Diana Duarte Lobo

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Affiliation

University of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Portugal

Publications

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Information about journal articles, updated at 02-03-2025, from platform CIÊNCIAVITAE.

A systematic screening assay identifies efficient small guide RNAs for CRISPR activation

Arvidsson, Elin; Lobo, Diana Duarte; Sabarese, Ermelinda; Duarte, Fabio; Nobre, Rui Jorge; Quintino, Luis; Lundberg, Cecilia, Frontiers in Bioengineering and Biotechnology. 13. 2025. https://doi.org/10.3389/fbioe.2025.1336313 . 10.3389/fbioe.2025.1336313 . Frontiers in Bioengineering and Biotechnology

Isolation of Adeno-associated Viral Vectors Through a Single-step and Semi-automated Heparin Affinity Chromatography Protocol

Lopes, Miguel M.; Lopes, Sara M.; Baganha, Rafael; Henriques, Carina; Silva, Ana C.; Lobo, Diana Duarte; Cortes, Luísa; de Almeida, Luís Pereira; Nobre, Rui Jorge, Journal of Visualized Experiments. 206. 2024. https://doi.org/10.3791/66550 . 10.3791/66550 . Journal of Visualized Experiments

Viral-based animal models in polyglutamine disorders

Carina Henriques; Miguel M Lopes; Ana C Silva; Diana D Lobo; Romina Aron Badin; Philippe Hantraye; Luís Pereira de Almeida; Rui Jorge Nobre, Brain. 2024. https://doi.org/10.1093/brain/awae012 . 10.1093/brain/awae012 . Brain

Extracellular vesicle-based delivery of silencing sequences for the treatment of Machado-Joseph disease/spinocerebellar ataxia type 3

Rufino-Ramos, David; Albuquerque, Patrícia R.; Leandro, Kevin; Carmona, Vitor; Martins, Inês M.; Fernandes, Rita; Henriques, Carina; et al, Molecular Therapy. 1275 - 1292. 5. 31. 2023. http://dx.doi.org/10.1016/j.ymthe.2023.04.001 . 10.1016/j.ymthe.2023.04.001 . Molecular Therapy

miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3

Nobre, Rui Jorge; Diana D. Lobo; Carina Henriques; Sonia P. Duarte; Sara M. Lopes; Ana C. Silva; Miguel M. Lopes; et al, Nucleic Acid Therapeutics. 2022. https://doi.org/10.1089/nat.2021.0020 . 10.1089/nat.2021.0020 . Nucleic Acid Therapeutics

All projects

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Information of exclusive responsibility of the researcher 02-03-2025 , from platform CIÊNCIAVITAE.

2023/03/01 - 2024/08/31

Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3

2022.06127.PTDC

Universidade de Coimbra

Funders: Fundação para a Ciência e a Tecnologia

2023/09/01 - 2026/08/31

NEURODIET - Molecular Mechanisms of Dietary Intervention on Neurodegeneration (PT001)

JPND/0001/2022

Universidade de Coimbra; Universidade Nova de Lisboa ¿Laboratório de Instrumentação Engenharia Biomédica e Física da Radiação

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2024/12/31

Overcoming the major roadblocks for successful AAV-based gene therapy in the CNS

2020.09668.BD

Universidade de Coimbra Instituto de Investigação Interdisciplinar

Funders: Fundação para a Ciência e a Tecnologia

2021/01/01 - 2025/10/31

Accelerating Research & Development for Advanced Therapies (ARDAT)

945473

PhD Student Fellow

Innovative Health Initiative

Funders: European Union; European Federation of Pharmaceutical Industries and Associations

2020/03

Laboratório de Análises Clínicas da Universidade de Coimbra - SARS-Cov2 Detection

LAC-UC

Other

Universidade de Coimbra

2020/06 - 2020/08

Validação expedita e Fabrico em larga escala de um dispositivo de sopro para colheita com inativação de amostras para deteção do SARS-CoV-2

269_596884125

Researcher

Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Interdisciplinar; ViraVector - Unidade de produção vectores virais para transferência de genes

Funders: Fundação para a Ciência e a Tecnologia; Agency for Clinical Research and Biomedical Innovation (AICIB)

2019/02/20 - 2019/09/30

Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA

NA

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: uniQure NV

2019/12 - 2020/01

A Therapeutic Strategy in Machado-Joseph Disease

CPD0020A01

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Blade Therapeutics

2018/09 -

Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3)

CSD3#IV0020

Researcher

Universidade de Coimbra Centro de Neurociências e Biologia Celular; Wave Life Sciences USA, Inc.

Funders: Wave Life Sciences USA, Inc.

2018/05/11 - 2020/12/31

BrainHealth 2020: Deteção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias

SAICT 000008 BrainHealth 2020

Research Fellow

CNC.IBILI

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