Ana Isabel Duarte

Liraglutide Protects Against Brain Amyloid-ß1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation

Ana I. Duarte; Emanuel Candeias; Inês N. Alves; Débora Mena; Daniela F. Silva; Nuno J. Machado; Elisa J. Campos; et al, International Journal of Molecular Sciences. 2020. https://doi.org/10.3390/ijms21051746 . 10.3390/ijms21051746 . International Journal of Molecular Sciences

Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging

Lietzau, Grazyna; Magni, Giulia; Kehr, Jan; Yoshitake, Takashi; Candeias, Emanuel; Duarte, Ana; Pettersson, Hans; et al, Neurobiology of Aging. 2020. http://dx.doi.org/10.1016/j.neurobiolaging.2020.01.004 . 10.1016/j.neurobiolaging.2020.01.004 . Neurobiology of Aging

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice

Pinho, Brígida R.; Duarte, Ana I.; Canas, Paula M.; Moreira, Paula I.; Murphy, Michael P.; Oliveira, Jorge M.A., Free Radical Biology and Medicine. 372 - 382. 146. 2020. http://dx.doi.org/10.1016/j.freeradbiomed.2019.11.021 . 10.1016/j.freeradbiomed.2019.11.021 . Free Radical Biology and Medicine

Current and emerging avenues for Alzheimer's disease drug targets

Duarte, Ana, Journal of Internal Medicine. 2019. http://dx.doi.org/10.1111/joim.12959 . 10.1111/joim.12959 . Journal of Internal Medicine

Brain insulin signalling, glucose metabolism and females' reproductive aging: A dangerous triad in Alzheimer's disease

A.I. Duarte; M.S. Santos; C.R. Oliveira; P.I. Moreira, Neuropharmacology. 2018. https://doi.org/10.1016/j.neuropharm.2018.01.044 . 10.1016/j.neuropharm.2018.01.044 . Neuropharmacology

Dual Therapy with Liraglutide and Ghrelin Promotes Brain and Peripheral Energy Metabolism in the R6/2 Mouse Model of Huntington’s Disease

Ana I. Duarte; Marie Sjögren; Maria S. Santos; Catarina R. Oliveira; Paula I. Moreira; Maria Björkqvist, Scientific Reports. 2018. https://doi.org/10.1038/s41598-018-27121-w . 10.1038/s41598-018-27121-w . Scientific Reports

Ghrelin rescues skeletal muscle catabolic profile in the R6/2 mouse model of Huntington's disease.

Sjögren M; Duarte AI; McCourt AC; Shcherbina L; Wierup N; Björkqvist M, Scientific reports. 2017. http://europepmc.org/abstract/med/29066728 . 10.1038/s41598-017-13713-5 . Scientific reports

Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.

Candeias E; Sebastião I; Cardoso S; Carvalho C; Santos MS; Oliveira CR; Moreira PI; Duarte AI, Molecular neurobiology. 2017. http://europepmc.org/abstract/med/28573460 . 10.1007/s12035-017-0622-3 . Molecular neurobiology

Histone Deacetylase Inhibitors Protect Against Pyruvate Dehydrogenase Dysfunction in Huntington's Disease

Luana Naia; Teresa Cunha-Oliveira; Joana Rodrigues; Tatiana R. Rosenstock; Ana Oliveira; Márcio Ribeiro; Catarina Carmo; et al, The Journal of Neuroscience. 2776 - 2794. 10. 37. 2017. https://doi.org/10.1523%2Fjneurosci.2006-14.2016 . 10.1523/JNEUROSCI.2006-14.2016 . The Journal of Neuroscience

Middle-Aged Diabetic Females and Males Present Distinct Susceptibility to Alzheimer Disease-like Pathology

Candeias, E.; Duarte, A.I.; Sebastião, I.; Fernandes, M.A.; Plácido, A.I.; Carvalho, C.; Correia, S.; et al, Molecular Neurobiology. 1 - 19. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991075553&partnerID=MN8TOARS . 10.1007/s12035-016-0155-1 . Molecular Neurobiology

Insulin and IGF-1 regularize energy metabolites in neural cells expressing full-length mutant huntingtin

Naia, L.; Ribeiro, M.; Rodrigues, J.; Duarte, A.I.; Lopes, C.; Rosenstock, T.R.; Hayden, M.R.; Rego, A.C., Neuropeptides. 73 - 81. 58. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957398906&partnerID=MN8TOARS . 10.1016/j.npep.2016.01.009 . Neuropeptides

Kaurane diterpenes as mitochondrial alterations preventive agents under experimental oxidative stress conditions

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., Pharmaceutical Biology. 705 - 711. 4. 54. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960361628&partnerID=MN8TOARS . 10.3109/13880209.2015.1072829 . Pharmaceutical Biology

The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases

Carvalho, C.; Correia, S.C.; Cardoso, S.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., Expert Review of Neurotherapeutics. 867 - 884. 8. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937838385&partnerID=MN8TOARS . 10.1586/14737175.2015.1058160 . Expert Review of Neurotherapeutics

Testosterone deficiency induced by progressive stages of diabetes mellitus impairs glucose metabolism and favors glycogenesis in mature rat Sertoli cells

Rato, L.; Alves, M.G.; Duarte, A.I.; Santos, M.S.; Moreira, P.I.; Cavaco, J.E.; Oliveira, P.F., International Journal of Biochemistry and Cell Biology. 1 - 10. 66. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936877372&partnerID=MN8TOARS . 10.1016/j.biocel.2015.07.001 . International Journal of Biochemistry and Cell Biology

Modulation of endoplasmic reticulum stress: An opportunity to prevent neurodegeneration?

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Carvalho, C.; Cardoso, S.; Oliveira, C.R.; Moreira, P.I., CNS and Neurological Disorders - Drug Targets. 518 - 533. 4. 14. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929628537&partnerID=MN8TOARS . CNS and Neurological Disorders - Drug Targets

Insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia

Sebastião, I.; Candeias, E.; Santos, M.S.; de Oliveira, C.R.; Moreira, P.I.; Duarte, A.I., Frontiers in Endocrinology. JUL. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905437740&partnerID=MN8TOARS . 10.3389/fendo.2014.00110 . Frontiers in Endocrinology

IGF-1 intranasal administration rescues Huntington's disease phenotypes in YAC128 mice

Lopes, C.; Ribeiro, M.; Duarte, A.I.; Humbert, S.; Saudou, F.; Pereira De Almeida, L.; Hayden, M.; Rego, A.C., Molecular Neurobiology. 1126 - 1142. 3. 49. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902546185&partnerID=MN8TOARS . 10.1007/s12035-013-8585-5 . Molecular Neurobiology

Insulin therapy modulates mitochondrial dynamics and biogenesis, autophagy and tau protein phosphorylation in the brain of type 1 diabetic rats

Santos, R.X.; Correia, S.C.; Alves, M.G.; Oliveira, P.F.; Cardoso, S.; Carvalho, C.; Duarte, A.I.; Santos, M.S.; Moreira, P.I., Biochimica et Biophysica Acta - Molecular Basis of Disease. 1154 - 1166. 7. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899789863&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.04.011 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

Cardoso, S.; Correia, S.; Carvalho, C.; Candeias, E.; Plácido, A.I.; Duarte, A.I.; Seiça, R.M.; Moreira, P.I., Journal of Bioenergetics and Biomembranes. 119 - 131. 1-2. 47. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922536968&partnerID=MN8TOARS . 10.1007/s10863-014-9580-x . Journal of Bioenergetics and Biomembranes

Pre-diabetes alters testicular PGC1-a/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

Rato, L.; Duarte, A.I.; Tomás, G.D.; Santos, M.S.; Moreira, P.I.; Socorro, S.; Cavaco, J.E.; Alves, M.G.; Oliveira, P.F., Biochimica et Biophysica Acta - Bioenergetics. 335 - 344. 3. 1837. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892411578&partnerID=MN8TOARS . 10.1016/j.bbabio.2013.12.008 . Biochimica et Biophysica Acta - Bioenergetics

The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: Implications for Alzheimer's disease

Plácido, A.I.; Pereira, C.M.F.; Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 1444 - 1453. 9. 1842. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903458925&partnerID=MN8TOARS . 10.1016/j.bbadis.2014.05.003 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Naia, L.; Ferreira, I.L.; Cunha-Oliveira, T.; Duarte, A.I.; Ribeiro, M.; Rosenstock, T.R.; Laço, M.N.; et al, Molecular Neurobiology. 331 - 348. 1. 51. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938698507&partnerID=MN8TOARS . 10.1007/s12035-014-8735-4 . Molecular Neurobiology

Mitochondrial-targeted protective properties of isolated diterpenoids from sideritis spp. in response to the deleterious changes induced by H 2O2

González-Burgos, E.; Duarte, A.I.; Carretero, M.E.; Moreira, P.I.; Gómez-Serranillos, M.P., Journal of Natural Products. 933 - 938. 5. 76. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878260967&partnerID=MN8TOARS . 10.1021/np400118d . Journal of Natural Products

Hyperglycemia, hypoglycemia and dementia: Role of mitochondria and uncoupling proteins

Cardoso, S.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., Current Molecular Medicine. 586 - 601. 4. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876735551&partnerID=MN8TOARS . 10.2174/1566524011313040010 . Current Molecular Medicine

Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic huntington's disease carriers

Silva, A.C.; Almeida, S.; Laço, M.; Duarte, A.I.; Domingues, J.; Oliveira, C.R.; Januário, C.; Rego, A.C., Mitochondrion. 801 - 809. 6. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887018742&partnerID=MN8TOARS . 10.1016/j.mito.2013.05.006 . Mitochondrion

Defective HIF signaling pathway and brain response to hypoxia in neurodegenera-tive diseases: Not an “Iffy” question!

Correia, S.C.; Carvalho, C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Candeias, E.; Duarte, A.I.; Moreira, P.I., Current Pharmaceutical Design. 6809 - 6822. 38. 19. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884829985&partnerID=MN8TOARS . Current Pharmaceutical Design

Crosstalk between diabetes and brain: Glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration

Duarte, A.I.; Candeias, E.; Correia, S.C.; Santos, R.X.; Carvalho, C.; Cardoso, S.; Plácido, A.; et al, Biochimica et Biophysica Acta - Molecular Basis of Disease. 527 - 541. 4. 1832. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873306844&partnerID=MN8TOARS . 10.1016/j.bbadis.2013.01.008 . Biochimica et Biophysica Acta - Molecular Basis of Disease

Metabolic regulation is important for spermatogenesis

Rato, L.; Alves, M.G.; Socorro, S.; Duarte, A.I.; Cavaco, J.E.; Oliveira, P.F., Nature Reviews Urology. 330 - 338. 6. 9. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862208844&partnerID=MN8TOARS . 10.1038/nrurol.2012.77 . Nature Reviews Urology

Insulin in central nervous system: More than just a peripheral hormone

Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., Journal of Aging Research. 2012. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868282388&partnerID=MN8TOARS . 10.1155/2012/384017 . Journal of Aging Research

The impairment of insulin signaling in Alzheimer's disease

Candeias, E.; Duarte, A.I.; Carvalho, C.; Correia, S.C.; Cardoso, S.; Santos, R.X.; Plácido, A.I.; Perry, G.; Moreira, P.I., IUBMB Life. 951 - 957. 12. 64. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870197271&partnerID=MN8TOARS . 10.1002/iub.1098 . IUBMB Life

Alzheimer disease as a vascular disorder: Where do mitochondria fit?

Correia, S.C.; Santos, R.X.; Cardoso, S.; Carvalho, C.; Candeias, E.; Duarte, A.I.; Plácido, A.I.; Santos, M.S.; Moreira, P.I., Experimental Gerontology. 878 - 886. 11. 47. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867725518&partnerID=MN8TOARS . 10.1016/j.exger.2012.07.006 . Experimental Gerontology

IGF-1 protects against diabetic features in an in vivo model of Huntington's disease

Duarte, A.I.; Petit, G.H.; Ranganathan, S.; Li, J.-Y.; Oliveira, C.R.; Brundin, P.; Björkqvist, M.; Rego, A.C., Experimental Neurology. 314 - 319. 2. 231. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052520685&partnerID=MN8TOARS . 10.1016/j.expneurol.2011.06.016 . Experimental Neurology

Mitochondrial-associated metabolic changes and neurodegeneration in Huntington's disease - from clinical features to the bench

Rosenstock, T.R.; Duarte, A.I.; Rego, A.C., Current Drug Targets. 1218 - 1236. 10. 11. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957993152&partnerID=MN8TOARS . Current Drug Targets

Food deprivation promotes oxidative imbalance in rat brain

Santos, R.X.; Cardoso, S.; Silva, S.; Correia, S.; Carvalho, C.; Crisóstomo, J.; Rodrigues, L.; et al, Journal of Food Science. 1. 74. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-58649112769&partnerID=MN8TOARS . 10.1111/j.1750-3841.2008.00982.x . Journal of Food Science

An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease

Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Rego, A.C.; Oliveira, C.R., Journal of Alzheimer's Disease. 741 - 761. 4. 16. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649687039&partnerID=MN8TOARS . 10.3233/JAD-2009-0972 . Journal of Alzheimer's Disease

Metformin protects the brain against the oxidative imbalance promoted by type 2 diabetes

Correia, S.; Carvalho, C.; Santos, M.S.; Proença, T.; Nunes, E.; Duarte, A.I.; Monteiro, P.; et al, Medicinal Chemistry. 358 - 364. 4. 4. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-50049125341&partnerID=MN8TOARS . 10.2174/157340608784872299 . Medicinal Chemistry

Insulin neuroprotection against oxidative stress is mediated by Akt and GSK-3ß signaling pathways and changes in protein expression

Duarte, A.I.; Santos, P.; Oliveira, C.R.; Santos, M.S.; Rego, A.C., Biochimica et Biophysica Acta - Molecular Cell Research. 994 - 1002. 6. 1783. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-43549087343&partnerID=MN8TOARS . 10.1016/j.bbamcr.2008.02.016 . Biochimica et Biophysica Acta - Molecular Cell Research

Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress

Duarte, A.I.; Proença, T.; Oliveira, C.R.; Santos, M.S.; Rego, A.C., Diabetes. 2863 - 2870. 10. 55. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750882488&partnerID=MN8TOARS . 10.2337/db06-0030 . Diabetes

Effect of chronic exposure to aluminium on isoform expression and activity of rat (Na+/K+)ATPase

Silva, V.S.; Duarte, A.I.; Rego, A.C.; Oliveira, C.R.; Gonçalves, P.P., Toxicological Sciences. 485 - 494. 2. 88. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27944510677&partnerID=MN8TOARS . 10.1093/toxsci/kfi324 . Toxicological Sciences

Insulin neuroprotection against oxidative stress in cortical neurons - Involvement of uric acid and glutathione antioxidant defenses

Duarte, A.I.; Santos, M.S.; Oliveira, C.R.; Rego, A.C., Free Radical Biology and Medicine. 876 - 889. 7. 39. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644623231&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2005.05.002 . Free Radical Biology and Medicine

Valsartan improves mitochondrial function in hearts submitted to acute ischemia

Monteiro, P.; Duarte, A.I.; Gonçalves, L.M.; Providência, L.A., European Journal of Pharmacology. 158 - 164. 2-3. 518. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-23644446746&partnerID=MN8TOARS . 10.1016/j.ejphar.2005.06.013 . European Journal of Pharmacology

Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia

Monteiro, P.; Duarte, A.I.; Gonçalves, L.M.; Moreno, A.; Provid^ncia, L.A., European Journal of Pharmacology. 123 - 128. 1-3. 503. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-7444267898&partnerID=MN8TOARS . 10.1016/j.ejphar.2004.09.003 . European Journal of Pharmacology

Carvedilol protects ischemic cardiac mitochondria by preventing oxidative stress | O carvedilol protege mitocôndrias cardíacas isquémicas de lesões induzidas por stress oxidativo

Carreira, R.; Duarte, A.; Monteiro, P.; Sancha Santos, M.; Rego, A.C.; Oliveira, C.R.; Gonçalves, L.M.; Providência, L.A., Revista Portuguesa de Cardiologia. 1447 - 1455. 11. 23. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244328526&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Oxidative stress affects synaptosomal ¿-aminobutyric acid and glutamate transport in diabetic rats: The role of insulin

Duarte, A.I.; Santos, M.S.; Seiça, R.; Oliveira, C.R., Diabetes. 2110 - 2116. 8. 53. 2004. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242787235&partnerID=MN8TOARS . 10.2337/diabetes.53.8.2110 . Diabetes

Insulin affects synaptosomal GABA and glutamate transport under oxidative stress conditions

Duarte, A.I.; Santos, M.S.; Seiça, R.; De Oliveira, C.R., Brain Research. 23 - 30. 1. 977. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037684715&partnerID=MN8TOARS . 10.1016/S0006-8993(03)02679-9 . Brain Research

Neuroprotection strategies: Effect of vinpocetinein in vitro oxidative stress models | Estratégias de neuroprotecção: Efeito da vimpocetina em modelos in vitro de stresse oxidativo

Pereira, C.; Agostinho, P.; Moreira, P.I.; Duarte, A.I.; Santos, M.S.; Oliveira, C.R., Acta Medica Portuguesa. 401 - 406. 6. 16. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644310235&partnerID=MN8TOARS . Acta Medica Portuguesa

Pyruvate improves mitochondrial bioenergetics in an ex-vivo animal model of myocardial ischemia | O piruvato melhora a energética mitocondrial num modelo animal ex-vivo de isquemia miocárdica global

Monteiro, P.; Duarte, A.; Moreno, A.; Gonçalves, L.; Providência, L.A., Revista Portuguesa de Cardiologia. 79 - 88. 1. 22. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347295997&partnerID=MN8TOARS . Revista Portuguesa de Cardiologia

Carvedilol improves energy production during acute global myocardial ischaemia

Monteiro, P.; Duarte, A.I.; Moreno, A.; Gonçalves, L.M.; Providência, L.A., European Journal of Pharmacology. 245 - 253. 1-3. 482. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344253727&partnerID=MN8TOARS . 10.1016/j.ejphar.2003.09.042 . European Journal of Pharmacology

Effect of oxidative stress on the uptake of GABA and glutamate in synaptosomes isolated from diabetic rat brain

Duarte, A.; Santos, M.; Seiça, R.; Resende De Oliveira, C., Neuroendocrinology. 179 - 186. 3. 72. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033761028&partnerID=MN8TOARS . Neuroendocrinology

Synaptosomes isolated from Goto-Kakizaki diabetic rat brain exhibit increased resistance to oxidative stress: Role of vitamin E

Santos, M.S.; Duarte, A.I.; Matos, M.J.; Proença, T.; Seiça, R.; Oliveira, C.R., Life Sciences. 3061 - 3073. 25. 67. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034634237&partnerID=MN8TOARS . Life Sciences

Synaptosomal response to oxidative stress: Effect of vinpocetine

Santos, M.S.; Duarte, A.I.; Moreira, P.I.; Oliveira, C.R., Free Radical Research. 57 - 66. 1. 32. 2000. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033988559&partnerID=MN8TOARS . Free Radical Research