High-throughput screening
miRNAs
Small molecules
Extracellular Vesicles
Regenerative Medicine
Stem Cells
Native and Bioengineered Extracellular Vehicles for Regenerative Medicine
Nature-inspired drug delivery systems
High-throughput phenotypic screening for Regenerative Medicine
Inspired by the basic principles of Cell Biology, ACT aims to restore/regenerate damaged/worn out tissues. The group uses (i) high-throughput screening approaches and stem cell-based assays to identify small molecules and miRNAs capable of enhancing tissue function and/or regeneration and (ii) nature-inspired delivery systems for in vivo delivery of the selected molecules. We are particularly interested on improving cell survival upon in vivo transplantation and on the use of extracellular vehicles as therapeutic tools, both in their native form as well as after modulation with molecules of interest.
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Information about journal articles, updated at 29-12-2024, from platform CIÊNCIAVITAE.
Exogenous loading of miRNAs into small extracellular vesicles
Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al, 2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids
High-throughput identification of small molecules that affect human embryonic vascular development.
Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 .
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D., 2010. Proceedings of the National Academy of Sciences of the United States of America. 13614 - 13619. 31. 107. 2010. 10.1073/pnas.1003600107 . Proceedings of the National Academy of Sciences of the United States of America
A small molecule approach to engineering vascularized tissue
Doorn, Joyce; Fernandes, Hugo A. M.; Le, Bach Q.; van de Peppel, Jeroen; van Leeuwen, Johannes P. T. M.; De Vries, Margreet R.; Aref, Zeen; et al, 2013. Biomaterials. 3053 - 3063. 12. 34. 2013. 10.1016/j.biomaterials.2012.12.037 . Biomaterials
Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells
Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al, 2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy
A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
Barradas, Ana M.C.; Fernandes, Hugo A.M.; Groen, Nathalie; Chai, Yoke Chin; Schrooten, Jan; van de Peppel, Jeroen; van Leeuwen, Johannes P.T.M.; van Blitterswijk, Clemens A.; de Boer, Jan, 2012. Biomaterials. 3205 - 3215. 11. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.01.020 . 10.1016/j.biomaterials.2012.01.020 . Biomaterials
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino, 2020. Nature Reviews Cardiology. 685 - 697. 11. 17. 2020. http://dx.doi.org/10.1038/s41569-020-0389-5 . 10.1038/s41569-020-0389-5 . Nature Reviews Cardiology
5 8 out of 8 Featured Publications
Information about journal articles, updated at 29-12-2024, from platform CIÊNCIAVITAE.
Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells
Vilaça, Andreia; Jesus, Carlos; Lino, Miguel; Hayman, Danika; Emanueli, Costanza; Terracciano, Cesare M.; Fernandes, Hugo; de Windt, Leon J.; Ferreira, Lino, 2024. Molecular Therapy - Nucleic Acids. 2024. http://dx.doi.org/10.1016/j.omtn.2024.102233 . 10.1016/j.omtn.2024.102233 . accepted Molecular Therapy - Nucleic Acids
POSEIDON: Peptidic Objects SEquence-based Interaction with cellular DOmaiNs: a new database and predictor
Preto, António J.; Caniceiro, Ana B.; Duarte, Francisco; Fernandes, Hugo; Ferreira, Lino; Mourão, Joana; Moreira, Irina S., 2024. Journal of Cheminformatics. 1. 16. 2024. http://dx.doi.org/10.1186/s13321-024-00810-7 . 10.1186/s13321-024-00810-7 . Journal of Cheminformatics
TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status
Ramos Rego, Inês; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; et al, 2023. Antioxidants. 2. 12. 2023. http://dx.doi.org/10.3390/antiox12020381 . 10.3390/antiox12020381 . Antioxidants
Intercellular transfer of miR-200c-3p impairs the angiogenic capacity of cardiac endothelial cells
Ottaviani, L.; Juni, R.P.; de Abreu, R.C.; Sansonetti, M.; Sampaio-Pinto, V.; Halkein, J.; Hegenbarth, J.C.; et al, 2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.03.002 . 10.1016/j.ymthe.2022.03.002 . Molecular Therapy
Extracellular vesicles enriched with an endothelial cell pro-survival microRNA affects skin tissue regeneration
Fernandes, Hugo; Zonnari, Alessandra; Abreu, Ricardo; Aday, Sezin; Barão, Marta; Albino, Inês; Lino, Miguel; et al, 2022. Molecular Therapy - Nucleic Acids. 307 - 327. 28. 2022. http://dx.doi.org/10.1016/j.omtn.2022.03.018 . 10.1016/j.omtn.2022.03.018 . Molecular Therapy - Nucleic Acids
Strategies and challenges for non-viral delivery of non-coding RNAs to the heart
Vilaça, Andreia; de Windt, Leon J.; Fernandes, Hugo; Ferreira, Lino, 2022. Trends in Molecular Medicine. 2022. http://dx.doi.org/10.1016/j.molmed.2022.10.002 . 10.1016/j.molmed.2022.10.002 . in press Trends in Molecular Medicine
MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease
Esteves, Marta; Abreu, Ricardo; Fernandes, Hugo; Serra-Almeida, Catarina; Martins, Patrícia A.T.; Barão, Marta; Cristóvão, Ana Clara; et al, 2022. Molecular Therapy. 2022. http://dx.doi.org/10.1016/j.ymthe.2022.06.003 . 10.1016/j.ymthe.2022.06.003 . Molecular Therapy
High-throughput screening of nanoparticles in drug delivery
Inês Tomé; Vitor Francisco; Hugo Fernandes; Lino Ferreira, 2021. APL Bioengineering. 2021. https://doi.org/10.1063/5.0057204 . 10.1063/5.0057204 . APL Bioengineering
Exogenous loading of miRNAs into small extracellular vesicles
Abreu, Ricardo C.; Ramos, Cristiana V.; Becher, Clarissa; Lino, Miguel; Jesus, Carlos; Costa Martins, Paula A.; Martins, Patrícia A. T.; et al, 2021. Journal of Extracellular Vesicles. 10. 10. 2021. http://dx.doi.org/10.1002/jev2.12111 . 10.1002/jev2.12111 . Journal of Extracellular Vesicles
A high-throughput screening platform to identify nanocarriers for efficient delivery of RNA-based therapies
Francisco, Vitor; Rebelo, Catarina; Rodrigues, Artur Filipe; Blersch, Josephine; Fernandes, Hugo; Ferreira, Lino, 2020. Methods. 2020. http://dx.doi.org/10.1016/j.ymeth.2020.12.002 . 10.1016/j.ymeth.2020.12.002 . Methods
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, 2020. Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers
Native and bioengineered extracellular vesicles for cardiovascular therapeutics
de Abreu, Ricardo Cerqueira; Fernandes, Hugo; da Costa Martins, Paula A.; Sahoo, Susmita; Emanueli, Costanza; Ferreira, Lino, 2020. Nature Reviews Cardiology. 685 - 697. 11. 17. 2020. http://dx.doi.org/10.1038/s41569-020-0389-5 . 10.1038/s41569-020-0389-5 . Nature Reviews Cardiology
The role of ENPP1/PC-1 in osteoinduction by calcium phosphate ceramics
Othman, Ziryan; Fernandes, Hugo; Groot, Arjan J.; Luider, Theo M.; Alcinesio, Alessandro; Pereira, Daniel de Melo; Guttenplan, Alexander P.M.; Yuan, Huipin; Habibovic, Pamela, 2019. Biomaterials. 12 - 24. 210. 2019. http://dx.doi.org/10.1016/j.biomaterials.2019.04.021 . 10.1016/j.biomaterials.2019.04.021 . Biomaterials
From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation
Honglin Chen; Danielle F. Baptista; Giuseppe Criscenti; João Crispim; Hugo Fernandes; Clemens van Blitterswijk; Roman Truckenmüller; Lorenzo Moroni, 2019. Nanoscale. 14312 - 14321. 30. 11. 2019. https://doi.org/10.1039/C8NR10108F . 10.1039/C8NR10108F . Nanoscale
A High-Throughput Screening Method to Identify Compounds Displaying Human Vascular Embryonic Toxicity
Rosa, Susana; Pitrez, Patrícia; Fernandes, Hugo; Ferreira, Lino, 2019. Current Protocols in Stem Cell Biology. 1. 50. 2019. http://dx.doi.org/10.1002/cpsc.93 . 10.1002/cpsc.93 . Current Protocols in Stem Cell Biology
Bioactive Tape With BMP-2 Binding Peptides Captures Endogenous Growth Factors and Accelerates Healing After Anterior Cruciate Ligament Reconstruction.
Crispim JF; Fu SC; Lee YW; Fernandes HAM; Jonkheijm P; Yung PSH; Saris DBF, 2018. The American journal of sports medicine. 2018. http://europepmc.org/abstract/med/30074814 . 10.1177/0363546518787507 . The American journal of sports medicine
Muscle-Secreted Factors Improve Anterior Cruciate Ligament Graft Healing: An In Vitro and In Vivo Analysis
Ghebes, Corina Adriana; Groen, Nathalie; Cheuk, Yau Chuk; Fu, Sai Chuen; Fernandes, Hugo Machado; Saris, Daniel B.F., 2018. Tissue Engineering Part A. 322 - 334. 3-4. 24. 2018. http://dx.doi.org/10.1089/ten.tea.2016.0546 . 10.1089/ten.tea.2016.0546 . Tissue Engineering Part A
Soft-molecular imprinted electrospun scaffolds to mimic specific biological tissues.
Criscenti G; De Maria C; Longoni A; van Blitterswijk CA; Fernandes HAM; Vozzi G; Moroni L, 2018. Biofabrication. 2018. http://europepmc.org/abstract/med/30024388 . 10.1088/1758-5090/aad48a . Biofabrication
Prolotherapy Induces an Inflammatory Response in Human Tenocytes In Vitro
Ekwueme, Emmanuel C.; Mohiuddin, Mahir; Yarborough, Jazmin A.; Brolinson, P. Gunnar; Docheva, Denitsa; Fernandes, Hugo A. M.; Freeman, Joseph W., 2017. Clinical Orthopaedics and Related Research®. 2117 - 2127. 8. 475. 2017. http://dx.doi.org/10.1007/s11999-017-5370-1 . 10.1007/s11999-017-5370-1 . Clinical Orthopaedics and Related Research®
High throughput screening of photocatalytic conversion of pharmaceutical contaminants in water
Romão, Joana; Barata, David; Ribeiro, Nelson; Habibovic, Pamela; Fernandes, Hugo; Mul, Guido, 2017. Environmental Pollution. 1199 - 1207. 220. 2017. http://dx.doi.org/10.1016/j.envpol.2016.11.015 . 10.1016/j.envpol.2016.11.015 . Environmental Pollution
High-throughput identification of small molecules that affect human embryonic vascular development.
Vazão H; Rosa S; Barata T; Costa R; Pitrez PR; Honório I; de Vries MR; et al, 2017. 2017. http://europepmc.org/abstract/med/28348206 . 10.1073/pnas.1617451114 .
TGF-ß1 activation in human hamstring cells through growth factor binding peptides on polycaprolactone surfaces
Crispim, J.; Fernandes, H.A.M.; Fu, S.C.; Lee, Y.W.; Jonkheijm, P.; Saris, D.B.F., 2017. Acta Biomaterialia. 165 - 178. 53. 2017. http://dx.doi.org/10.1016/j.actbio.2017.01.066 . 10.1016/j.actbio.2017.01.066 . Acta Biomaterialia
Means of enhancing bone fracture healing: optimal cell source, isolation methods and acoustic stimulation.
Ghebes CA; Braham MV; Zeegers AV; Renard AJ; Fernandes H; Saris DB, 2016. 2016. http://europepmc.org/abstract/med/27955656 .
High-Throughput Screening Assay Identifies Small Molecules Capable of Modulating the BMP-2 and TGF-ß1 Signaling Pathway
Ghebes, Corina-Adriana; van Lente, Jéré; Post, Janine Nicole; Saris, Daniel B. F.; Fernandes, Hugo, 2016. SLAS DISCOVERY: Advancing Life Sciences R&D. 40 - 50. 1. 22. 2016. http://dx.doi.org/10.1177/1087057116669346 . 10.1177/1087057116669346 . SLAS DISCOVERY: Advancing Life Sciences R&D
Anterior cruciate ligament- and hamstring tendon-derived cells: in vitro differential properties of cells involved in ACL reconstruction
Ghebes, Corina Adriana; Kelder, Cindy; Schot, Thomas; Renard, Auke J.; Pakvis, Dean F. M.; Fernandes, Hugo; Saris, Daniel B., 2015. Journal of Tissue Engineering and Regenerative Medicine. 1077 - 1088. 4. 11. 2015. http://dx.doi.org/10.1002/term.2009 . 10.1002/term.2009 . Journal of Tissue Engineering and Regenerative Medicine
Cross-Talk Between Human Tenocytes and Bone Marrow Stromal Cells Potentiates Extracellular Matrix Remodeling In Vitro
Ekwueme, Emmanuel C.; Shah, Jay V.; Mohiuddin, Mahir; Ghebes, Corina A.; Crispim, João F.; Saris, Daniël B.F.; Fernandes, Hugo A.M.; Freeman, Joseph W., 2015. Journal of Cellular Biochemistry. 684 - 693. 3. 117. 2015. http://dx.doi.org/10.1002/jcb.25353 . 10.1002/jcb.25353 . Journal of Cellular Biochemistry
High throughput screening assay for the identification of compounds enhancing collagenous extracellular matrix production by ATDC5 cells.
Le B; Fernandes H; Bouten C; Karperien M; van Blitterswijk C; de Boer J, 2015. 2015. http://europepmc.org/abstract/med/25604243 . 10.1089/ten.TEC.2014.0088 .
Spatiotemporal proliferation of human stromal cells adjusts to nutrient availability and leads to stanniocalcin-1 expression in vitro and in vivo
Higuera, Gustavo A.; Fernandes, Hugo; Spitters, Tim W.G.M.; van de Peppel, Jeroen; Aufferman, Nils; Truckenmueller, Roman; Escalante, Maryana; et al, 2015. Biomaterials. 190 - 202. 61. 2015. http://dx.doi.org/10.1016/j.biomaterials.2015.05.017 . 10.1016/j.biomaterials.2015.05.017 . Biomaterials
A small molecule approach to engineering vascularized tissue
Doorn, Joyce; Fernandes, Hugo A. M.; Le, Bach Q.; van de Peppel, Jeroen; van Leeuwen, Johannes P. T. M.; De Vries, Margreet R.; Aref, Zeen; et al, 2013. Biomaterials. 3053 - 3063. 12. 34. 2013. 10.1016/j.biomaterials.2012.12.037 . Biomaterials
Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes
Thakkar, Shraddha; Ghebes, Corina A.; Ahmed, Maqsood; Kelder, Cindy; van Blitterswijk, Clemens A.; Saris, Daniel; Fernandes, Hugo A. M.; Moroni, Lorenzo, 2013. Biofabrication. 2. 5. 2013. 10.1088/1758-5082/5/2/025003 . Biofabrication
Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells
Barradas, Ana M. C.; Monticone, Veronica; Hulsman, Marc; Danoux, Charlene; Fernandes, Hugo; Birgani, Zeinab Tahmasebi; Barrere-de Groot, Florence; et al, 2013. Integrative Biology. 920 - 931. 7. 5. 2013. 10.1039/c3ib40027a . Integrative Biology
Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and ß-tricalcium phosphate.
Prins HJ; Fernandes H; Rozemuller H; van Blitterswijk C; de Boer J; Martens AC, 2012. 2012. http://europepmc.org/abstract/med/23255230 . 10.1002/term.1681 .
Endothelial Differentiation of Mesenchymal Stromal Cells
Portalska, Karolina Janeczek; Leferink, Anne; Groen, Nathalie; Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan, 2012. Plos One. 10. 7. 2012. 10.1371/journal.pone.0046842 . Plos One
A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
Barradas, Ana M.C.; Fernandes, Hugo A.M.; Groen, Nathalie; Chai, Yoke Chin; Schrooten, Jan; van de Peppel, Jeroen; van Leeuwen, Johannes P.T.M.; van Blitterswijk, Clemens A.; de Boer, Jan, 2012. Biomaterials. 3205 - 3215. 11. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.01.020 . 10.1016/j.biomaterials.2012.01.020 . Biomaterials
The influence of genetic factors on the osteoinductive potential of calcium phosphate ceramics in mice
Barradas, Ana M.C.; Yuan, Huipin; van der Stok, Johan; Le Quang, Bach; Fernandes, Hugo; Chaterjea, Anindita; Hogenes, Marieke C.H.; et al, 2012. Biomaterials. 5696 - 5705. 23. 33. 2012. http://dx.doi.org/10.1016/j.biomaterials.2012.04.021 . 10.1016/j.biomaterials.2012.04.021 . Biomaterials
'Smart' biomaterials and osteoinductivity
Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D., 2011. Nature Reviews Rheumatology. 1 - 1. 4. 7. 2011. 10.1038/nrrheum.2010.210-c1 . Nature Reviews Rheumatology
Fabrication of Bioactive Composite Scaffolds by Electrospinning for Bone Regeneration
Nandakumar, Anandkumar; Fernandes, Hugo; de Boer, Jan; Moroni, Lorenzo; Habibovic, Pamela; van Blitterswijk, Clemens A., 2010. Macromolecular Bioscience. 1365 - 1373. 11. 10. 2010. http://dx.doi.org/10.1002/mabi.201000145 . 10.1002/mabi.201000145 . Macromolecular Bioscience
Effect of Chordin-Like 1 on MC3T3-E1 and Human Mesenchymal Stem Cells
Fernandes, Hugo; Dechering, Koen; van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Mentink, Anouk; van Blitterswijk, Clemens; de Boer, Jan, 2010. Cells Tissues Organs. 443 - 452. 6. 191. 2010. 10.1159/000281825 . Cells Tissues Organs
In vivo evaluation of highly macroporous ceramic scaffolds for bone tissue engineering
Teixeira, S.; Fernandes, H.; Leusink, A.; van Blitterswijk, C.; Ferraz, M. P.; Monteiro, F. J.; de Boer, J., 2010. Journal of Biomedical Materials Research Part a. 567 - 575. 2. 93A. 2010. 10.1002/jbm.a.32532 . Journal of Biomedical Materials Research Part a
Osteoinductive ceramics as a synthetic alternative to autologous bone grafting
Yuan, Huipin; Fernandes, Hugo; Habibovic, Pamela; de Boer, Jan; Barradas, Ana M. C.; de Ruiter, Ad; Walsh, William R.; van Blitterswijk, Clemens A.; de Bruijn, Joost D., 2010. Proceedings of the National Academy of Sciences of the United States of America. 13614 - 13619. 31. 107. 2010. 10.1073/pnas.1003600107 . Proceedings of the National Academy of Sciences of the United States of America
In Vitro and In Vivo Bioluminescent Imaging of Hypoxia in Tissue-Engineered Grafts
Liu, Jun; Barradas, Ana; Fernandes, Hugo; Janssen, Frank; Papenburg, Bernke; Stamatialis, Dimitrios; Martens, Anton; van Blitterswijk, Clemens; de Boer, Jan, 2010. Tissue Engineering Part C-Methods. 479 - 485. 3. 16. 2010. 10.1089/ten.tec.2009.0278 . Tissue Engineering Part C-Methods
Endogenous Collagen Influences Differentiation of Human Multipotent Mesenchymal Stromal Cells
Fernandes, Hugo; Mentink, Anouk; Bank, Ruud; Stoop, Reinout; van Blitterswijk, Clemens; de Boer, Jan, 2010. Tissue Engineering Part a. 1693 - 1702. 5. 16. 2010. 10.1089/ten.tea.2009.0341 . Tissue Engineering Part a
Growth, Metabolism, and Growth Inhibitors of Mesenchymal Stem Cells
Schop, Deborah; Janssen, Frank W.; van Rijn, Linda D.S.; Fernandes, Hugo; Bloem, Rolf M.; de Bruijn, Joost D.; van Dijkhuizen-Radersma, Riemke, 2009. Tissue Engineering Part A. 1877 - 1886. 8. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2008.0345 . 10.1089/ten.tea.2008.0345 . Tissue Engineering Part A
cAMP/PKA Signaling Inhibits Osteogenic Differentiation and Bone Formation in Rodent Models
Siddappa, Ramakrishnaiah; Mulder, Winfried; Steeghs, Ilse; van de Klundert, Christine; Fernandes, Hugo; Liu, Jun; Arends, Roel; van Blitterswijk, Clemens; de Boer, Jan, 2009. Tissue Engineering Part A. 2135 - 2143. 8. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2008.0512 . 10.1089/ten.tea.2008.0512 . Tissue Engineering Part A
The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells
Fernandes, Hugo; Dechering, Koen; Van Someren, Eugene; Steeghs, Ilse; Apotheker, Marion; Leusink, Anouk; Bank, Ruud; et al, 2009. Tissue Engineering Part A. 3857 - 3867. 12. 15. 2009. http://dx.doi.org/10.1089/ten.tea.2009.0011 . 10.1089/ten.tea.2009.0011 . Tissue Engineering Part A
Extracellular matrix and tissue engineering applications
Fernandes, Hugo; Moroni, Lorenzo; van Blitterswijk, Clemens; de Boer, Jan, 2009. Journal of Materials Chemistry. 5474 - 5484. 31. 19. 2009. 10.1039/b822177d . Journal of Materials Chemistry
Mesenchymal stem cell proliferation and morphological analysis on interconnected macroporous structures
Teixeira, S.; Fernandes, H.M.; De Boer, J.; Ferraz, M.P.; Monteiro, F.J., 2007. Key Engineering Materials. 1129 - 1132. 330-332 II. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846317063&partnerID=MN8TOARS . Key Engineering Materials
The response of human mesenchymal stem cells to osteogenic signals and its impact on bone tissue engineering.
Siddappa, Ramakrishnaiah; Fernandes, Hugo; Liu, Jun; van Blitterswijk, Clemens; de Boer, Jan, 2007. Current stem cell research & therapy. 209 - 20. 3. 2. 2007. 10.2174/157488807781696267 . Current stem cell research & therapy
5 48 out of 48 Publications
Best paper award 2010-11 (Dutch Bone and Mineral Society; Nov 2011)
Science factor (best scientific project) (University Twente; Mar 2010)
Finalist UTBusiness (best business plan) (University Twente; Mar 2010)
FCT Scientific Employment Stimulus award
CEECIND/01880/2018
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