Publications
Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.
Increased Synaptic ATP Release and CD73-Mediated Formation of Extracellular Adenosine in the Control of Behavioral and Electrophysiological Modifications Caused by Chronic Stress
Liliana Dias; Daniela Pochmann; Cristina Lemos; Henrique B. Silva; Joana I. Real; Francisco Q. Gonçalves; Daniel Rial; et al, ACS Chemical Neuroscience. 2023. http://dx.doi.org/10.1021/acschemneuro.2c00810 . 10.1021/acschemneuro.2c00810 . ACS Chemical Neuroscience
Increased ATP Release and Higher Impact of Adenosine A2A Receptors on Corticostriatal Plasticity in a Rat Model of Presymptomatic Parkinson’s Disease
Francisco Q. Gonçalves; Filipe C. Matheus; Henrique B. Silva; Joana I. Real; Daniel Rial; Ricardo J. Rodrigues; Jean-Pierre Oses; et al, Molecular Neurobiology. 2023. http://dx.doi.org/10.1007/s12035-022-03162-1 . 10.1007/s12035-022-03162-1 . Molecular Neurobiology
Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer
Ângela Valério-Fernandes; Nuno A. Fonseca; Nélio Gonçalves; Ana F. Cruz; Marta I. Pereira; Ana C. Gregório; Vera Moura; et al, Cancers. 2022. https://doi.org/10.3390/cancers14092217 . 10.3390/cancers14092217 . Cancers
Adenosine A2A receptors control synaptic remodeling in the adult brain
Xinli Xu; Rui O. Beleza; Francisco Q. Gonçalves; Sergio Valbuena; Sofia Alçada-Morais; Nélio Gonçalves; Joana Magalhães; et al, Scientific Reports. 2022. http://dx.doi.org/10.1038/s41598-022-18884-4 . 10.1038/s41598-022-18884-4 . Scientific Reports
Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction
Elisabete Augusto; Francisco Q. Gonçalves; Joana E. Real; Henrique B. Silva; Daniela Pochmann; Tiago S. Silva; Marco Matos; et al, Neurobiology of Disease. 2021. http://dx.doi.org/10.1016/j.nbd.2021.105441 . 10.1016/j.nbd.2021.105441 . Neurobiology of Disease
The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway
Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, Cancers. 3052 - 3052. 12. 13. 2021. https://doi.org/10.3390/cancers13123052 . 10.3390/cancers13123052 . Cancers
Cancer Stem Cells and Nucleolin as Drivers of Carcinogenesis
Laura Sofia Carvalho; Nélio Gonçalves; Nuno André Fonseca; João Nuno Moreira, Pharmaceuticals. 60 - 60. 1. 14. 2021. https://doi.org/10.3390/ph14010060 . 10.3390/ph14010060 . Pharmaceuticals
GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure
Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, Nano Today. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today
Current challenges and emerging opportunities of CAR-T cell therapies
Abreu, Teresa; Fonseca, Nuno A.; Gonçalves, Nélio; Moreira, João Nuno, Journal of Controlled Release. 246 - 261. 319. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077491524&partnerID=MN8TOARS . 10.1016/j.jconrel.2019.12.047 . published Journal of Controlled Release
Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine
Gonçalves, Francisco Queiroz (9913-5AC8-052C); Lopes, João; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al, Neurobiology of Disease. 132. 2019. http://dx.doi.org/10.1016/j.nbd.2019.104570 . 10.1016/j.nbd.2019.104570 . published Neurobiology of Disease
Metabotropic glutamate type 5 receptor requires contactin-associated protein 1 to control memory formation
Morató, Xavier; Luján, R.; Gonçalves, Nélio; Watanabe, M.; Altafaj, X.; Carvalho, Ana Luisa; Fernández-Dueñas, V.; Cunha, Rodrigo A.; Ciruela, Francisco, Human molecular genetics. 3528 - 3541. 20. 27. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054354803&partnerID=MN8TOARS . 10.1093/hmg/ddy264 . published Human molecular genetics
Adenosine A2A receptors in the rat prelimbic medial prefrontal cortex control delay-based cost-benefit decision making
Leffa, D.T.; Pandolfo, P.; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Caroline M.; Real, Joana; Silva, António Carvalho; et al, Frontiers in Molecular Neuroscience. 11. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059003991&partnerID=MN8TOARS . 10.3389/fnmol.2018.00475 . published Frontiers in Molecular Neuroscience
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions
Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Lisiane O. Porciúncula; Simões, Ana; Augusto, Elisabete; Henrique B. Silva; Machado, Nuno J.; Gonçalves, Nélio; et al, eneuro. ENEURO.0385 - 18.2018. 2018. https://doi.org/10.1523/ENEURO.0385-18.2018 . 10.1523/ENEURO.0385-18.2018 . published eneuro
Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia
Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Prediger, Rui D.; Hirai, H.; Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 407 - 418. 3. 81. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013441188&partnerID=MN8TOARS . 10.1002/ana.24867 . published Annals of Neurology
Adenosine A2A receptors in the amygdala control synaptic plasticity and contextual fear memory
Simões, Ana; Gonçalves, Nélio; Kaster, Manuella; Simões, Ana Teresa Antunes (E715-7062-B946); Nunes, A.; Pereira de Almeida, Luis Fernando Morgado; Goosens, K.A.; Rial, Daniel; Cunha, Rodrigo A., Neuropsychopharmacology. 2862 - 2871. 12. 41. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978777019&partnerID=MN8TOARS . 10.1038/npp.2016.98 . published Neuropsychopharmacology
Depression as a glial-based synaptic dysfunction
Rial, Daniel; Lemos, C.; Pinheiro, H.; Duarte, J.M.; Gonçalves, Francisco Queiroz (9913-5AC8-052C); Real, Joana; Prediger, R.D.; et al, Frontiers in Cellular Neuroscience. 1 - 11. JAN2016. 9. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957876863&partnerID=MN8TOARS . 10.3389/fncel.2015.00521 . published Frontiers in Cellular Neuroscience
Early synaptic deficits in the APP/PS1 mouse model of Alzheimer’s disease involve neuronal adenosine A2A receptors
Viana da Silva, Silvia; Haberl, Matthias Georg; Zhang, Pei; Bethge, Philipp; Lemos, Cristina; Gonçalves, Nélio; Gorlewicz, Adam; et al, Nature Communications. 1. 7. 2016. http://dx.doi.org/10.1038/ncomms11915 . 10.1038/ncomms11915 . published Nature Communications
Erratum: Optogenetic activation of intracellular adenosine A2A Receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory (Molecular Psychiatry (2015) 20, 1339-1349 DOI:10.1038/mp.2014.182)
Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946495951&partnerID=MN8TOARS . 10.1038/mp.2015.43 . published Molecular Psychiatry
Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease
Duarte-Neves, Joana; Gonçalves, Nélio; Cunha-Santos, Janete; Simões, Ana Teresa Antunes (E715-7062-B946); den Dunnen, W.F.A.; Hirai, H.; Kügler, Sebastian; Cavadas, Claudia; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 5451 - 5463. 19. 24. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943793236&partnerID=MN8TOARS . 10.1093/hmg/ddv271 . published Human Molecular Genetics
Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory
Li, P.; Rial, Daniel; Canas, Paula Margarida Gomes (1C11-C5F1-BC01); Yoo, J.-H.; Li, W.; Zhou, X.; Wang, Y.; et al, Molecular Psychiatry. 1339 - 1349. 11. 20. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946498281&partnerID=MN8TOARS . 10.1038/mp.2014.182 . published Molecular Psychiatry
Calpain inhibition reduces ataxin-3 cleavage alleviating neuropathology and motor impairments in mouse models of machado-Joseph disease
Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Nobre, Rui Jorge; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Human Molecular Genetics. 4932 - 4944. 18. 23. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906821927&partnerID=MN8TOARS . 10.1093/hmg/ddu209 . published Human Molecular Genetics
Potentiation of radiotherapy by a localized antiangiogenic gene therapy
Crokart, Nathalie; Danhier, Fabienne; Daugimont, Liévin; Gonçalves, Nélio; Jordan, B.F.; Grégoire, V.; Feron, Olivier; et al, Radiotherapy and Oncology. 252 - 258. 2. 107. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879019526&partnerID=MN8TOARS . 10.1016/j.radonc.2013.03.018 . published Radiotherapy and Oncology
Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
Gomes, Catarina; Ferreira, Raquel; George, Jimmy; Sanches, Rui; Rodrigues, Diana I; Gonçalves, Nélio; Cunha, Rodrigo A., Journal of Neuroinflammation. 1. 10. 2013. http://dx.doi.org/10.1186/1742-2094-10-16 . 10.1186/1742-2094-10-16 . published Journal of Neuroinflammation
Caffeine and adenosine A2A receptor inactivation decrease striatal neuropathology in a lentiviral-based model of Machado-Joseph disease
Gonçalves, Nélio; Simões, Ana Teresa Antunes (E715-7062-B946); Cunha, Rodrigo A.; Pereira de Almeida, Luis Fernando Morgado, Annals of Neurology. 655 - 666. 5. 73. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878306815&partnerID=MN8TOARS . 10.1002/ana.23866 . published Annals of Neurology
Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease
Simões, Ana Teresa Antunes (E715-7062-B946); Gonçalves, Nélio; Koeppen, Arnulf; Déglon, Nicole; Kügler, Sebastian; Duarte, Carlos B.; Pereira de Almeida, Luis Fernando Morgado, Brain. 2428 - 2439. 8. 135. 2012. http://dx.doi.org/10.1093/brain/aws177 . 10.1093/brain/aws177 . published Brain
5 25 out of 25 Publications
All projects
Information of exclusive responsibility of the researcher 01-12-2024 , from platform CIÊNCIAVITAE.
2018/07 - 2021/07
A2A receptors control axon formation during neuronal development: new strategies to arrest epileptogenesis.
PTDC/MED-NEU/28160/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2017/01/01 - 2019/05/31
CANCEL-STEM: Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
POCI-01-0145-FEDER-016390
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2017/01 - 2019/05
Towards a single therapy against triple negative breast cancer and neuroblastoma by nucleolin-mediated multicellular targeting with a synergistic drug combination.
ENMed/0005/2015
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2016/05 - 2019/04
Role of astrocytes in the control of memory-focus on adenosine A2A receptors
Provided by PTCRIS: 142785
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2016/05 - 2018/10
Hybrid ionotropic receptors: a new concept of receptor
Provided by PTCRIS: 142196
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2015/11 - 2018/10
P2Y1 receptor-CRMP2 control synaptic loss and memory impairment in early Alzheimer’s Disease
NIRG-15-361884
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Alzheimer's Association
2014/09 - 2015
The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer’s disease.
MB-98-2014
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Santa Casa da Misericórdia de Lisboa
2014 - 2016
Role of adenosine A2A receptors in the accumbens and amygdala in the control of chronic stress neuropathology.
-
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Brain and Behavior Research Foundation
2013 - 2016
Caffeine alleviation of MJD/SCA3
2013 41(1)
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: National Ataxia Foundation (NAF)
2013/12 - 2015
New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning
09-68-ESR-FP-010
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Defense Advanced Research Projects Agency
2012/04 - 2014/09
Role of accumbens and amygdala in the control of chronic stress neuropathology
Provided by PTCRIS: 122254
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2011/10 - 2013/11
New Treatments for Stress-induced Dysregulation of Circuits Regulating Reward, Fear, and Habit Learning
DARPA-09-68-ESR-FP-010
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Defense Advanced Research Projects Agency
2011/04/01 - 2014/08/30
Cell to cell transport of alpha-synuclein in Parkinson´s Disease. The progression factor?
PTDC/SAU-NMC/109955/2009
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/02 - 2013/04
The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors
99307
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2010/03 - 2012/02
Role of adenosine A2A receptors in microglia and glutamatergic synapses in the control of synaptic plasticity and brain damage
108668
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2007/04/02 - 2007/06/28
Tumoral microenvironment study after the electroporation of a plasmid coding for an antiangiogenic factor.
LSHB-CT-2005-512127
Other
Université catholique de Louvain Louvain Drug Research Institute
Funders: European Commission Sixth Framework Programme
2007 - 2013
Aging, Stress and Chronic Diseases: From Mechanisms to Therapeutics
CENTRO-07-ST24-FEDER-002006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Universidade de Coimbra Instituto de Investigação Interdisciplinar
5 17 out of 17 projects
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