Neuroscience and Disease
Neurobiology of Mental Disorders
Fear/Anxiety
Rett syndrome
Down syndrome
MeCP2
NT3-TrkC
Research lines
NT3-TrkC signaling in the regulation of fear memories
MeCP2 and early-life stress interaction effects on anxiety
Fear/Anxiety
Rett syndrome
Down syndrome
MeCP2
NT3-TrkC
NT3-TrkC signaling in the regulation of fear memories
MeCP2 and early-life stress interaction effects on anxiety
We are centered in understanding the neural substrates and molecular mechanisms underlying emotion (fear and anxiety), cognition (learning and memory) and how emotion-cognition dysfunction contributes to the development of psychiatric disorders. To address these questions, we use Human Genetics and Mouse Models of Disease. We have a strong expertise in rodent behavior, we combine genetic and pharmacological tools with stereotactic interventions and we use molecular, cellular and genetic readouts.
Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.
MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress
Beatriz Rodrigues; Ricardo A. Leitão; Mónica Santos; Alexander Trofimov; Mariline Silva; Ângela S. Inácio; Mónica Abreu; et al, 2024. Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02715-1 . 10.1038/s41380-024-02715-1 . Molecular Psychiatry
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Masella, Gianluca; Silva, Francisca; Corti, Elisa; Azkona, Garikoitz; Madeira, Maria Francisca; Tomé, Ângelo R.; Ferreira, Samira G.; et al, 2024. Molecular Psychiatry. 2024. http://dx.doi.org/10.1038/s41380-024-02412-z . 10.1038/s41380-024-02412-z . in press Molecular Psychiatry
TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory
Francisca Silva; Gianluca Masella; Maria Francisca Madeira; Carlos B. Duarte; Mónica Santos, 2023. Molecular Neurobiology. 2023. https://doi.org/10.1007/s12035-023-03292-0 . 10.1007/s12035-023-03292-0 . Molecular Neurobiology
MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
María Abellán-Álvaro; Oliver Stork; Carmen Agustín-Pavón; Mónica Santos, 2021. Journal of Neurodevelopmental Disorders. 2021. https://doi.org/10.1186/s11689-021-09409-7 . 10.1186/s11689-021-09409-7 . Journal of Neurodevelopmental Disorders
Male-specific features are reduced in Mecp2-null mice: analyses of vasopressinergic innervation, pheromone production and social behaviour
Elena Martínez-Rodríguez; Ana Martín-Sánchez; Emre Kul; Aparajita Bose; Francisco José Martínez-Martínez; Oliver Stork; Fernando Martínez-García; et al, 2020. Brain Structure and Function. 2219 - 2238. 7. 225. 2020. https://doi.org/10.1007/s00429-020-02122-6 . 10.1007/s00429-020-02122-6 . Brain Structure and Function
Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system
Martínez-Rodríguez, Elena; Martín-Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Stork, Oliver; Martínez-García, Fernando; et al, 2019. Brain Structure and Function. 1647 - 1658. 4. 224. 2019. http://dx.doi.org/10.1007/s00429-019-01860-6 . 10.1007/s00429-019-01860-6 . published Brain Structure and Function
Erratum: Correction: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy (PLoS genetics (2017) 13 3 (e1006684))
Altmüller, F.; Pothula, S.; Annamneedi, A.; Nakhaei-Rad, S.; Montenegro-Venegas, C.; Pina-Fernández, E.; Marini, C.; et al, 2017. PLoS genetics. e1006843 - e1006843. 6. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054771599&partnerID=MN8TOARS . 10.1371/journal.pgen.1006843 . PLoS genetics
Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome
Castro, Hoanna; Kul, Emre; Buijsen, Ronald A.M.; Severijnen, Lies-Anne W.F.M.; Willemsen, Rob; Hukema, Renate K.; Stork, Oliver; Santos, Mónica, 2017. Human Molecular Genetics. 2133 - 2145. 11. 26. 2017. http://dx.doi.org/10.1093/hmg/ddx108 . 10.1093/hmg/ddx108 . published Human Molecular Genetics
Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.
Altmüller F; Pothula S; Annamneedi A; Nakhaei-Rad S; Montenegro-Venegas C; Pina-Fernández E; Marini C; et al, 2017. PLoS genetics. 2017. http://europepmc.org/abstract/med/28346493 . 10.1371/journal.pgen.1006684 . PLoS genetics
Infralimbic Neurotrophin-3 Infusion Rescues Fear Extinction Impairment in a Mouse Model of Pathological Fear
D'Amico, Davide; Gener, Thomas; de Lagrán, Maria Martínez; Sanchez-Vives, Maria V; Santos, Mónica; Dierssen, Mara, 2016. Neuropsychopharmacology. 462 - 472. 2. 42. 2016. http://dx.doi.org/10.1038/npp.2016.154 . 10.1038/npp.2016.154 . published Neuropsychopharmacology
Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) Motor Dysfunction Modeled in Mice
Foote, Molly; Arque, Gloria; Berman, Robert F.; Santos, Mónica, 2016. The Cerebellum. 611 - 622. 5. 15. 2016. http://dx.doi.org/10.1007/s12311-016-0797-6 . 10.1007/s12311-016-0797-6 . published The Cerebellum
Genome-wide miR-155 and miR-802 target gene identification in the hippocampus of Ts65Dn Down syndrome mouse model by miRNA sponges
Bofill-De Ros, Xavier; Santos, Mónica; Vila-Casadesús, Maria; Villanueva, Eneko; Andreu, Nuria; Dierssen, Mara; Fillat, Cristina, 2015. BMC Genomics. 1. 16. 2015. http://dx.doi.org/10.1186/s12864-015-2160-6 . 10.1186/s12864-015-2160-6 . published BMC Genomics
From neural to genetic substrates of panic disorder: Insights from human and mouse studies
Santos, Mónica; D’Amico, Davide; Dierssen, Mara, 2015. European Journal of Pharmacology. 127 - 141. 759. 2015. http://dx.doi.org/10.1016/j.ejphar.2015.03.039 . 10.1016/j.ejphar.2015.03.039 . published European Journal of Pharmacology
Identification of key genes involved in Down syndrome pathogenesis by gene therapy,Identificación de genes clave implicados en el síndrome de Down mediante terapia génica
Fillat, C.; Bofill-De Ros, X.; Santos, M.; Martín, E.D.; Andreu, N.; Villanueva, E.; D'Amico, D.; Dierssen, M.; Altafaj, X., 2014. SD Revista Medica Internacional sobre el Sindrome de Down. 21 - 28. 2. 18. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940262370&partnerID=MN8TOARS . 10.1016/S1138-2074(14)70049-1 . published SD Revista Medica Internacional sobre el Sindrome de Down
Hippocampal Hyperexcitability Underlies Enhanced Fear Memories in TgNTRK3, a Panic Disorder Mouse Model
Santos, M.; D'Amico, D.; Spadoni, O.; Amador-Arjona, A.; Stork, O.; Dierssen, M., 2013. Journal of Neuroscience. 15259 - 15271. 38. 33. 2013. http://dx.doi.org/10.1523/jneurosci.2161-13.2013 . 10.1523/jneurosci.2161-13.2013 . published Journal of Neuroscience
Rett syndrome with and without detected MECP2 mutations: An attempt to redefine phenotypes
Temudo, Teresa; Santos, Mónica; Ramos, Elisabete; Dias, Karin; Vieira, José Pedro; Moreira, Ana; Calado, Eulália; et al, 2011. Brain and Development. 69 - 76. 1. 33. 2011. http://dx.doi.org/10.1016/j.braindev.2010.01.004 . 10.1016/j.braindev.2010.01.004 . published Brain and Development
Monoamine deficits in the brain of methyl-CpG binding protein 2 null mice suggest the involvement of the cerebral cortex in early stages of Rett syndrome
Santos, M.; Summavielle, T.; Teixeira-Castro, A.; Silva-Fernandes, A.; Duarte-Silva, S.; Marques, F.; Martins, L.; et al, 2010. Neuroscience. 453 - 467. 2. 170. 2010. http://dx.doi.org/10.1016/j.neuroscience.2010.07.010 . 10.1016/j.neuroscience.2010.07.010 . published Neuroscience
Mutations in the MECP2 Gene Are Not a Major Cause of Rett Syndrome-Like or Related Neurodevelopmental Phenotype in Male Patients
Santos, Mónica; Temudo, Teresa; Kay, Teresa; Carrilho, Inês; Medeira, Ana; Cabral, Helena; Gomes, Roseli; et al, 2009. Journal of Child Neurology. 49 - 55. 1. 24. 2009. http://dx.doi.org/10.1177/0883073808321043 . 10.1177/0883073808321043 . published Journal of Child Neurology
The C677T Polymorphism inMTHFRIs Not Associated with Migraine in Portugal
Ferro, Anabela; Castro, Maria-José; Lemos, Carolina; Santos, Mónica; Sousa, Alda; Pereira-Monteiro, José; Sequeiros, Jorge; Maciel, Patrícia, 2008. Disease Markers. 107 - 113. 2. 25. 2008. http://dx.doi.org/10.1155/2008/178679 . 10.1155/2008/178679 . published Disease Markers
Analysis of Highly Conserved Regions of the 3’UTR of MECP2 Gene in Patients with Clinical Diagnosis of Rett Syndrome and Other Disorders Associated with Mental Retardation
Santos, Mónica; Yan, Jin; Temudo, Teresa; Oliveira, Guiomar; Vieira, José Pedro; Fen, Jinong; Sommer, Steve; Maciel, Patrícia, 2008. Disease Markers. 319 - 324. 6. 24. 2008. http://dx.doi.org/10.1155/2008/738401 . 10.1155/2008/738401 . published Disease Markers
T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population
Carvalho, A.; Santos, M.; Maciel, P.; Rodrigues, F., 2008. Multiple Sclerosis Journal. 550 - 552. 4. 14. 2008. http://dx.doi.org/10.1177/1352458507084594 . 10.1177/1352458507084594 . published Multiple Sclerosis Journal
Corrigendum to "Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans" [J. Neuroimmunol. 179 (2006) 108-116] (DOI:10.1016/j.jneuroim.2006.06.003)
Ban, M.; Booth, D.; Heard, R.; Stewart, G.; Goris, A.; Vandenbroeck, K.; Dubois, B.; et al, 2007. Journal of Neuroimmunology. 175 - 176. 1-2. 189. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548554091&partnerID=MN8TOARS . 10.1016/j.jneuroim.2007.08.003 . Journal of Neuroimmunology
Stereotypies in Rett syndrome: Analysis of 83 patients with and without detected MECP2 mutations
Temudo, T.; Oliveira, P.; Santos, M.; Dias, K.; Vieira, J.; Moreira, A.; Calado, E.; et al, 2007. Neurology. 1183 - 1187. 15. 68. 2007. http://dx.doi.org/10.1212/01.wnl.0000259086.34769.78 . 10.1212/01.wnl.0000259086.34769.78 . published Neurology
MECP2 coding sequence and 3'UTR variation in 172 unrelated autistic patients
Coutinho, Ana M.; Oliveira, Guiomar; Katz, Cécile; Feng, Jinong; Yan, Jin; Yang, Chunmei; Marques, Carla; et al, 2007. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 475 - 483. 4. 144B. 2007. http://dx.doi.org/10.1002/ajmg.b.30490 . 10.1002/ajmg.b.30490 . published American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
An explanation for another familial case of Rett syndrome: maternal germline mosaicism
Venâncio, Margarida; Santos, Mónica; Pereira, Susana Aires; Maciel, Patrícia; Saraiva, Jorge M, 2007. European Journal of Human Genetics. 902 - 904. 8. 15. 2007. http://dx.doi.org/10.1038/sj.ejhg.5201835 . 10.1038/sj.ejhg.5201835 . published European Journal of Human Genetics
Evidence for abnormal early development in a mouse model of Rett syndrome.
Santos M; Silva-Fernandes A; Oliveira P; Sousa N; Maciel P; Santos, M.; Silva-Fernandes, A.; et al, 2007. Genes, Brain and Behavior. 277 - 286. 3. 6. 2007. http://europepmc.org/abstract/med/16848781 . 10.1111/j.1601-183X.2006.00258.x . published Genes, Brain and Behavior
Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
The GAMES Collaborative Group, 2006. Journal of Neuroimmunology. 108 - 116. 1-2. 179. 2006. http://dx.doi.org/10.1016/j.jneuroim.2006.06.003 . 10.1016/j.jneuroim.2006.06.003 . published Journal of Neuroimmunology
Chromatin remodeling and neuronal function: exciting links
Santos, M.; Coelho, P. A.; Maciel, P., 2006. Genes, Brain and Behavior. 80 - 91. 5. 2006. http://dx.doi.org/10.1111/j.1601-183x.2006.00227.x . 10.1111/j.1601-183x.2006.00227.x . published Genes, Brain and Behavior
APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers
Burwick, R. M.; Ramsay, P. P.; Haines, J. L.; Hauser, S. L.; Oksenberg, J. R.; Pericak-Vance, M. A.; Schmidt, S.; et al, 2006. Neurology. 1373 - 1383. 9. 66. 2006. http://dx.doi.org/10.1212/01.wnl.0000210531.19498.3f . 10.1212/01.wnl.0000210531.19498.3f . published Neurology
Detection of heterozygous deletions and duplications in the MECP2 gene in Rett syndrome by Robust Dosage PCR (RD-PCR)
Shi, Jinxiu; Shibayama, Akane; Liu, Qiang; Nguyen, Vu Q.; Feng, Jinong; Santos, Monica; Temudo, Teresa; Maciel, Patricia; Sommer, Steve S., 2005. Human Mutation. 505 - 505. 5. 25. 2005. http://dx.doi.org/10.1002/humu.9338 . 10.1002/humu.9338 . published Human Mutation
Genotypes at the APOE and SCA2 loci do not predict the course of multiple sclerosis in patients of Portuguese origin
Santos, Mónica; do Carmo Costa, Maria; Rio, Maria Edite; Sá, Maria José; Monteiro, Marta; Valença, Angela; Sá, Alfredo; et al, 2004. Multiple Sclerosis Journal. 153 - 157. 2. 10. 2004. http://dx.doi.org/10.1191/1352458504ms998oa . 10.1191/1352458504ms998oa . published Multiple Sclerosis Journal
A whole genome screen for association with multiple sclerosis in Portuguese patients
Santos, M.; Pinto-Basto, J.; Rio, M.E.; Sá, M.J.; Valença, A.; Sá, A.; Dinis, J.; et al, 2003. Journal of Neuroimmunology. 112 - 115. 1-2. 143. 2003. http://dx.doi.org/10.1016/j.jneuroim.2003.08.023 . 10.1016/j.jneuroim.2003.08.023 . published Journal of Neuroimmunology
5 32 out of 32 Publications
CGC Genetics award Professor Doutor Amândio Tavares (3rd position). Clinical and Genetic Study of Rett Syndrome in Portugal
Premi Biennal d’Investigació Ramon Trias Fargas. Aprenent sobre la síndrome de Down de la mà dels vírus
Marie Sklodowska-Curie Action Seal of Excellence, European Commission. NT3/TrkC signaling in the regulation of fear memories (#889234),
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