Publications
Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.
Gut-first Parkinson’s disease is encoded by a transmissible gut dysbiome.
Munoz Pinto, Mario; Candeias, Emanuel; Esteves, Ana Raquel; Ana Branco Maranha Tiago 301C-9125-034E; Melo-Marques I; João Duarte Magalhães; Reis Carneiro, Diogo; et al, 2024. submitted
Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease
Magalhães, João Duarte; Candeias, Emanuel; Melo-Marques, Inês; Abreu, António E.; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra Morais; Empadinhas, Nuno, International Journal of Molecular Sciences. 6. 25. 2024. http://dx.doi.org/10.3390/ijms25063423 . 10.3390/ijms25063423 . International Journal of Molecular Sciences
Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson¿s disease
D. Magalhães, João; Candeias, Emanuel; Melo-Marques, Inês; Silva, Diana F.; Esteves, A. Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, Cellular and Molecular Life Sciences. 6. 80. 2023. http://dx.doi.org/10.1007/s00018-023-04819-3 . 10.1007/s00018-023-04819-3 . Cellular and Molecular Life Sciences
LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease
Esteves, A. Raquel; Silva, Diana F.; Banha, Diogo; Candeias, Emanuel; Guedes, Beatriz; Cardoso, Sandra M., Redox Biology. 63. 2023. http://dx.doi.org/10.1016/j.redox.2023.102714 . 10.1016/j.redox.2023.102714 . Redox Biology
The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease
Magalhães, João D.; Esteves, Ana Raquel; Candeias, Emanuel; Silva, Diana F.; Empadinhas, Nuno; Cardoso, Sandra Morais, International Journal of Molecular Sciences. 5. 24. 2023. http://dx.doi.org/10.3390/ijms24054339 . 10.3390/ijms24054339 . International Journal of Molecular Sciences
Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1a/SIRT3 Pathway
Diniz, Antónia; Alves, Marco G.; Candeias, Emanuel; Duarte, Ana I.; Moreira, Paula I.; Silva, Branca M.; Oliveira, Pedro F.; Rato, Luís, International Journal of Molecular Sciences. 16. 23. 2022. http://dx.doi.org/10.3390/ijms23168912 . 10.3390/ijms23168912 . International Journal of Molecular Sciences
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria
Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, Gut. gutjnl - 2021. 2021. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . Gut
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons
Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . Journal of Neuroinflammation
Liraglutide Protects Against Brain Amyloid-ß1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
Candeias, Emanuel, International Journal of Molecular Sciences. 2020. http://dx.doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences
Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging
Candeias, Emanuel, Neurobiology of Aging. 2020. http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.004 . 10.1016/j.neurobiolaging.2020.01.004 . Neurobiology of Aging
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease
Candeias, Emanuel, Molecules. 2019. http://dx.doi.org/10.3390/molecules24030587 . 10.3390/molecules24030587 . Molecules
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates
Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry
Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug
Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics
Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats
Candeias, Emanuel, Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-017-0622-3 . 10.1007/s12035-017-0622-3 . Molecular Neurobiology
Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology
Candeias, Emanuel, Molecular Neurobiology. 2017. http://dx.doi.org/10.1007/s12035-016-0155-1 . 10.1007/s12035-016-0155-1 . Molecular Neurobiology
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide
Candeias, Emanuel, World Journal of Diabetes. 2015. http://dx.doi.org/10.4239/wjd.v6.i6.807 . 10.4239/wjd.v6.i6.807 . World Journal of Diabetes
Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection
Candeias, Emanuel, Journal of Bioenergetics and Biomembranes. 2015. http://dx.doi.org/10.1007/s10863-014-9580-x . 10.1007/s10863-014-9580-x . Journal of Bioenergetics and Biomembranes
Modulation of Endoplasmic Reticulum Stress: An Opportunity to Prevent Neurodegeneration?
Candeias, Emanuel, CNS & Neurological Disorders - Drug Targets. 2015. http://dx.doi.org/10.2174/1871527314666150429112353 . 10.2174/1871527314666150429112353 . CNS & Neurological Disorders - Drug Targets
The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases
Candeias, Emanuel, Expert Review of Neurotherapeutics. 2015. http://dx.doi.org/10.1586/14737175.2015.1058160 . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics
Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia
Candeias, Emanuel, Frontiers in Endocrinology. 2014. http://dx.doi.org/10.3389/fendo.2014.00110 . 10.3389/fendo.2014.00110 . Frontiers in Endocrinology
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease
Candeias, Emanuel, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2014. http://dx.doi.org/10.1016/j.bbadis.2014.05.003 . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins
Candeias, Emanuel, Current Molecular Medicine. 2013. http://dx.doi.org/10.2174/1566524011313040010 . 10.2174/1566524011313040010 . Current Molecular Medicine
Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question!
Candeias, Emanuel, Current Pharmaceutical Design. 2013. http://dx.doi.org/10.2174/1381612811319380013 . 10.2174/1381612811319380013 . Current Pharmaceutical Design
Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration
Candeias, Emanuel, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. http://dx.doi.org/10.1016/j.bbadis.2013.01.008 . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Alzheimer disease as a vascular disorder: Where do mitochondria fit?
Candeias, Emanuel, Experimental Gerontology. 2012. http://dx.doi.org/10.1016/j.exger.2012.07.006 . 10.1016/j.exger.2012.07.006 . Experimental Gerontology
Insulin signaling, glucose metabolism and mitochondria: Major players in Alzheimer's disease and diabetes interrelation
Candeias, Emanuel, Brain Research. 2012. http://dx.doi.org/10.1016/j.brainres.2011.12.063 . 10.1016/j.brainres.2011.12.063 . Brain Research
The impairment of insulin signaling in Alzheimer's disease
Candeias, Emanuel, IUBMB Life. 2012. http://dx.doi.org/10.1002/iub.1098 . 10.1002/iub.1098 . IUBMB Life
5 27 out of 27 Publications
All projects
Information of exclusive responsibility of the researcher 03-11-2024 , from platform CIÊNCIAVITAE.
2021 - 2024
The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992 ¿)
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2021 - 2024
The Gut-Immune-Brain Axis in Parkinson disease
PTDC/MED-NEU/3644/2020 (248.992 ¿)
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2018/06/15 - 2021/06/14
O papel dos mecanismos de controlo de qualidade da perda da homeostase proteica nas doenças neurodegenerativas associadas à idade
PTDC/MED-NEU/30712/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2012/05/01 - 2014/10/31
Impacto da terapia com exendina-4 nos mecanismos moleculares subjacentes à disfunção cerebral associada à diabetes tipo 2 a longo prazo
PTDC/SAU-TOX/117481/2010
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade da Beira Interior
Funders: Fundação para a Ciência e a Tecnologia
2011/03/01 - 2013/08/31
Pré-condicionamento via mitocôndria: potencial efeito neuroprotector na doença de Alzheimer
PTDC/SAU-NMC/110990/2009
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
We use cookies to improve your visit to our website.