C. Henrique Alves

Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur

Peter M.J. Quinn; António F Ambrósio; Henrique Alves (CH ALVES), Antioxidants. 2022. https://www.mdpi.com/2076-3921/11/8/1554 . 10.3390/antiox11081554 . Antioxidants

AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Buck, Thilo M.; Vos, Rogier M.; Alves, C. Henrique; Wijnholds, Jan, Molecular Therapy - Methods & Clinical Development. 423 - 441. 20. 2021. http://dx.doi.org/10.1016/j.omtm.2020.12.012 . 10.1016/j.omtm.2020.12.012 . in press Molecular Therapy - Methods & Clinical Development

IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formation

Alves, C. Henrique, Scientific Reports. 1. 11. 2021. http://dx.doi.org/10.1038/s41598-021-89625-2 . 10.1038/s41598-021-89625-2 . Scientific Reports

Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1

Nanda Boon; Henrique Alves (CH ALVES); Aat A. Mulder; Charlotte A. Andriessen; Thilo M. Buck; Peter M.J. Quinn; Rogier M. Vos; et al, International Journal of Molecular Sciences. 7. 22. 2021. https://www.mdpi.com/1422-0067/22/7/3563 . 10.3390/ijms22073563 . published International Journal of Molecular Sciences

TRAP1 in Oxidative Stress and Neurodegeneration

Alves, C. Henrique, Antioxidants. 1829 - 1829. 11. 10. 2021. http://dx.doi.org/10.3390/antiox10111829 . 10.3390/antiox10111829 . Antioxidants

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation.

Alves, C. Henrique, Acta neuropathologica communications. 2020. https://doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . Acta neuropathologica communications

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

Alves, C. Henrique, Cells. 2020. http://dx.doi.org/10.3390/cells9051217 . 10.3390/cells9051217 . Cells

Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

Alves, C. Henrique, PLOS Biology. 2020. http://dx.doi.org/10.1371/journal.pbio.3000470 . 10.1371/journal.pbio.3000470 . PLOS Biology

CD4+ CCR6+ T cells, but not gd T cells, are important for the IL-23R-dependent progression of antigen-induced inflammatory arthritis in mice.

Alves, C. Henrique, European journal of immunology. 245 - 255. 2. 50. 2020. https://doi.org/10.1002/eji.201948112 . 10.1002/eji.201948112 . European journal of immunology

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

Peter M. Quinn; Thilo M. Buck; Aat A. Mulder; Charlotte Ohonin; C. Henrique Alves; Rogier M. Vos; Monika Bialecka; et al, Stem Cell Reports. 2019. https://doi.org/10.1016%2Fj.stemcr.2019.03.002 . 10.1016/j.stemcr.2019.03.002 . Stem Cell Reports

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity

Alves, C. Henrique, International Journal of Molecular Sciences. 2019. http://dx.doi.org/10.3390/ijms20174069 . 10.3390/ijms20174069 . International Journal of Molecular Sciences

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function.

Quinn PM; Alves CH; Klooster J; Wijnholds J, Human molecular genetics. 2018. http://europepmc.org/abstract/med/29893966 . 10.1093/hmg/ddy194 . Human molecular genetics

Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype.

Quinn PM; Mulder AA; Henrique Alves C; Desrosiers M; Vries SI; Klooster J; Dalkara D; et al, Human molecular genetics. 2018. http://europepmc.org/abstract/med/30239717 . 10.1093/hmg/ddy337 . Human molecular genetics

NTPDase2 as a Surface Marker to Isolate Flow Cytometrically a Müller Glial Cell Enriched Population from Dissociated Neural Retinae

Alves, Celso, Journal of Neuroscience and Neurosurgery. 2018. https://www.boffinaccess.com/open-access-journals/journal-of-neuroscience-and-neurosurgery/jan-wijnholds-jnn-1-117.php . 10.31021/jnn.20181117 . Journal of Neuroscience and Neurosurgery

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon

Dudok, J.J.; Murtaza, M.; Henrique Alves, C.; Rashbass, P.; Wijnholds, J., Neuroscience Research. 12 - 23. 108. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973121794&partnerID=MN8TOARS . 10.1016/j.neures.2016.01.001 . Neuroscience Research

Dendritic Cell-Specific Deletion of ß-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis.

Alves CH; Ober-Blöbaum JL; Brouwers-Haspels I; Asmawidjaja PS; Mus AM; Razawy W; Molendijk M; Clausen BE; Lubberts E, 2015. http://europepmc.org/abstract/med/26587585 . 10.1371/journal.pone.0142972 .

Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside—a Comprehensive Review

Alves, C.H.; Farrell, E.; Vis, M.; Colin, E.M.; Lubberts, E., Clinical Reviews in Allergy and Immunology. 1 - 21. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84949527714&partnerID=MN8TOARS . 10.1007/s12016-015-8522-7 . Clinical Reviews in Allergy and Immunology

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

Pellissier, L.P.; Quinn, P.M.; Henrique Alves, C.; Vos, R.M.; Klooster, J.; Flannery, J.G.; Alexander Heimel, J.; Wijnholds, J., Human Molecular Genetics. 3104 - 3118. 11. 24. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930711055&partnerID=MN8TOARS . 10.1093/hmg/ddv062 . Human Molecular Genetics

The CRB1 and adherens junction complex proteins in retinal development and maintenance

Alves, C.H.; Pellissier, L.P.; Wijnholds, J., Progress in Retinal and Eye Research. 35 - 52. 40. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899107438&partnerID=MN8TOARS . 10.1016/j.preteyeres.2014.01.001 . Progress in Retinal and Eye Research

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa

Alves, C.H.; Pellissier, L.P.; Vos, R.M.; Garrido, M.G.; Sothilingam, V.; Seide, C.; Beck, S.C.; et al, Human Molecular Genetics. 3384 - 3401. 13. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902342968&partnerID=MN8TOARS . 10.1093/hmg/ddu048 . Human Molecular Genetics

Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis

Pellissier, L.P.; Alves, C.H.; Quinn, P.M.; Vos, R.M.; Tanimoto, N.; Lundvig, D.M.S.; Dudok, J.J.; et al, PLoS Genetics. 12. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892774024&partnerID=MN8TOARS . 10.1371/journal.pgen.1003976 . PLoS Genetics

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background

Alves, C.H.; Bossers, K.; Vos, R.M.; Essing, A.H.W.; Swagemakers, S.; Van Der Spek, P.J.; Verhaagen, J.; Wijnholds, J., PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891919002&partnerID=MN8TOARS . 10.1371/journal.pone.0082532 . PLoS ONE

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene

Alves, C.H.; Sanz sanz, A.; Park, B.; Pellissier, L.P.; Tanimoto, N.; Beck, S.C.; Huber, G.; et al, Human Molecular Genetics. 35 - 50. 1. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871222436&partnerID=MN8TOARS . 10.1093/hmg/dds398 . Human Molecular Genetics

Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor

Quintela, T.; Gonçalves, I.; Martinho, A.; Alves, C.H.; Saraiva, M.J.; Rocha, P.; Santos, C.R.A., Journal of Molecular Neuroscience. 152 - 158. 3. 44. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=MN8TOARS . 10.1007/s12031-010-9398-x . Journal of Molecular Neuroscience

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification

Park, B.; Alves, C.H.; Lundvig, D.M.; Tanimoto, N.; Beck, S.C.; Huber, G.; Richard, F.; et al, Journal of Neuroscience. 17230 - 17241. 47. 31. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-81855184636&partnerID=MN8TOARS . 10.1523/JNEUROSCI.4430-11.2011 . Journal of Neuroscience

17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway

Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A., Cellular and Molecular Neurobiology. 475 - 483. 4. 29. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS . 10.1007/s10571-008-9339-1 . Cellular and Molecular Neurobiology

Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice

Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A., Journal of Molecular Neuroscience. 41 - 49. 1. 38. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS . 10.1007/s12031-008-9157-4 . Journal of Molecular Neuroscience

5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway

Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A., Brain Research. 18 - 26. 1229. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS . 10.1016/j.brainres.2008.06.095 . Brain Research

Transthyretin is up-regulated by sex hormones in mice liver

Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A., Molecular and Cellular Biochemistry. 137 - 142. 1-2. 317. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS . 10.1007/s11010-008-9841-2 . Molecular and Cellular Biochemistry