Maria Manuel da Cruz Silva

Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmacophore Approach

Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R., PLOS ONE. 1. 12. 2017. http://dx.doi.org/10.1371/journal.pone.0170846 . 10.1371/journal.pone.0170846 . published PLOS ONE

Neurosteroids: Can a 2alpha,3alpha-epoxy ring make up for the 3alpha-hydroxyl group?

Kasal, Alexander; Budešínský, Miloš; Mareš, Pavel; Krištofíková, Zdena; Leitão, Alcino J.; Melo, Maria Luisa Sá e; Silva, Maria Manuel C., Steroids. 12 - 18. 105. 2016. http://dx.doi.org/10.1016/j.steroids.2015.11.007 . 10.1016/j.steroids.2015.11.007 . published Steroids

Oxysterols and related sterols: Chemical, biochemical and biological aspects

Sá e Melo, Maria Luisa; Cruz Silva, Maria Manuel; Iuliano, Luigi; Lizard, Gérard, Steroids. 117 - 118. 99. 2015. http://dx.doi.org/10.1016/j.steroids.2015.05.006 . 10.1016/j.steroids.2015.05.006 . published Steroids

Anticancer steroids: Linking natural and semi-synthetic compounds

Salvador, J.A.R.; Carvalho, J.F.S.; Neves, M.A.C.; Silvestre, S.M.; Leitão, A.J.; Silva, M.M.C.; Sá E Melo, M.L., Natural Product Reports. 324 - 374. 2. 30. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872556406&partnerID=MN8TOARS . 10.1039/c2np20082a . published Natural Product Reports

5a,6a-Epoxy-7-norcholestan-3ß-yl acetate

Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.M.; Carvalho, J.F.S.; Cruz Silva, M.M., Acta Crystallographica Section E: Structure Reports Online. 1. 68. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855383781&partnerID=MN8TOARS . 10.1107/S1600536811054249 . published Acta Crystallographica Section E: Structure Reports Online

Biocatalytic transformations of steroids: Focus on hydrolase-catalyzed reactions

Silva, M.M.C.; Carvalho, J.F.; Riva, S.; Sá e Melo, M.L., Current Organic Chemistry. 928 - 941. 6. 15. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80051807267&partnerID=MN8TOARS . 10.2174/138527211794518871 . published Current Organic Chemistry

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR

Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L., Journal of Medicinal Chemistry. 6375 - 6393. 18. 54. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052798129&partnerID=MN8TOARS . 10.1021/jm200803d . published Journal of Medicinal Chemistry

Selective cytotoxicity of oxysterols through structural modulation on rings A and B. Synthesis, in vitro evaluation, and SAR.

Silva, MMC, Journal of Medicinal Chemistry. 2011. http://pubs.acs.org/doi/pdf/10.1021/jm200803d . 10.1021/jm200803d. . Journal of Medicinal Chemistry

Sterols as anticancer agents: Synthesis of ring-B oxygenated steroids, cytotoxic profile, and comprehensive SAR analysis

Carvalho, J.F.S.; Silva, M.M.C.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L., Journal of Medicinal Chemistry. 7632 - 7638. 21. 53. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149265180&partnerID=MN8TOARS . 10.1021/jm1007769 . published Journal of Medicinal Chemistry

Efficient trans-diaxial hydroxylation of ¿5-steroids

Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L., Tetrahedron. 2455 - 2462. 13. 66. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77349102219&partnerID=MN8TOARS . 10.1016/j.tet.2010.01.089 . Tetrahedron

Efficient chemoenzymatic synthesis, cytotoxic evaluation, and SAR of epoxysterols

Carvalho, J.F.S.; Cruz Silva, M.M.; Moreira, J.N.; Simões, S.; Sá E Melo, M.L., Journal of Medicinal Chemistry. 4007 - 4019. 13. 52. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649968077&partnerID=MN8TOARS . 10.1021/jm9003973 . published Journal of Medicinal Chemistry

Highly efficient epoxidation of unsaturated steroids using magnesium bis(monoperoxyphthalate) hexahydrate

Carvalho, J.F.S.; Silva, M.M.C.; Sá e Melo, M.L., Tetrahedron. 2773 - 2781. 14. 65. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-60949095554&partnerID=MN8TOARS . 10.1016/j.tet.2009.01.100 . published Tetrahedron

Cyanosilylation at pregnane side-chains: Selective synthesis and crystal structure of 20(R)-silylated cyanohydrins

Cruz Silva, M.M.; Andrade, L.C.R.; Paixão, J.A.; De Almeida, M.J.; Sá E Melo, M.L., Steroids. 145 - 151. 3. 70. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14844315734&partnerID=MN8TOARS . 10.1016/j.steroids.2004.10.011 . published Steroids

Biocatalyzed generation of molecular diversity: Selective modification of the saponin asiaticoside

Monti, D.; Candido, A.; Cruz Silva, M.M.; Kren, V.; Riva, S.; Danieli, B., Advanced Synthesis and Catalysis. 1168 - 1174. 7-8. 347. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-20544436676&partnerID=MN8TOARS . 10.1002/adsc.200505047 . published Advanced Synthesis and Catalysis

Regioselective enzymatic acylation of vicinal diols of steroids

Silva, M.M.C.; Riva, S.; Sá E Melo, M.L., Tetrahedron. 3065 - 3073. 12. 61. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644432451&partnerID=MN8TOARS . 10.1016/j.tet.2005.01.104 . published Tetrahedron

Highly selective lipase-mediated discrimination of diastereomeric 5,6-epoxysteroids

Cruz Silva, M.M.; Riva, S.; Sá E Melo, M.L., Tetrahedron Asymmetry. 1173 - 1179. 7. 15. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642634574&partnerID=MN8TOARS . 10.1016/j.tetasy.2004.02.010 . published Tetrahedron Asymmetry

The biocatalyzed stereoselective preparation of polycyclic cyanohydrins

Cruz Silva, M.M.; Sá E Melo, M.L.; Parolin, M.; Tessaro, D.; Riva, S.; Danieli, B., Tetrahedron Asymmetry. 21 - 27. 1. 15. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787843&partnerID=MN8TOARS . 10.1016/j.tetasy.2003.11.003 . published Tetrahedron Asymmetry

Hydroxytamoxifen interaction with human erythrocyte membrane and induction of permeabilization and subsequent hemolysis

Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A., Toxicology in Vitro. 615 - 622. 6. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034754864&partnerID=MN8TOARS . 10.1016/S0887-2333(01)00079-0 . published Toxicology in Vitro

Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure

Cruz Silva, M.M.; Madeira, V.M.C.; Almeida, L.M.; Custódio, J.B.A., Biochimica et Biophysica Acta - Biomembranes. 49 - 61. 1. 1464. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033966237&partnerID=MN8TOARS . 10.1016/S0005-2736(99)00237-0 . published Biochimica et Biophysica Acta - Biomembranes