diagnosis and Monitoring

Martins, Ivana; Ribeiro, Ilda Patrícia; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Melo, Joana Barbosa; Carreira, Isabel Marques, Genes. 3. 12. 2021. http://dx.doi.org/10.3390/genes12030349 . 10.3390/genes12030349 . Genes

Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients

Goncalves, AC; Alves, R; Baldeiras, I; Jorge, J; Marques, B; Paiva, A; Oliveiros, B; et al, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021. 10.3389/fcell.2021.701328 . FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Oxymestane, a cytostatic steroid derivative of exemestane with greater antitumor activity in non-estrogen-dependent cell lines

Pires, Ana S.; Varela, Carla L.; Marques, Inês A.; Abrantes, Ana M.; Gonçalves, Cristina; Rodrigues, Tiago; Matafome, Paulo; et al, The Journal of Steroid Biochemistry and Molecular Biology. 212. 2021. http://dx.doi.org/10.1016/j.jsbmb.2021.105950 . 10.1016/j.jsbmb.2021.105950 . The Journal of Steroid Biochemistry and Molecular Biology

Anti-Aging Effect of Urolithin A on Bovine Oocytes In Vitro

Fonseca, Élisa; Marques, Carla Cruz; Pimenta, Jorge; Jorge, Joana; Baptista, Maria Conceição; Gonçalves, Ana Cristina; Pereira, Rosa M. L. N., Animals. 7. 11. 2021. http://dx.doi.org/10.3390/ani11072048 . 10.3390/ani11072048 . Animals

DNA Methylation Is Correlated with Oxidative Stress in Myelodysplastic Syndrome—Relevance as Complementary Prognostic Biomarkers

Gonçalves, Ana Cristina; Alves, Raquel; Baldeiras, Inês; Marques, Bárbara; Oliveiros, Bárbara; Pereira, Amélia; Nascimento Costa, José Manuel; et al, Cancers. 13. 13. 2021. http://dx.doi.org/10.3390/cancers13133138 . 10.3390/cancers13133138 . Cancers

Kinetics of radium-223 and its effects on survival, proliferation and DNA damage in lymph-node and bone metastatic prostate cancer cell lines

Marques, Inês A.; Abrantes, Ana M.; Pires, Ana S.; Neves, Ana R.; Caramelo, Francisco J.; Rodrigues, Tiago; Matafome, Paulo; et al, International Journal of Radiation Biology. 714 - 726. 5. 97. 2021. http://dx.doi.org/10.1080/09553002.2021.1906462 . 10.1080/09553002.2021.1906462 . International Journal of Radiation Biology

Can peripheral blood provide good DNA methylation biomarkers in myelodysplastic syndrome?

Jorge, Joana; Gonçalves, Ana Cristina; Cortesão, Emília; Pires, Ana Cláudia; Alves, Raquel; Geraldes, Catarina; Pereira, Amélia; et al, Journal of Molecular and Clinical Medicine. 1. 4. 2021. http://dx.doi.org/10.31083/j.jmcm.2021.01.015 . 10.31083/j.jmcm.2021.01.015 . Journal of Molecular and Clinical Medicine

Impact of cancer metabolism on therapy resistance – Clinical implications

Gonçalves, Ana Cristina; Richiardone, Elena; Jorge, Joana; Polónia, Bárbara; Xavier, Cristina P.R.; Salaroglio, Iris Chiara; Riganti, Chiara; et al, Drug Resistance Updates. 59. 2021. http://dx.doi.org/10.1016/j.drup.2021.100797 . 10.1016/j.drup.2021.100797 . Drug Resistance Updates

Resistance to Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia—From Molecular Mechanisms to Clinical Relevance

Alves, Raquel; Gonçalves, Ana Cristina; Rutella, Sergio; Almeida, António M.; De Las Rivas, Javier; Trougakos, Ioannis P.; Sarmento Ribeiro, Ana Bela, Cancers. 19. 13. 2021. http://dx.doi.org/10.3390/cancers13194820 . 10.3390/cancers13194820 . Cancers

High-intensity, high-volume exercise in addition to school exercise classes reduces endothelial progenitor cells, inflammation and catabolism in adolescent boys

Henriques, Magda; Fernandes, Raquel; Gonçalves, Ana Cristina; Ribeiro, Ilda Patrícia; Santos, Rui; Fardilha, Margarida; Ferreira, Rita; Ribeiro, Fernando, European Journal of Preventive Cardiology. 2255 - 2258. 19. 27. 2020. http://dx.doi.org/10.1177/2047487319884793 . 10.1177/2047487319884793 . European Journal of Preventive Cardiology

Iodine-131 metabolic radiotherapy leads to cell death and genomic alterations through NIS overexpression on cholangiocarcinoma

Brito, A.; Abrantes, A; Teixo, R.; Pires, A.; Ribeiro, A.; Ferreira, R.; Fernandes, A.; et al, International Journal of Oncology. 2020. http://dx.doi.org/10.3892/ijo.2020.4957 . 10.3892/ijo.2020.4957 . in press International Journal of Oncology

Synthesis, Characterization and Evaluation of the Antibacterial and Antitumor Activity of HalogenatedSalen Copper (II) Complexes derived from Camphoric Acid

Pires, AS; Batista, J; Murtinho, D; Nogueira, C; Karamysheva, A; Luisa Ramos, M; Milne, BF; et al, APPLIED ORGANOMETALLIC CHEMISTRY. 2020. 10.1002/aoc.5569 . APPLIED ORGANOMETALLIC CHEMISTRY

Flow cytometry and targeted immune transcriptomics identify distinct profiles in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors with or without interferon-a

Alves, R.; McArdle, S.; Vadakekolathu, J.; Goncalves, AC; Freitas-Tavares, P.; Pereira, A.; Almeida, AM; Sarmento-Ribeiro, AB; Rutella, Sergio, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-019-02194-x . 10.1186/s12967-019-02194-x . published Journal of Translational Medicine

miR-29b and retinoic acid co-delivery: a promising tool to induce a synergistic antitumoral effect in non-small cell lung cancer cells

Magalhães, Mariana; Jorge, Joana; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Carvalho, Rui; Figueiras, Ana; Santos, Ana Cláudia; Veiga, Francisco, Drug Delivery and Translational Research. 1367 - 1380. 5. 10. 2020. http://dx.doi.org/10.1007/s13346-020-00768-7 . 10.1007/s13346-020-00768-7 . Drug Delivery and Translational Research

Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumor-imaging and photodynamic therapy of cancer

Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A.M.; Brites, Gonçalo; Nascimento, Bruno F.O.; Brito, Ana F.; Casalta-Lopes, João; et al, European Journal of Medicinal Chemistry. 200. 2020. http://dx.doi.org/10.1016/j.ejmech.2020.112468 . 10.1016/j.ejmech.2020.112468 . European Journal of Medicinal Chemistry

GuttaFlow® Bioseal Cytotoxicity Assessment: In Vitro Study

Ferreira, Inês; Laranjo, Mafalda; Marto, Carlos Miguel; Casalta-Lopes, João; Serambeque, Beatriz; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; et al, Molecules. 18. 25. 2020. http://dx.doi.org/10.3390/molecules25184297 . 10.3390/molecules25184297 . Molecules

Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target

Lapa, Beatriz; Gonçalves, Ana Cristina; Jorge, Joana; Alves, Raquel; Pires, Ana Salomé; Abrantes, Ana Margarida; Coucelo, Margarida; et al, Medical Oncology. 8. 37. 2020. http://dx.doi.org/10.1007/s12032-020-01394-6 . 10.1007/s12032-020-01394-6 . Medical Oncology

Cytotoxic Effects of Zoom® Whitening Product in Human Fibroblasts

Marto, Carlos Miguel; Laranjo, Mafalda; Paula, Anabela; Coelho, Ana Sofia; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana Cristina; et al, Materials. 7. 13. 2020. http://dx.doi.org/10.3390/ma13071491 . 10.3390/ma13071491 . Materials

Synthetic Calcium Phosphate Ceramics as a Potential Treatment for Bisphosphonate-Related Osteonecrosis of the Jaw

Paulo, S.; Laranjo, M.; Abrantes, AM; Casalta-Lopes, J.; Santos, K.; Gonçalves, AC; Paula, AB; et al, Materials. 11. 12. 2019. http://dx.doi.org/10.3390/ma12111840 . 10.3390/ma12111840 . published Materials

Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines

Jorge, Joana; Petronilho, Sara; Alves, Raquel; Coucelo, Margarida; Gonçalves, Ana Cristina; Nascimento Costa, José Manuel; Sarmento-Ribeiro, Ana Bela, Investigational New Drugs. 369 - 377. 2. 38. 2019. http://dx.doi.org/10.1007/s10637-019-00796-2 . 10.1007/s10637-019-00796-2 . Investigational New Drugs

Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast Activity.

Gonçalves, Ana, Materials (Basel, Switzerland). 2019. http://europepmc.org/articles/PMC6479701 . 10.3390/ma12071184 . Materials (Basel, Switzerland)

The emergence of drug resistance to targeted cancer therapies: Clinical evidence

Sarmento-Ribeiro, AB; Scorilas, A.; Gonçalves, AC; Efferth, T.; Trougakos, IP, Drug Resistance Updates. 47. 2019. http://dx.doi.org/10.1016/j.drup.2019.100646 . 10.1016/j.drup.2019.100646 . in press Drug Resistance Updates

Cytotoxic effects of a chlorhexidine mouthwash and of an enzymatic mouthwash on human gingival fibroblasts

Coelho, Ana Sofia; Laranjo, Mafalda; Gonçalves, Ana Cristina; Paula, Anabela; Paulo, Siri; Abrantes, Ana Margarida; Caramelo, Francisco; et al, Odontology. 260 - 270. 2. 108. 2019. http://dx.doi.org/10.1007/s10266-019-00465-z . 10.1007/s10266-019-00465-z . Odontology

The multi-factorial nature of clinical multidrug resistance in cancer

Assaraf, YG; Brozovic, A.; Gonçalves, AC; Jurkovicova, D.; Line, A.; Machuqueiro, M.; Saponara, S.; et al, Drug Resistance Updates. 46. 2019. http://dx.doi.org/10.1016/j.drup.2019.100645 . 10.1016/j.drup.2019.100645 . published Drug Resistance Updates

MicroRNA signature refine response prediction in CML

Raquel Alves; Ana Cristina Gonçalves; Joana Jorge; Gilberto Marques; Dino Luís; André B. Ribeiro; Paulo Freitas-Tavares; et al, Scientific Reports. 2019. https://doi.org/10.1038/s41598-019-46132-9 . 10.1038/s41598-019-46132-9 . Scientific Reports

Everolimus in combination with Imatinib overcomes resistance in Chronic myeloid leukaemia

Alves, R.; Gonçalves, AC; Jorge, J.; Alves, J.; Alves da Silva, A.; Freitas-Tavares, P.; Nascimento Costa, JM; Almeida, AM; Sarmento-Ribeiro, AB., Medical Oncology. 3. 36. 2019. http://dx.doi.org/10.1007/s12032-019-1253-5 . 10.1007/s12032-019-1253-5 . published Medical Oncology

ECM-enriched alginate hydrogels for bioartificial pancreas: an ideal niche to improve insulin secretion and diabetic glucose profile

Crisóstomo, J.; Pereira, AM; Bidarra, SJ; Gonçalves, AC; Granja, PL; Coelho, JFJ; Barrias, CC; Seiça, R., Journal of Applied Biomaterials & Functional Materials. 4. 17. 2019. http://dx.doi.org/10.1177/2280800019848923 . 10.1177/2280800019848923 . published Journal of Applied Biomaterials & Functional Materials

miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells

Magalhaes, M; Almeida, M; Tavares da Silva, E; Roleira, FMF; Varela, C; Jorge, J; Goncalves, AC; et al, EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018. 10.1016/j.ejps.2018.07.021 . EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumor Growth

Pires, AS; Marques, CR; Encarnacao, JC; Abrantes, AM; Marques, IA; Laranjo, M; Oliveira, R; et al, FRONTIERS IN PHYSIOLOGY. 2018. 10.3389/fphys.2018.00911 . FRONTIERS IN PHYSIOLOGY

Advances on photodynamic therapy of melanoma through novel ring-fused 5,15-diphenylchlorins

Pereira, N.A.M.; Laranjo, M.; Pina, J.; Oliveira, A.S.R.; Ferreira, J.D.; Sánchez-Sánchez, C.; Casalta-Lopes, J.; et al, European Journal of Medicinal Chemistry. 395 - 408. 146. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041347469&partnerID=MN8TOARS . 10.1016/j.ejmech.2017.12.093 . European Journal of Medicinal Chemistry

Intestinal Epithelial Stem Cells: Distinct Behavior After Surgical Injury and Teduglutide Administration

Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Alves, R.; Matafome, P.; Seiça, R.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Castro-Sousa, F., Journal of Investigative Surgery. 243 - 252. 3. 31. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016505953&partnerID=MN8TOARS . 10.1080/08941939.2017.1294217 . Journal of Investigative Surgery

Tissular growth factors profile after teduglutide administration on an animal model of intestinal anastomosis,Perfil tisular de factores de crecimiento postadministración de teduglutida en un modelo animal de anastomosis intestinal

da Costa, B.P.; Gonçalves, A.C.; Abrantes, A.M.; Alves, R.; Matafome, P.; Sarmento-Ribeiro, R.S.A.B.; Botelho, M.F.; Castro-Sousa, F., Nutricion Hospitalaria. 185 - 193. 1. 35. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044216245&partnerID=MN8TOARS . 10.20960/nh.1326 . Nutricion Hospitalaria

Butyrate, a dietary fiber derivative that improves irinotecan effect in colon cancer cells

Encarnação, J.C.; Pires, A.S.; Amaral, R.A.; Gonçalves, T.J.; Laranjo, M.; Casalta-Lopes, J.E.; Gonçalves, A.C.; et al, Journal of Nutritional Biochemistry. 183 - 192. 56. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044448260&partnerID=MN8TOARS . 10.1016/j.jnutbio.2018.02.018 . Journal of Nutritional Biochemistry

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

da Costa, Beatriz Pinto; Goncalves, Ana Cristina; Abrantes, Ana Margarida; Matafome, Paulo; Seica, Raquel; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco, Acta Cirurgica Brasileira. 648 - 661. 8. 32. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000410613900007&KeyUID=WOS:000410613900007 . 10.1590/s0102-865020170080000007 . Acta Cirurgica Brasileira

Effects of resistance exercise on endothelial progenitor cell mobilization in women

Fernando Ribeiro; Ilda P. Ribeiro; Ana C. Gonçalves; Alberto J. Alves; Elsa Melo; Raquel Fernandes; Rui Costa; et al, Scientific Reports. 1. 7. 2017. https://doi.org/10.1038%2Fs41598-017-18156-6 . 10.1038/s41598-017-18156-6 . Scientific Reports

Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis

Goncalves, Ana Cristina; Alves, Raquel; Baldeiras, Ines; Cortesao, Emilia; Carda, Jose Pedro; Branco, Claudia C.; Oliveiros, Barbara; et al, Molecular Carcinogenesis. 130 - 148. 1. 56. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000389930000010&KeyUID=WOS:000389930000010 . 10.1002/mc.22478 . Molecular Carcinogenesis

Effects of teduglutide on histological parameters of intestinal anastomotic healing

Costa, Beatriz P.; Cipriano, Maria A.; Goncalves, Ana C.; Abrantes, Ana M.; Matafome, Paulo; Seica, Raquel; Sarmento-Ribeiro, Ana B.; Filomena Botelho, M.; Castro-Sousa, Francisco, European Surgery-Acta Chirurgica Austriaca. 218 - 227. 5. 49. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000413620500004&KeyUID=WOS:000413620500004 . 10.1007/s10353-017-0478-9 . European Surgery-Acta Chirurgica Austriaca

Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis

Costa, Beatriz P.; Goncalves, Ana C.; Abrantes, Ana M.; Matafome, Paulo; Seica, Raquel; Sarmento-Ribeiro, Ana B.; Botelho, Maria Filomena; Castro-Sousa, Francisco, Journal of Surgical Research. 87 - 98. 216. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000408042400012&KeyUID=WOS:000408042400012 . 10.1016/j.jss.2017.04.022 . Journal of Surgical Research

Glioblastoma entities express subtle differences in molecular composition and response to treatment

Balça-Silva, J.; Matias, D.; Do Carmo, A.; Dubois, L.G.; Gonçalves, A.C.; Girao, H.; Silva Canedo, N.H.; et al, Oncology Reports. 1341 - 1352. 3. 38. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026351572&partnerID=MN8TOARS . 10.3892/or.2017.5799 . Oncology Reports

L744,832 and Everolimus Induce Cytotoxic and Cytostatic Effects in Non-Hodgkin Lymphoma Cells

Mendes, J.; Gonçalves, A.C.; Alves, R.; Jorge, J.; Pires, A.; Ribeiro, A.; Sarmento-Ribeiro, A.B., Pathology and Oncology Research. 301 - 309. 2. 22. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961205328&partnerID=MN8TOARS . 10.1007/s12253-015-9998-4 . Pathology and Oncology Research

New approach for treatment of primary liver tumors: The role of quercetin

Brito, A.F.; Ribeiro, M.; Abrantes, A.M.; Mamede, A.C.; Laranjo, M.; Casalta-Lopes, J.E.; Gonçalves, A.C.; et al, Nutrition and Cancer. 250 - 266. 2. 68. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962649551&partnerID=MN8TOARS . 10.1080/01635581.2016.1145245 . Nutrition and Cancer

Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile

Pires, Ana Salome; Marques, Claudia Raquel; Encarnacao, Joao Carlos; Abrantes, Ana Margarida; Mamede, Ana Catarina; Laranjo, Mafalda; Goncalves, Ana Cristina; Sarmento-Ribeiro, Ana Bela; Botelho, Maria Filomena, European Journal of Cell Biology. 208 - 218. 6-7. 95. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000377727300004&KeyUID=WOS:000377727300004 . 10.1016/j.ejcb.2016.04.001 . European Journal of Cell Biology

Impact of splenic artery ligation after major hepatectomy on liver function, regeneration and viability

Carrapita, J.; Abrantes, A.M.; Campelos, S.; Goncalves, A.C.; Cardoso, D.; Sarmento-Ribeiro, A.B.; Rocha, C.; et al, Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991065517&partnerID=MN8TOARS . 10.1038/srep34731 . Scientific Reports

The role of immune system exhaustion on cancer cell escape and anti-tumor immune induction after irradiation

Mendes, Fernando; Domingues, Catia; Rodrigues-Santos, Paulo; Abrantes, Ana Margarida; Goncalves, Ana Cristina; Estrela, Jessica; Encarnacao, Joao; et al, Biochimica Et Biophysica Acta-Reviews on Cancer. 168 - 175. 2. 1865. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000376546200008&KeyUID=WOS:000376546200008 . 10.1016/j.bbcan.2016.02.002 . Biochimica Et Biophysica Acta-Reviews on Cancer

Aberrant p15, p16, p53, and DAPK Gene Methylation in Myelomagenesis: Clinical and Prognostic Implications

Geraldes, C.; Gonçalves, A.C.; Cortesão, E.; Pereira, M.I.; Roque, A.; Paiva, A.; Ribeiro, L.; Nascimento-Costa, J.M.; Sarmento-Ribeiro, A.B., Clinical Lymphoma, Myeloma and Leukemia. 713 - 720.e2. 12. 16. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994827373&partnerID=MN8TOARS . 10.1016/j.clml.2016.08.016 . Clinical Lymphoma, Myeloma and Leukemia

Oxidative stress levels are correlated with P15 and P16 gene promoter methylation in myelodysplastic syndrome patients

Gonçalves AC; Cortesão E; B Oliveiros; Alves V; Espadana AI; Rito L; Magalhães E; et al, Clin Exp Med.. 1 - 10. 17. 2015. 10.1007/s10238-015-0357-2 . published Clin Exp Med.

Oxidative stress and mitochondrial dysfunction play a role in myelodysplastic syndrome development, diagnosis, and prognosis: a pilot study

Gonçalves AC; Cortesão E; B Oliveiros; Alves V; Espadana AI; Rito LC; Magalhães E; et al, Free Radic Res.. 1081 - 1094. 49. 2015. 10.3109/10715762.2015.1035268 . published Free Radic Res.

Serum erythropoietin as prognostic marker in myelodysplastic syndromes | Eritropoietina sérica como marcador prognóstico em síndrome mielodisplásica

Cortesão, E.; Tenreiro, R.; Ramos, S.; Pereira, M.; César, P.; Carda, J.P.; Gomes, M.; et al, Acta Medica Portuguesa. 720 - 725. 6. 28. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000368526700009&KeyUID=WOS:000368526700009 . 10.20344/amp.6518 . Acta Medica Portuguesa

Drug transporters play a key role in the complex process of Imatinib resistance in vitro

Alves R; Fonseca AR; Gonçalves AC; Ferreira-Teixeira M; Lima J; Abrantes AM; Alves V; et al, Leukemia Research. 355 - 360. 3. 39. 2015. 10.1016/j.leukres.2014.12.008 . published Leukemia Research

Influence of P53 on the radiotherapy response of hepatocellular carcinoma

Gomes, A.R.; Abrantes, A.M.; Brito, A.F.; Laranjo, M.; Casalta-Lopes, J.E.; Gonçalves, A.C.; Sarmento-Ribeiro, A.B.; Botelho, M.F.; Tralhão, J.G., Clinical and molecular hepatology. 257 - 267. 3. 21. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84982246163&partnerID=MN8TOARS . 10.3350/cmh.2015.21.3.257 . Clinical and molecular hepatology

The importance of radiotherapy on diffuse large B cell lymphoma treatment: a current review

Mendes, F.; Domingues, C.; Teixo, R.; Abrantes, A.M.; Gonçalves, A.C.; Nobre-Gois, I.; Jacobetty, M.; et al, Cancer and Metastasis Reviews. 511 - 525. 3. 34. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942191574&partnerID=MN8TOARS . 10.1007/s10555-015-9581-1 . Cancer and Metastasis Reviews

Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine fused chlorins as very active photodynamic agents for melanoma cells

Pereira, N.A.M.; Laranjo, M.; Pineiro, M.; Serra, A.C.; Santos, K.; Teixo, R.; Abrantes, A.M.; et al, European Journal of Medicinal Chemistry. 374 - 380. 103. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84941638935&partnerID=MN8TOARS . 10.1016/j.ejmech.2015.08.059 . European Journal of Medicinal Chemistry

Lung cancer: The immune system and radiation

Mendes, F.; Antunes, C.; Abrantes, A.M.; Gonçalves, A.C.; Nobre-Gois, I.; Sarmento, A.B.; Botelho, M.F.; Rosa, M.S., British Journal of Biomedical Science. 78 - 84. 2. 72. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942614118&partnerID=MN8TOARS . 10.1080/09674845.2015.11666801 . British Journal of Biomedical Science

Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma

Mamede, A.C.; Guerra, S.; Laranjo, M.; Carvalho, M.J.; Oliveira, R.C.; Gonçalves, A.C.; Alves, R.; et al, Medical Oncology. 12. 32. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945290678&partnerID=MN8TOARS . 10.1007/s12032-015-0702-z . Medical Oncology

Chemical characterization and cytotoxic potential of an ellagitannin-enriched fraction from Fragaria vesca leaves

Liberal, J.; Costa, G.; Carmo, A.; Vitorino, R.; Marques, C.; Domingues, M.R.; Domingues, P.; et al, Arabian Journal of Chemistry. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951196550&partnerID=MN8TOARS . 10.1016/j.arabjc.2015.11.014 . Arabian Journal of Chemistry

Effects of X-radiation on lung cancer cells: the interplay between oxidative stress and P53 levels

Mendes, Fernando; Sales, Tiago; Domingues, Catia; Schugk, Susann; Abrantes, Ana Margarida; Goncalves, Ana Cristina; Teixo, Ricardo; et al, Medical Oncology. 12. 32. 2015. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365128200011&KeyUID=WOS:000365128200011 . 10.1007/s12032-015-0712-x . Medical Oncology

Fluorine-18 Fluorodeoxyglucose Uptake in Hepatocellular Carcinoma: Correlation with Glucose Transporters and p53 Expression

Brito AF; Abrantes AM; Ribeiro M; Oliveira R; Casalta-Lopes JE; Gonçalves AC; Sarmento-Ribeiro AB; Tralhão JG; Botelho MF, Journal of Clinical and Experimental Hepatology. 1 - 10. 1. 2015. 10.1016/j.jceh.2015.05.003 . published Journal of Clinical and Experimental Hepatology

Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles

Santos K; Laranjo M; Abrantes AM; Brito AF; Gonçalves AC; Sarmento-Ribeiro AB; Botelho MF; et al, European Journal of Medicinal Chemistry. 273 - 281. 79. 22. 2014. 10.1016/j.ejmech.2014.04.008 . published European Journal of Medicinal Chemistry

Microenvironment influence on human colon adenocarcinoma phenotypes and matrix metalloproteinase-2, p53 and b-catenin tumor expressions from identical monoclonal cell tumor in the orthotopic model in athymic nude rats

Priolli DG; Abrantes AM; Neves S; Gonçalves AC; Lopes CO; Martinez NP; Cardinalli IA; Sarmento-Ribeiro AB; Botelho MF, Scand J Gastroenterol. 309 - 316. 3. 49. 2014. 10.3109/00365521.2013.869350 . published Scand J Gastroenterol

Beyond the Limits of Oxygen: Effects of Hypoxia in a Hormone-Independent Prostate Cancer Cell Line

Mamede AC; Abrantes AM; Pedrosa L; Casalta-Lopes JE; Pires AS; Teixo RJ; Gonçalves AC; et al, ISRN Oncology. 1 - 8. 2013. 2013. 10.1155/2013/918207 . published ISRN Oncology

2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies

Laranjo M; Serra AC; Abrantes AM; Piñeiro M; Gonçalves AC; Casalta-Lopes JE; Carvalho L; et al, Photodiagnosis and Photodynamic Therapy. 51 - 61. 1. 10. 2013. 10.1016/j.pdpdt.2012.05.003 . published Photodiagnosis and Photodynamic Therapy

Study of hepatocellular function in the murine model following hepatic artery selective clamping

Tralhão, JG; Abrantes, AM; Gonçalves, AC; Hoti, E; Laranjo, M; Martins, R; Oliveiros, B; et al, Acta Cirurgica Brasileira. 2013. 10.1590/s0102-86502013000900006 . Acta Cirurgica Brasileira

Selenium compounds induced ros-dependent apoptosis in myelodysplasia cells

Gonçalves, A.C.; Barbosa-Ribeiro, A.; Alves, V.; Silva, T.; Sarmento-Ribeiro, A.B., Biological Trace Element Research. 440 - 447. 3. 154. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882704182&partnerID=MN8TOARS . 10.1007/s12011-013-9749-x . Biological Trace Element Research

Oxidative stress mediates apoptotic effects of ascorbate and dehydroascorbate in human Myelodysplasia cells in vitro

Gonçalves AC; Alves V; Silva T; Carvalho C; Oliveira CR; Sarmento-Ribeiro AB, Toxicology in Vitro. 1542 - 1549. 5. 27. 2013. 10.1016/j.tiv.2013.03.009 . published Toxicology in Vitro

Effect of miR-34b overexpression on the radiosensitivity of non-small cell lung cancer cell lines

Balça-Silva, J.; Neves, S.S.; Gonçalves, A.C.; Abrantes, A.M.; Casalta-Lopes, J.; Botelho, M.F.; Sarmento-Ribeiro, A.B.; Silva, H.C., Anticancer Research. 1603 - 1610. 5. 32. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861496878&partnerID=MN8TOARS . Anticancer Research

Cytotoxicity of Ascorbic Acid in a Human Colorectal Adenocarcinoma Cell Line (WiDr): in vitro and in vivo studies

Mamede AC; Pires AS; Abrantes AM; Tavares SD; Gonçalves AC; Casalta-Lopes JE; Sarmento-Ribeiro AB; Maia JM; Botelho MF, Nutrition and Cancer. 1049 - 1057. 7. 64. 2012. 10.1080/01635581.2012.713539 . published Nutrition and Cancer

Acção anti-cancerígena da Quercetina no Carcinoma Hepatocelular: o papel do GLUT-1

Brito A; Ribeiro M; Abrantes AM; Gonçalves AC; Sarmento-Ribeiro AB; Tralhão JG; Botelho MF, Revista Portuguesa de Cirurgia. 22 - 20. 25. 2012. published Revista Portuguesa de Cirurgia

Tumour hypoxia and technetium tracers: In vivo studies

Abrantes, A.M.; Serra, E.; Gonçalves, C.; Oliveiros, B.; Laranjo, M.; Sarmento-Ribeiro, A.B.; Rocha-Gonsalves, A.; Botelho, M.F., Current Radiopharmaceuticals. 99 - 105. 2. 5. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857137003&partnerID=MN8TOARS . 10.2174/1874471011205020099 . Current Radiopharmaceuticals

Hepatocellular Carcinoma and Chemotherapy: The Role of p53

Brito AF; Abrantes AM; Pinto-Costa C; Gomes AR; Mamede AC; Casalta-Lopes JE; Gonçalves AC; et al, Chemotherapy. 381 - 386. 5. 58. 2012. 10.1159/000343656 . published Chemotherapy

Synthesis of new 2-galactosylthiazolidine-4-carboxylic acid amides. Antitumor evaluation against melanoma and breast cancer cells

Serra AC; Rocha-Gonsalves AM; Laranjo M; Abrantes AM; Gonçalves AC; Sarmento-Ribeiro AB; Botelho MF, European Journal of Medicinal Chemistry. 398 - 402. 53. 2012. 10.1016/j.ejmech.2012.04.003 . published European Journal of Medicinal Chemistry

Farnesyltransferase inhibitors: Molecular evidence of therapeutic efficacy in acute lymphoblastic leukemia through cyclin D1 inhibition

Costa, C.B.; Casalta-Lopes, J.; Andrade, C.; Moreira, D.; Oliveira, A.C.; Gonçalves, A.C.; Alves, V.; et al, Anticancer Research. 831 - 838. 3. 32. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858765853&partnerID=MN8TOARS . Anticancer Research

Efflux Pumps Modulation in Colorectal Adenocarcinoma Cell Lines: The Role of Nuclear Medicine

Casalta-Lopes, J; Abrantes, AM; Laranjo, M; Rio, J; Gonçalves, AC; Oliveiros, B; Sarmento-Ribeiro, AB; Botelho, MF, Journal of Cancer Therapy. 2011. 10.4236/jct.2011.23056 . Journal of Cancer Therapy

Hypoxia-induced redox alterations and their correlation with 99mTc-MIBI and 99mTc-HL-91 uptake in colon cancer cells

Abrantes AM; Serra ME; Gonçalves AC; Rio J; Oliveiros B; Laranjo M; Rocha-Gonsalves AM; Sarmento-Ribeiro AB; Botelho MF, Nuclear Medicine and Biology. 125 - 132. 2. 37. 2010. 10.1016/j.nucmedbio.2009.11.001 . published Nuclear Medicine and Biology

Efeitos da radiação ionizante de 140 KeV em linhas celulares

Oliveira R; Abrantes AM; Rio J; Gonçalves AC; Sarmento-Ribeiro AB; Carreira IM; Botelho MF, Radioproteção. 60 - 69. 16 e 17. 2. 2010. published Radioproteção

All projects

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Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.

2023/03/06 - 2024/09/05

Early biomarkers to stop vascular dysfunction associated with obesity and type 2 diabetes

2022.04526.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023

Clinical Relevance of non-invasive biomarkers in bone and soft tissue tumors

NRC-LPCC/CIMAGO 2023

Principal investigator

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2023

Clinical Relevance of non-invasive biomarkers in bone and soft tissue tumors

NRC-LPCC/CIMAGO 2023

Principal investigator

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2023

Relevância clínica das plaquetas como biomarcadores não invasivos no Mieloma Múltiplo - Um estudo piloto

APCL 2023

Researcher

Associação Portuguesa Contra a Leucemia; Sociedade Portuguesa de Hematologia; Amgen Biofarmaceutica Lda

2022/01

Synthetic lethality in acute myeloid leukemia – Role of DNA damage response

CIMAGO 04/22

Principal investigator

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022/01 -

Evaluation of molecular mechanisms of resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma

CIMAGO 05/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022/01 -

The role of platelets in diagnosis, prognosis and therapeutic monitoring in diffuse large B-cell lymphoma

CIMAGO 06/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022/01 -

HemaCirc: CircRNAs as an innovative tool in hematological neoplasms

CIMAGO 08/22

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2022/11 -

Clinical implications of DNA damage repair in acute myeloid leucemia

SPH02/22

Principal investigator

Sociedade Portuguesa de Hematologia

2021/01/01 - 2025/12/31

Center for Innovative Biomedicine and Biotechnology - Associate Laboratory

LA/P/0058/2020

Universidade de Coimbra; Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/02 -

Clinical relevance of platelets as non-invasive biomarkers in diffuse large B-cell lymphoma – A pilot study

NRC-LPCC/CIMAGO 2020

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2021/02 -

Clinical relevance of platelets as non-invasive biomarkers in diffuse large B-cell lymphoma – A pilot study

NRC-LPCC/CIMAGO 2020

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2020 - 2023

CôaMedPlants-Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley

COA/BRB/0019/2019

Researcher

Fundação para a Ciência e a Tecnologia

Funders: Fundação para a Ciência e a Tecnologia

2019/01 - 2019/12

EPO-EPOR axis in MDS - Clinical relevance as prognostic and drug response biomarker

LPCC-NRC/CIMAGO 2019

Principal investigator

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro

2019/01/01 - 2019/12/31

CNC. IBILI

UID/NEU/04539/2019

Universidade de Coimbra; Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2019 - 2021

Red Transfronteriza de Innovación en Diagnóstico Precoz de Leucemia para un envejecimiento saludable IDIAL-NET

POCTEP 2308

Researcher

2018 - 2022

New diagnostic and therapeutic tools against multidrug resistant tumors - COST action

CA17104

Researcher

2018 - 2019

Molecular Characterization and Clinical Relevance of the crosstalk between the NRF2/KEAP1 axis and Erythropoietin in Hematopoietic Stem Cell - Clinical Relevance in Myelodysplastic Syndromes.

02/19

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro; Sociedade Portuguesa de Hematologia

2018 - 2019

Identification of new response markers to Bortezomib and Lenalidomide treatment in patients with multiple myeloma – The role of NF-kB and NRF2/KEAP1

04/18

Researcher

Liga Portuguesa Contra o Cancro Núcleo Regional do Centro; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2018 - 2019

The NRF2-KEAP1 axis as a potential prognostic biomarker and therapeutic target in chronic lymphocytic leukemia

03/18

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia; Sociedade Portuguesa de Hematologia

2016/01 - 2018/12

Crosstalk between perivascular adipose tissue and blood vessels in obesity and vascular dysfunction

grant.Provided by PTCRIS: 143079

Funders: Stichting Weten

2016 - 2019

The Role of Exercise Training in the Treatment of Resistant Hypertension

PTDC/DTP-DES/1725/2014

Researcher

Fundação para a Ciência e a Tecnologia

Funders: Fundação para a Ciência e a Tecnologia

2016/07/01 - 2019/12/31

Crosstalk between perivascular adipose tissue and blood vessels in obesity and vascular dysfunction

PTDC/BIM-MET/4447/2014

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2016 - 2018

Epigenetic in chronic lymphocytic leukemia B - Impact in prognosis and therapy

FMUC-BST-2016-220

Researcher

Universidade de Coimbra Faculdade de Medicina; Banco Santander Totta

2014 - 2019

The role of microRNAs for chronic myeloid leukemia therapeutic selection

FMUC-BST-2016-214

Researcher

Universidade de Coimbra Faculdade de Medicina; Banco Santander Totta; Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012 - 2016

Modulação redox em neoplasias hematológicas – O NRF2 com novo marcador e alvo terapêutico

10/12

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012 - 2018

Characterization of Cellular and Molecular mechanisms involved in Sensitivity and Resistance to BCR-ABL targeted therapies in Chronic Myelogenous Leukemia

18/12

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2012 - 2013

The cross-talk between oxidative stress and epigenetics – A possible route in myeloid leukemia

GAI/2012

Researcher

Universidade de Coimbra Faculdade de Medicina

2012/04/01 - 2015/09/30

Pathways of adipose tissue dysfunction: a route for obesity- related cancer

PTDC/SAU-MET/121133/2010

Universidade de Coimbra; Centro Hospitalar e Universitário de Coimbra EPE

Funders: Fundação para a Ciência e a Tecnologia

2011/04/04 - 2014/10/02

Synthesis and Pre-clinical Evaluation of Novel Estradiol-Based Indium Complexes for Targeted Radiotherapy of Tumors

PTDC/QUI-QUI/111891/2009

Universidade de Lisboa Instituto Superior Técnico; Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2009 - 2016

Avaliação da relação entre o stress oxidativo e modulação epigenética em neoplasias hematológicas - Papel da variabilidade genética/epigenética no risco de desenvolver neoplasias hematológicas e/ou resistência ao tratamento

22/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2016

Caracterização Clínica e Molecular da Síndrome Mielodisplásica – Implicações no Prognóstico e Terapêutica

24/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2014

Importância Clínica de Novos Marcadores Moleculares e Celulares no Cancro Colorectal

25/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2009 - 2015

Alterações Celulares e Moleculares no Mieloma Múltiplo – Implicações Clínicas e Terapêuticas

23/09

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2008 - 2010

Apo2L/TRAIL as new therapeutic approach in cancer

02/08

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2007 - 2009

Nutrição e alterações epigenéticas na síndrome mielodisplásica – implicações prognósticas e terapêuticas

07/07

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2006 - 2008

Development of a cellular system for the study of Cr(VI)-induced lung carcinogenesis

16/06

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2006 - 2008

Estudo do efeito da clampagem per-operatória (manobra de Pringle) na função hepatocelular no modelo animal com fígado normal e com hepatocarcinoma

05/06

Researcher

Associação de Apoio ao Centro de Investigação em Meio Ambiente Genética e Oncobiologia

2005 - 2006

Evaluation of Ubiquitin/Proteasome system in patients with Chronic Lymphocytic Leukaemias – Bortezomib as a potential therapeutic approach

JC-2005

Researcher

Janssen-Cilag Farmacêutica Lda

2005 - 2007

Protein Kinase inhibitors – Molecular and cellular mechanisms of drug resistance to Enzastaurin

LILLY 2005

Researcher

Lilly Portugal Produtos Farmacêuticos Lda

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