Publications
Information about journal articles, updated at 24-11-2024, from platform CIÊNCIAVITAE.
Editorial: Drug discovery for emerging and neglected tropical diseases: advances, challenges and perspectives
Alcântara, Laura; Franco, Caio; Moretti, Nilmar; Pilger, Denise, Frontiers in Drug Discovery. 1346042. 3. 2023. http://dx.doi.org/10.3389/fddsv.2023.1346042 . 10.3389/fddsv.2023.1346042 . published Frontiers in Drug Discovery
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi In Vitro and In Vivo
Pandey, Ramendra P.; Nascimento, Marilda Savoia; Franco, C. H.; Bortoluci, Karina; Silva, Marcelo Nunes; Zingales, Bianca; Gibaldi, Daniel; et al, Antimicrobial Agents and Chemotherapy. 2022. 10.1128/aac.00284-22 . published Antimicrobial Agents and Chemotherapy
In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)
Pereira, Catarina G.; Moraes, Carolina Borsoi; Franco, Caio H.; Feltrin, Clarissa; Grougnet, Raphaël; Barbosa, Euzébio Guimarães; Panciera, Michele; et al, Plants. 11. 10. 2021. 10.3390/plants10112235 . published Plants
Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes
Matutino Bastos, Tanira; Botelho Pereira Soares, Milena; Haddad Franco, Caio; Alcântara, Laura; Antonini, Lorenzo; Sabatino, Manuela; Mautone, Nicola; et al, International Journal of Molecular Sciences. 10. 21. 2020. 10.3390/ijms21103659 . published International Journal of Molecular Sciences
On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors
Bonatto, Vinicius; Batista, Pedro Henrique Jatai; Cianni, Lorenzo; De Vita, Daniela; Silva, Daniel G.; Cedron, Rodrigo; Tezuka, Daiane Y.; et al, RSC Medicinal Chemistry. 1275 - 1284. 11. 11. 2020. 10.1039/d0md00097c . published RSC Medicinal Chemistry
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity
Franco, Caio H.; Warhurst, David C.; Bhattacharyya, Tapan; Au, Ho Y.A.; Le, Hai; Giardini, Miriam A.; Pascoalino, Bruno S.; et al, International Journal for Parasitology: Drugs and Drug Resistance. 107 - 120. 13. 2020. 10.1016/j.ijpddr.2020.06.001 . published International Journal for Parasitology: Drugs and Drug Resistance
Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity
Conrado, Gabrielly Galdino; Grazzia, Nathalia; de Oliveira, Adriana da Silva S.; Franco, Caio Haddad; Moraes, Carolina Borsoi; Gadelha, Fernanda Ramos; Miguel, Danilo Ciccone; Garcia, Vera Lucia, Planta Medica. 782 - 789. 11. 86. 2020. 10.1055/a-1179-1003 . published Planta Medica
Discovery of new potent hits against intracellular Trypanosoma cruzi by QSAR-based virtual screening
Cleber C. Melo-Filho; Rodolpho C. Braga; Eugene N. Muratov; Caio Haddad Franco; Carolina B. Moraes; Lucio H. Freitas-Junior; Carolina Horta Andrade, European Journal of Medicinal Chemistry. 649 - 659. 163. 2019. 10.1016/j.ejmech.2018.11.062 . published European Journal of Medicinal Chemistry
Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and genomics
Borsari, Chiara; Dolores Jimenez-Anton, Maria; Eick, Julia; Bifeld, Eugenia; Jose Torrado, Juan; Isabel Olias-Molero, Ana; Jesus Corral, Maria; et al, European Journal of Medicinal Chemistry. 2019. 10.1016/J.EJMECH.2019.111676 . published European Journal of Medicinal Chemistry
Drug Discovery for Chagas Disease: Impact of Different Host Cell Lines on Assay Performance and Hit Compound Selection
Caio Haddad Franco; Laura Maria Alcântara; Eric Chatelain; Lucio Freitas-Junior; Carolina Borsoi Moraes, Tropical Medicine and Infectious Disease. 82 - 82. 2. 4. 2019. 10.3390/tropicalmed4020082 . published Tropical Medicine and Infectious Disease
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement
Gomes, Juliana C.; Cianni, Lorenzo; Ribeiro, Jean; dos Reis Rocho, Fernanda; da Costa Martins Silva, Samelyn; Batista, Pedro Henrique Jatai; Moraes, Carolina Borsoi; et al, Bioorganic & Medicinal Chemistry. 22. 27. 2019. 10.1016/j.bmc.2019.115083 . published Bioorganic & Medicinal Chemistry
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections
Linciano, Pasquale; Pozzi, Cecilia; dello Iacono, Lucia; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; et al, Journal of Medicinal Chemistry. 2019. 10.1021/ACS.JMEDCHEM.8B02021 . published Journal of Medicinal Chemistry
Antimicrobial, antiparasitic and antiproliferative effects of the extract of Bacillus safensis SG-32 isolated from a Brazilian oil reservoir
Rodrigues e Silva Tiago; Vaz dos Santos Neto Eugenio; Lucia Tasca Goiz Ruiz Ana; Ann Foglio Mary; Haddad Franco Caio; Borsoi Moraes Carolina; Maia de Oliveira Valéria, African Journal of Microbiology Research. 897 - 907. 37. 12. 2018. 10.5897/ajmr2018.8940 . published African Journal of Microbiology Research
Tetracycline@silver ions-functionalized mesoporous silica for high bactericidal activity at ultra-low concentration
Karim Bouchmella; Felipe Davi Campanaro; Gabriela Borba Mondo; Murilo Izidoro Santos; Caio Haddad Franco; Carolina Borsoi Moraes; Christine Biolley; Ahmad Mehdi; Mateus Borba Cardoso, Nanomedicine. 14. 13. 2018. 10.2217/nnm-2018-0027 . published Nanomedicine
Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation
Fabricio Castro Machado; Caio Haddad Franco; Jose Vitorino dos Santos Neto; Karina Luiza Dias-Teixeira; Carolina Borsoi Moraes; Ulisses Gazos Lopes; Bertal Huseyin Aktas; Sergio Schenkman, Scientific Reports. 1. 8. 2018. 10.1038/s41598-018-23259-9 . published Scientific Reports
Bacteria from Antarctic environments: diversity and detection of antimicrobial, antiproliferative, and antiparasitic activities
Tiago R. Silva; Alysson W. F. Duarte; Michel R. Z. Passarini; Ana Lucia T. G. Ruiz; Caio Haddad Franco; Carolina Borsoi Moraes; Itamar Soares de Melo; et al, Polar Biology. 1505 - 1519. 7. 41. 2018. 10.1007/s00300-018-2300-y . published Polar Biology
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections
Linciano, P.; Moraes, C.B.; Alcantara, L.M.; Franco, C.H.; Pascoalino, B.; Freitas-Junior, L.H.; Macedo, S.; et al, European Journal of Medicinal Chemistry. 423 - 434. 146. 2018. 10.1016/j.ejmech.2018.01.043 . published European Journal of Medicinal Chemistry
Investigating the structure-activity relationships of N’-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds
Palace-Berl, F.; Pasqualoto, K.F.M.; Zingales, B.; Moraes, C.B.; Bury, M.; Franco, C.H.; da Silva Neto, A.L.; et al, European Journal of Medicinal Chemistry. 29 - 40. 144. 2018. 10.1016/j.ejmech.2017.12.011 . published European Journal of Medicinal Chemistry
A comparative study of warheads for design of cysteine protease inhibitors
Daniel G. Silva; Jean F.R. Ribeiro; Daniela De Vita; Lorenzo Cianni; Caio Haddad Franco; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; et al, Bioorganic & Medicinal Chemistry Letters. 5031 - 5035. 22. 27. 2017. 10.1016/j.bmcl.2017.10.002 . published Bioorganic & Medicinal Chemistry Letters
Synthesis and trypanocidal activity of a library of 4-substituted 2-(1H-pyrrolo[3,2-c]pyridin-2-yl)propan-2-ols
Balfour, M.N.; Franco, C.H.; Moraes, C.B.; Freitas-Junior, L.H.; Stefani, H.A., European Journal of Medicinal Chemistry. 202 - 212. 128. 2017. 10.1016/j.ejmech.2017.01.040 . published European Journal of Medicinal Chemistry
Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
Chiara Borsari; Nuno Santarem; Juan Torrado; Ana Isabel Olías; María Jesús Corral; Catarina Baptista; Sheraz Gul; et al, European Journal of Medicinal Chemistry. 1129 - 1135. 126. 2017. 10.1016/j.ejmech.2016.12.017 . published European Journal of Medicinal Chemistry
Design, synthesis and antitrypanosomal activity of some nitrofurazone 1,2,4-triazolic bioisosteric analogues
Silva, F.T.; Franco, C.H.; Favaro, D.C.; Freitas-Junior, L.H.; Moraes, C.B.; Ferreira, E.I., European Journal of Medicinal Chemistry. 553 - 560. 121. 2016. 10.1016/j.ejmech.2016.04.065 . published European Journal of Medicinal Chemistry
Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors
Damien Bosc; Elisabeth Mouray; Sandrine Cojean; Caio Haddad Franco; Philippe M. Loiseau; Lucio H. Freitas-Junior; Carolina Borsoi Moraes; Philippe Grellier; Joëlle Dubois, European Journal of Medicinal Chemistry. 173 - 186. 109. 2016. 10.1016/j.ejmech.2015.12.045 . published European Journal of Medicinal Chemistry
Novel drug discovery for Chagas disease
Carolina B. Moraes; Caio H. Franco, Expert Opinion on Drug Discovery. 447 - 455. 5. 11. 2016. 10.1517/17460441.2016.1160883 . published Expert Opinion on Drug Discovery
Mutagenic potential of lettuce grown from irradiated seeds
Caio Haddad Franco; Valter H.M. dos Santos; Luciana P. Silva; Valter Arthur; Regildo M.G. Silva, Scientia Horticulturae. 27 - 30. 182. 2015. 10.1016/j.scienta.2014.11.011 . published Scientia Horticulturae
Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development
Moraes, C.B.; Giardini, M.A.; Kim, H.; Franco, C.H.; Araujo-Junior, A.M.; Schenkman, S.; Chatelain, E.; Freitas-Junior, L.H., Scientific Reports. 1 - 11. 4. 2014. 10.1038/srep04703 . published Scientific Reports
Chemosensitization potential of P-glycoprotein inhibitors in malaria parasites
Laura M. Alcantara; Junwon Kim; Carolina B. Moraes; Caio H. Franco; Kathrin D. Franzoi; Sukjun Lee; Lucio H. Freitas-Junior; Lawrence S. Ayong, Experimental Parasitology. 235 - 243. 2. 134. 2013. 10.1016/j.exppara.2013.03.022 . published Experimental Parasitology
5 27 out of 27 Publications
All projects
Information of exclusive responsibility of the researcher 24-11-2024 , from platform CIÊNCIAVITAE.
2022 - 2023
Identification of host microRNAs regulating the infection of macrophages by invasive and non-invasive Salmonella strains
EXPL/BIA-MIC/1251/2021
Principal investigator
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia
2019 - 2022
Large-scale identification and functional characterization of host microRNAs regulating infection by clinically relevant Staphylococcus aureus strains
POCI-01-0145-FEDER-029999
Post-doc Fellow
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia
2018 - 2019
Development of an in vitro antibiofilm screening assay against strains of S. aureus and S. epidermidis
FUSP3236
Post-doc Fellow
Universidade de São Paulo Instituto de Ciencias Biomédicas; Eurofarma Laboratórios
Funders: Fundação de Apoio a Universidade de São Paulo
2017 - 2019
Identification of starting points for drug discovery and target identification against major neglected diseases
MMV2016
PhD Student Fellow
Laboratório Nacional de Biociências; Centro Nacional de Pesquisa em Energia e Materiais; Universidade de São Paulo
Funders: Medicines for Malaria Venture
2014 - 2017
NMTrypl - New Drugs for Trypanosomatidic Infections
603240
PhD Student Fellow
Laboratório Nacional de Biociências; Centro Nacional de Pesquisa em Energia e Materiais
Funders: European Commission Seventh Framework Programme for Research and Technological Development Regions of Knowledge
2014 - 2018
Discovery of broad spectrum compounds against Trypanosoma cruzi throughout high content screening
141635/2014-2
PhD Student Fellow
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
2010 - 2013
Determination of generic doses of ionizing radiation for quarantine treatment
800405
Scientific Initiation Fellow
Universidade de São Paulo Centro de Energia Nuclear na Agricultura
5 7 out of 7 projects
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