Clinical relevance of non-invasive biomarkers in bone and soft tissue tumors

Overview

Project Summary

Bone and soft tissue sarcoma are rare and with high biological and clinical heterogeneity. These features highlight the need for more predictive and personalized biomarkers that ensure a better post-treatment follow-up. 

Main Goals

This project aims to develop a molecular signature in the peripheral blood of bone and soft tissue sarcoma patients for improved diagnosis, prognosis, and real-time monitoring of disease progression and metastasis. Utilizing liquid biopsies, specifically circulating tumor cells, cell-free circulating DNA (cfDNA), cell-free circulating tumor RNA (ctRNA), extracellular vesicles (EVs), and tumor-educated platelets (TEPs), the study seeks to identify the most effective methodology among these components. The goal is to provide a non-invasive and comprehensive approach to enhance the understanding and management of these rare and heterogeneous tumors.

Project Details