Francisco Ambrósio

TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

Ramos Rego, Inês; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; et al, Antioxidants. 2. 12. 2023. http://dx.doi.org/10.3390/antiox12020381 . 10.3390/antiox12020381 . Antioxidants

Comparative Analysis of Retinal Organotypic Cultures and In Vivo Axotomized Retinas

González-Riquelme, María José; Lucas-Ruiz, Fernando; Galindo-Romero, Caridad; Boia, Raquel; Ambrósio, António Francisco; Vidal-Sanz, Manuel; Raquel Santiago, Ana; Agudo-Barriuso, Marta, International Journal of Molecular Sciences. 4. 24. 2023. http://dx.doi.org/10.3390/ijms24043481 . 10.3390/ijms24043481 . International Journal of Molecular Sciences

Neonatal testosterone voids sexually differentiated microglia morphology and behavior

Simões-Henriques, Carla Filipa; Rodrigues-Neves, A. Catarina; Sousa, Fábio J.; Gaspar, Rita; Almeida, Inês; Baptista, Filipa I.; Ambrósio, António F.; Gomes, Catarina A., Frontiers in Endocrinology. 14. 2023. http://dx.doi.org/10.3389/fendo.2023.1102068 . 10.3389/fendo.2023.1102068 . Frontiers in Endocrinology

Self-reported visual function and psychosocial impact of visual loss in <i>EYS</i>-associated retinal degeneration in a Portuguese population

Marques, João Pedro; Machado Soares, Ricardo; Simão, Sílvia; Abuzaitoun, Rebhi; Andrews, Chris; Alves, C. Henrique; Ambrósio, António Francisco; et al, Ophthalmic Genetics. 1 - 7. 2023. http://dx.doi.org/10.1080/13816810.2023.2191708 . 10.1080/13816810.2023.2191708 . Ophthalmic Genetics

Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

Batista, Ana; Guimarães, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, Frontiers in Aging Neuroscience. 15. 2023. http://dx.doi.org/10.3389/fnagi.2023.1161847 . 10.3389/fnagi.2023.1161847 . Frontiers in Aging Neuroscience

Attention-Deficit/Hyperactivity Disorder Animal Model Presents Retinal Alterations and Methylphenidate Has a Differential Effect in ADHD versus Control Conditions

Sanches, Eliane S.; Boia, Raquel; Leitão, Ricardo A.; Madeira, Maria H.; Fontes-Ribeiro, Carlos A.; Ambrósio, António Francisco; Fernandes, Rosa; Silva, Ana Paula, Antioxidants. 4. 12. 2023. http://dx.doi.org/10.3390/antiox12040937 . 10.3390/antiox12040937 . Antioxidants

Retinal imaging in animal models: Searching for biomarkers of neurodegeneration

Batista, Ana; Guimarães, Pedro; Serranho, Pedro; Nunes, Ana; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; et al, Frontiers in Ophthalmology. 3. 2023. http://dx.doi.org/10.3389/fopht.2023.1156605 . 10.3389/fopht.2023.1156605 . Frontiers in Ophthalmology

Maternal diabetes affects rat offspring retinal structure and function: Sex-specific vulnerabilities at infancy

Realinho, Ana M.; Boia, Raquel; Paiva, Beatriz; Correia, Raquel G.; Gaspar, Rita; Ambrósio, António F.; Baptista, Filipa I., Life Sciences. 327. 2023. http://dx.doi.org/10.1016/j.lfs.2023.121852 . 10.1016/j.lfs.2023.121852 . Life Sciences

The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system

Santos, Paulo F.; Fazendeiro, Beatriz; Luca, Francis C.; Ambrósio, António Francisco; Léger, Hélène, European Journal of Cell Biology. 2. 102. 2023. http://dx.doi.org/10.1016/j.ejcb.2023.151333 . 10.1016/j.ejcb.2023.151333 . European Journal of Cell Biology

Neuroinflammation and gliosis in the injured and contralateral retinas after unilateral optic nerve crush

Cabrera-Maqueda, José María; Boia, Raquel; Lucas-Ruiz, Fernando; González-Riquelme, María José; Ambrósio, António Francisco; Santiago, Ana Raquel; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Galindo-Romero, Caridad, Experimental Eye Research. 235. 2023. http://dx.doi.org/10.1016/j.exer.2023.109627 . 10.1016/j.exer.2023.109627 . Experimental Eye Research

Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage

Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Ferreira, Hugo; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al, Journal of Controlled Release. 469 - 481. 343. 2022. http://dx.doi.org/10.1016/j.jconrel.2022.02.001 . 10.1016/j.jconrel.2022.02.001 . Journal of Controlled Release

Profiling Microglia in a Mouse Model of Machado–Joseph Disease

Campos, Ana Bela; Duarte-Silva, Sara; Fernandes, Bruno; das Neves, Sofia Pereira; Marques, Fernanda; Teixeira-Castro, Andreia; Neves-Carvalho, Andreia; et al, Biomedicines. 2. 10. 2022. http://dx.doi.org/10.3390/biomedicines10020237 . 10.3390/biomedicines10020237 . Biomedicines

The Duration of Stress Determines Sex Specificities in the Vulnerability to Depression and in the Morphologic Remodeling of Neurons and Microglia

Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António F.; Rodrigues, Ana João; Gomes, Catarina A., Frontiers in Behavioral Neuroscience. 16. 2022. http://dx.doi.org/10.3389/fnbeh.2022.834821 . 10.3389/fnbeh.2022.834821 . Frontiers in Behavioral Neuroscience

Lab-on-a-chip technologies for minimally invasive molecular sensing of diabetic retinopathy

Maria Vieira; Rosa Fernandes; António F. Ambrósio; Vanessa Cardoso; Mariana Carvalho; Peng Weng Kung; Miguel António Dias Neves; Inês Mendes Pinto, Lab on a Chip. 2022. https://doi.org/10.1039/D1LC01138C . 10.1039/D1LC01138C . Lab on a Chip

Oxidative Stress, Neuroinflammation and Neurodegeneration: The Chicken, the Egg and the Dinosaur

Peter M. J. Quinn; António Francisco Ambrósio; Celso Henrique Alves, Antioxidants. 2022. https://doi.org/10.3390/antiox11081554 . 10.3390/antiox11081554 . Antioxidants

Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado–Joseph Disease

Ana Bela Campos; Sara Duarte-Silva; Bruno Fernandes; Bárbara Coimbra; Jonas Campos; Daniela Monteiro-Fernandes; Andreia Teixeira-Castro; António Francisco Ambrósio; Patrícia Maciel, Cells. 2022. https://doi.org/10.3390/cells11132022 . 10.3390/cells11132022 . Cells

Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis

Amorim, Madania; Martins, Beatriz; Caramelo, Francisco; Gonçalves, Conceição; Trindade, Grimalde; Simão, Jorge; Barreto, Patrícia; et al, Frontiers in Medicine. 9. 2022. http://dx.doi.org/10.3389/fmed.2022.873483 . 10.3389/fmed.2022.873483 . Frontiers in Medicine

Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease

Guimarães, Pedro; Serranho, Pedro; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, Frontiers in Aging Neuroscience. 14. 2022. http://dx.doi.org/10.3389/fnagi.2022.832195 . 10.3389/fnagi.2022.832195 . Frontiers in Aging Neuroscience

Stage-independent biomarkers for Alzheimer’s disease from the living retina: an animal study

Ferreira, Hugo; Serranho, Pedro; Guimarães, Pedro; Trindade, Rita; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, Scientific Reports. 1. 12. 2022. http://dx.doi.org/10.1038/s41598-022-18113-y . 10.1038/s41598-022-18113-y . Scientific Reports

Microglia sequelae: brain signature of innate immunity in schizophrenia

Rodrigues-Neves, A. Catarina; Ambrósio, António. F.; Gomes, Catarina A., Translational Psychiatry. 1. 12. 2022. http://dx.doi.org/10.1038/s41398-022-02197-1 . 10.1038/s41398-022-02197-1 . Translational Psychiatry

Defining milestones for the study of remyelination using the cuprizone mouse model: How early is early?

Palavra, Filipe; Viana, Sofia D.; Henriques, Sara; Dinis, João; Martins, João; Madeira, Maria H.; Santiago, Raquel; et al, Multiple Sclerosis and Related Disorders. 63. 2022. http://dx.doi.org/10.1016/j.msard.2022.103886 . 10.1016/j.msard.2022.103886 . Multiple Sclerosis and Related Disorders

Microglial Extracellular Vesicles as Vehicles for Neurodegeneration Spreading

Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Ferreira-Rodrigues, Magda; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel, Biomolecules. 6. 11. 2021. http://dx.doi.org/10.3390/biom11060770 . 10.3390/biom11060770 . Biomolecules

The value of choroidal thickness in diabetic macular oedema is contradictory

António Campos; Elisa J. Campos; João Martins; António Francisco Ambrósio; Rufino Silva, Acta Ophthalmologica. 2021. https://doi.org/10.1111/aos.14529 . 10.1111/aos.14529 . Acta Ophthalmologica

TRAP1 in Oxidative Stress and Neurodegeneration

Ramos Rego, Inês; Santos Cruz, Beatriz; Ambrósio, António Francisco; Alves, Celso Henrique, Antioxidants. 11. 10. 2021. http://dx.doi.org/10.3390/antiox10111829 . 10.3390/antiox10111829 . Antioxidants

Sex-specific changes in peripheral metabolism in a model of chronic anxiety induced by prenatal stress

Ferreira, Ana Sofia; Galvão, Sofia; Gaspar, Rita; Rodrigues-Neves, Ana C.; Ambrósio, António F.; Matafome, Paulo; Gomes, Catarina A.; Baptista, Filipa I., European Journal of Clinical Investigation. 12. 51. 2021. http://dx.doi.org/10.1111/eci.13639 . 10.1111/eci.13639 . European Journal of Clinical Investigation

Retina and Brain Display Early and Differential Molecular and Cellular Changes in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Ana Catarina Rodrigues-Neves; Rafael Carecho; Sónia Catarina Correia; Cristina Carvalho; Elisa Julião Campos; Filipa Isabel Baptista; Paula Isabel Moreira; António Francisco Ambrósio, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-021-02316-x . 10.1007/s12035-021-02316-x . Molecular Neurobiology

Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease

Ferreira, Hugo; Martins, João; Moreira, Paula I.; Ambrósio, António Francisco; Castelo-Branco, Miguel; Serranho, Pedro; Bernardes, Rui, Aging. 9433 - 9454. 7. 13. 2021. http://dx.doi.org/10.18632/aging.202916 . 10.18632/aging.202916 . Aging

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa I.; Pinto, Luísa; Ambrósio, António F.; Rodrigues, Ana João; Gomes, Catarina A., Neurobiology of Stress. 14. 2021. http://dx.doi.org/10.1016/j.ynstr.2021.100302 . 10.1016/j.ynstr.2021.100302 . Neurobiology of Stress

Activation of Adenosine A3 Receptor Inhibits Microglia Reactivity Elicited by Elevated Pressure

Joana Ferreira-Silva; Inês D. Aires; Raquel Boia; António Francisco Ambrósio; Ana Raquel Santiago, International Journal of Molecular Sciences. 7218 - 7218. 19. 21. 2020. https://doi.org/10.3390/ijms21197218 . 10.3390/ijms21197218 . International Journal of Molecular Sciences

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

Pedro, Joana Reis; Moura, Liane I.F.; Valério-Fernandes, Ângela; Baptista, Filipa I.; Gaspar, Joana M.; Pinheiro, Bárbara S.; Lemos, Cristina; et al, Brain Research Bulletin. 106 - 115. 161. 2020. http://dx.doi.org/10.1016/j.brainresbull.2020.05.004 . 10.1016/j.brainresbull.2020.05.004 . Brain Research Bulletin

Microglia Contribution to the Regulation of the Retinal and Choroidal Vasculature in Age-Related Macular Degeneration

C. Henrique Alves; Rosa Fernandes; Ana Raquel Santiago; António Francisco Ambrósio, Cells. 2020. https://doi.org/10.3390/cells9051217 . 10.3390/cells9051217 . Cells

Extracellular Vesicles and MicroRNA: Putative Role in Diagnosis and Treatment of Diabetic Retinopathy

Beatriz Martins; Madania Amorim; Flávio Reis; António Francisco Ambrósio; Rosa Fernandes, Antioxidants. 705 - 705. 8. 9. 2020. https://doi.org/10.3390/antiox9080705 . 10.3390/antiox9080705 . Antioxidants

The Benefits of Flavonoids in Diabetic Retinopathy

Ana L. Matos; Diogo F. Bruno; António F. Ambrósio; Paulo F. Santos, Nutrients. 3169 - 3169. 10. 12. 2020. https://doi.org/10.3390/nu12103169 . 10.3390/nu12103169 . Nutrients

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)

Salobrar-García, Elena; Rodrigues-Neves, Ana C.; Ramírez, Ana I.; de Hoz, Rosa; Fernández-Albarral, José A.; López-Cuenca, Inés; Ramírez, José M.; Ambrósio, António F.; Salazar, Juan J., International Journal of Molecular Sciences. 3. 21. 2020. http://dx.doi.org/10.3390/ijms21030816 . 10.3390/ijms21030816 . International Journal of Molecular Sciences

Keep an eye on adenosine: Its role in retinal inflammation

Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Catarina; Santos, Paulo Fernando; Ambrósio, António Francisco, Pharmacology & Therapeutics. 2020. http://dx.doi.org/10.1016/j.pharmthera.2020.107513 . 10.1016/j.pharmthera.2020.107513 . Pharmacology & Therapeutics

Neuropeptide Y system mRNA expression changes in the hippocampus of a type I diabetes rat model

Campos, Elisa J.; Martins, João; Brudzewsky, Dan; Woldbye, David P.D.; Ambrósio, António F., Annals of Anatomy - Anatomischer Anzeiger. 227. 2020. http://dx.doi.org/10.1016/j.aanat.2019.151419 . 10.1016/j.aanat.2019.151419 . Annals of Anatomy - Anatomischer Anzeiger

Neuroprotective Strategies for Retinal Ganglion Cell Degeneration: Current Status and Challenges Ahead

Boia, Raquel; Ruzafa, Noelia; Aires, Inês Dinis; Pereiro, Xandra; Ambrósio, António Francisco; Vecino, Elena; Santiago, Ana Raquel, International Journal of Molecular Sciences. 7. 21. 2020. http://dx.doi.org/10.3390/ijms21072262 . 10.3390/ijms21072262 . International Journal of Molecular Sciences

Activation of adenosine A3 receptor protects retinal ganglion cells from degeneration induced by ocular hypertension

Boia, Raquel; Salinas-Navarro, Manuel; Gallego-Ortega, Alejandro; Galindo-Romero, Caridad; Aires, Inês D.; Agudo-Barriuso, Marta; Ambrósio, António Francisco; Vidal-Sanz, Manuel; Santiago, Ana Raquel, Cell Death & Disease. 5. 11. 2020. http://dx.doi.org/10.1038/s41419-020-2593-y . 10.1038/s41419-020-2593-y . Cell Death & Disease

Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells

Aires, Inês Dinis; Ribeiro-Rodrigues, Teresa; Boia, Raquel; Catarino, Steve; Girão, Henrique; Ambrósio, António Francisco; Santiago, Ana Raquel, Glia. 2705 - 2724. 12. 68. 2020. http://dx.doi.org/10.1002/glia.23880 . 10.1002/glia.23880 . Glia

Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

Socodato, Renato; Portugal, Camila C.; Canedo, Teresa; Rodrigues, Artur; Almeida, Tiago O.; Henriques, Joana F.; Vaz, Sandra H.; et al, Cell Reports. 12. 31. 2020. http://dx.doi.org/10.1016/j.celrep.2020.107796 . 10.1016/j.celrep.2020.107796 . Cell Reports

Sex differences in offspring neurodevelopment, cognitive performance and microglia morphology associated with maternal diabetes: Putative targets for insulin therapy

Sousa, Fábio J.; Correia, Raquel G.; Cruz, Alexandra F.; Martins, Joana M.; Rodrigues, Matilde S.; Gomes, Catarina A.; Ambrósio, António F.; Baptista, Filipa I., Brain, Behavior, & Immunity - Health. 5. 2020. http://dx.doi.org/10.1016/j.bbih.2020.100075 . 10.1016/j.bbih.2020.100075 . Brain, Behavior, & Immunity - Health

Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses

Rodrigues, Flávia S. C.; Campos, António; Martins, João; Ambrósio, António Francisco; Campos, Elisa J., ACS Biomaterials Science & Engineering. 6587 - 6597. 12. 6. 2020. http://dx.doi.org/10.1021/acsbiomaterials.0c01347 . 10.1021/acsbiomaterials.0c01347 . ACS Biomaterials Science & Engineering

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. Henrique, Acta Neuropathologica Communications. 1. 8. 2020. http://dx.doi.org/10.1186/s40478-020-01062-w . 10.1186/s40478-020-01062-w . Acta Neuropathologica Communications

Choroidal and retinal structural, cellular and vascular changes in a rat model of Type 2 diabetes

Campos, António; Martins, João; Campos, Elisa J.; Silva, Rufino; Ambrósio, António Francisco, Biomedicine & Pharmacotherapy. 132. 2020. http://dx.doi.org/10.1016/j.biopha.2020.110811 . 10.1016/j.biopha.2020.110811 . Biomedicine & Pharmacotherapy

Inflammatory cells proliferate in the choroid and retina without choroidal thickness change in early Type 1 diabetes

Campos, António; Campos, Elisa J.; Martins, João; Rodrigues, Flávia S.C.; Silva, Rufino; Ambrósio, António Francisco, Experimental Eye Research. 199. 2020. http://dx.doi.org/10.1016/j.exer.2020.108195 . 10.1016/j.exer.2020.108195 . Experimental Eye Research

Sexual dimorphism of the adult human retina assessed by optical coherence tomography

Nunes, Ana; Serranho, Pedro; Quental, Hugo; Ambrósio, António F.; Castelo-Branco, Miguel; Bernardes, Rui, Health and Technology. 913 - 924. 4. 10. 2020. http://dx.doi.org/10.1007/s12553-020-00428-3 . 10.1007/s12553-020-00428-3 . Health and Technology

Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease

Ferreira, Hugo; Martins, João; Nunes, Ana; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco; Serranho, Pedro; Bernardes, Rui, Health and Technology. 875 - 883. 4. 10. 2020. http://dx.doi.org/10.1007/s12553-020-00413-w . 10.1007/s12553-020-00413-w . published Health and Technology

Electrochemical Immunosensor for TNFa-Mediated Inflammatory Disease Screening

Cruz, Andrea; Queirós, Raquel; Abreu, Catarina M.; Barata, Catarina; Fernandes, Rosa; Silva, Rufino; Ambrósio, Antonio F.; et al, ACS Chemical Neuroscience. 2676 - 2682. 6. 10. 2019. http://dx.doi.org/10.1021/acschemneuro.9b00036 . 10.1021/acschemneuro.9b00036 . ACS Chemical Neuroscience

Blockade of microglial adenosine A2A receptor suppresses elevated pressure-induced inflammation, oxidative stress, and cell death in retinal cells

Aires, Inês Dinis; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Madeira, Maria Helena; Marques, Carla; Ambrósio, António Francisco; Santiago, Ana Raquel, Glia. 896 - 914. 5. 67. 2019. http://dx.doi.org/10.1002/glia.23579 . 10.1002/glia.23579 . Glia

A longitudinal multimodal in vivo molecular imaging study of the 3xTg-AD mouse model shows progressive early hippocampal and taurine loss

Chiquita, Samuel; Ribeiro, Mário; Castelhano, João; Oliveira, Francisco; Sereno, José; Batista, Marta; Abrunhosa, Antero; et al, Human Molecular Genetics. 2174 - 2188. 13. 28. 2019. http://dx.doi.org/10.1093/hmg/ddz045 . 10.1093/hmg/ddz045 . Human Molecular Genetics

Retinal texture biomarkers may help to discriminate between Alzheimer’s, Parkinson’s, and healthy controls

Nunes, Ana; Silva, Gilberto; Duque, Cristina; Januário, Cristina; Santana, Isabel; Ambrósio, António Francisco; Castelo-Branco, Miguel; Bernardes, Rui, PLOS ONE. 6. 14. 2019. http://dx.doi.org/10.1371/journal.pone.0218826 . 10.1371/journal.pone.0218826 . PLOS ONE

Interplay Between Macular Retinal Changes and White Matter Integrity in Early Alzheimer’s Disease

Alves, Carolina; Jorge, Lília; Canário, Nádia; Santiago, Beatriz; Santana, Isabel; Castelhano, João; Ambrósio, António Francisco; Bernardes, Rui; Castelo-Branco, Miguel, Journal of Alzheimer's Disease. 723 - 732. 3. 70. 2019. http://dx.doi.org/10.3233/jad-190152 . 10.3233/jad-190152 . Journal of Alzheimer's Disease

Microglia cytoarchitecture in the brain of adenosine A2A receptor knockout mice: Brain region and sex specificities

Simões-Henriques, Carla; Mateus-Pinheiro, Miguel; Gaspar, Rita; Pinheiro, Helena; Mendes Duarte, Joana; Baptista, Filipa I.; Canas, Paula M.; et al, European Journal of Neuroscience. 2019. http://dx.doi.org/10.1111/ejn.14561 . 10.1111/ejn.14561 . European Journal of Neuroscience

Diminished O-GlcNAcylation in Alzheimer's disease is strongly correlated with mitochondrial anomalies

Pinho, Tiffany S.; Correia, Sónia C.; Perry, George; Ambrósio, António Francisco; Moreira, Paula I., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2048 - 2059. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.10.037 . 10.1016/j.bbadis.2018.10.037 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel

Chiquita, Samuel; Rodrigues-Neves, Ana C.; Baptista, Filipa I.; Carecho, Rafael; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António F., Molecular Neurobiology. 5416 - 5435. 8. 56. 2019. http://dx.doi.org/10.1007/s12035-018-1461-6 . 10.1007/s12035-018-1461-6 . Molecular Neurobiology

Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study

Chiquita, Samuel; Campos, Elisa J.; Castelhano, João; Ribeiro, Mário; Sereno, José; Moreira, Paula I.; Castelo-Branco, Miguel; Ambrósio, António Francisco, Alzheimer's Research & Therapy. 1. 11. 2019. http://dx.doi.org/10.1186/s13195-019-0542-8 . 10.1186/s13195-019-0542-8 . Alzheimer's Research & Therapy

Porous poly(e-caprolactone) implants: A novel strategy for efficient intraocular drug delivery

Boia, Raquel; Dias, Paulo A.N.; Martins, Joana M.; Galindo-Romero, Caridad; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al, Journal of Controlled Release. 331 - 348. 316. 2019. http://dx.doi.org/10.1016/j.jconrel.2019.09.023 . 10.1016/j.jconrel.2019.09.023 . Journal of Controlled Release

Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice

Aires, Inês Dinis; Madeira, Maria Helena; Boia, Raquel; Rodrigues-Neves, Ana Catarina; Martins, Joana Margarida; Ambrósio, António Francisco; Santiago, Ana Raquel, Scientific Reports. 1. 9. 2019. http://dx.doi.org/10.1038/s41598-019-53627-y . 10.1038/s41598-019-53627-y . Scientific Reports

In Vivo Characterization of Corneal Changes in a Type 1 Diabetic Animal Model

Caixinha, Miguel; Oliveira, Pedro; Aires, Inês D.; Ambrósio, António Francisco; Santiago, Ana Raquel; Santos, Mário; Santos, Jaime, Ultrasound in Medicine & Biology. 823 - 832. 3. 45. 2019. http://dx.doi.org/10.1016/j.ultrasmedbio.2018.11.002 . 10.1016/j.ultrasmedbio.2018.11.002 . Ultrasound in Medicine & Biology

Evaluation of markers of outcome in real-world treatment of diabetic macular edema

Campos, António; Campos, Elisa J; do Carmo, Anália; Caramelo, Francisco; Martins, João; Sousa, João P; Ambrósio, António Francisco; Silva, Rufino, Eye and Vision. 1. 5. 2018. http://dx.doi.org/10.1186/s40662-018-0119-9 . 10.1186/s40662-018-0119-9 . Eye and Vision

Sweet Stress: Coping With Vascular Dysfunction in Diabetic Retinopathy

Santiago, Ana R.; Boia, Raquel; Aires, Inês D.; Ambrósio, António F.; Fernandes, Rosa, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00820 . 10.3389/fphys.2018.00820 . Frontiers in Physiology

Choroidal thickness changes stratified by outcome in real-world treatment of diabetic macular edema

Campos, António; Campos, Elisa J.; do Carmo, Anália; Patrício, Miguel; Castro de Sousa, João P.; Ambrósio, António Francisco; Silva, Rufino, Graefe's Archive for Clinical and Experimental Ophthalmology. 1857 - 1865. 10. 256. 2018. http://dx.doi.org/10.1007/s00417-018-4072-z . 10.1007/s00417-018-4072-z . Graefe's Archive for Clinical and Experimental Ophthalmology

Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies

Baptista, Filipa I.; Pinheiro, Helena; Gomes, Catarina A.; Ambrósio, António F., Molecular Neurobiology. 2202 - 2210. 3. 56. 2018. http://dx.doi.org/10.1007/s12035-018-1227-1 . 10.1007/s12035-018-1227-1 . Molecular Neurobiology

Region-specific control of microglia by adenosine A2A receptors: uncoupling anxiety and associated cognitive deficits in female rats

Duarte, Joana Mendes; Gaspar, Rita; Caetano, Liliana; Patrício, Patrícia; Soares-Cunha, Carina; Mateus-Pinheiro, António; Alves, Nuno Dinis; et al, Glia. 182 - 192. 1. 67. 2018. http://dx.doi.org/10.1002/glia.23476 . 10.1002/glia.23476 . Glia

The Quadruple Helix-Based Innovation Model of Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study

Malva, João O.; Amado, Alda; Rodrigues, Alexandra; Mota-Pinto, Anabela; Cardoso, Ana F.; Teixeira, Ana M.; Todo-Bom, Ana; et al, Frontiers in Medicine. 5. 2018. http://dx.doi.org/10.3389/fmed.2018.00132 . 10.3389/fmed.2018.00132 . Frontiers in Medicine

Elevated Pressure Changes the Purinergic System of Microglial Cells

Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; et al, Frontiers in Pharmacology. 9. 2018. http://dx.doi.org/10.3389/fphar.2018.00016 . 10.3389/fphar.2018.00016 . Frontiers in Pharmacology

Blockade of microglial adenosine A2A receptor impacts inflammatory mechanisms, reduces ARPE-19 cell dysfunction and prevents photoreceptor loss in vitro

Madeira, M. H.; Rashid, K.; Ambrósio, A. F.; Santiago, A. R.; Langmann, T., Scientific Reports. 1. 8. 2018. http://dx.doi.org/10.1038/s41598-018-20733-2 . 10.1038/s41598-018-20733-2 . Scientific Reports

Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of rat retina

Campos, Elisa J; Martins, João; Brudzewsky, Dan; Correia, Sandra; Santiago, Ana R; Woldbye, David PD; Ambrósio, António F, Clinical & Experimental Ophthalmology. 783 - 795. 7. 46. 2018. http://dx.doi.org/10.1111/ceo.13176 . 10.1111/ceo.13176 . Clinical & Experimental Ophthalmology

Adenosine A2A Receptor Blockade Modulates Glucocorticoid-Induced Morphological Alterations in Axons, But Not in Dendrites, of Hippocampal Neurons

Pinheiro, Helena; Gaspar, Rita; Baptista, Filipa I.; Fontes-Ribeiro, Carlos A.; Ambrósio, António F.; Gomes, Catarina A., Frontiers in Pharmacology. 9. 2018. http://dx.doi.org/10.3389/fphar.2018.00219 . 10.3389/fphar.2018.00219 . Frontiers in Pharmacology

The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation

Gonçalves, Andreia; Almeida, Luísa; Silva, Ana Paula; Fontes-Ribeiro, Carlos; Ambrósio, António F.; Cristóvão, Armando; Fernandes, Rosa, Biomedicine & Pharmacotherapy. 833 - 838. 102. 2018. http://dx.doi.org/10.1016/j.biopha.2018.03.144 . 10.1016/j.biopha.2018.03.144 . Biomedicine & Pharmacotherapy

Elevated Glucose and Interleukin-1ß Differentially Affect Retinal Microglial Cell Proliferation

Baptista, Filipa I.; Aveleira, Célia A.; Castilho, Áurea F.; Ambrósio, António F., Mediators of Inflammation. 1 - 11. 2017. 2017. http://dx.doi.org/10.1155/2017/4316316 . 10.1155/2017/4316316 . Mediators of Inflammation

Having a Coffee Break: The Impact of Caffeine Consumption on Microglia-Mediated Inflammation in Neurodegenerative Diseases

Madeira, Maria H.; Boia, Raquel; Ambrósio, António F.; Santiago, Ana R., Mediators of Inflammation. 1 - 12. 2017. 2017. http://dx.doi.org/10.1155/2017/4761081 . 10.1155/2017/4761081 . Mediators of Inflammation

Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

Portugal, Camila C.; Socodato, Renato; Canedo, Teresa; Silva, Cátia M.; Martins, Tânia; Coreixas, Vivian S. M.; Loiola, Erick C.; et al, Science Signaling. 472. 10. 2017. http://dx.doi.org/10.1126/scisignal.aal2005 . 10.1126/scisignal.aal2005 . Science Signaling

Opening eyes to nanomedicine: Where we are, challenges and expectations on nanotherapy for diabetic retinopathy

Campos, Elisa J.; Campos, António; Martins, João; Ambrósio, António Francisco, Nanomedicine: Nanotechnology, Biology and Medicine. 2101 - 2113. 6. 13. 2017. http://dx.doi.org/10.1016/j.nano.2017.04.008 . 10.1016/j.nano.2017.04.008 . Nanomedicine: Nanotechnology, Biology and Medicine

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

Boia, Raquel; Elvas, Filipe; Madeira, Maria H; Aires, Inês D; Rodrigues-Neves, Ana C; Tralhão, Pedro; Szabó, Eszter C; et al, Cell Death & Disease. e3065 - e3065. 10. 8. 2017. http://dx.doi.org/10.1038/cddis.2017.451 . 10.1038/cddis.2017.451 . Cell Death & Disease

Calcium Dobesilate Is Protective against Inflammation and Oxidative/Nitrosative Stress in the Retina of a Type 1 Diabetic Rat Model

Voabil, Paula; Liberal, Joana; Leal, Ermelindo C.; Bauer, Jacques; Cunha-Vaz, José; Santiago, Ana Raquel; Ambrósio, António Francisco, Ophthalmic Research. 150 - 161. 3. 58. 2017. http://dx.doi.org/10.1159/000478784 . 10.1159/000478784 . Ophthalmic Research

Impact of Neuroinflammation on Hippocampal Neurogenesis: Relevance to Aging and Alzheimer's Disease

Valero, J.; Bernardino, L.; Cardoso, F.L.; Silva, A.P.; Fontes-Ribeiro, C.; Ambrósio, A.F.; Malva, J.O.; et al, Journal of Alzheimer's Disease. S161 - S168. s1. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029488785&partnerID=MN8TOARS . 10.3233/JAD-170239 . Journal of Alzheimer's Disease

Modeling Human Glaucoma: Lessons from the in vitro Models

Aires, Inês Dinis; Ambrósio, António Francisco; Santiago, Ana Raquel, Ophthalmic Research. 77 - 86. 2. 57. 2016. http://dx.doi.org/10.1159/000448480 . 10.1159/000448480 . Ophthalmic Research

Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure–induced transient ischemic injury

Madeira, Maria H.; Boia, Raquel; Elvas, Filipe; Martins, Tiago; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel, Translational Research. 112 - 128. 169. 2016. http://dx.doi.org/10.1016/j.trsl.2015.11.005 . 10.1016/j.trsl.2015.11.005 . Translational Research

Obesity and brain inflammation: a focus on multiple sclerosis

Palavra, F.; Almeida, L.; Ambrósio, A. F.; Reis, F., Obesity Reviews. 211 - 224. 3. 17. 2016. http://dx.doi.org/10.1111/obr.12363 . 10.1111/obr.12363 . Obesity Reviews

Therapeutic Opportunities for Caffeine and A2A Receptor Antagonists in Retinal Diseases

Boia, Raquel; Ambrósio, António Francisco; Santiago, Ana Raquel, Ophthalmic Research. 212 - 218. 4. 55. 2016. http://dx.doi.org/10.1159/000443893 . 10.1159/000443893 . Ophthalmic Research

The Adenosinergic System in Diabetic Retinopathy

Vindeirinho, J.; Santiago, A. R.; Cavadas, C.; Ambrósio, A. F.; Santos, P. F., Journal of Diabetes Research. 1 - 8. 2016. 2016. http://dx.doi.org/10.1155/2016/4270301 . 10.1155/2016/4270301 . Journal of Diabetes Research

Protective Effect of a GLP-1 Analog on Ischemia-Reperfusion Induced Blood–Retinal Barrier Breakdown and Inflammation

Gonçalves, Andreia; Lin, Cheng-Mao; Muthusamy, Arivalagan; Fontes-Ribeiro, Carlos; Ambrósio, António F.; Abcouwer, Steven F.; Fernandes, Rosa; Antonetti, David A., Investigative Opthalmology & Visual Science. 6. 57. 2016. http://dx.doi.org/10.1167/iovs.15-19006 . 10.1167/iovs.15-19006 . Investigative Opthalmology & Visual Science

Caffeine administration prevents retinal neuroinflammation and loss of retinal ganglion cells in an animal model of glaucoma

Madeira, Maria H.; Ortin-Martinez, Arturo; Nadal-Nícolas, Francisco; Ambrósio, António F.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; Santiago, Ana Raquel, Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep27532 . 10.1038/srep27532 . Scientific Reports

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

Caetano, L; Pinheiro, H; Patrício, P; Mateus-Pinheiro, A; Alves, N D; Coimbra, B; Baptista, F I; et al, Molecular Psychiatry. 1035 - 1043. 7. 22. 2016. http://dx.doi.org/10.1038/mp.2016.173 . 10.1038/mp.2016.173 . Molecular Psychiatry

Viewing the choroid: where we stand, challenges and contradictions in diabetic retinopathy and diabetic macular oedema

Campos, António; Campos, Elisa J.; Martins, João; Ambrósio, António Francisco; Silva, Rufino, Acta Ophthalmologica. 446 - 459. 5. 95. 2016. http://dx.doi.org/10.1111/aos.13210 . 10.1111/aos.13210 . Acta Ophthalmologica

Neuropeptide Y system in the retina: From localization to function

Santos-Carvalho, Ana; Ambrósio, António Francisco; Cavadas, Cláudia, Progress in Retinal and Eye Research. 19 - 37. 47. 2015. http://dx.doi.org/10.1016/j.preteyeres.2015.03.001 . 10.1016/j.preteyeres.2015.03.001 . Progress in Retinal and Eye Research

Long-term exposure to high glucose increases the content of several exocytotic proteins and of vesicular GABA transporter in cultured retinal neural cells

Baptista, Filipa I.; Castilho, Áurea F.; Gaspar, Joana M.; Liberal, Joana T.; Aveleira, Célia A.; Ambrósio, António F., Neuroscience Letters. 56 - 61. 602. 2015. http://dx.doi.org/10.1016/j.neulet.2015.06.044 . 10.1016/j.neulet.2015.06.044 . Neuroscience Letters

Adenosine A2AR blockade prevents neuroinflammation-induced death of retinal ganglion cells caused by elevated pressure

Madeira, Maria H.; Elvas, Filipe; Boia, Raquel; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; Ambrósio, António Francisco; Santiago, Ana Raquel, Journal of Neuroinflammation. 1. 12. 2015. http://dx.doi.org/10.1186/s12974-015-0333-5 . 10.1186/s12974-015-0333-5 . Journal of Neuroinflammation

Effects of drugs of abuse on the central neuropeptide Y system

Gonçalves, Joana; Martins, João; Baptista, Sofia; Ambrósio, António Francisco; Silva, Ana Paula, Addiction Biology. 755 - 765. 4. 21. 2015. http://dx.doi.org/10.1111/adb.12250 . 10.1111/adb.12250 . Addiction Biology

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases

Madeira, Maria H.; Boia, Raquel; Santos, Paulo F.; Ambrósio, António F.; Santiago, Ana R., Mediators of Inflammation. 1 - 15. 2015. 2015. http://dx.doi.org/10.1155/2015/673090 . 10.1155/2015/673090 . Mediators of Inflammation

Disruption of a Neural Microcircuit in the Rod Pathway of the Mammalian Retina by Diabetes Mellitus

Castilho, A.; Ambrosio, A. F.; Hartveit, E.; Veruki, M. L.; Castilho, Á.; Ambrósio, A.F.; Veruki, M.L., Journal of Neuroscience. 5422 - 5433. 13. 35. 2015. http://dx.doi.org/10.1523/jneurosci.5285-14.2015 . 10.1523/jneurosci.5285-14.2015 . Journal of Neuroscience

Sildenafil Acutely Decreases Visual Responses in ON and OFF Retinal Ganglion Cells

Martins, João; Kolomiets, Bogdan; Caplette, Romain; Sahel, José-Alain; Castelo-Branco, Miguel; Ambrósio, António F.; Picaud, Serge, Investigative Opthalmology & Visual Science. 4. 56. 2015. http://dx.doi.org/10.1167/iovs.14-15964 . 10.1167/iovs.14-15964 . Investigative Opthalmology & Visual Science

Diabetic hyperglycemia reduces Ca2+ permeability of extrasynaptic AMPA receptors in AII amacrine cells

Castilho, Áurea; Madsen, Eirik; Ambrósio, António F.; Veruki, Margaret L.; Hartveit, Espen, Journal of Neurophysiology. 1545 - 1553. 3. 114. 2015. http://dx.doi.org/10.1152/jn.00295.2015 . 10.1152/jn.00295.2015 . Journal of Neurophysiology

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective ActionsIn Vitro

Martins, João; Elvas, Filipe; Brudzewsky, Dan; Martins, Tânia; Kolomiets, Bogdan; Tralhão, Pedro; Gøtzsche, Casper R.; et al, ASN Neuro. 4. 7. 2015. http://dx.doi.org/10.1177/1759091415598292 . 10.1177/1759091415598292 . ASN Neuro

Adenosine A 3 receptor activation is neuroprotective against retinal neurodegeneration

Galvao, Joana; Elvas, Filipe; Martins, Tiago; Cordeiro, M. Francesca; Ambrósio, António Francisco; Santiago, Ana Raquel, Experimental Eye Research. 65 - 74. 140. 2015. http://dx.doi.org/10.1016/j.exer.2015.08.009 . 10.1016/j.exer.2015.08.009 . Experimental Eye Research

Inside the Diabetic Brain: Role of Different Players Involved in Cognitive Decline

Gaspar, Joana M.; Baptista, Filipa I.; Macedo, M. Paula; Ambrósio, António F., ACS Chemical Neuroscience. 131 - 142. 2. 7. 2015. http://dx.doi.org/10.1021/acschemneuro.5b00240 . 10.1021/acschemneuro.5b00240 . ACS Chemical Neuroscience

Glia-Mediated Retinal Neuroinflammation as a Biomarker in Alzheimer's Disease

Madeira, Maria Helena; Ambrósio, António Francisco; Santiago, Ana Raquel, Ophthalmic Research. 204 - 211. 4. 54. 2015. http://dx.doi.org/10.1159/000440887 . 10.1159/000440887 . Ophthalmic Research

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling

Carreira, Bruno P.; Morte, Maria I.; Santos, Ana I.; Lourenço, Ana S.; Ambrósio, António F.; Carvalho, Caetana M.; Araújo, Inês M., Frontiers in Cellular Neuroscience. 8. 2014. http://dx.doi.org/10.3389/fncel.2014.00343 . 10.3389/fncel.2014.00343 . Frontiers in Cellular Neuroscience

Emerging novel roles of neuropeptide Y in the retina: From neuromodulation to neuroprotection

Santos-Carvalho, Ana; Álvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, Cláudia, Progress in Neurobiology. 70 - 79. 112. 2014. http://dx.doi.org/10.1016/j.pneurobio.2013.10.002 . 10.1016/j.pneurobio.2013.10.002 . Progress in Neurobiology

Dipeptidyl peptidase-IV inhibition prevents blood–retinal barrier breakdown, inflammation and neuronal cell death in the retina of type 1 diabetic rats

Gonçalves, Andreia; Marques, Catarina; Leal, Ermelindo; Ribeiro, Carlos F.; Reis, Flávio; Ambrósio, António F.; Fernandes, Rosa, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1454 - 1463. 9. 1842. 2014. http://dx.doi.org/10.1016/j.bbadis.2014.04.013 . 10.1016/j.bbadis.2014.04.013 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: Implications for axonal transport

Baptista, Filipa I.; Pinto, Maria J.; Elvas, Filipe; Martins, Tiago; Almeida, Ramiro D.; Ambrósio, António F., Experimental Eye Research. 91 - 103. 127. 2014. http://dx.doi.org/10.1016/j.exer.2014.07.011 . 10.1016/j.exer.2014.07.011 . Experimental Eye Research

c-Src function is necessary and sufficient for triggering microglial cell activation

Socodato, Renato; Portugal, Camila C.; Domith, Ivan; Oliveira, Nádia A.; Coreixas, Vivian S. M.; Loiola, Erick C.; Martins, Tânia; et al, Glia. 497 - 511. 3. 63. 2014. http://dx.doi.org/10.1002/glia.22767 . 10.1002/glia.22767 . Glia

Role of Microglia Adenosine A2AReceptors in Retinal and Brain Neurodegenerative Diseases

Santiago, Ana R.; Baptista, Filipa I.; Santos, Paulo F.; Cristóvão, Gonçalo; Ambrósio, António F.; Cunha, Rodrigo A.; Gomes, Catarina A., Mediators of Inflammation. 1 - 13. 2014. 2014. http://dx.doi.org/10.1155/2014/465694 . 10.1155/2014/465694 . Mediators of Inflammation

Regulation of claudins in blood-tissue barriers under physiological and pathological states

Gonçalves, Andreia; Ambrósio, António Francisco; Fernandes, Rosa; Ambrósio, A.F., Tissue Barriers. 3. 1. 2013. http://dx.doi.org/10.4161/tisb.24782 . 10.4161/tisb.24782 . Tissue Barriers

Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons

Morte, Maria I.; Carreira, Bruno P.; Falcão, Maria J.; Ambrósio, António F.; Soares-da-Silva, Patrício; Araújo, Inês M.; Carvalho, Caetana M., Toxicology in Vitro. 2193 - 2202. 8. 27. 2013. http://dx.doi.org/10.1016/j.tiv.2013.09.008 . 10.1016/j.tiv.2013.09.008 . Toxicology in Vitro

Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose

Gaspar, J.M.; Martins, A.; Cruz, R.; Rodrigues, C.M.P.; Ambrósio, A.F.; Santiago, A.R., Neuroscience. 380 - 388. 253. 2013. http://dx.doi.org/10.1016/j.neuroscience.2013.08.053 . 10.1016/j.neuroscience.2013.08.053 . Neuroscience

Diabetes Alters KIF1A and KIF5B Motor Proteins in the Hippocampus

Baptista, Filipa I.; Pinto, Maria J.; Elvas, Filipe; Almeida, Ramiro D.; Ambrósio, António F., PLoS ONE. 6. 8. 2013. http://dx.doi.org/10.1371/journal.pone.0065515 . 10.1371/journal.pone.0065515 . PLoS ONE

Differential Contribution of the Guanylyl Cyclase-Cyclic GMP-Protein Kinase G Pathway to the Proliferation of Neural Stem Cells Stimulated by Nitric Oxide

Carreira, Bruno P.; Morte, Maria Inês; Lourenço, Ana Sofia; Santos, Ana Isabel; Inácio, Ângela; Ambrósio, António F.; Carvalho, Caetana M.; Araújo, Inês M., Neurosignals. 1 - 13. 1-2. 21. 2013. http://dx.doi.org/10.1159/000332811 . 10.1159/000332811 . Neurosignals

Methamphetamine-induced nitric oxide promotes vesicular transport in blood–brain barrier endothelial cells

Martins, Tânia; Burgoyne, Thomas; Kenny, Bridget-Ann; Hudson, Natalie; Futter, Clare E.; Ambrósio, António F.; Silva, Ana P.; Greenwood, John; Turowski, Patric, Neuropharmacology. 74 - 82. 65. 2013. http://dx.doi.org/10.1016/j.neuropharm.2012.08.021 . 10.1016/j.neuropharm.2012.08.021 . Neuropharmacology

Neuropeptide Y Receptors Y1 and Y2 are Present in Neurons and Glial Cells in Rat Retinal Cells in Culture

Santos-Carvalho, Ana; Aveleira, Célia A.; Elvas, Filipe; Ambrósio, António Francisco; Cavadas, Cláudia, Investigative Opthalmology & Visual Science. 1. 54. 2013. http://dx.doi.org/10.1167/iovs.12-10776 . 10.1167/iovs.12-10776 . Investigative Opthalmology & Visual Science

Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate

Santos-Carvalho, A; Elvas, F; Álvaro, A R; Ambrósio, A F; Cavadas, C, Cell Death & Disease. e636 - e636. 5. 4. 2013. http://dx.doi.org/10.1038/cddis.2013.160 . 10.1038/cddis.2013.160 . Cell Death & Disease

Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal model

Gonçalves, A.; Leal, E.; Paiva, A.; Teixeira Lemos, E.; Teixeira, F.; Ribeiro, C. F.; Reis, F.; Ambrósio, A. F.; Fernandes, R., Diabetes, Obesity and Metabolism. 454 - 463. 5. 14. 2012. http://dx.doi.org/10.1111/j.1463-1326.2011.01548.x . 10.1111/j.1463-1326.2011.01548.x . Diabetes, Obesity and Metabolism

Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose

Costa, G.N.; Vindeirinho, J.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F., Molecular and Cellular Neuroscience. 113 - 123. 1. 50. 2012. http://dx.doi.org/10.1016/j.mcn.2012.04.003 . 10.1016/j.mcn.2012.04.003 . Molecular and Cellular Neuroscience

Elevated glucose concentration changes the content and cellular localization of AMPA receptors in the retina but not in the hippocampus

Castilho, A.F.; Liberal, J.T.; Baptista, F.I.; Gaspar, J.M.; Carvalho, A.L.; Ambrósio, A.F., Neuroscience. 23 - 32. 219. 2012. http://dx.doi.org/10.1016/j.neuroscience.2012.05.056 . 10.1016/j.neuroscience.2012.05.056 . Neuroscience

Calcium-permeable a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors Trigger Neuronal Nitric-oxide Synthase Activation to Promote Nerve Cell Death in an Src Kinase-dependent Fashion

Socodato, Renato; Santiago, Felipe N.; Portugal, Camila C.; Domingues, Ana F.; Santiago, Ana R.; Relvas, João B.; Ambrósio, António F.; Paes-de-Carvalho, Roberto, Journal of Biological Chemistry. 38680 - 38694. 46. 287. 2012. http://dx.doi.org/10.1074/jbc.m112.353961 . 10.1074/jbc.m112.353961 . Journal of Biological Chemistry

Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity

Castilho, Áurea F.; Aveleira, Célia A.; Leal, Ermelindo C.; Simões, Núria F.; Fernandes, Carolina R.; Meirinhos, Rita I.; Baptista, Filipa I.; Ambrósio, António F., PLoS ONE. 8. 7. 2012. http://dx.doi.org/10.1371/journal.pone.0042428 . 10.1371/journal.pone.0042428 . PLoS ONE

Nitric Oxide Modulates Sodium Vitamin C Transporter 2 (SVCT-2) Protein Expression via Protein Kinase G (PKG) and Nuclear Factor-¿B (NF-¿B)

Portugal, Camila Cabral; Encarnação, Thaísa Godinho da; Socodato, Renato; Moreira, Sarah Rodrigues; Brudzewsky, Dan; Ambrósio, António Francisco; Paes-de-Carvalho, Roberto, Journal of Biological Chemistry. 3860 - 3872. 6. 287. 2012. http://dx.doi.org/10.1074/jbc.m111.260166 . 10.1074/jbc.m111.260166 . Journal of Biological Chemistry

Effects of 3,4-Methylenedioxymethamphetamine Administration on Retinal Physiology in the Rat

Martins, João; Castelo-Branco, Miguel; Batista, Ana; Oliveiros, Bárbara; Santiago, Ana Raquel; Galvão, Joana; Fernandes, Eduarda; et al, PLoS ONE. 12. 6. 2011. http://dx.doi.org/10.1371/journal.pone.0029583 . 10.1371/journal.pone.0029583 . PLoS ONE

Methamphetamine transiently increases the blood–brain barrier permeability in the hippocampus: Role of tight junction proteins and matrix metalloproteinase-9

Martins, Tânia; Baptista, Sofia; Gonçalves, Joana; Leal, Ermelindo; Milhazes, Nuno; Borges, Fernanda; Ribeiro, Carlos F.; et al, Brain Research. 28 - 40. 1411. 2011. http://dx.doi.org/10.1016/j.brainres.2011.07.013 . 10.1016/j.brainres.2011.07.013 . Brain Research

Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina

Baptista, Filipa I.; Gaspar, Joana M.; Cristóvão, Armando; Santos, Paulo F.; Köfalvi, Attila; Ambrósio, António F., Brain Research. 257 - 269. 1383. 2011. http://dx.doi.org/10.1016/j.brainres.2011.01.071 . 10.1016/j.brainres.2011.01.071 . Brain Research

Nitric Oxide Stimulates the Proliferation of Neural Stem Cells Bypassing the Epidermal Growth Factor Receptor

Carreira, Bruno Pereira; Morte, Maria Inês; Inácio, Ângela; Costa, Gabriel; Rosmaninho-Salgado, Joana; Agasse, Fabienne; Carmo, Anália; et al, STEM CELLS. N/A - N/A. 2010. http://dx.doi.org/10.1002/stem.444 . 10.1002/stem.444 . STEM CELLS

High glucose and interleukin-1ß downregulate interleukin-1 type I receptor (IL-1RI) in retinal endothelial cells by enhancing its degradation by a lysosome-dependent mechanism

Aveleira, Célia; Castilho, Áurea; Baptista, Filipa; Simões, Núria; Fernandes, Carolina; Leal, Ermelindo; Ambrósio, António Francisco, Cytokine. 279 - 286. 3. 49. 2010. http://dx.doi.org/10.1016/j.cyto.2009.11.014 . 10.1016/j.cyto.2009.11.014 . Cytokine

High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia

Pereira, Tiago de Oliveira Simões; da Costa, Gabriel Nascimento Ferreira; Santiago, Ana Raquel Sarabando; Ambrósio, António Francisco; dos Santos, Paulo Fernando Martins, Brain Research. 129 - 138. 1316. 2010. http://dx.doi.org/10.1016/j.brainres.2009.12.034 . 10.1016/j.brainres.2009.12.034 . Brain Research

Diabetes differentially affects the content of exocytotic proteins in hippocampal and retinal nerve terminals

Gaspar, J.M.; Baptista, F.I.; Galvão, J.; Castilho, Á.F.; Cunha, R.A.; Ambrósio, A.F., Neuroscience. 1589 - 1600. 4. 169. 2010. http://dx.doi.org/10.1016/j.neuroscience.2010.06.021 . 10.1016/j.neuroscience.2010.06.021 . Neuroscience

Long-term exposure to high glucose induces changes in the content and distribution of some exocytotic proteins in cultured hippocampal neurons

Gaspar, J.M.; Castilho, Á.; Baptista, F.I.; Liberal, J.; Ambrósio, A.F., Neuroscience. 981 - 992. 4. 171. 2010. http://dx.doi.org/10.1016/j.neuroscience.2010.10.019 . 10.1016/j.neuroscience.2010.10.019 . Neuroscience

Evaluation of the Impact of Diabetes on Retinal Metabolites by NMR Spectroscopy

Santiago, A. R.; Garrido, M. J.; Cristóvão, A. J.; Duarte, J. M. N.; Carvalho, R. A.; Ambrósio, A. F., Current Eye Research. 992 - 1001. 11. 35. 2010. http://dx.doi.org/10.3109/02713683.2010.500113 . 10.3109/02713683.2010.500113 . Current Eye Research

TNF-  Signals Through PKC /NF- B to Alter the Tight Junction Complex and Increase Retinal Endothelial Cell Permeability

Aveleira, C. A.; Lin, C.-M.; Abcouwer, S. F.; Ambrosio, A. F.; Antonetti, D. A., Diabetes. 2872 - 2882. 11. 59. 2010. http://dx.doi.org/10.2337/db09-1606 . 10.2337/db09-1606 . Diabetes

Calcium Dobesilate Inhibits the Alterations in Tight Junction Proteins and Leukocyte Adhesion to Retinal Endothelial Cells Induced by Diabetes

Leal, E. C.; Martins, J.; Voabil, P.; Liberal, J.; Chiavaroli, C.; Bauer, J.; Cunha-Vaz, J.; Ambrosio, A. F., Diabetes. 2637 - 2645. 10. 59. 2010. http://dx.doi.org/10.2337/db09-1421 . 10.2337/db09-1421 . Diabetes

Neuropeptide Y inhibits [Ca2+]ichanges in rat retinal neurons through NPY Y1, Y4, and Y5receptors

Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, Journal of Neurochemistry. 1508 - 1515. 5. 109. 2009. http://dx.doi.org/10.1111/j.1471-4159.2009.06079.x . 10.1111/j.1471-4159.2009.06079.x . Journal of Neurochemistry

High glucose and oxidative/nitrosative stress conditions induce apoptosis in retinal endothelial cells by a caspase-independent pathway

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.; Ambrósio, António F., Experimental Eye Research. 983 - 991. 5. 88. 2009. http://dx.doi.org/10.1016/j.exer.2008.12.010 . 10.1016/j.exer.2008.12.010 . Experimental Eye Research

High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures

Costa, G.; Pereira, T.; Neto, A.M.; Cristóvão, A.J.; Ambrósio, A.F.; Santos, P.F., Journal of Neuroscience Research. 1375 - 1380. 6. 87. 2009. http://dx.doi.org/10.1002/jnr.21956 . 10.1002/jnr.21956 . Journal of Neuroscience Research

Diabetes changes the levels of ionotropic glutamate receptors in the rat retina.

Santiago AR; Gaspar JM; Baptista FI; Cristóvão AJ; Santos PF; Kamphuis W; Ambrósio AF; et al, Molecular Vision. 1620 - 1630. 15. 2009. http://europepmc.org/abstract/med/19693289 . Molecular Vision

Müller Cells Do Not Influence Leukocyte Adhesion to Retinal Endothelial Cells

Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Aurea F.; Baptista, Filipa I.; Ambrósio, António F., Ocular Immunology and Inflammation. 173 - 179. 4. 16. 2008. http://dx.doi.org/10.1080/09273940802204535 . 10.1080/09273940802204535 . Ocular Immunology and Inflammation

Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca2+]i Changes Evoked by Kainate in Hippocampal Neurons

Santiago, Ana R.; Carvalho, Caetana M.; Carvalho, Arsélio P.; Ambrósio, António F., Neurochemical Research. 1501 - 1508. 8. 33. 2008. http://dx.doi.org/10.1007/s11064-008-9618-8 . 10.1007/s11064-008-9618-8 . Neurochemical Research

Neuropeptide Y stimulates retinal neural cell proliferation - involvement of nitric oxide

Álvaro, Ana Rita; Martins, João; Araújo, Inês M.; Rosmaninho-Salgado, Joana; Ambrósio, António F.; Cavadas, Cláudia, Journal of Neurochemistry. 2501 - 2510. 6. 105. 2008. http://dx.doi.org/10.1111/j.1471-4159.2008.05334.x . 10.1111/j.1471-4159.2008.05334.x . Journal of Neurochemistry

Diabetes changes ionotropic glutamate receptor subunit expression level in the human retina

Santiago, Ana R.; Hughes, John M.; Kamphuis, Willem; Schlingemann, Reinier O.; Ambrósio, António F., Brain Research. 153 - 159. 1198. 2008. http://dx.doi.org/10.1016/j.brainres.2007.12.030 . 10.1016/j.brainres.2007.12.030 . Brain Research

Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy

Álvaro, A.R.; Martins, J.; Costa, A.C.; Fernandes, E.; Carvalho, F.; Ambrósio, A.F.; Cavadas, C., Neuroscience. 97 - 105. 1. 152. 2008. http://dx.doi.org/10.1016/j.neuroscience.2007.12.027 . 10.1016/j.neuroscience.2007.12.027 . Neuroscience

Inducible Nitric Oxide Synthase Isoform Is a Key Mediator of Leukostasis and Blood-Retinal Barrier Breakdown in Diabetic Retinopathy

Leal, Ermelindo C.; Manivannan, Ayyakkannu; Hosoya, Ken-Ichi; Terasaki, Tetsuya; Cunha-Vaz, Jose´; Ambro´sio, Anto´nio Francisco; Forrester, John V., Investigative Opthalmology & Visual Science. 11. 48. 2007. http://dx.doi.org/10.1167/iovs.07-0112 . 10.1167/iovs.07-0112 . Investigative Opthalmology & Visual Science

High glucose induces caspase-independent cell death in retinal neural cells

Santiago, A.R.; Cristóvão, A.J.; Santos, P.F.; Carvalho, C.M.; Ambrósio, A.F., Neurobiology of Disease. 464 - 472. 3. 25. 2007. http://dx.doi.org/10.1016/j.nbd.2006.10.023 . 10.1016/j.nbd.2006.10.023 . Neurobiology of Disease

Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

Araújo, I M; Carreira, B P; Pereira, T; Santos, P F; Soulet, D; Inácio, Â; Bahr, B A; et al, Cell Death & Differentiation. 1635 - 1646. 9. 14. 2007. http://dx.doi.org/10.1038/sj.cdd.4402171 . 10.1038/sj.cdd.4402171 . Cell Death & Differentiation

NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells

Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, Neurochemistry International. 757 - 763. 5. 50. 2007. http://dx.doi.org/10.1016/j.neuint.2007.01.010 . 10.1016/j.neuint.2007.01.010 . Neurochemistry International

Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

Duarte, João M.N.; Oliveira, Catarina R.; Ambrósio, António F.; Cunha, Rodrigo A., Neurochemistry International. 144 - 150. 2. 48. 2006. http://dx.doi.org/10.1016/j.neuint.2005.08.008 . 10.1016/j.neuint.2005.08.008 . Neurochemistry International

High glucose and diabetes increase the release of [3H]-d-aspartate in retinal cell cultures and in rat retinas

Santiago, Ana R.; Pereira, Tiago S.; Garrido, Manuel J.; Cristóvão, Armando J.; Santos, Paulo F.; Ambrósio, António F., Neurochemistry International. 453 - 458. 6-7. 48. 2006. http://dx.doi.org/10.1016/j.neuint.2005.10.013 . 10.1016/j.neuint.2005.10.013 . Neurochemistry International

Elevated Glucose Changes the Expression of Ionotropic Glutamate Receptor Subunits and Impairs Calcium Homeostasis in Retinal Neural Cells

Santiago, Ana R.; Rosa, Susana C.; Santos, Paulo F.; Cristo´va~o, Armando J.; Barber, Alistair J.; Ambro´sio, Anto´nio F., Investigative Opthalmology & Visual Science. 9. 47. 2006. http://dx.doi.org/10.1167/iovs.06-0085 . 10.1167/iovs.06-0085 . Investigative Opthalmology & Visual Science

Erratum: Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons (Journal of Neurochemistry (2004) 91 (1322-1331))

Araújo, I.M.; Verdasca, M.J.; Leal, E.C.; Bahr, B.A.; Ambrósio, A.F.; Carvalho, A.P.; Carvalho, C.M., Journal of Neurochemistry. 996 - 996. 4. 92. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644260452&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.03043.x . Journal of Neurochemistry

Old and New Drug Targets in Diabetic Retinopathy: From Biochemical Changes to Inflammation and Neurodegeneration

Leal, E.; Santiago, A.; Ambrosio, A., Current Drug Target -CNS & Neurological Disorders. 421 - 434. 4. 4. 2005. http://dx.doi.org/10.2174/1568007054546162 . 10.2174/1568007054546162 . Current Drug Target -CNS & Neurological Disorders

Early calpain-mediated proteolysis following AMPA receptor activation compromises neuronal survival in cultured hippocampal neurons

Araújo, Inês M.; Verdasca, Maria J.; Leal, Ermelindo C.; Bahr, Ben A.; Ambrósio, António F.; Carvalho, Arsélio P.; Carvalho, Caetana M., Journal of Neurochemistry. 1322 - 1331. 6. 91. 2004. http://dx.doi.org/10.1111/j.1471-4159.2004.02811.x . 10.1111/j.1471-4159.2004.02811.x . Journal of Neurochemistry

Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A Comparative Study between Carbamazepine, Oxcarbazepine, and Two New Putative Antiepileptic Drugs, BIA 2-024 and BIA 2-093

Araujo, Ines M.; Ambrosio, Antonio Francisco; Leal, Ermelindo C.; Verdasca, Maria Joao; Malva, Joao Oliveira; Soares-da-Silva, Patricio; Carvalho, Arselio Pato; Carvalho, Caetana Monteiro, Epilepsia. 1498 - 1505. 12. 45. 2004. http://dx.doi.org/10.1111/j.0013-9580.2004.14104.x . 10.1111/j.0013-9580.2004.14104.x . Epilepsia

Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite

Araújo, Inês M.; Verdasca, Maria J.; Ambrósio, António F.; Carvalho, Caetana M., NeuroReport. 2007 - 2011. 13. 15. 2004. http://dx.doi.org/10.1097/00001756-200409150-00003 . 10.1097/00001756-200409150-00003 . NeuroReport

Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons.

Araújo IM; Ambrósio AF; Leal EC; Santos PF; Carvalho AP; Carvalho CM; Araújo, I.M.; et al, Journal of Neurochemistry. 791 - 800. 3. 85. 2003. http://europepmc.org/abstract/med/12694405 . 10.1046/j.1471-4159.2003.01731.x . Journal of Neurochemistry

Cobalt staining of hippocampal neurons mediated by non-desensitizing activation of AMPA but not kainate receptors

Malva, João Oliveira; Vieira, Ana P.; Ambrósio, António F.; Oliveira, Catarina R., NeuroReport. 847 - 850. 6. 14. 2003. http://dx.doi.org/10.1097/00001756-200305060-00014 . 10.1097/00001756-200305060-00014 . NeuroReport

Mechanisms of action of carbamazepine and their derivatives, oxcarbazepine, BIA 2-093 and BIA 2-024

Ambrósio, António F.; Soares-da-Silva, Patrício; Carvalho, Caetana M.; Carvalho, Arsélio P.; Ambrósio, A.F.; Soares-da-Silva, P.; Carvalho, C.M.; Carvalho, A.P., Neurochemical Research. 121 - 130. 1/2. 27. 2002. http://dx.doi.org/10.1023/a:1014814924965 . 10.1023/a:1014814924965 . Neurochemical Research

Role of kainate receptor activation and desensitization on the [Ca2+]ichanges in cultured rat hippocampal neurons

Silva, Ana P.; Malva, João O.; Ambrósio, António F.; Salgado, António J.; Carvalho, Arsélio P.; Carvalho, Caetana M., Journal of Neuroscience Research. 378 - 386. 5. 65. 2001. http://dx.doi.org/10.1002/jnr.1164 . 10.1002/jnr.1164 . Journal of Neuroscience Research

Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels11Abbreviations: AED, antiepileptic drug; CBZ, carbamazepine; OXC, oxcarbazepine; and 4-AP, 4-aminopyridine.

Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Soares-da-Silva, Patricio; Carvalho, Arsélio P.; Carvalho, Caetana M.; Ambrósio, A.F.; et al, Biochemical Pharmacology. 1271 - 1275. 10. 61. 2001. http://dx.doi.org/10.1016/s0006-2952(01)00584-6 . 10.1016/s0006-2952(01)00584-6 . Biochemical Pharmacology

Role of desensitization of AMPA receptors on the neuronal viability and on the [Ca2+]ichanges in cultured rat hippocampal neurons

Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Mesquita, José F.; Carvalho, Arsélio P.; Carvalho, Caetana M., European Journal of Neuroscience. 2021 - 2031. 6. 12. 2000. http://dx.doi.org/10.1046/j.1460-9568.2000.00091.x . 10.1046/j.1460-9568.2000.00091.x . European Journal of Neuroscience

Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024

Ambrósio, António F; Silva, Ana P; Araújo, Inês; Malva, João O; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P; Carvalho, Caetana M, European Journal of Pharmacology. 191 - 201. 2. 406. 2000. http://dx.doi.org/10.1016/s0014-2999(00)00659-2 . 10.1016/s0014-2999(00)00659-2 . European Journal of Pharmacology

Carbamazepine inhibits L-type Ca2+ channels in cultured rat hippocampal neurons stimulated with glutamate receptor agonists

Ambrósio, António F.; Silva, Ana P.; Malva, João O.; Soares-da-Silva, Patri´cio; Carvalho, Arsélio P.; Carvalho, Caetana M.; Ambrósio, A.F.; et al, Neuropharmacology. 1349 - 1359. 9. 38. 1999. http://dx.doi.org/10.1016/s0028-3908(99)00058-1 . 10.1016/s0028-3908(99)00058-1 . Neuropharmacology

Increase of the intracellular Ca2+ concentration mediated by transport of glutamate into rat hippocampal synaptosomes: characterization of the activated voltage sensitive Ca2+ channels

Malva, J; Ambrósio, A.F., Neurochemistry International. 7 - 16. 1. 32. 1998. http://dx.doi.org/10.1016/s0197-0186(97)00048-x . 10.1016/s0197-0186(97)00048-x . Neurochemistry International

Inhibition of N-, P/Q- and other types of Ca2+ channels in rat hippocampal nerve terminals by the adenosine A1 receptor

Ambrósio, António F; Malva, João O; Carvalho, Arsélio P; Carvalho, Caetana M, European Journal of Pharmacology. 301 - 310. 2-3. 340. 1997. http://dx.doi.org/10.1016/s0014-2999(97)01451-9 . 10.1016/s0014-2999(97)01451-9 . European Journal of Pharmacology

Modulation of Glutamate Release from Rat Hippocampal Synaptosomes by Nitric Oxide

Sequeira, Sónia M.; Ambrósio, António F.; Malva, João O.; Carvalho, Arsélio P.; Carvalho, Caetana M., Nitric Oxide. 315 - 329. 4. 1. 1997. http://dx.doi.org/10.1006/niox.1997.0144 . 10.1006/niox.1997.0144 . Nitric Oxide

Modulation of Ca2+ channels by activation of adenosine A1 receptors in rat striatal glutamatergic nerve terminals

Ambrósio, António F.; Malva, João O.; Carvalho, Arsélio P.; Carvalho, Caetana M., Neuroscience Letters. 163 - 166. 3. 220. 1996. http://dx.doi.org/10.1016/s0304-3940(96)13252-3 . 10.1016/s0304-3940(96)13252-3 . Neuroscience Letters

A functionally active presynaptic high-affinity kainate receptor in the rat hippocampal CA3 subregion

Malva, J.O.; Ambrósio, A.F.; Cunha, R.A.; Ribeiro, J.A.; Carvalho, A.P.; Carvalho, C.M.; Malva, João O.; et al, Neuroscience Letters. 83 - 86. 2. 185. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912732&partnerID=MN8TOARS . 10.1016/0304-3940(94)11230-G . Neuroscience Letters

Involvement of class A calcium channels in the KCl induced Ca2+ influx in hippocampal synaptosomes

Malva, Joa˜o O.; Ambrósio, António F.; Carvalho, Arsélio P.; Duarte, Carlos B.; Carvalho, Caetana M., Brain Research. 242 - 245. 1-2. 696. 1995. http://dx.doi.org/10.1016/0006-8993(95)00816-9 . 10.1016/0006-8993(95)00816-9 . Brain Research