João Pedro Oliveira da Silva Paulino Lopes

Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure

Lopes, C.R.; Amaral, I.M.; Pereira, M.F.; Lopes, J.P.; Madeira, D.; Canas, P.M.; Cunha, R.A.; Agostinho, P., Journal of Neurochemistry. 556 - 567. 5. 160. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124559190&partnerID=MN8TOARS . 10.1111/jnc.15575 . Journal of Neurochemistry

Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.

Valada P; Alçada-Morais S; Cunha RA; Lopes JP, International journal of molecular sciences. 2022. http://europepmc.org/abstract/med/36142422 . 10.3390/ijms231810510 . International journal of molecular sciences

The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.

Valada P; Hinz S; Vielmuth C; Lopes CR; Cunha RA; Müller CE; Lopes JP, Purinergic signalling. 2022. http://europepmc.org/abstract/med/36156760 . 10.1007/s11302-022-09899-7 . Purinergic signalling

l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory

Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al, The FASEB Journal. 8. 35. 2021. http://dx.doi.org/10.1096/fj.202100336r . 10.1096/fj.202100336r . The FASEB Journal

Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices

Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al, Scientific Reports. 1. 11. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS . 10.1038/s41598-021-89964-0 . Scientific Reports

Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade

Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas, Molecular Neurobiology. 2021. https://doi.org/10.1007/s12035-020-02275-9 . 10.1007/s12035-020-02275-9 . Molecular Neurobiology

Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.

Lopes, João, Neurobiology of disease. 2020. https://doi.org/10.1016/j.nbd.2020.105137 . 10.1016/j.nbd.2020.105137 . Neurobiology of disease

The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors

João P. Lopes; Anna Pliássova; Rodrigo A. Cunha, Biochemical Pharmacology. 313 - 321. 166. 2019. https://doi.org/10.1016/j.bcp.2019.06.008 . 10.1016/j.bcp.2019.06.008 . Biochemical Pharmacology

Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . Neurobiology of Disease

What is the extracellular calcium concentration within brain synapses?

João Pedro Lopes; Rodrigo A. Cunha, Journal of Neurochemistry. 435 - 437. 4. 149. 2019. https://doi.org/10.1111/jnc.14696 . 10.1111/jnc.14696 . Journal of Neurochemistry

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice

Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F., Journal of Neurochemistry. 796 - 809. 6. 148. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS . 10.1111/jnc.14653 . Journal of Neurochemistry

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al, Neurobiology of Disease. 72 - 81. 117. 2018. http://dx.doi.org/10.1016/j.nbd.2018.05.024 . 10.1016/j.nbd.2018.05.024 . Neurobiology of Disease

The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P, 2016. http://europepmc.org/abstract/med/26497029 . 10.1007/s12035-015-9491-9 .

The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system

Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al, Journal of Neurochemistry. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS . 10.1111/jnc.13109 . Journal of Neurochemistry

Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease

Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A., PLoS ONE. 2. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS . 10.1371/journal.pone.0056870 . PLoS ONE

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity

Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A., Brain and Behavior. 67 - 74. 2. 3. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS . 10.1002/brb3.118 . Brain and Behavior

Cdk5: Multitasking between physiological and pathological conditions

Lopes, J.P.; Agostinho, P., Progress in Neurobiology. 49 - 63. 1. 94. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS . 10.1016/j.pneurobio.2011.03.006 . Progress in Neurobiology

Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Aging Cell. 64 - 77. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS . 10.1111/j.1474-9726.2009.00536.x . Aging Cell

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cell Cycle. 97 - 104. 1. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS . Cell Cycle

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology

Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M., Journal of Alzheimer's Disease. 541 - 549. 3. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS . 10.3233/JAD-2009-0993 . Journal of Alzheimer's Disease

Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Current Alzheimer Research. 205 - 212. 3. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS . 10.2174/156720509788486590 . Current Alzheimer Research

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides

Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula, Cell Cycle. 97 - 104. 1. 8. 2009. http://dx.doi.org/10.4161/cc.8.1.7506 . 10.4161/cc.8.1.7506 . Cell Cycle

Overactivation of calcineurin induced by amyloid-beta and prion proteins

Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R., Neurochemistry International. 1226 - 1233. 6. 52. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS . 10.1016/j.neuint.2008.01.005 . Neurochemistry International

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies

Lopes, J.P.; Oliveira, C.R.; Agostinho, P., Cellular and Molecular Neurobiology. 943 - 957. 7. 27. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS . 10.1007/s10571-007-9224-3 . Cellular and Molecular Neurobiology

Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente

Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A., Revista Portuguesa de Pneumologia. 5. 9. 2003. http://dx.doi.org/10.1016/s0873-2159(15)30711-x . 10.1016/s0873-2159(15)30711-x . Revista Portuguesa de Pneumologia