Susana P. Pereira

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Pereira, Susana P.; Diniz, Mariana S.; Tavares, Ludgero C.; Cunha-Oliveira, Teresa; Li, Cun; Cox, Laura A.; Nijland, Mark J.; Nathanielsz, Peter W.; Oliveira, Paulo J., International Journal of Molecular Sciences. 20. 24. 2023. http://dx.doi.org/10.3390/ijms242015192 . 10.3390/ijms242015192 . International Journal of Molecular Sciences

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Diniz, Mariana S.; Grilo, Luís F.; Tocantins, Carolina; Falcão-Pires, Inês; Pereira, Susana P., Metabolites. 7. 13. 2023. http://dx.doi.org/10.3390/metabo13070845 . 10.3390/metabo13070845 . Metabolites

Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation

Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M.; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; et al, European Journal of Clinical Investigation. 11. 53. 2023. http://dx.doi.org/10.1111/eci.14069 . 10.1111/eci.14069 . European Journal of Clinical Investigation

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Grilo, Luís F.; Martins, João D.; Diniz, Mariana S.; Tocantins, Carolina; Cavallaro, Chiara H.; Baldeiras, Inês; Cunha-Oliveira, Teresa; et al, Clinical Science. 1347 - 1372. 17. 137. 2023. http://dx.doi.org/10.1042/cs20230048 . 10.1042/cs20230048 . published Clinical Science

Exposure to Obesogenic Environments during Perinatal Development Modulates Offspring Energy Balance Pathways in Adipose Tissue and Liver of Rodent Models

Sousa, Diana; Rocha, Mariana; Amaro, Andreia; Ferreira-Junior, Marcos Divino; Cavalcante, Keilah Valéria Naves; Monteiro-Alfredo, Tamaeh; Barra, Cátia; et al, Nutrients. 5. 15. 2023. http://dx.doi.org/10.3390/nu15051281 . 10.3390/nu15051281 . Nutrients

The birth of cardiac disease: mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring

Carolina Tocantins; Mariana S. Diniz; Luís F. Grilo; Susana P. Pereira, WIREs Mechanisms of Disease. 2022. https://onlinelibrary.wiley.com/doi/10.1002/wsbm.1555 . 10.1002/wsbm.1555 . accepted WIREs Mechanisms of Disease

Exercise-Boosted Mitochondrial Remodeling in Parkinson's Disease

Juan Carlos MAGAÑA GALLARDO; Cláudia Deus; Deus, CM; Maria Giné-Garriga; Joel Montane; Pereira SP, Biomedicines. 3228 - 3228. 12. 10. 2022. http://dx.doi.org/10.3390/biomedicines10123228 . 10.3390/biomedicines10123228 . Biomedicines

The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming?

Luís F. Grilo; Mariana S. Diniz; Carolina Tocantins; Ana Luísa Areia; Pereira SP, Obesities. 236 - 255. 3. 2. 2022. http://dx.doi.org/10.3390/obesities2030019 . 10.3390/obesities2030019 . Obesities

The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

Mariana S. Diniz; Carolina Tocantins; Luis F. Grilo; Pereira SP, Diabetology. 2022. https://susy.mdpi.com/user/manuscripts/review_info/b82370c44de6e15f27ed2e711c9e17a0 . 10.3390/diabetology3040044 . Diabetology

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Ricardo Amorim; Inês C.M. Simões; José Teixeira; Fernando Cagide; Yaiza Potes; Pedro Soares; Adriana Carvalho; et al, Redox Biology. 102400 - 102400. 55. 2022. http://dx.doi.org/10.1016/j.redox.2022.102400 . 10.1016/j.redox.2022.102400 . Redox Biology

Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic fat accumulation and liver mitochondrial respiratory capacity in mothers and male offspring

Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Pereira, Susana; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; et al, Metabolism. 116. 2021. http://dx.doi.org/10.1016/j.metabol.2021.154704 . 10.1016/j.metabol.2021.154704 . Metabolism

Metabolic Disease Programming: from Mitochondria to Epigenetics, Glucocorticoid Signaling and Beyond

Luis F. Grilo; Carolina Tocantins; Mariana S. Diniz; Rodrigo Mello Gomes; Paulo J. Oliveira; Paulo Matafome; Susana P. Pereira, European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13625 . 10.1111/eci.13625 . European Journal of Clinical Investigation

Improving pollutants environmental risk assessment using a multi model toxicity determination with in vitro, bacterial, animal and plant model systems: The case of the herbicide alachlor

Susana P. Pereira; Sandra M.A. Santos; Maria A.S. Fernandes; Cláudia M. Deus; João D. Martins; Maria C. Pedroso de Lima; Joaquim A.F. Vicente; Romeu A. Videira; Amália S. Jurado, Environmental Pollution. 117239 - 117239. 286. 2021. https://doi.org/10.1016/j.envpol.2021.117239 . 10.1016/j.envpol.2021.117239 . accepted Environmental Pollution

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Inês C. M. Simões; Ricardo Amorim; José Teixeira; Agnieszka Karkucinska-Wieckowska; Adriana Carvalho; Susana P. Pereira; Rui F. Simões; et al, International Journal of Molecular Sciences. 6848 - 6848. 13. 22. 2021. https://doi.org/10.3390/ijms22136848 . 10.3390/ijms22136848 . International Journal of Molecular Sciences

Sex-dependent vulnerability of fetal nonhuman primate cardiac mitochondria to moderate maternal nutrient reduction

Susana P. Pereira; Ludgero C. Tavares; Ana I. Duarte; Inês Baldeiras; Teresa Cunha-Oliveira; João D. Martins; Maria S. Santos; et al, Clinical Science. 2021. https://doi.org/10.1042/CS20201339 . 10.1042/CS20201339 . Clinical Science

Corrigendum to ‘A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients’. [Redox Biology 45 (2021) 102037]

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, Redox Biology. 47. 2021. http://dx.doi.org/10.1016/j.redox.2021.102117 . 10.1016/j.redox.2021.102117 . Redox Biology

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Cláudia M. Deus; Susana P. Pereira; Teresa Cunha-Oliveira; José Teixeira; Rui F. Simões; Fernando Cagide; Sofia Benfeito; et al, Redox Biology. 2021. https://doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . Redox Biology

P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress

Bárbara Sousa; Joana Pereira; Ricardo Marques; Luís F. Grilo; Susana P. Pereira; Vilma A. Sardão; Fernando Schmitt; Paulo J. Oliveira; Joana Paredes, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165964 . 10.1016/j.bbadis.2020.165964 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples

Luís F. Grilo; João D. Martins; Chiara H. Cavallaro; Peter W. Nathanielsz; Paulo J. Oliveira; Susana P. Pereira, Toxicology in Vitro. 2020. http://dx.doi.org/10.1016/j.tiv.2020.104996 . 10.1016/j.tiv.2020.104996 . Toxicology in Vitro

Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Early Cardiac Mitochondrial Molecular and Functional Responses to Acute Anthracycline Treatment in Wistar Rats

Pereira, Gonçalo C; Pereira, Susana P; Pereira, Francisco B; Lourenço, Nuno; Lumini, José A; Pereira, Claudia V; Bjork, James A; et al, Toxicological Sciences. 2019. http://dx.doi.org/10.1093/toxsci/kfz026 . 10.1093/toxsci/kfz026 . Toxicological Sciences

Metabolic and Phenotypic Characterization of Human Skin Fibroblasts After Forcing Oxidative Capacity

Susana P Pereira; Cláudia M Deus; Teresa L Serafim; Teresa Cunha-Oliveira; Paulo J Oliveira, Toxicological Sciences. 2018. https://doi.org/10.1093/toxsci/kfy068 . 10.1093/toxsci/kfy068 . Toxicological Sciences

Cardiac cytochrome c and cardiolipin depletion during anthracycline-induced chronic depression of mitochondrial function

Pereira, Gonçalo C; Pereira, Susana P; Tavares, Ludgero C; Carvalho, Filipa S; Magalhães-Novais, Silvia; Barbosa, Inês A; Santos, Maria S; et al, 95 - 104. 30. 2016. http://hdl.handle.net/10316/47559 . 10.1016/j.mito.2016.07.005 .

Determination of metabolic viability and cell mass using a tandem resazurin/sulforhodamine B assay

Silva, F.S.G.; Starostina, I.G.; Ivanova, V.V.; Rizvanov, A.A.; Oliveira, P.J.; Pereira, S.P., Current Protocols in Toxicology. 1 - 15. 2016. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026657309&partnerID=MN8TOARS . 10.1002/cptx.1 . Current Protocols in Toxicology

Analysis of Bj fibroblasts mitochondrial respiratory chain function under glucose starvation and exposure to different doses of rotenone: Implications for neurogenerative diseases

Ivanova, V.V.; Starostina, I.G.; Martynova, E.V.; Pereira, S.P.; Oliveira, P.J.; Rizvanov, A.A.; Ivanova, V. V.; et al, Genes and Cells. 40 - 46. 4. 10. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962218626&partnerID=MN8TOARS . Genes and Cells

Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation

Pereira, Susana P.; Oliveira, Paulo J.; Tavares, Ludgero C.; Moreno, António J.; Cox, Laura A.; Nathanielsz, Peter W.; Nijland, Mark J., American Journal of Physiology-Renal Physiology. F1217 - F1228. 11. 308. 2015. http://dx.doi.org/10.1152/ajprenal.00419.2014 . 10.1152/ajprenal.00419.2014 . American Journal of Physiology-Renal Physiology

Gene Expression Profiling of H9c2 Myoblast Differentiation towards a Cardiac-Like Phenotype

Ana Branco; Susana P. Pereira; Susana Gonzalez; Oleg Gusev; Albert A. Rizvanov; Paulo J. Oliveira; Branco, Ana F.; et al, PLoS One. 1 - 10. 29. 2015. http://www.ncbi.nlm.nih.gov/pubmed/26121149 . 10.1371/journal.pone.0129303. . published PLoS One

Dioxin-induced acute cardiac mitochondrial oxidative damage and increased activity of ATP-sensitive potassium channels in Wistar rats

Pereira, Susana P.; Pereira, Gonçalo C.; Pereira, Cláudia V.; Carvalho, Filipa S.; Cordeiro, Marília H.; Mota, Paula C.; Ramalho-Santos, João; Moreno, António J.; Oliveira, Paulo J., Environmental Pollution. 281 - 290. 180. 2013. http://dx.doi.org/10.1016/j.envpol.2013.05.049 . 10.1016/j.envpol.2013.05.049 . Environmental Pollution

Mitochondrionopathy phenotype in doxorubicin-treated Wistar rats depends on treatment protocol and is cardiac-specific

Pereira, Gonçalo C; Pereira, Susana P; Pereira, Claudia V; Lumini, José A; Magalhães, José; Ascensão, António; Santos, Maria S; et al, PLoS ONE. e38867 - e38867. 6. 7. 2012. http://hdl.handle.net/10316/47554 . 10.1371/journal.pone.0038867 . published PLoS ONE

Acute effects of TCDD administration: Special emphasis on testicular and sperm mitochondrial function

Mota, P.C.; Tavares, R.S.; Cordeiro, M.; Pereira, S.P.; Publicover, S.J.; Oliveira, P.J.; Ramalho-Santos, J.; et al, Asian Pacific Journal of Reproduction. 269 - 276. 4. 1. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929141935&partnerID=MN8TOARS . 10.1016/S2305-0500(13)60091-3 . published Asian Pacific Journal of Reproduction

Differential effects of p,p'-DDE on testis and liver mitochondria: implications for reproductive toxicology

Mota, Paula C; Cordeiro, Marília; Pereira, Susana P; Oliveira, Paulo J; Moreno, António J; Ramalho-Santos, João; Paula C. Mota; et al, Reproductive Toxicology. 80 - 85. 1. 31. 2011. http://hdl.handle.net/10316/47553 . 10.1016/j.reprotox.2010.09.010 . published Reproductive Toxicology

Sub-chronic administration of doxorubicin to Wistar rats results in oxidative stress and unaltered apoptotic signaling in the lung

Machado, Nuno G; Baldeiras, Inês; Pereira, Gonçalo C; Pereira, Susana P; Oliveira, Paulo J; Nuno G. Machado; Inês Baldeiras; et al, Chemico-Biological Interactions. 478 - 486. 3. 188. 2010. http://hdl.handle.net/10316/47552 . 10.1016/j.cbi.2010.09.027 . published Chemico-Biological Interactions

Investigating drug-induced mitochondrial toxicity: a biosensor to increase drug safety?

Pereira, Cláudia V; Moreira, Ana C; Pereira, Susana P; Machado, Nuno G; Carvalho, Filipa S; Sardão, Vilma A; Oliveira, Paulo J; et al, Current Drug Safety. 34 - 54. 1. 4. 2009. http://www.ncbi.nlm.nih.gov/pubmed/19149524 . 10.2174/157488609787354440 . Current Drug Safety

Can drug safety be predicted and animal experiments reduced by using isolated mitochondrial fractions?

Pereira, S.P.; Pereira, G.C.; Moreno, A.J.; Oliveira, P.J., ATLA Alternatives to Laboratory Animals. 355 - 365. 4. 37. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449604749&partnerID=MN8TOARS . ATLA Alternatives to Laboratory Animals

Toxicity assessment of the herbicide metolachlor comparative effects on bacterial and mitochondrial model systems

Susana P. Pereira; Maria A.S. Fernandes; João D. Martins; Maria S. Santos; António J. Moreno; Joaquim A.F. Vicente; Romeu A. Videira; et al, Toxicology in Vitro. 1585 - 1590. 8. 23. 2009. http://www.sciencedirect.com/science/article/pii/S0887233309001702 . 10.1016/j.tiv.2009.06.032 . published Toxicology in Vitro

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

Susana Cardoso; Renato X. Santos; Cristina Carvalho; Sónia Correia; Gonçalo C. Pereira; Susana P. Pereira; Paulo J. Oliveira; et al, Free Radical Biology and Medicine. 1395 - 1402. 10. 45. 2008. http://www.sciencedirect.com/science/article/pii/S089158490800470X . 10.1016/j.freeradbiomed.2008.08.008 . published Free Radical Biology and Medicine

Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-1211 (etaftoron), and OSI-3802] on rat liver mitochondrial bioenergetics and on the physical properties of membrane lipid bilayers: Relevance to the length of the alkoxyl chain in positions 3 and 5 of the DHP ring

Fernandes, Maria A. S.; Pereira, Susana P. S.; Jurado, Amália S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Duburs, Gunars; et al, The 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in p. 195 - 204. 3. 173. 2008. http://hdl.handle.net/10316/5293 . 10.1016/j.cbi.2008.03.001 . published The 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in p