Sandra Morais Cardoso

The Role of Bacteria–Mitochondria Communication in the Activation of Neuronal Innate Immunity: Implications to Parkinson’s Disease

João D. Magalhães; Ana Raquel Esteves; Emanuel Candeias; Diana F. Silva; Nuno Empadinhas; Sandra Morais Cardoso; João Duarte Magalhães, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24054339 . 10.3390/ijms24054339 . accepted International Journal of Molecular Sciences

Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria

Esteves, A Raquel; Munoz-Pinto, Mário F; Nunes-Costa, Daniela; Candeias, Emanuel; Silva, Diana F; Magalhães, João D; Pereira-Santos, A Raquel; et al, Gut. 73 - 89. 1. 72. 2023. http://dx.doi.org/10.1136/gutjnl-2021-326023 . 10.1136/gutjnl-2021-326023 . published Gut

The Impact of microRNAs on Mitochondrial Function and Immunity: Relevance to Parkinson’s Disease

Beatriz F. S. Guedes; Sandra Morais Cardoso; Ana Raquel Esteves, Biomedicines. 2023. https://doi.org/10.3390/biomedicines11051349 . 10.3390/biomedicines11051349 . Biomedicines

Rivastigmine–Benzimidazole Hybrids as Promising Multitarget Metal-Modulating Compounds for Potential Treatment of Neurodegenerative Diseases

David Vicente-Zurdo; Leonardo Brunetti; Luca Piemontese; Beatriz Guedes; Sandra M. Cardoso; Daniel Chavarria; Fernanda Borges; et al, International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24098312 . 10.3390/ijms24098312 . International Journal of Molecular Sciences

Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson’s disease

João D. Magalhães; Emanuel Candeias; Inês Melo-Marques; Diana F. Silva; A. Raquel Esteves; Nuno Empadinhas; Sandra Morais Cardoso, Cellular and Molecular Life Sciences. 2023. https://doi.org/10.1007/s00018-023-04819-3 . 10.1007/s00018-023-04819-3 . Cellular and Molecular Life Sciences

LPS-induced mitochondrial dysfunction regulates innate immunity activation and a-synuclein oligomerization in Parkinson's disease

A. Raquel Esteves; Diana F. Silva; Diogo Banha; Emanuel Candeias; Beatriz Guedes; Sandra M. Cardoso, Redox Biology. 2023. https://doi.org/10.1016/j.redox.2023.102714 . 10.1016/j.redox.2023.102714 . Redox Biology

Parkinson's Disease: A Multisystem Disorder

Costa, Helena Nunes; Esteves, Ana Raquel; Empadinhas, Nuno; Cardoso, Sandra Morais, Neuroscience Bulletin. 113 - 124. 1. 39. 2023. http://dx.doi.org/10.1007/s12264-022-00934-6 . 10.1007/s12264-022-00934-6 . published Neuroscience Bulletin

Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease

Daniela Marinho; Ildete Luísa Ferreira; Ricardo Lorenzoni; Sandra M. Cardoso; Isabel Santana; A. Cristina Rego, Aging Cell. 2023. https://doi.org/10.1111/acel.13895 . 10.1111/acel.13895 . Aging Cell

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

David Vicente-Zurdo; Noelia Rosales-Conrado; M. Eugenia León-González; Leonardo Brunetti; Luca Piemontese; A. Raquel Pereira-Santos; Sandra M. Cardoso; et al, Biomedicines. 2022. https://doi.org/10.3390/biomedicines10071510 . 10.3390/biomedicines10071510 . Biomedicines

Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation

Silva, Diana Filipa; Empadinhas, Nuno; Cardoso, Sandra Morais; Esteves, Ana Raquel, Antioxidants. 11. 11. 2022. http://dx.doi.org/10.3390/antiox11112141 . 10.3390/antiox11112141 . published Antioxidants

The neuromicrobiology of Parkinson’s disease: A unifying theory

Mario F. Munoz-Pinto; Nuno Empadinhas; Sandra M. Cardoso, Ageing Research Reviews. 101396 - 101396. 70. 2021. https://doi.org/10.1016/j.arr.2021.101396 . 10.1016/j.arr.2021.101396 . published Ageing Research Reviews

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Cardoso SM, Autophagy. 2021. https://doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.

Cardoso SM, Biomolecules. 2021. https://europepmc.org/articles/PMC7830597 . 10.3390/biom11010111 . Biomolecules

The Mitochondrial Ribosome: A World of Opportunities for Mitochondrial Dysfunction Toward Parkinson's Disease

Gonçalves, Ana Mafalda; Pereira-Santos, Ana Raquel; Esteves, Ana Raquel; Cardoso, Sandra M.; Empadinhas, Nuno, Antioxidants & Redox Signaling. 694 - 711. 8. 34. 2021. http://dx.doi.org/10.1089/ars.2019.7997 . 10.1089/ars.2019.7997 . published Antioxidants & Redox Signaling

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

Fernandes, Tânia; Resende, Rosa; Silva, Diana F.; Marques, Ana P.; Santos, Armanda E.; Cardoso, Sandra M.; Domingues, M. Rosário; Moreira, Paula I.; Pereira, Cláudia F., Biomedicines. 8. 9. 2021. http://dx.doi.org/10.3390/biomedicines9080881 . 10.3390/biomedicines9080881 . Biomedicines

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

João Duarte Magalhães; Lígia Fão; Rita Vilaça; Sandra Morais Cardoso; Ana Cristina Rego, Biomedicines. 2021. https://doi.org/10.3390/biomedicines9111625 . 10.3390/biomedicines9111625 . Biomedicines

Microbial BMAA and the Pathway for Parkinson’s Disease Neurodegeneration

Nunes-Costa, Daniela; Magalhães, João Duarte; G-Fernandes, Maria; Cardoso, Sandra Morais; Empadinhas, Nuno, Frontiers in Aging Neuroscience. 12. 2020. http://dx.doi.org/10.3389/fnagi.2020.00026 . 10.3389/fnagi.2020.00026 . Frontiers in Aging Neuroscience

Differential protein expression in diverse brain areas of Parkinson’s and Alzheimer’s disease patients

Esteves, A. R.; Cardoso, S. M., Scientific Reports. 1. 10. 2020. http://dx.doi.org/10.1038/s41598-020-70174-z . 10.1038/s41598-020-70174-z . Scientific Reports

Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons

Silva, Diana F.; Candeias, Emanuel; Esteves, A. Raquel; Magalhães, João D.; Ferreira, I. Luísa; Nunes-Costa, Daniela; Rego, A. Cristina; Empadinhas, Nuno; Cardoso, Sandra M., Journal of Neuroinflammation. 1. 17. 2020. http://dx.doi.org/10.1186/s12974-020-02004-y . 10.1186/s12974-020-02004-y . published Journal of Neuroinflammation

Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Fancellu, Gaia; Chand, Karam; Tomás, Daniel; Orlandini, Elisabetta; Piemontese, Luca; Silva, Diana F.; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, Journal of Enzyme Inhibition and Medicinal Chemistry. 211 - 226. 1. 35. 2020. http://dx.doi.org/10.1080/14756366.2019.1689237 . 10.1080/14756366.2019.1689237 . Journal of Enzyme Inhibition and Medicinal Chemistry

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

Chaves, Sílvia; Resta, Simonetta; Rinaldo, Federica; Costa, Marina; Josselin, Romane; Gwizdala, Karolina; Piemontese, Luca; et al, Molecules. 4. 25. 2020. http://dx.doi.org/10.3390/molecules25040985 . 10.3390/molecules25040985 . Molecules

Donepezil-based hybrids as multifunctional anti-Alzheimer's disease chelating agents: Effect of positional isomerization

Costa, Marina; Josselin, Romane; Silva, Diana F.; Cardoso, Sandra M.; May, Nóra V.; Chaves, Sílvia; Santos, M. Amélia, Journal of Inorganic Biochemistry. 2020. http://dx.doi.org/10.1016/j.jinorgbio.2020.111039 . 10.1016/j.jinorgbio.2020.111039 . Journal of Inorganic Biochemistry

New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease

Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos, Molecules. 2019. http://www.mdpi.com/1420-3049/24/3/587 . 10.3390/molecules24030587 . Molecules

Is Alzheimer’s disease an inflammasomopathy?

Pereira, Claudia F.; Santos, Armanda E.; Moreira, Paula I.; Pereira, Ana Catarina; Sousa, Fabio J.; Cardoso, Sandra M.; Cruz, M. Teresa, Ageing Research Reviews. 56. 2019. http://dx.doi.org/10.1016/j.arr.2019.100966 . 10.1016/j.arr.2019.100966 . Ageing Research Reviews

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

Esteves, A.R.; Palma, A.M.; Gomes, R.; Santos, D.; Silva, D.F.; Cardoso, S.M., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2008 - 2023. 8. 1865. 2019. http://dx.doi.org/10.1016/j.bbadis.2018.11.014 . 10.1016/j.bbadis.2018.11.014 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

The Role of Beclin-1 Acetylation on Autophagic Flux in Alzheimer’s Disease

A. Raquel Esteves; Filipa Filipe; João D. Magalhães; Diana F. Silva; Sandra M. Cardoso, Molecular Neurobiology. 5654 - 5670. 8. 56. 2019. https://doi.org/10.1007/s12035-019-1483-8 . 10.1007/s12035-019-1483-8 . Molecular Neurobiology

Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy.

Hiremathad A; Chand K; Tolayan L; Rajeshwari; Keri RS; Esteves AR; Cardoso SM; Chaves S; Santos MA, Journal of inorganic biochemistry. 2018. http://europepmc.org/abstract/med/29182921 . 10.1016/j.jinorgbio.2017.11.015 . Journal of inorganic biochemistry

Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.

Molecular neurobiology. 2018. http://europepmc.org/abstract/med/28168426 . 10.1007/s12035-017-0420-y . Molecular neurobiology

Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease

Hiremathad, Asha; Keri, Rangappa S.; Esteves, A. Raquel; Cardoso, Sandra M.; Chaves, Sílvia; Santos, M. Amélia, European Journal of Medicinal Chemistry. 255 - 267. 148. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.02.023 . 10.1016/j.ejmech.2018.02.023 . European Journal of Medicinal Chemistry

The Microbiome-Mitochondria Dance in Prodromal Parkinson’s Disease

Cardoso, Sandra M.; Empadinhas, Nuno, Frontiers in Physiology. 9. 2018. http://dx.doi.org/10.3389/fphys.2018.00471 . 10.3389/fphys.2018.00471 . Frontiers in Physiology

Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols

Melo, Karla P.; Silva, Carolliny M.; Almeida, Michael F.; Chaves, Rodrigo S.; Marcourakis, Tania; Cardoso, Sandra M.; Demasi, Marilene; Netto, Luis E. S.; Ferrari, Merari F. R., Neurotoxicity Research. 410 - 420. 2. 35. 2018. http://dx.doi.org/10.1007/s12640-018-9966-3 . 10.1007/s12640-018-9966-3 . Neurotoxicity Research

Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

Luca Piemontese; Daniel Tomás; Asha Hiremathad; Vito Capriati; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Journal of Enzyme Inhibition and Medicinal Chemistry. 1212 - 1224. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1491564 . 10.1080/14756366.2018.1491564 . Journal of Enzyme Inhibition and Medicinal Chemistry

Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug

Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos, Metallomics. 1460 - 1475. 10. 10. 2018. https://doi.org/10.1039/C8MT00143J . 10.1039/C8MT00143J . Metallomics

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.

Cardoso SM, 2017. http://europepmc.org/abstract/med/27311773 .

Effects of mild running on substantia nigra during early neurodegeneration.

Almeida MF; Silva CM; Chaves RS; Lima NCR; Almeida RS; Melo KP; Demasi M; et al, Journal of sports sciences. 2017. http://europepmc.org/abstract/med/28895489 . 10.1080/02640414.2017.1378494 . Journal of sports sciences

Tacrine-allyl/propargylcysteine-benzothiazole trihybrids as potential anti-Alzheimer´s drug candidates

Sandra Morais Cardoso, RSC Advances . 2016. https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra03455a#!divCitation . published RSC Advances

New Tacrine Hybrids with Natural-Based Cysteine Derivatives as Multitargeted Drugs for Potential Treatment of Alzheimer's Disease.

Keri RS; Quintanova C; Chaves S; Silva DF; Cardoso SM; Santos MA, 2016. http://europepmc.org/abstract/med/26256122 . 10.1111/cbdd.12633 .

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.

Esteves AR; Cardoso SM, 2016. http://europepmc.org/abstract/med/26740081 .

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Acevedo Arozena A; Adachi H; et al, 2016. http://europepmc.org/abstract/med/26799652 . 10.1080/15548627.2015.1100356 .

Calcium and redox homeostasis in Alzheimer's disease: a focus on the endoplasmic reticulum

Sandra Morais Cardoso; Fonseca AC, Therapeutic Targets for Neurological Diseases. 2015. http://dx.doi.org/10.14800/ttnd.428 . 10.14800/ttnd.428 . Therapeutic Targets for Neurological Diseases

The Upshot of LRRK2 Inhibition to Parkinson's Disease Paradigm.

Esteves AR; G-Fernandes M; Santos D; Januário C; Cardoso SM, 2015. http://europepmc.org/abstract/med/25394383 . 10.1007/s12035-014-8980-6 .

The Impact of Mitochondrial Fusion and Fission Modulation in Sporadic Parkinson's Disease.

Santos D; Esteves AR; Silva DF; Januário C; Cardoso SM, 2015. http://europepmc.org/abstract/med/25218511 . 10.1007/s12035-014-8893-4 .

Special focus on autophagy.

Cardoso SM, 2015. http://europepmc.org/abstract/med/25844484 . 10.1089/dna.2015.1501 .

Design, Synthesis and Bioevaluation of Tacrine Hybrids with Cinnamate and Cinnamylideneacetate Derivatives as Potential Anti-Alzheimer Drug Candidates

Sandra Morais Cardoso, Medicinal Chemical Communications. 2015. https://pubs.rsc.org/en/content/articlelanding/2015/MD/c5md00236b#!divAbstract . published Medicinal Chemical Communications

The role of proteotoxic stress in vascular dysfunction in the pathogenesis of Alzheimer’s disease

Fonseca, Ana Catarina R.G.; Resende, Rosa; Cardoso, Sandra M.; Pereira, Cláudia F., Endoplasmic Reticulum Stress in Diseases. 1. 2. 2015. http://dx.doi.org/10.1515/ersc-2015-0005 . 10.1515/ersc-2015-0005 . Endoplasmic Reticulum Stress in Diseases

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

Esteves, A.R.; Gozes, I.; Cardoso, S.M., Biochimica et Biophysica Acta - Molecular Basis of Disease. 7 - 21. 1. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887706170&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.10.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Amyloid-Beta Disrupts Calcium and Redox Homeostasis in Brain Endothelial Cells

Fonseca, A.C.R.G.; Moreira, P.I.; Oliveira, C.R.; Cardoso, S.M.; Pinton, P.; Pereira, C.F., Molecular Neurobiology. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901537197&partnerID=MN8TOARS . 10.1007/s12035-014-8740-7 . Molecular Neurobiology

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

Esteves, A.R.; Swerdlow, R.H.; Cardoso, S.M., Experimental Neurology. 206 - 216. 261. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905511765&partnerID=MN8TOARS . 10.1016/j.expneurol.2014.05.025 . Experimental Neurology

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

Fonseca, A.C.; Oliveira, C.R.; Pereira, C.F.; Cardoso, S.M., Biochimica et Biophysica Acta - Molecular Cell Research. 1150 - 1161. 6. 1843. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896111540&partnerID=MN8TOARS . 10.1016/j.bbamcr.2014.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1-40 peptide in brain endothelial cells

Fonseca, A.C.R.G.; Ferreiro, E.; Oliveira, C.R.; Cardoso, S.M.; Pereira, C.F., Biochimica et Biophysica Acta - Molecular Basis of Disease. 2191 - 2203. 12. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883780939&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.08.007 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

Silva, D.F.; Selfridge, J.E.; Lu, J.; Lezi, E.; Roy, N.; Hutfles, L.; Burns, J.M.; et al, Human Molecular Genetics. 3931 - 3946. 19. 22. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888799219&partnerID=MN8TOARS . 10.1093/hmg/ddt247 . Human Molecular Genetics

Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease

Keri, R.S.; Quintanova, C.; Marques, S.M.; Esteves, A.R.; Cardoso, S.M.; Santos, M.A., Bioorganic and Medicinal Chemistry. 4559 - 4569. 15. 21. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879689184&partnerID=MN8TOARS . 10.1016/j.bmc.2013.05.028 . Bioorganic and Medicinal Chemistry

Mitochondria drive autophagy pathology via microtubule disassembly: A new hypothesis for Parkinson disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., Autophagy. 112 - 114. 1. 9. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872195238&partnerID=MN8TOARS . 10.4161/auto.22443 . Autophagy

Multifunctional iron-chelators with protective roles against neurodegenerative diseases

Nunes, A.; Marques, S.M.; Quintanova, C.; Silva, D.F.; Cardoso, S.M.; Chaves, S.; Santos, M.A., Dalton Transactions. 6058 - 6073. 17. 42. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875780884&partnerID=MN8TOARS . 10.1039/c3dt50406a . Dalton Transactions

Prodromal metabolic phenotype in MCI cybrids: Implications for Alzheimer's disease

Silva, D.F.; Santana, I.; Esteves, A.R.; Baldeiras, I.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., Current Alzheimer Research. 180 - 190. 2. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875000768&partnerID=MN8TOARS . 10.2174/1567205011310020008 . Current Alzheimer Research

Mitochondrial metabolic control of microtubule dynamics impairs the autophagic pathway in Parkinson's disease

Cardoso, S.M.; Esteves, A.R.; Arduno, D.M., Neurodegenerative Diseases. 38 - 40. 1-4. 10. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860223145&partnerID=MN8TOARS . 10.1159/000332601 . Neurodegenerative Diseases

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D.M.; Esteves, A.R.; Cortes, L.; Silva, D.F.; Patel, B.; Grazina, M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Human Molecular Genetics. 4680 - 4702. 21. 21. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867828156&partnerID=MN8TOARS . 10.1093/hmg/dds309 . Human Molecular Genetics

Ubiquitin proteasome system in Parkinson's disease: A keeper or a witness?

Martins-Branco, D.; Esteves, A.R.; Santos, D.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Januario, C.; Cardoso, S.M., Experimental Neurology. 89 - 99. 2. 238. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866521159&partnerID=MN8TOARS . 10.1016/j.expneurol.2012.08.008 . Experimental Neurology

Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: Role of mitochondrial reactive oxygen species and HIF-1a

Correia, S.C.; Santos, R.X.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R.; Moreira, P.I., Neurobiology of Disease. 206 - 218. 1. 45. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-81955160758&partnerID=MN8TOARS . 10.1016/j.nbd.2011.08.005 . Neurobiology of Disease

Mitochondrial dynamics and neuronal fate in Parkinson's disease

Santos, D.; Cardoso, S.M., Mitochondrion. 428 - 437. 4. 12. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861695750&partnerID=MN8TOARS . 10.1016/j.mito.2012.05.002 . Mitochondrion

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; et al, Autophagy. 445 - 544. 4. 8. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862295360&partnerID=MN8TOARS . 10.4161/auto.19496 . Autophagy

Amyloid ß-induced ER stress is enhanced under mitochondrial dysfunction conditions

Costa, R.O.; Ferreiro, E.; Martins, I.; Santana, I.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Neurobiology of Aging. 4. 33. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856951448&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2011.04.011 . Neurobiology of Aging

Therapeutic intervention at cellular quality control systems in Alzheimer's and Parkinson's diseases

Arduino, D.M.; Esteves, A.R.; Silva, D.F.F.; Martins-Branco, D.; Santos, D.; Pimentel, D.F.G.; Cardoso, S.M., Current Pharmaceutical Design. 3446 - 3459. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055080733&partnerID=MN8TOARS . 10.2174/138161211798072481 . Current Pharmaceutical Design

The mitochondrial cascade hypothesis for parkinson's disease

Cardoso, S.M., Current Pharmaceutical Design. 3390 - 3397. 31. 17. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80055076405&partnerID=MN8TOARS . 10.2174/138161211798072508 . Current Pharmaceutical Design

Mitochondrial dysfunction: The road to alpha-synuclein oligomerization in PD

Cardoso, S.M.; Esteves, A.R.; Arduíno, D.M.; Silva, D.F.F.; Oliveira, C.R., Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952169319&partnerID=MN8TOARS . 10.4061/2011/693761 . Parkinson's Disease

Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors

Šebestík, J.; Marques, S.M.; Falé, P.L.; Santos, S.; Arduíno, D.M.; Cardoso, S.M.; Oliveira, C.R.; Serralheiro, M.L.M.; Santos, M.A., Journal of Enzyme Inhibition and Medicinal Chemistry. 485 - 497. 4. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959882783&partnerID=MN8TOARS . 10.3109/14756366.2010.529806 . Journal of Enzyme Inhibition and Medicinal Chemistry

Mitochondrial fusion/fission, transport and autophagy in Parkinson's disease: When mitochondria get nasty

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M., Parkinson's Disease. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953286639&partnerID=MN8TOARS . 10.4061/2011/767230 . Parkinson's Disease

Mitochondria: The common upstream driver of amyloid-ß and tau pathology in Alzheimers disease

Silva, D.F.F.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., Current Alzheimer Research. 563 - 572. 5. 8. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959926983&partnerID=MN8TOARS . 10.2174/156720511796391872 . Current Alzheimer Research

Amyloid-ß-induced mitochondrial dysfunction impairs the autophagic lysosomal pathway in a tubulin dependent pathway

Silva, D.F.F.; Esteves, A.R.; Arduino, D.M.; Oliveira, C.R.; Cardoso, S.M., Journal of Alzheimer's Disease. 565 - 581. 3. 26. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053559887&partnerID=MN8TOARS . 10.3233/JAD-2011-110423 . Journal of Alzheimer's Disease

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1a Destabilization

Finley, L.; Carracedo, A.; Lee, J.; Souza, A.; Egia, A.; Zhang, J.; Teruya-Feldstein, J.; et al, Cancer Cell. 416 - 428. 3. 19. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952501323&partnerID=MN8TOARS . 10.1016/j.ccr.2011.02.014 . Cancer Cell

Polymorphic variation in cytochrome oxidase subunit genes

Lu, J.; Wang, K.; Rodova, M.; Esteves, R.; Berry, D.; Lezi, E.L.; Crafter, A.; et al, Journal of Alzheimer's Disease. 141 - 154. 1. 21. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954963850&partnerID=MN8TOARS . 10.3233/JAD-2010-100123 . Journal of Alzheimer's Disease

Cross-talk between mitochondria and proteasome in Parkinson's disease pathogenesis

Branco, D.M.; Arduino, D.M.; Raquel Esteves, A.; Silva, D.F.F.; Cardoso, S.M.; Oliveira, C.R., Frontiers in Aging Neuroscience. MAY. 2. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350452&partnerID=MN8TOARS . 10.3389/fnagi.2010.00017 . Frontiers in Aging Neuroscience

Microtubule depolymerization potentiates alpha-synuclein oligomerization

Esteves, A. Raquel, Frontiers in Aging Neuroscience. 1. 2010. http://dx.doi.org/10.3389/neuro.24.005.2009 . 10.3389/neuro.24.005.2009 . Frontiers in Aging Neuroscience

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

Cardoso, S.M.; Pereira, C.F.; Moreira, P.I.; Arduino, D.M.; Esteves, A.R.; Oliveira, C.R., Experimental Neurology. 294 - 298. 2. 223. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952549554&partnerID=MN8TOARS . 10.1016/j.expneurol.2009.06.008 . Experimental Neurology

Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer

Esteves, A.R.; Lu, J.; Rodova, M.; Onyango, I.; Lezi, E.; Dubinsky, R.; Lyons, K.E.; et al, Journal of Neurochemistry. 674 - 682. 3. 113. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950661030&partnerID=MN8TOARS . 10.1111/j.1471-4159.2010.06631.x . Journal of Neurochemistry

Mitochondrial-dependent apoptosis in Huntington's disease human cybrids

Ferreira, I.L.; Nascimento, M.V.; Ribeiro, M.; Almeida, S.; Cardoso, S.M.; Grazina, M.; Pratas, J.; et al, Experimental Neurology. 243 - 255. 2. 222. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77549084450&partnerID=MN8TOARS . 10.1016/j.expneurol.2010.01.002 . Experimental Neurology

Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Neurobiology of Disease. 723 - 730. 3. 37. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949120541&partnerID=MN8TOARS . 10.1016/j.nbd.2009.12.011 . Neurobiology of Disease

Mitochondrial metabolism modulation: A new therapeutic approach for Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Oliveira, C.R.; Cardoso, S.M., CNS and Neurological Disorders - Drug Targets. 105 - 119. 1. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949908141&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

ER stress-mediated apoptotic pathway induced by aß peptide requires the presence of functional mitochondria

Costa, R.O.; Ferreiro, E.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Alzheimer's Disease. 625 - 636. 2. 20. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954516455&partnerID=MN8TOARS . 10.3233/JAD-2010-091369 . Journal of Alzheimer's Disease

Mitochondria as a therapeutic target in Alzheimer's disease and diabetes

Moreira, P.I.; Cardoso, S.M.; Pereira, C.M.; Santos, M.S.; Oliveira, C.R., CNS and Neurological Disorders - Drug Targets. 492 - 511. 6. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-75849136180&partnerID=MN8TOARS . 10.2174/187152709789824651 . CNS and Neurological Disorders - Drug Targets

ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 neuron-like cells

Arduíno, D.M.; Raquel Esteves, A.; Filipa Domingues, A.; Pereira, C.M.F.; Cardoso, S.M.; Oliveira, C.R., BMB Reports. 719 - 724. 11. 42. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-73449102905&partnerID=MN8TOARS . BMB Reports

Endoplasmic reticulum and mitochondria interplay mediates apoptotic cell death: Relevance to Parkinson's disease

Arduíno, D.M.; Esteves, A.R.; Cardoso, S.M.; Oliveira, C.R., Neurochemistry International. 341 - 348. 5. 55. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649342203&partnerID=MN8TOARS . 10.1016/j.neuint.2009.04.004 . Neurochemistry International

Oxidative stress involvement in a-synuclein oligomerization in Parkinson's disease cybrids

Esteves, A.R.; Arduíno, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Antioxidants and Redox Signaling. 439 - 448. 3. 11. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58849086657&partnerID=MN8TOARS . 10.1089/ars.2008.2247 . Antioxidants and Redox Signaling

New hydroxypyridinone iron-chelators as potential anti-neurodegenerative drugs

Arduino, D.; Silva, D.; Cardoso, S.M.; Chaves, S.; Oliveira, C.R.; Santos, M.A., Frontiers in Bioscience. 6763 - 6774. 17. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049107811&partnerID=MN8TOARS . Frontiers in Bioscience

Calpain-mediated MPP+ toxicity in mitochondrial DNA depleted cells

Domingues, A.F.; Esteves, A.R.F.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Neurotoxicity Research. 31 - 38. 1. 13. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649157955&partnerID=MN8TOARS . 10.1007/BF03033365 . Neurotoxicity Research

Involvement of mitochondria in endoplasmic reticulum stress-induced apoptotic cell death pathway triggered by the prion peptide PrP 106-126

Ferreiro, E.; Costa, R.; Marques, S.; Cardoso, S.M.; Oliveira, C.R.; Pereira, C.M.F., Journal of Neurochemistry. 766 - 776. 3. 104. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-38049162500&partnerID=MN8TOARS . 10.1111/j.1471-4159.2007.05048.x . Journal of Neurochemistry

Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

Domingues, A.F.; Arduíno, D.M.; Esteves, A.R.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Free Radical Biology and Medicine. 820 - 825. 6. 45. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-54949100005&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2008.06.007 . Free Radical Biology and Medicine

Mitochondrial function in Parkinson's disease cybrids containing an nt2 neuron-like nuclear background

Esteves, A.R.F.; Domingues, A.F.; Ferreira, I.L.; Januário, C.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M., Mitochondrion. 219 - 228. 3. 8. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45449100897&partnerID=MN8TOARS . 10.1016/j.mito.2008.03.004 . Mitochondrion

The key role of mitochondria in Alzheimer's disease

Moreira, P.I.; Cardoso, S.M.; Santos, M.S.; Oliveira, C.R., Journal of Alzheimer's Disease. 101 - 110. 2. 9. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746066329&partnerID=MN8TOARS . Journal of Alzheimer's Disease

Mitochondrial dysfunction and caspase activation in rat cortical neurons treated with cocaine or amphetamine

Cunha-Oliveira, T.; Rego, A.C.; Cardoso, S.M.; Borges, F.; Swerdlow, R.H.; Macedo, T.; de Oliveira, C.R., Brain Research. 44 - 54. 1. 1089. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646756208&partnerID=MN8TOARS . 10.1016/j.brainres.2006.03.061 . Brain Research

Neurodegenerative pathways in Parkinson's disease: Therapeutic strategies

Cardoso, S.M.; Moreira, P.I.; Agostinho, P.; Pereira, C.; Oliveira, C.R.; Cardoso, S.; Moreira, P.; Oliveira, C., Current Drug Targets: CNS and Neurological Disorders. 405 - 419. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144431757&partnerID=MN8TOARS . 10.2174/1568007054546072 . Current Drug Targets: CNS and Neurological Disorders

The role of calcineurin in amyloid-ß-peptides-mediated cell death

Cardoso, S.M.; Oliveira, C.R., Brain Research. 1 - 7. 1-2. 1050. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-21544459062&partnerID=MN8TOARS . 10.1016/j.brainres.2005.04.078 . Brain Research

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies

Pereira, C.; Agostinho, P.; Moreira, P.I.; Cardoso, S.M.; Oliveira, C.R.; Moreira, P.; Cardoso, S.; Oliveira, C., Current Drug Targets: CNS and Neurological Disorders. 383 - 403. 4. 4. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23144463734&partnerID=MN8TOARS . 10.2174/1568007054546117 . Current Drug Targets: CNS and Neurological Disorders

Protective effect of zinc on amyloid-ß 25-35 and 1-40 mediated toxicity

Cardoso, S.M.; Rego, A.C.; Pereira, C.; Oliveira, C.R., Neurotoxicity Research. 273 - 281. 4. 7. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27744456147&partnerID=MN8TOARS . 10.1007/BF03033885 . Neurotoxicity Research

Mitochondria dysfunction of Alzheimer's disease cybrids enhances Aß toxicity

Cardoso, S.M.; Santana, I.; Swerdlow, R.H.; Oliveira, C.R., Journal of Neurochemistry. 1417 - 1426. 6. 89. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042513691&partnerID=MN8TOARS . 10.1111/j.1471-4159.2004.02438.x . Journal of Neurochemistry

Cytochrome c oxidase is decreased in Alzheimer's disease platelets

Cardoso, S.M.; Proença, M.T.; Santos, S.; Santana, I.; Oliveira, C.R., Neurobiology of Aging. 105 - 110. 1. 25. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348111546&partnerID=MN8TOARS . 10.1016/S0197-4580(03)00033-2 . Neurobiology of Aging

Cell Degeneration Induced by Amyloid-ß Peptides: Implications for Alzheimer's Disease

Pereira, Cláudia; Ferreiro, Elisabete; Cardoso, Sandra Morais; de Oliveira, Catarina Resende; Pereira, C.; Ferreiro, E.; Cardoso, S.M.; De Oliveira, C.R., Journal of Molecular Neuroscience. 097 - 104. 1-2. 23. 2004. http://dx.doi.org/10.1385/jmn:23:1-2:097 . 10.1385/jmn:23:1-2:097 . Journal of Molecular Neuroscience

Apoptotic cell death induced by hydrogen peroxide in NT2 parental and mitochondrial DNA depleted cells

Cardoso, S.M.; Rego, A.C.; Penacho, N.; Oliveira, C.R., Neurochemistry International. 693 - 698. 5. 45. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042590296&partnerID=MN8TOARS . 10.1016/j.neuint.2004.03.003 . Neurochemistry International

Glutathione cycle impairment mediates Aß-induced cell toxicity

Cardoso, S.M.; Oliveira, C.R., Free Radical Research. 241 - 250. 3. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037361527&partnerID=MN8TOARS . 10.1080/1071576021000041023 . Free Radical Research

Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid ß peptides

Cardoso, S.M.; Oliveira, C.R., Free Radical Research. 967 - 973. 9. 37. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141838915&partnerID=MN8TOARS . 10.1080/10715760310001595757 . Free Radical Research

Functional mitochondria are required for amyloid beta-mediated neurotoxicity.

Cardoso, S.M.; Santos, S.; Swerdlow, R.H.; Oliveira, C.R., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1439 - 1441. 8. 15. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035378322&partnerID=MN8TOARS . The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Mitochondrial function is differentially affected upon oxidative stress

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Free Radical Biology and Medicine. 3 - 13. 1-2. 26. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345222531&partnerID=MN8TOARS . 10.1016/S0891-5849(98)00205-6 . Free Radical Biology and Medicine

The protective effect of vitamin E, idebenone and reduced glutathione on free radical mediated injury in rat brain synaptosomes

Cardoso, S.M.; Pereira, C.; Oliveira, C.R., Biochemical and Biophysical Research Communications. 703 - 710. 3. 246. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032577242&partnerID=MN8TOARS . 10.1006/bbrc.1998.8563 . Biochemical and Biophysical Research Communications