Publications
Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.
Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella
Mendonça, Liliana S.; Henriques, Daniel; Fernandes, Vanessa; Moreira, Ricardo; Brás, João; Duarte, Sónia; Schwamborn, Jens C.; de Almeida, Luís Pereira, Scientific Reports. 1. 14. 2024. http://dx.doi.org/10.1038/s41598-024-53542-x . 10.1038/s41598-024-53542-x . Scientific Reports
MicroRNAs as cornerstones in Machado-Joseph disease pathogenesis: Development of a microRNA-based gene therapy
D Santos; L Pereira de Almeida, S P Duarte, Human Gene Therapy. A1 - A212. 23-24. 33. 2022. http://dx.doi.org/10.1089/hum.2022.29225.abstracts . 10.1089/hum.2022.29225.abstracts . published Human Gene Therapy
MiRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3
Rui Jorge Nobre; Diana D. Lobo; Carina Henriques; Sonia P. Duarte; Sara M. Lopes; Ana C. Silva; Miguel M. Lopes; et al, Nucleic Acid Therapeutics. 2021. https://doi.org/10.1089/nat.2021.0020 . 10.1089/nat.2021.0020 . Nucleic Acid Therapeutics
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky, Autophagy. 2021. https://www.tandfonline.com/doi/citedby/10.1080/15548627.2020.1797280?scroll=top&needAccess=true . 10.1080/15548627.2020.1797280 . published Autophagy
Upregulation of let-7 microrna in mouse models of Machado-Joseph disease ameliorates neuropathology and motor phenotype
Sónia Patrícia Duarte; Beatriz Estremores; Janete Cunha-Santos; Catarina Miranda; João Barata; Albert La Spada; Luis Pereira de Almeida, European Journal of Clinical Investigation. 101 - 221. S1. 49. 2019. http://dx.doi.org/10.1111/eci.13109 . 10.1111/eci.13109 . published European Journal of Clinical Investigation
Autophagy activation induced by let-7 microRNA overexpression counteracts disease phenotype in Machado-Joseph disease mouse models
Duarte, Sónia; Estremores, Beatriz; Cunha-Santos, Janete; Miranda, Catarina; Barata, João; La Spada, Albert; De Almeida, Luis, Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00026 . 10.3389/conf.fncel.2019.01.00026 . published Frontiers in Cellular Neuroscience
Antisense oligonucleotide therapeutics in neurodegenerative diseases: the case of polyglutamine disorders
Silva, Ana C; Lobo, Diana D; Martins, Inês M; Lopes, Sara M; Henriques, Carina; Duarte, Sónia P; Dodart, Jean-Cosme; Nobre, Rui Jorge; Pereira de Almeida, Luis, Brain. 407 - 429. 2. 143. 2019. http://dx.doi.org/10.1093/brain/awz328 . 10.1093/brain/awz328 . published Brain
Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease
Oliveira Miranda, C.; Marcelo, A.; Silva, T.P.; Barata, J.; Vasconcelos-Ferreira, A.; Pereira, D.; Nóbrega, C.; et al, Molecular Therapy. 2131 - 2151. 9. 26. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050950218&partnerID=MN8TOARS . 10.1016/j.ymthe.2018.07.007 . published Molecular Therapy
Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy
Dubinsky, A.N.; Dastidar, S.G.; Hsu, C.L.; Zahra, R.; Djakovic, S.N.; Duarte, S.; Esau, C.C.; et al, Cell Metabolism. 626 - 638. 4. 20. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907967415&partnerID=MN8TOARS . 10.1016/j.cmet.2014.09.001 . published Cell Metabolism
Preventive cancer stem cell-based vaccination reduces liver metastasis development in a rat colon carcinoma syngeneic model
Duarte, S.; Momier, D.; Baqué, P.; Casanova, V.; Loubat, A.; Samson, M.; Guigonis, J.-M.; et al, Stem Cells. 423 - 432. 3. 31. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874818661&partnerID=MN8TOARS . 10.1002/stem.1292 . published Stem Cells
Folate-associated lipoplexes mediate efficient gene delivery and potent antitumoral activity in vitro and in vivo
Duarte, S.; Faneca, H.; Lima, M.C.P.D., International Journal of Pharmaceutics. 365 - 377. 2. 423. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856552664&partnerID=MN8TOARS . 10.1016/j.ijpharm.2011.12.035 . published International Journal of Pharmaceutics
Isolation of head and neck squamous carcinoma cancer stem-like cells in a syngeneic mouse model and analysis of hypoxia effect
Duarte, S.; Loubat, A.; Momier, D.; Topi, M.; Faneca, H.; Pedroso De Lima, M.C.; Carle, G.F.; Pierrefite-Carle, V., Oncology Reports. 1057 - 1062. 3. 28. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865312688&partnerID=MN8TOARS . 10.3892/or.2012.1904 . published Oncology Reports
Suicide gene therapy in cancer: Where do we stand now?
Duarte, S.; Carle, G.; Faneca, H.; Lima, M.C.P.D.; Pierrefite-Carle, V., Cancer Letters. 160 - 170. 2. 324. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864392111&partnerID=MN8TOARS . 10.1016/j.canlet.2012.05.023 . published Cancer Letters
Non-covalent association of folate to lipoplexes: A promising strategy to improve gene delivery in the presence of serum
Duarte, S.; Faneca, H.; Pedroso De Lima, M.C., Journal of Controlled Release. 264 - 272. 3. 149. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951941675&partnerID=MN8TOARS . 10.1016/j.jconrel.2010.10.032 . published Journal of Controlled Release
S413-PV cell penetrating peptide and cationic liposomes act synergistically to mediate intracellular delivery of plasmid DNA
Trabulo, Sara; Mano, Miguel; Faneca, Henrique; Cardoso, Ana Luísa; Duarte, Sónia; Henriques, Ana; Paiva, Artur; et al, The Journal of Gene Medicine. 1210 - 1222. 11. 10. 2008. http://dx.doi.org/10.1002/jgm.1247 . 10.1002/jgm.1247 . published The Journal of Gene Medicine
Preparation of plasmid DNA polyplexes from alkaline lysates by a two-step aqueous two-phase extraction process
Duarte, S.P.; Fortes, A.G.; Prazeres, D.M.F.; Marcos, J.C., Journal of Chromatography A. 105 - 112. 1-2. 1164. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548030710&partnerID=MN8TOARS . 10.1016/j.chroma.2007.06.061 . published Journal of Chromatography A
5 16 out of 16 Publications
All projects
Information of exclusive responsibility of the researcher 17-11-2024 , from platform CIÊNCIAVITAE.
2023/03/01
Pre-clinical evaluation of the brain-targeting AAV-PHP.eB encoding cholesterol hydroxylase CYP46A1 as a therapeutic strategy for spinocerebellar ataxia type 3 - towards the understanding of the neuroprotective mechanism
2022.04788.PTDC
Researcher
Funders: Fundação para a Ciência e a Tecnologia
2023/01/01
Direct Conversion of Astrocytes into Cerebellar Neurons as an Innovative Treatment for Spinocerebellar Ataxia Type-3
2022.06127.PTDC
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia
2023/09/01
CinTech - Technological Hub for Innovation, Translation and Industrialization of Complex Injectable Drugs
12345
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2022
greenLabsCIBB (gLCIBB)
gLCIBB
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2021/09/16 - 2024
"Repurposing FDA-approved Drugs as microRNA-specific modifiers towards a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)"
Trampoline Grant 23755
Principal investigator
Center for Neurosciences and Cell Biology; Universidade de Coimbra Instituto de Investigação Interdisciplinar
Funders: AFM-Téléthon
2021/09/01 - 2024/02/28
MicroRNA-specific small molecule modifiers as a new and promising therapeutic approach for Machado-Joseph disease/spinocerebellar ataxia type 3 (MJD/SCA3)
NAF Young Investigator Award
Principal investigator
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: National Ataxia Foundation
2021/01/01 - 2025/12/31
Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2020/01/01 - 2023/12/31
Center for Innovative Biomedicine and Biotechnology
UIDB/04539/2020
Researcher
Funders: Fundação para a Ciência e a Tecnologia
2020/07 -
"miRSilencing" project
international collaborative project between the Center for Neuroscience and Cell Biology (CNC, UC, Portugal) and PTC Therapeutics (USA)
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB); Center for Neuroscience and Cell Biology, University of Coimbra (CNC-UC)
Funders: PTC Therapeutics Inc
2020 - 2022/02/28
Intravenous delivery of the brain-targeting AAV-PHPeB encoding the cholesterol hydroxylase CYP46A1 into a mouse model of spinocerebellar ataxia type 3: a promising non-invasive therapeutic strategy
686213
Researcher
Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: National Ataxia Foundation
2019 - 2021/12
Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) - SCA-CYP (International Consortium)
E-Rare-3 JTC 2017 (International Consortium)
Researcher
CNC.IBILI; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2019/02 - 2019/10
Targeting ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using AAV5 and an artificial microRNA
International Collaborative Project between CNC and uniQure Company
Researcher
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: uniQure NV
2018/06 - 2021/06
The impact of induced pluripotent stem cells-derived neuroepithelial stem cells transplantation in Machado-Joseph disease
POCI-01-0145-FEDER-030737
Researcher
Center for Neurosciences and Cell Biology
Funders: Comissão de Coordenação e Desenvolvimento Regional do Centro; Fundação para a Ciência e a Tecnologia
2018/05/01 -
Collaboration with Wave Life Sciences company, uniQure and Brainvectis in the development of a gene therapy product applied to neurodegenerative disorders, particularly to polyglutamine disorders.
INTERNATIONAL NETWORKS
Researcher
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2018/05 -
"Targeting mutant ATXN3 for the treatment of Spinocerebellar Ataxia 3 (SCA3) using allele-specific ASOs
International collaborative project between CNC and Wave Life Sciences USA, Inc
Researcher
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Wave Life Sciences USA, Inc
2018 -
Lab management (organizing/ordering/managing the lab products, space/people in the lab)
LAB MANAGMENT
Other
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2018/07/06 - 2022/04/05
Role of microRNA deregulation in Machado-Joseph Disease: On the development of a microRNA-based therapeutic strategy
POCI-01-0145-FEDER-032309
Principal investigator
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Fundação para a Ciência e a Tecnologia; Comissão de Coordenação e Desenvolvimento Regional do Centro
2017/03/27 - 2020/03/26
LifeSciences ByCENTRO
CENTRO-01-0246-FEDER-000011
Researcher
CNC.IBILI; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE)
2017/01 - 2020/12
BRAIN HEALTH 2020-Detecção Precoce,Neuro-modulação e TerapiasAvançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
Center for Neurosciences and Cell Biology
Funders: Centro2020 - Programa Operacional Centro 2020 (FEDER/FSE); Foundation for Science and Technology (Lisbon, Portugal)
2016/04 - 2020/05
ModelPolyQ: Advanced models of polyglutamine disorders (HD, SCA3 and SCA7)
JPCOFUND/0005/2015 (International Consortium)
Researcher
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: EU Joint Programme Neurodegenerative Disease Research
2016/04 - 2019/03
Gene repair and repression strategies to alleviate Machado-Joseph disease
PTDC/NEU-NMC/0084/2014
Researcher
Center for Neurosciences and Cell Biology
Funders: Foundation for Science and Technology (Lisbon, Portugal)
2016 - 2020/05
JPND European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative
JPCOFUND/0001/2015-ESMI (International Consortium)
Researcher
Center for Neurosciences and Cell Biology; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
Funders: EU Joint Programme Neurodegenerative Disease Research
2015/01 - 2017/12
“CNC. IBILI”
UID/NEU/04539/2013
Researcher
Center for Neurosciences and Cell Biology
Funders: Foundation for Science and Technology (Lisbon, Portugal)
2015/03 - 2018/12
Roles and mechanisms of synuclein and ataxin-3 spreading in Parkinson and Machado-Joseph diseases
JPND SynSpread: CD/0001/2013 (International consortium)
Researcher
Center for Neurosciences and Cell Biology
Funders: EU Joint Programme Neurodegenerative Disease Research; Foundation for Science and Technology (Lisbon, Portugal)
2013/03 - 2015/06
Combined therapeutic approach based on miRNA modulation towards glioblastoma multiforme: A novel targeted lipid-based nanosystem for systemic delivery
PTDC/DTP-FTO/0265/2012
Researcher
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2013/03 - 2015/08
Exploring miRNA contribution to amyloid-b-metabolism: development of a novel lentiviral platform for multiple miRNA expression in Alzheimer´s disease
PTDC/BIM-MEC/0651/2012
Researcher
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2013/03 - 2016/02
Machado-Joseph-Disease, protein aggregation, protein degradation, stem cell biology, proteostasis, neurodegeneration
E-Rare4/0003/2012 (International consortium)
Researcher
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2013 -
Collaboration with La Spada AR, who first discovered polyglutamine disorders at the University of Duke
INTERNATIONAL NETWORK
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Centro de Inovação em Biomedicina e Biotecnologia (CIBB)
2013/02/01 - 2018/07/04
Investigating the role of the Let-7 microRNA in Machado-Joseph disease
SFRH/BPD/87552/2012
Post-doc Fellow
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2012/06 - 2012/12
Non-invasive Non-viral Silencing of Machado-Joseph disease
PTDC/SAU-FAR/116535/2010
Research Fellow
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2008/03/01 - 2012/03/01
ON THE DEVELOPMENT OF ANTITUMOURAL THERAPEUTIC STRATEGIES: Suicide gene therapy mediated by lipid-based systems and cancer stem cell-based vaccination
SFRH/BD/32797/2007
PhD Student Fellow
Universidade de Coimbra Faculdade de Ciencias e Tecnologia; Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2007/06 - 2008/02
Development of a novel approach for anti-tumor therapy based on the S413-PV cell penetrating peptide to improve the intracellular delivery of therapeutic proteins and nucleic acids
PTDC/BIO/65627/2006
Research Fellow
Center for Neurosciences and Cell Biology
Funders: Fundação para a Ciência e a Tecnologia
2005/01 - 2007/05
Preparação de agentes para Terapia Molecular por purificação e condensação simultânea de plasmídeos em sistemas de duas fases aquosas
POCTI BIO/47245/2002
Research Fellow
Universidade do Minho
Funders: Universidade do Minho
5 33 out of 33 projects
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