Publications
Information about journal articles, updated at 29-03-2026, from platform CIÊNCIAVITAE.
Extracellular vesicles-associated AAVs for the treatment of Machado-Joseph disease
Henriques, Carina; Albuquerque, Patrícia; Rufino-Ramos, David; Lopes, Miguel M.; Leandro, Kevin; Miranda, Catarina O.; Almeida, Rita; et al, Molecular Therapy. 161 - 178. 1. 34. 2026. https://doi.org/10.1016/j.ymthe.2025.10.022 . 10.1016/j.ymthe.2025.10.022 . Molecular Therapy
Fatal Familial Insomnia: A Puzzle of a Rare Disease in Need of More Research
Duarte, Raquel; Carvalhas-Almeida, Catarina; Santos, Bárbara; Gaspar, Laetitia S.; Amaral, Sara Varela; Félix, Rita; Durães, João; et al, Frontiers for Young Minds. 13. 2025. https://doi.org/10.3389/frym.2025.1523273 . 10.3389/frym.2025.1523273 . Frontiers for Young Minds
Circadian rhythms are disrupted in patients and preclinical models of Machado-Joseph disease
Ribeiro, Rodrigo F N; Pereira, Dina; Lopes, Sara M; Reis, Tiago; Silva, Patrick; Lobo, Diana D; Gaspar, Laetitia S; et al, Brain. 4127 - 4142. 11. 148. 2025. https://doi.org/10.1093/brain/awaf199 . 10.1093/brain/awaf199 . Brain
Systematic review of changes in extracellular vesicles associated with obstructive sleep apnoea: implications for diagnosis and treatment
Santos, Bárbara; Ramalho, Bárbara; Relógio, Angela; Cavadas, Cláudia; Gaspar, Laetitia S.; Álvaro, Ana Rita, European Respiratory Review. 178. 34. 2025. https://doi.org/10.1183/16000617.0073-2025 . 10.1183/16000617.0073-2025 . European Respiratory Review
The Medication Patterns of Spinocerebellar Ataxia Type 3 Mutation Carriers Enrolled in the ESMI Cohort
Silva, Patrick; Costa, Marina A.; Gaspar, Laetitia; Durães, João; Cunha, Inês; Ribeiro, Joana A; Januário, Cristina; et al, CNS Drugs. 233 - 246. 2. 40. 2025. https://doi.org/10.1007/s40263-025-01237-w . 10.1007/s40263-025-01237-w . CNS Drugs
Circadian Biology in Obstructive Sleep Apnea-Associated Cardiovascular Disease
Gaspar, Laetitia S.; Pyakurel, Santoshi; Xu, Na; D'Souza, Shane P.; Koritala, Bala S.C., Journal of Molecular and Cellular Cardiology. 116 - 132. 202. 2025. https://doi.org/10.1016/j.yjmcc.2025.03.008 . 10.1016/j.yjmcc.2025.03.008 . Journal of Molecular and Cellular Cardiology
A comparative analysis of commercial kits for enhanced circular mRNA production: yield, profile, and in vitro assessment
Pereira, D.; Valdeira, A.S.; Gaspar, Laetitia S; De Luca, P.; Perdigao, P.; Lopes, S. M.; Silva, F.S.; et al, HUMAN GENE THERAPY. E515 - E516. 36. 2025. HUMAN GENE THERAPY
Maximizing Yield and Functionality in saRNA Production: A Comparative Study of Commercial Kits and In Vitro Transcription Conditions
Gaspar, Laetitia S; Marques, B.; Pereira, Dina; De Luca, P.; Perdigao, P.; Lopes, S. M.; Perfeito, R.; et al, HUMAN GENE THERAPY. E512 - E512. 36. 2025. HUMAN GENE THERAPY
Optimizing in vitro transcription methods for enhanced mRNA-based therapeutics
De Luca, P.; Lopes, S. M.; Pereira, D.; Gaspar, Laetitia S; Marques, B.; Perdigao, P.; A. Melo; et al, HUMAN GENE THERAPY. E513 - E514. 36. 2025. HUMAN GENE THERAPY
Comparative Analysis of Transfection Kits for Linear, Self-Amplifying, and Circular RNA
Miranda, C; Perfeito, R.; Duarte, S.P; Paulo, C; Rodrigues, MT; Gaspar, L.S; Pereira, D; et al, HUMAN GENE THERAPY. E514 - E515. 36. 2025. HUMAN GENE THERAPY
The mystery of fatal familial insomnia
Duarte, Raquel; Carvalhas-Almeida, Catarina; Santos, Bárbara; Gaspar, Laetitia S; Varela Amaral, Sara; Cardoso, Joao; Félix, Rita, Frontiers for Young Minds. 2024. submitted Frontiers for Young Minds
Murine Pro-Inflammatory Responses to Acute and Sustained Intermittent Hypoxia: Implications for Obstructive Sleep Apnea Research
Bala S. C. Koritala; Laetitia S. Gaspar; Shweta S. Bhadri; Kyla S. Massie; Yin Yeng Lee; Jiffin Paulose; David F. Smith, The Laryngoscope. 2024. https://doi.org/10.1002/lary.30915 . 10.1002/lary.30915 . The Laryngoscope
Systematic review of miRNA expression changes in Obstructive Sleep Apnea: insights into associated pathways and contribution to disease
Gaspar, L.S.; Capitão, A.; Santos, B.; Mendes, A. Ferreira; Cavadas, C.; Moreira, I.S.; Álvaro, A.R., Sleep Medicine. S389 - S390. 115. 2024. https://doi.org/10.1016/j.sleep.2023.11.1049 . 10.1016/j.sleep.2023.11.1049 . Sleep Medicine
Assessment of circadian rhythm markers and clock genes expression in patients with Chronic Insomnia
Carvalhas-Almeida, C.; Capitão, A.; Gaspar, Laetitia S; Ferreira, M.; Serra, J.; Moita, J.; Cavadas, C.; Alvaro, A., Sleep Medicine. 115. 2024. Sleep Medicine
Clock genes profiles as a diagnostic tool using machine learning in chronic insomnia-A pilot study
Carvalhas-Almeida, C.; Alves, J.; Araujo, T.; Santos, Bárbara; Gaspar, Laetitia S; Ferreira, M.; Sousa Fontes Serra, J.T.M; et al, JOURNAL OF SLEEP RESEARCH. 33. 2024. JOURNAL OF SLEEP RESEARCH
Treatment with Continuous Positive Airway Pressure Alters Transcriptomic and Epigenomic Signatures of Obstructive Sleep Apnea
Gaspar, Laetitia S; Smith, David F.; Pyakurel, Santoshi; Santos, Bárbara; Carvalhas-Almeida, Catarina; Ferreira, Mafalda; Moita, Joaquim; et al., European Respiratory Journal. 2024. submitted European Respiratory Journal
A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia
Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al, Neuropathology and Applied Neurobiology. 2. 49. 2023. https://doi.org/10.1111/nan.12892 . 10.1111/nan.12892 . Neuropathology and Applied Neurobiology
A standardised protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia
Santana, Magda M.; Gaspar, Laetitia S.; Pinto, Maria M.; Silva, Patrick; Adão, Diana; Pereira, Dina; Ribeiro, Joana Afonso; et al, Neuropathology and Applied Neurobiology. 2. 49. 2023. http://dx.doi.org/10.1111/nan.12892 . 10.1111/nan.12892 . published Neuropathology and Applied Neurobiology
Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression
Koritala, Bala S. C.; Lee, Yin Yeng; Gaspar, Laetitia S.; Bhadri, Shweta S.; Su, Wen; Wu, Gang; Francey, Lauren J.; et al, PLOS Biology. 5. 21. 2023. http://dx.doi.org/10.1371/journal.pbio.3002139 . 10.1371/journal.pbio.3002139 . published PLOS Biology
Peripheral biomarkers to diagnose obstructive sleep apnea in adults: A systematic review and meta-analysis
Gaspar, Laetitia S.; Santos-Carvalho, Ana; Santos, Bárbara; Carvalhas-Almeida, Catarina; Barros-Viegas, Ana Teresa; Oliveiros, Bárbara; Donato, Helena; et al, Sleep Medicine Reviews. 64. 2022. http://dx.doi.org/10.1016/j.smrv.2022.101659 . 10.1016/j.smrv.2022.101659 . published Sleep Medicine Reviews
Intermittent Hypoxia Alters the Circadian Expression of Clock Genes in Mouse Brain and Liver
Koritala, Bala S. C.; Lee, Yin Yeng; Bhadri, Shweta S.; Gaspar, Laetitia S.; Stanforth, Corinne; Wu, Gang; Ruben, Marc D.; Francey, Lauren J.; Smith, David F., Genes. 10. 12. 2021. http://dx.doi.org/10.3390/genes12101627 . 10.3390/genes12101627 . published Genes
Long-term continuous positive airway pressure treatment ameliorates biological clock disruptions in obstructive sleep apnea
Gaspar, Laetitia S.; Hesse, Janina; Yalçin, Müge; Santos, Bárbara; Carvalhas-Almeida, Catarina; Ferreira, Mafalda; Moita, Joaquim; et al, EBioMedicine. 65. 2021. http://dx.doi.org/10.1016/j.ebiom.2021.103248 . 10.1016/j.ebiom.2021.103248 . published EBioMedicine
Common risk factors and therapeutic targets in obstructive sleep apnea and osteoarthritis: An unexpectable link?
Gaspar, Laetitia S.; Sousa, Cátia; Álvaro, Ana Rita; Cavadas, Cláudia; Mendes, Alexandrina Ferreira, Pharmacological Research. 164. 2021. http://dx.doi.org/10.1016/j.phrs.2020.105369 . 10.1016/j.phrs.2020.105369 . published Pharmacological Research
The Superpowers of Our Sleep
Gaspar, Laetitia S.; Santos, Bárbara; Barros-Viegas, Ana Teresa; Cardoso, João; Varela Amaral, Sara; Carvalhas-Almeida, Catarina; Santos-Carvalho, Ana; Cavadas, Cláudia; Álvaro, Ana Rita, Frontiers for Young Minds. 8. 2020. http://dx.doi.org/10.3389/frym.2020.540052 . 10.3389/frym.2020.540052 . published Frontiers for Young Minds
Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellular Vesicles for Transcriptional Research
Gaspar, Laetitia S.; Santana, Magda M.; Henriques, Carina; Pinto, Maria M.; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Nobre, Rui Jorge; Pereira de Almeida, Luís, Molecular Therapy - Methods & Clinical Development. 723 - 737. 18. 2020. http://dx.doi.org/10.1016/j.omtm.2020.07.012 . 10.1016/j.omtm.2020.07.012 . published Molecular Therapy - Methods & Clinical Development
Trehalose alleviates the phenotype of Machado–Joseph disease mouse models
Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia S.; Nóbrega, Clévio; et al, Journal of Translational Medicine. 1. 18. 2020. http://dx.doi.org/10.1186/s12967-020-02302-2 . 10.1186/s12967-020-02302-2 . published Journal of Translational Medicine
The importance of determining circadian parameters in pharmacological studies
Gaspar, Laetitia S.; Álvaro, Ana Rita; Carmo-Silva, Sara; Mendes, Alexandrina Ferreira; Relógio, Angela; Cavadas, Cláudia, British Journal of Pharmacology. 2827 - 2847. 16. 176. 2019. http://dx.doi.org/10.1111/bph.14712 . 10.1111/bph.14712 . published British Journal of Pharmacology
Obstructive Sleep Apnea and Hallmarks of Aging
Gaspar, Laetitia S.; Álvaro, Ana Rita; Moita, Joaquim; Cavadas, Cláudia, Trends in Molecular Medicine. 675 - 692. 8. 23. 2017. http://dx.doi.org/10.1016/j.molmed.2017.06.006 . 10.1016/j.molmed.2017.06.006 . Trends in Molecular Medicine
5 28 out of 28 Publications
All projects
Information of exclusive responsibility of the researcher 29-03-2026 , from platform CIÊNCIAVITAE.
2024 - 2029
The European Rare Diseases Research Alliance (ERDERA)
-
2024/01 - 2029/12
GeneT
101059981
2023/01 - 2025/12
CInTech
C644865576-00000005
Post-doc
2022/06 - 2023
Science also sleeps: raising awareness about good (and bad) sleep habits
SaS
Universidade de Coimbra Instituto de Investigação Interdisciplinar; Universidade de Coimbra Centro de Estudos Interdisciplinares do Século XX
Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar
2022/11 - 2023/07
BDforMJD
CENTRO-01-0145-FEDER-181240
2022/10 - 2023/10
OSAscreener
NA
2022/02/01 - 2023/01/31
Sleep2BeHappy
Integration into Research Grant Fellow
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
Funders: ResMed Foundation
2021/02/01 - 2022/01/31
Sleep4All
Integration into Research Grant Fellow
Centro de Neurociências e Biologia Celular, Universidade de Coimbra, Portugal
Funders: ResMed Foundation
2018/07/06 - 2021/07/05
A detecção precoce da Apneia do Sono como uma nova estratégia para atrasar o envelhecimento
PTDC/MEC-MCI/29002/2017
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2018/07 - 2022/10
NoOSAnoAGING
POCI-01-0145-FEDER-029002
PhD Student Fellow
2018/03 - 2019/03
SleepApneaID
CENTRO-01-0246-FEDER-000017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Inov C 2020; Centro 2020
2016/12/01 - 2017/12/31
ESMI: European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
5 12 out of 12 projects
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