Metabolismo, Envelhecimento e Doença
Organelle Crosstalk in Aging and Disease
Interação entre organelos
mitocôndria
lisosomas, reticulo endoplasmático
peroxissomas
núcleo
multi-ómica, envelhecimento
Interação entre organelos
mitocôndria
lisosomas, reticulo endoplasmático
peroxissomas
núcleo
multi-ómica, envelhecimento
As células operam como pequenas máquinas onde os diferentes componentes (organelos) têm de estar coordenados, como num carro. Quando a coordenação entre os organelos é perdida, surgem patologias que afetam músculos (incluindo o coração), fígado, olhos, ouvidos e sistema nervoso. O objetivo do nosso laboratório é decifrar como os organelos celulares interagem para evitar doenças causadas pela perda dessa coordenação. Para tal, utilizamos modelos animais (rato) e celulares (humano, rato, rato) para investigar essas questões e desenvolver novas estratégias terapêuticas para doenças neurodegenerativas, musculares e outras.
Informação sobre artigos em revista, actualizada a 24-11-2024, a partir da plataforma CIÊNCIAVITAE.
Lack of peroxisomal catalase affects heat shock response inCaenorhabditis elegans
Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko, 2023. Life Science Alliance. 2023. https://doi.org/10.26508/lsa.202201737 . 10.26508/lsa.202201737 . Life Science Alliance
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; Da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; et al, 2022. Life Science Alliance. 3. 5. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122904549&partnerID=MN8TOARS . 10.26508/lsa.202101185 . Life Science Alliance
Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Silvia Maglioni; Alfonso Schiavi; Marlen Melcher; Vanessa Brinkmann; Zhongrui Luo; Anna Laromaine; Nuno Raimundo; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-29972-4 . 10.1038/s41467-022-29972-4 . Nature Communications
Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease
Cláudia M. Deus; José Teixeira; Nuno Raimundo; Paolo Tucci; Fernanda Borges; Luciano Saso; Paulo J. Oliveira, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13820 . 10.1111/eci.13820 . European Journal of Clinical Investigation
Feeding and lipophagy: it takes guts to deliver
Nuno Raimundo, 2022. The EMBO Journal. 2022. https://doi.org/10.15252/embj.2022112180 . 10.15252/embj.2022112180 . The EMBO Journal
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.
2021. Redox biology. 2021. https://europepmc.org/articles/PMC8220403 . 10.1016/j.redox.2021.102037 . Redox biology
Editorial: Autophagy and related transcription factors in liver and gut diseases
Eid, N.; Menon, M.B.; Thomes, P.; Zeng, T.; Raimundo, N.; Fernandez-Checa, J.C.; Wang, L.; et al, 2020. Frontiers in Pharmacology. 10. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079427744&partnerID=MN8TOARS . 10.3389/fphar.2019.01610 . Frontiers in Pharmacology
Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration
Deus, Cláudia M.; Yambire, King Faisal; Oliveira, Paulo J.; Raimundo, Nuno, 2020. Trends in Molecular Medicine. 71 - 88. 1. 26. 2020. http://dx.doi.org/10.1016/j.molmed.2019.10.009 . 10.1016/j.molmed.2019.10.009 . published Trends in Molecular Medicine
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Gowrisankaran, Sindhuja; Houy, Sébastien; del Castillo, Johanna G. Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.; et al, 2020. Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-14993-8 . 10.1038/s41467-020-14993-8 . Nature Communications
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
Sathyanarayanan, Udhayabhaskar; Musa, Marina; Bou Dib, Peter; Raimundo, Nuno; Milosevic, Ira; Krisko, Anita, 2020. Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-19104-1 . 10.1038/s41467-020-19104-1 . Nature Communications
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects
Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, Garik V.; Abdelmohsen, Kotb; Andreux, Pénélope; Bagdonaite, Ieva; Barzilai, Nir; Brunak, Søren; Cabreiro, Filipe; et al, 2020. Aging. 2020. http://dx.doi.org/10.18632/aging.202454 . 10.18632/aging.202454 . Aging
Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss
Zhao, Jingjing; Li, Gen; Zhao, Xuan; Lin, Xin; Gao, Yunge; Raimundo, Nuno; Li, Geng-Lin; et al, 2020. Aging. 2020. http://dx.doi.org/10.18632/aging.102977 . 10.18632/aging.102977 . Aging
Editorial: Mitochondrial Communication in Physiology, Disease and Aging
Raimundo, Nuno; Krisko, Anita, 2019. Frontiers in Cell and Developmental Biology. 7. 2019. http://dx.doi.org/10.3389/fcell.2019.00054 . 10.3389/fcell.2019.00054 . published Frontiers in Cell and Developmental Biology
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
Yambire, King Faisal; Fernandez-Mosquera, Lorena; Steinfeld, Robert; Mühle, Christiane; Ikonen, Elina; Milosevic, Ira; Raimundo, Nuno, 2019. eLife. 8. 2019. http://dx.doi.org/10.7554/elife.39598 . 10.7554/elife.39598 . published eLife
Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
Barriocanal-Casado, Eliana; Hidalgo-Gutiérrez, Agustín; Raimundo, Nuno; González-García, Pilar; Acuña-Castroviejo, Darío; Escames, Germaine; López, Luis C., 2019. EBioMedicine. 511 - 523. 42. 2019. http://dx.doi.org/10.1016/j.ebiom.2019.03.025 . 10.1016/j.ebiom.2019.03.025 . published EBioMedicine
Mitochondrial fission requires DRP1 but not dynamins
Fonseca, Tiago Branco; Sánchez-Guerrero, Ángela; Milosevic, Ira; Raimundo, Nuno, 2019. Nature. E34 - E42. 7761. 570. 2019. http://dx.doi.org/10.1038/s41586-019-1296-y . 10.1038/s41586-019-1296-y . published Nature
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis
Fernandez-Mosquera, Lorena; Yambire, King Faisal; Couto, Renata; Pereyra, Leonardo; Pabis, Kamil; Ponsford, Amy H.; Diogo, Cátia V.; et al, 2019. Autophagy. 1572 - 1591. 9. 15. 2019. http://dx.doi.org/10.1080/15548627.2019.1586256 . 10.1080/15548627.2019.1586256 . published Autophagy
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
King Faisal Yambire; Lorena Fernandez-Mosquera; Robert Steinfeld; Christiane Mühle; Elina Ikonen; Ira Milosevic; Nuno Raimundo, 2019. eLife. 2019. https://doi.org/10.7554/eLife.39598 . 10.7554/eLife.39598 . eLife
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Yambire, King Faisal; Rostosky, Christine; Watanabe, Takashi; Pacheu-Grau, David; Torres-Odio, Sylvia; Sanchez-Guerrero, Angela; Senderovich, Ola; et al, 2019. eLife. 8. 2019. http://dx.doi.org/10.7554/elife.51031 . 10.7554/elife.51031 . published eLife
Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling
Musa, Marina; Peric, Matea; Bou Dib, Peter; Sobocanec, Sandra; Šaric, Ana; Lovric, Anita; Rudan, Marina; et al, 2018. Aging. 2407 - 2427. 9. 10. 2018. http://dx.doi.org/10.18632/aging.101560 . 10.18632/aging.101560 . published Aging
Cross-organelle communication at the core of longevity
Raimundo, Nuno; Kriško, Anita, 2018. Aging. 15 - 16. 1. 10. 2018. http://dx.doi.org/10.18632/aging.101373 . 10.18632/aging.101373 . published Aging
Mitochondrial adventures at the organelle society
Cátia V. Diogo; King Faisal Yambire; Lorena Fernández Mosquera; Tiago Branco F.; Nuno Raimundo, 2018. Biochemical and Biophysical Research Communications. 87 - 93. 1. 500. 2018. https://doi.org/10.1016/j.bbrc.2017.04.124 . 10.1016/j.bbrc.2017.04.124 . published Biochemical and Biophysical Research Communications
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation
Simão, Daniel; Silva, Marta M.; Terrasso, Ana P.; Arez, Francisca; Sousa, Marcos F.Q.; Mehrjardi, Narges Z.; Šaric, Tomo; et al, 2018. Stem Cell Reports. 552 - 564. 2. 11. 2018. http://dx.doi.org/10.1016/j.stemcr.2018.06.020 . 10.1016/j.stemcr.2018.06.020 . published Stem Cell Reports
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
Peric, Matea; Lovric, Anita; Šaric, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolic, Andrea; et al, 2017. Aging Cell. 994 - 1005. 5. 16. 2017. http://dx.doi.org/10.1111/acel.12623 . 10.1111/acel.12623 . published Aging Cell
Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis
Fernández-Mosquera, Lorena; Diogo, Cátia V.; Yambire, King Faisal; Santos, Gabriela L.; Luna Sánchez, Marta; Bénit, Paule; Rustin, Pierre; et al, 2017. Scientific Reports. 1. 7. 2017. http://dx.doi.org/10.1038/srep45076 . 10.1038/srep45076 . published Scientific Reports
Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
Peric, Matea; Dib, Peter Bou; Dennerlein, Sven; Musa, Marina; Rudan, Marina; Lovric, Anita; Nikolic, Andrea; et al, 2016. Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep28751 . 10.1038/srep28751 . Scientific Reports
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
John D. Murdoch; Christine M. Rostosky; Sindhuja Gowrisankaran; Amandeep S. Arora; Sandra-Fausia Soukup; Ramon Vidal; Vincenzo Capece; et al, 2016. Cell Reports. 1071 - 1086. 4. 17. 2016. http://dx.doi.org/10.1016/j.celrep.2016.09.058 . 10.1016/j.celrep.2016.09.058 . published Cell Reports
Mechanisms of communication between mitochondria and lysosomes
Raimundo, Nuno; Fernández-Mosquera, Lorena; Yambire, King Faisal; Diogo, Cátia V., 2016. The International Journal of Biochemistry & Cell Biology. 345 - 349. 79. 2016. http://dx.doi.org/10.1016/j.biocel.2016.08.020 . 10.1016/j.biocel.2016.08.020 . published The International Journal of Biochemistry & Cell Biology
Mitochondrial DNA stress primes the antiviral innate immune response
West, A. Phillip; Khoury-Hanold, William; Staron, Matthew; Tal, Michal C.; Pineda, Cristiana M.; Lang, Sabine M.; Bestwick, Megan; et al, 2015. Nature. 553 - 557. 7548. 520. 2015. http://dx.doi.org/10.1038/nature14156 . 10.1038/nature14156 . published Nature
Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness
McKay, Sharen E.; Yan, Wayne; Nouws, Jessica; Thormann, Maximilian J.; Raimundo, Nuno; Khan, Abdul; Santos-Sacchi, Joseph; Song, Lei; Shadel, Gerald S., 2015. The American Journal of Pathology. 3132 - 3140. 12. 185. 2015. http://dx.doi.org/10.1016/j.ajpath.2015.08.014 . 10.1016/j.ajpath.2015.08.014 . published The American Journal of Pathology
Mitochondrial pathology: stress signals from the energy factory
Raimundo, Nuno, 2014. Trends in Molecular Medicine. 282 - 292. 5. 20. 2014. http://dx.doi.org/10.1016/j.molmed.2014.01.005 . 10.1016/j.molmed.2014.01.005 . published Trends in Molecular Medicine
Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity
Schroeder, Elizabeth A.; Raimundo, Nuno; Shadel, Gerald S., 2013. Cell Metabolism. 954 - 964. 6. 17. 2013. http://dx.doi.org/10.1016/j.cmet.2013.04.003 . 10.1016/j.cmet.2013.04.003 . published Cell Metabolism
Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness
Raimundo, Nuno; Song, Lei; Shutt, Timothy E.; McKay, Sharen E.; Cotney, Justin; Guan, Min-Xin; Gilliland, Thomas C.; et al, 2012. Cell. 716 - 726. 4. 148. 2012. http://dx.doi.org/10.1016/j.cell.2011.12.027 . 10.1016/j.cell.2011.12.027 . published Cell
Revisiting the TCA cycle: signaling to tumor formation
Raimundo, Nuno; Baysal, Bora E.; Shadel, Gerald S., 2011. Trends in Molecular Medicine. 641 - 649. 11. 17. 2011. http://dx.doi.org/10.1016/j.molmed.2011.06.001 . 10.1016/j.molmed.2011.06.001 . published Trends in Molecular Medicine
Mitochondrial myopathy induces a starvation-like response
Tyynismaa, Henna; Carroll, Christopher J.; Raimundo, Nuno; Ahola-Erkkilä, Sofia; Wenz, Tina; Ruhanen, Heini; Guse, Kilian; et al, 2010. Human Molecular Genetics. 3948 - 3958. 20. 19. 2010. http://dx.doi.org/10.1093/hmg/ddq310 . 10.1093/hmg/ddq310 . published Human Molecular Genetics
Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas
Raimundo, N; Vanharanta, S; Aaltonen, L A; Hovatta, I; Suomalainen, A, 2009. Oncogene. 1261 - 1273. 9. 28. 2009. http://dx.doi.org/10.1038/onc.2008.472 . 10.1038/onc.2008.472 . published Oncogene
A "radical" mitochondrial view of autophagy-related pathology
Raimundo, Nuno; Shadel, Gerald S., 2009. Aging. 354 - 356. 4. 1. 2009. http://dx.doi.org/10.18632/aging.100037 . 10.18632/aging.100037 . published Aging
Differential metabolic consequences of fumarate hydratase and respiratory chain defects
Raimundo, Nuno; Ahtinen, Jouni; Fumic, Ksenija; Baric, Ivo; Remes, Anne M.; Renkonen, Risto; Lapatto, Risto; Suomalainen, Anu, 2008. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 287 - 294. 5. 1782. 2008. http://dx.doi.org/10.1016/j.bbadis.2008.01.008 . 10.1016/j.bbadis.2008.01.008 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action
Guarino, Maria P.; Afonso, Ricardo A.; Raimundo, Nuno; Raposo, João F.; Macedo, M. Paula, 2003. American Journal of Physiology-Gastrointestinal and Liver Physiology. G588 - G594. 4. 284. 2003. http://dx.doi.org/10.1152/ajpgi.00423.2002 . 10.1152/ajpgi.00423.2002 . published American Journal of Physiology-Gastrointestinal and Liver Physiology
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