Pedro Perdigão

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Publications

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Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.

Effective AAV-mediated gene replacement therapy in retinal organoids modelling AIPL1-associated LCA4

Sai, Hali; Ollington, Bethany; Rezek, Farah O.; Chai, Niuzheng; Lane, Amelia; Georgiadis, Tassos; Bainbridge, James; et al, Molecular Therapy - Nucleic Acids. 2024. http://dx.doi.org/10.1016/j.omtn.2024.102148 . 10.1016/j.omtn.2024.102148 . published Molecular Therapy - Nucleic Acids

CRISPR-Cas9 correction of a nonsense mutation in LCA5 rescues lebercilin expression and localization in human retinal organoids

Afanasyeva, Tess A.V.; Athanasiou, Dimitra; Perdigao, Pedro R.L.; Whiting, Kae R.; Duijkers, Lonneke; Astuti, Galuh D.N.; Bennett, Jean; et al, Molecular Therapy - Methods & Clinical Development. 522 - 531. 29. 2023. http://dx.doi.org/10.1016/j.omtm.2023.05.012 . 10.1016/j.omtm.2023.05.012 . published Molecular Therapy - Methods & Clinical Development

A Novel Genetic Variant in MBD5 Associated with Severe Epilepsy and Intellectual Disability: Potential Implications on Neural Primary Cilia

Martins, Mariana; Oliveira, Ana Rafaela; Martins, Solange; Vieira, José Pedro; Perdigão, Pedro; Fernandes, Ana Rita; de Almeida, Luís Pereira; et al, International Journal of Molecular Sciences. 16. 24. 2023. http://dx.doi.org/10.3390/ijms241612603 . 10.3390/ijms241612603 . published International Journal of Molecular Sciences

Extracellular communication between brain cells through functional transfer of Cre mRNA

Rufino-Ramos, David; Leandro, K; Perdigão, Pedro (0F1E-EFD6-AF01); O'Brien, K; Pinto, MM; Santana, MM; van Solinge, TS; et al, Molecular Therapy. 2023. in press Molecular Therapy

Retinal Organoids from an AIPL1 CRISPR/Cas9 Knockout Cell Line Successfully Recapitulate the Molecular Features of LCA4 Disease

Pedro Perdigão; Bethany Ollington; Hali Sai; Amy Leung; Almudena Sacristan-Reviriego; Jacqueline van der Spuy, International Journal of Molecular Sciences. 2023. https://www.mdpi.com/1422-0067/24/6/5912 . 10.3390/ijms24065912 . International Journal of Molecular Sciences

Induced Pluripotent Stem Cells and Genome-Editing Tools in Determining Gene Function and Therapy for Inherited Retinal Disorders

Benati, D; Leung, A; Perdigão, P; Toulis, V; van der Spuy, J; Recchia, A, International Journal of Molecular Sciences. 23. 23. 2023. https://www.mdpi.com/1422-0067/23/23/15276 . published International Journal of Molecular Sciences

Investigation of PTC124-mediated translational readthrough in a retinal organoid model of AIPL1-associated Leber congenital amaurosis

Leung, Amy; Sacristan-Reviriego, Almudena; Perdigão, Pedro R.L.; Sai, Hali; Georgiou, Michalis; Kalitzeos, Angelos; Carr, Amanda-Jayne F.; et al, Stem Cell Reports. 2187 - 2202. 10. 17. 2022. http://dx.doi.org/10.1016/j.stemcr.2022.08.005 . 10.1016/j.stemcr.2022.08.005 . published Stem Cell Reports

Translational readthrough as a potential therapeutic for AIPL1-associated Leber Congenital Amaurosis in a patient-derived iPSC-retinal organoid model

Leung, A; Sacristan-Reviriego, A; Perdigão, Pedro (0F1E-EFD6-AF01); Sai, H; Georgiou, M; Kalitzeos, A; Carr, AJ; et al, bioRxiv. 2021. https://doi.org/10.1101/2021.12.17.473147 . published bioRxiv

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs

Sladen, Paul E.; Perdigão, Pedro R.L.; Salsbury, Grace; Novoselova, Tatiana; van der Spuy, Jacqueline; Chapple, J. Paul; Yu-Wai-Man, Patrick; Cheetham, Michael E., Molecular Therapy - Nucleic Acids. 432 - 443. 26. 2021. http://dx.doi.org/10.1016/j.omtn.2021.08.015 . 10.1016/j.omtn.2021.08.015 . published Molecular Therapy - Nucleic Acids

Protein Delivery of Cell-Penetrating Zinc-Finger Activators Stimulates Latent HIV-1-Infected Cells

Perdigão, Pedro R.L.; Cunha-Santos, Catarina; Barbas, Carlos F.; Santa-Marta, Mariana; Goncalves, Joao, Molecular Therapy - Methods & Clinical Development. 145 - 158. 18. 2020. http://dx.doi.org/10.1016/j.omtm.2020.05.016 . 10.1016/j.omtm.2020.05.016 . published Molecular Therapy - Methods & Clinical Development

Inhibition of HIV replication through siRNA carried by CXCR4-targeted chimeric nanobody.

Cunha-Santos, C; Perdigao, PRL; Oliveira, JG; Cardoso, M; Manuel, A; Taveira, N; Goncalves, J, Cellular and molecular life sciences : CMLS. 2019. https://doi.org/10.1007/s00018-019-03334-8 . 10.1007/s00018-019-03334-8 . published Cellular and molecular life sciences : CMLS

Reactivation of Latent HIV-1 Expression by Engineered TALE Transcription Factors.

Perdigão, Pedro; Gaj, T; Santa-Marta, M; Barbas III, C; Goncalves, J, PloS one. 2016. http://europepmc.org/articles/PMC4774903 . 10.1371/journal.pone.0150037 . PloS one

All projects

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Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.

2024/01/01 - 2029/12/31

GeneT: The Gene Therapy CoE at the Center of Portugal

101059981

Researcher

Universidade de Coimbra

Funders: European Commission

2024/03/01 - 2025/02/28

Engineering RNA-Targeting CRISPR/Cas13 for the Treatment of Spinocerebellar Ataxia Type 3

25124

Principal investigator

Universidade de Coimbra

Funders: AFM-Téléthon

2023/08/01 - 2025/12/31

CiNTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs

C644865576-00000005

Researcher

Universidade de Coimbra

Funders: European Commission

2022 - 2023

(Less)PlasticBrain: Bio Replacing Plasticizers - Impact in the Human Brain Development

(Less)PlasticBrain

Funders: Banco Santander Portugal

2022 - 2023

(Less)PlasticBrain: Bio Replacing Plasticizers - Impact in the Human Brain Development

(Less)PlasticBrain

Researcher

Universidade de Coimbra

Funders: Banco Santander Portugal

2022/01/01 - 2023/12/31

Genome editing to rescue Machado-Joseph disease by alternative splicing

EXPL/MED-NEU/0936/2021

Principal investigator

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2021/10/01 -

Machado-Joseph Disease iPSC Cell Models for Medium Throughput Drug Screening

CT 0091995

Post-doc

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Institut Servier SAS

2020/06/01 - 2023/05/31

Rescue of inherited retinal degeneration by CRISPR base editing

5129 / 5130

Other

University College London Institute of Ophthalmology

Funders: Fight for Sight Foundation

2018/07/01 - 2021/09/30

Blocking neurodegeneration by spreading of gene silencers

PTDC/BTM-SAL/29716/2017

Universidade de Coimbra Centro de Neurociências e Biologia Celular

Funders: Fundação para a Ciência e a Tecnologia

2017/11/15 - 2019/07/12

Developing a photoreceptor model of AIPL1 LCA from patient derived induced pluripotent stem cells

R170015A

Post-doc

University College London Institute of Ophthalmology

Funders: Moorfields Eye Hospital

2016/01/01 - 2016/06/30

HIV-1 ERADICATION BY SITE-DIRECTED INTEGRATION

info:eu-repo/grantAgreement/FCT/3599-PPCDT/123638/PT

Research Fellow

Funders: Fundação para a Ciência e a Tecnologia

2014/03/01 - 2016/08/31

An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes

HIVERA/0003/2013

Instituto de Medicina Molecular João Lobo Antunes; Instituto de Medicina Molecular João Lobo Antunes

Funders: Fundação para a Ciência e a Tecnologia

2014/03 - 2015/12

HIV-1 ERADICATION BY SITE-DIRECTED INTEGRATION

Provided by PTCRIS: 123638

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2014/03 - 2016/02

An innovative approach to deliver dual-targeting HIV entry inhibitors using cationic liposomes

Provided by PTCRIS: 135858

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2013/01 - 2015/03

Strategic Project - UI 775 - 2013-2014

Provided by PTCRIS: 133003

Funders: Fundação para a Ciência e a Tecnologia

2012/01/01 - 2012/12/31

Nanotechnology against viral latency: Sensor strategies to eliminate HIV-1 infected cells.

Design New Approaches to Cure HIV Infection (Round 6)

Universidade de Lisboa Instituto de Investigação do Medicamento

Funders: Bill & Melinda Gates Foundation

2012/01/01 - 2015/12

ERADICATION OF HIV-1 INFECTED CELLS BY TARGETING NANOPARTICLES CARRYING THERAPEUTIC PLASMIDS

info:eu-repo/grantAgreement/FCT/SFRH/SFRH2%FBD2%F819412%F2011/PT

PhD Student Fellow

Funders: Fundação para a Ciência e a Tecnologia

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