Cell Reprogramming
Epigenetics
Hematopoietic Stem Cell
Dendritic Cell
Immunotherapy
Engineering Cell Fates for Regenerative Medicine: Programming Blood Cell Types
Programming, Reprogramming and Developmental Biology
Development of New Therapies
The focus of our laboratory is to understand the molecular determinants underlying cell reprogramming and hematopoietic specification. In humans, the multiple differentiated cell states are normally stable and inherited through cell division. Under certain conditions, cell fate can, however, be modified or reversed. Cell reprogramming can be achieved experimentally in different ways, including nuclear transfer, cell fusion or expression of transcription factors. The emergent ability to directly reprogram somatic cells into desired hematopoietic cell-types is opening avenues to the discovery of new therapies for immune and blood diseases. Our approach focuses on Hematopoietic Stem Cells (HSCs), for their remarkable regenerative potential, and Dendritic Cells (DCs), as key mediators of immunity.
Aims:
Our research will increase the understanding of the intrinsic determinants underlying hematopoietic progenitor and effector cell developmental specification. This knowledge may allow the re-creation of these unique cell identities from any human cell. Ultimately, we believe that our research will contribute to personalized hematopoietic regeneration by employing human programmed HSCs for patient-specific cell transplantation. In addition, DC reprogramming is allowing us to develop new ways to modulate the immune response. This represents a unique opportunity to merge the field of cell reprogramming and cancer immunotherapy and may result in the development of powerful new therapeutics for cancer and other diseases resulting from a dysfunctional immune system.
Information about journal articles, updated at 17-11-2024, from platform CIÊNCIAVITAE.
High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells
Diana Pádua; Paula Figueira; Mariana Pinto; André Filipe Maia; Joana Peixoto; Raquel T. Lima; António Pombinho; et al, 2023. Cancers. 15. 2023. 10.3390/cancers15174406 . Cancers
GATA2 mitotic bookmarking is required for definitive haematopoiesis
Rita Silvério-Alves; Ilia Kurochkin; Anna Rydström; Camila Vazquez Echegaray; Jakob Haider; Matthew Nicholls; Christina Rode; et al, 2023. Nature Communications. 4645. 14. 2023. https://www.nature.com/articles/s41467-023-40391-x . 10.1038/s41467-023-40391-x . Nature Communications
Restoring tumor immunogenicity with dendritic cell reprogramming
Olga Zimmermannova; Alexandra G. Ferreira; Ervin Ascic; Marta Velasco Santiago; Ilia Kurochkin; Morten Hansen; Özcan Met; et al, 2023. Science Immunology. 85. 8. 2023. 10.1126/sciimmunol.add4817 . Science Immunology
Reprogramming Cancer Cells to Antigen-presenting Cells
Alexandra G Ferreira; Olga Zimmermannova; Ilia Kurochkin; Ervin Ascic; Fritiof Åkerström; Pereira, Carlos-Filipe, 2023. Bio-Protocol. 2023. Bio-Protocol
Orchestrating an immune response to cancer with cellular reprogramming
Olga Zimmermannova; Alexandra Gabriela Ferreira ; Pereira, Carlos-Filipe, 2023. Genes & Immunity. 2023. Genes & Immunity
Reprogramming Stars #10: Modeling Cancer with Cellular Reprogramming - An Interview with Dr. Dung-Fang Lee
Lee, D.-F.; Pereira, C.-F., 2023. Cellular Reprogramming. 2 - 6. 1. 25. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85148250551&partnerID=MN8TOARS . 10.1089/cell.2023.29081.dfl . Cellular Reprogramming
Reprogramming Stars #5: Regeneration, a Natural Reprogramming Process—An Interview with Dr. Nicholas Leigh
Leigh, Nicholas D.; Pereira, Carlos-Filipe, 2022. Cellular Reprogramming. 2 - 8. 1. 24. 2022. http://dx.doi.org/10.1089/cell.2022.29055.nl . 10.1089/cell.2022.29055.nl . Cellular Reprogramming
Reprogramming Stars #6: A Venture Based in Cellular Reprogramming-An Interview with Dr. Cristiana Pires
Pires, C.F.; Pereira, C.-F., 2022. Cellular Reprogramming. 57 - 62. 2. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127473849&partnerID=MN8TOARS . 10.1089/cell.2022.29061.cp . Cellular Reprogramming
Reprogramming Stars #8: A Synthetic Biology Approach to Cellular Reprogramming - An Interview with Dr. Katie Galloway
Galloway, K.E.; Pereira, C.-F., 2022. Cellular Reprogramming. 151 - 162. 4. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136909415&partnerID=MN8TOARS . 10.1089/cell.2022.29068.kg . Cellular Reprogramming
Reprogramming Stars #9: Spacing Out Cellular Reprogramming - An Interview with Dr. Valentina Fossati
Fossati, V.; Pereira, C.-F., 2022. Cellular Reprogramming. 107. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584650&partnerID=MN8TOARS . 10.1089/cell.2022.29074.vf . Cellular Reprogramming
Call for Special Issue Papers: Cellular Reprogramming 25th Anniversary Deadline for Manuscript Submission: April 30, 2023
Pereira, C.-F., 2022. Cellular reprogramming. 315 - 316. 6. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144584647&partnerID=MN8TOARS . 10.1089/cell.2022.29073.cfp . Cellular reprogramming
Single-cell transcriptional profiling informs efficient reprogramming of human somatic cells to cross-presenting dendritic cells
Rosa, F.F.; Pires, C.F.; Kurochkin, I.; Halitzki, E.; Zahan, T.; Arh, N.; Zimmermannová, O.; et al, 2022. Science immunology. eabg5539 - eabg5539. 69. 7. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125875360&partnerID=MN8TOARS . 10.1126/sciimmunol.abg5539 . Science immunology
Reprogramming Stars #7: Dynamic Pluripotent Stem Cell States and Their Applications-An Interview with Dr. Jun Wu
Wu, J.; Pereira, C.-F.; Lu, Y.R., 2022. Cellular Reprogramming. 105 - 110. 3. 24. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85132269580&partnerID=MN8TOARS . 10.1089/cell.2022.29064.jc . Cellular Reprogramming
Reprogramming Stars #4: A Reprogramming Approach for Parkinson's Disease—An Interview with Dr. Malin Parmar
Parmar, Malin; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 319 - 325. 6. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29049.mp . 10.1089/cell.2021.29049.mp . Cellular Reprogramming
Ontogenic Shifts in Cellular Fate are Linked to Proteotype Changes in Lineage-Biased Hematopoietic Progenitor Cells
Pereira, Carlos-Filipe, 2021. Cell Reports. 2021. in press Cell Reports
Reprogramming Stars #1: Genome Programming Through the Cell Cycle—An Interview with Dr. Tomomi Tsubouchi
Tsubouchi, Tomomi; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 153 - 157. 3. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29039.tt . 10.1089/cell.2021.29039.tt . Cellular Reprogramming
Reprogramming Stars #2: Reprogramming Towards Neural Lineages—An Interview with Dr. Henrik Ahlenius
Ahlenius, Henrik; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 200 - 205. 4. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29044.ha . 10.1089/cell.2021.29044.ha . Cellular Reprogramming
Reprogramming Stars #3: Mechanisms of iPSC Reprogramming—An Interview with Dr. Keisuke Kaji
Kaji, Keisuke; Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 264 - 269. 5. 23. 2021. http://dx.doi.org/10.1089/cell.2021.29046.kk . 10.1089/cell.2021.29046.kk . Cellular Reprogramming
Cell Fate Reprogramming in the Era of Cancer Immunotherapy
Zimmermannova, Olga; Caiado, Inês; Ferreira, Alexandra G.; Pereira, Carlos-Filipe, 2021. Frontiers in Immunology. 12. 2021. http://dx.doi.org/10.3389/fimmu.2021.714822 . 10.3389/fimmu.2021.714822 . Frontiers in Immunology
Reprogramming, The Journal
Pereira, Carlos-Filipe, 2021. Cellular Reprogramming. 2021. http://dx.doi.org/10.1089/cell.2021.0036 . 10.1089/cell.2021.0036 . Cellular Reprogramming
HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer
Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia, 2021. Current Oncology. 56 - 67. 1. 29. 2021. http://dx.doi.org/10.3390/curroncol29010005 . 10.3390/curroncol29010005 . Current Oncology
A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin
Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al, 2020. Cancers. 2. 12. 2020. http://dx.doi.org/10.3390/cancers12020495 . 10.3390/cancers12020495 . Cancers
Direct Reprogramming of Mouse Embryonic Fibroblasts to Conventional Type 1 Dendritic Cells by Enforced Expression of Transcription Factors
Rosa, Fábio; Pires, Cristiana; Zimmermannova, Olga; Pereira, Carlos-Filipe, 2020. BIO-PROTOCOL. 10. 10. 2020. http://dx.doi.org/10.21769/bioprotoc.3619 . 10.21769/bioprotoc.3619 . BIO-PROTOCOL
Mononuclear phagocyte regulation by the transcription factor Blimp-1 in health and disease
Ulmert, Isabel; Henriques-Oliveira, Luís; Pereira, Carlos-Filipe; Lahl, Katharina, 2020. Immunology. 303 - 313. 4. 161. 2020. http://dx.doi.org/10.1111/imm.13249 . 10.1111/imm.13249 . Immunology
Induction of human hemogenesis in adult fibroblasts by defined factors and hematopoietic coculture
Daniel, M.G.; Sachs, D.; Bernitz, J.M.; Fstkchyan, Y.; Rapp, K.; Satija, N.; Law, K.; et al, 2019. FEBS Letters. 3266 - 3287. 23. 593. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074051202&partnerID=MN8TOARS . 10.1002/1873-3468.13621 . FEBS Letters
Understanding and Modulating Immunity With Cell Reprogramming
Pires, C.F.; Rosa, F.F.; Kurochkin, I.; Pereira, C.-F., 2019. Frontiers in Immunology. 10. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077260284&partnerID=MN8TOARS . 10.3389/fimmu.2019.02809 . Frontiers in Immunology
Is immunotherapy the holy grail for pancreatic cancer?
Andersson, R.; Pereira, C.-F.; Bauden, M.; Ansari, D., 2019. Immunotherapy. 1435 - 1438. 17. 11. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85076450369&partnerID=MN8TOARS . 10.2217/imt-2019-0164 . Immunotherapy
Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
Silvério-Alves, R.; Gomes, A.M.; Kurochkin, I.; Moore, K.A.; Pereira, C.-F., 2019. Journal of visualized experiments : JoVE. 153. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075191300&partnerID=MN8TOARS . 10.3791/60112 . Journal of visualized experiments : JoVE
Direct reprogramming of fibroblasts into antigen-presenting dendritic cells
Rosa, Fabio F.; Pires, Cristiana F.; Kurochkin, Ilia; Ferreira, Alexandra G.; Gomes, Andreia M.; Palma, Luis G.; Shaiv, Kritika; et al, 2018. Science Immunology. 30. 3. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452571800002&KeyUID=WOS:000452571800002 . 10.1126/sciimmunol.aau4292 . Science Immunology
Ihor R. Lemischka (1953-2017)
Ivanova, Natalia; Pereira, Carlos-Filipe; Lee, Dung-Fang, 2018. Cell Stem Cell. 16 - +. 1. 22. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000419306500008&KeyUID=WOS:000419306500008 . 10.1016/j.stem.2017.12.015 . Cell Stem Cell
Cooperative Transcription Factor Induction Mediates Hemogenic Reprogramming
Gomes, Andreia M.; Kurochkin, Ilia; Chang, Betty; Daniel, Michael; Law, Kenneth; Satija, Namita; Lachmann, Alexander; et al, 2018. Cell Reports. 2821 - +. 10. 25. 2018. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000452894600018&KeyUID=WOS:000452894600018 . 10.1016/j.celrep.2018.11.032 . Cell Reports
INDUCTION OF HEMOGENIC REPROGRAMMING IN HUMAN FIBROBLASTS
Gomes, A.; Pereira, C. -F.; Chang, B.; Kurochkin, I.; Daniel, M.; Law, K.; Satija, N.; et al, 2017. Haematologica. 102. 2017. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000404127006340&KeyUID=WOS:000404127006340 . Haematologica
Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate
Freire, A.G.; Waghray, A.; Soares-da-Silva, F.; Resende, T.P.; Lee, D.-F.; Pereira, C.-F.; Nascimento, D.S.; Lemischka, I.R.; Pinto-do-Ó, P., 2017. Stem Cell Reports. 136 - 148. 1. 9. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021126795&partnerID=MN8TOARS . 10.1016/j.stemcr.2017.05.025 . Stem Cell Reports
High-throughput identification of small molecules that affect human embryonic vascular development
Vazão, H.; Rosa, S.; Barata, T.; Costa, R.; Pitrez, P.R.; Honório, I.; De Vries, M.R.; et al, 2017. Proceedings of the National Academy of Sciences of the United States of America. E3022 - E3031. 15. 114. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035214278&partnerID=MN8TOARS . 10.1073/pnas.1617451114 . Proceedings of the National Academy of Sciences of the United States of America
MECHANISMS UNDERLYING HUMAN HEMOGENIC REPROGRAMMING
Gomes, Andreia; Pereira, Carlos-Filipe; Papatsenko, Dmitri; Moore, Kateri Ann; Lemischka, Ihor, 2016. Experimental Hematology. S75 - S76. 9. 44. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600129&KeyUID=WOS:000382184600129 . 10.1016/j.exphem.2016.06.144 . Experimental Hematology
The stem cell niche finds its true north
Agnete Kirkeby; Thomas Perlmann; Carlos-Filipe Pereira, 2016. Development. 2877 - 2881. 16. 143. 2016. https://doi.org/10.1242/dev.140095 . 10.1242/dev.140095 . Development
ZERO FOOTPRINT INDUCTION OF HUMAN HEMOGENESIS TO STUDY PATHOLOGIC DEVELOPMENTAL HEMATOPOIESIS IN FANCONI ANEMIA
Daniel, Michael; Fstkchyan, Yesai; Gomes, Andreia; Pereira, Carlos-Filipe; Lemischka, Ihor; Moore, Kateri Ann, 2016. Experimental Hematology. S65 - S65. 9. 44. 2016. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000382184600098&KeyUID=WOS:000382184600098 . 10.1016/j.exphem.2016.06.112 . Experimental Hematology
Reprogramming mouse embryonic fibroblasts with transcription factors to induce a hemogenic program
Daniel, M.G.; Pereira, C.-F.; Bernitz, J.M.; Lemischka, I.R.; Moore, K., 2016. Journal of Visualized Experiments. 118. 2016. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015946426&partnerID=MN8TOARS . 10.3791/54372 . Journal of Visualized Experiments
Hematopoietic Reprogramming In Vitro Informs In Vivo Identification of Hemogenic Precursors to Definitive Hematopoietic Stem Cells
Pereira, C.-F.; Chang, B.; Gomes, A.; Bernitz, J.; Papatsenko, D.; Niu, X.; Swiers, G.; et al, 2016. Developmental Cell. 525 - 539. 5. 36. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959312876&partnerID=MN8TOARS . 10.1016/j.devcel.2016.02.011 . Developmental Cell
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm
Waghray, A.; Saiz, N.; Jayaprakash, A.D.; Freire, A.G.; Papatsenko, D.; Pereira, C.-F.; Lee, D.-F.; et al, 2015. Stem Cell Reports. 97 - 110. 1. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937523983&partnerID=MN8TOARS . 10.1016/j.stemcr.2015.05.009 . Stem Cell Reports
Making a Hematopoietic Stem Cell.
Daniel MG; Pereira CF; Lemischka IR; Moore KA, 2015. 2015. http://europepmc.org/abstract/med/26526106 . 10.1016/j.tcb.2015.10.002 .
DIRECT CONVERSION FROM MOUSE FIBROBLASTS INFORMS THE IDENTIFICATION OF HEMOGENIC PRECURSOR CELLS IN VIVO
Pereira, Carlos-Filipe; Chang, Betty; Niu, Xiaohong; Gomes, Andreia; Swiers, Gemma; Azzoni, Emanuele; Schaniel, Christoph; et al, 2014. Experimental Hematology. S55 - S55. 8. 42. 2014. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000340344300196&KeyUID=WOS:000340344300196 . Experimental Hematology
"There will be blood" from fibroblasts
Pereira, C.-F.; Lemischka, I.R.; Moore, K., 2014. Cell Cycle. 335 - 336. 3. 13. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896884486&partnerID=MN8TOARS . 10.4161/cc.27507 . Cell Cycle
'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells
Pereira, C.-F.; Lemischka, I.R.; Moore, K., 2014. EMBO Journal. 1511 - 1513. 14. 33. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904561142&partnerID=MN8TOARS . 10.15252/embj.201488980 . EMBO Journal
Induction of a hemogenic program in mouse fibroblasts.
Pereira, Carlos-Filipe; Chang, Betty; Qiu, Jiajing; Niu, Xiaohong; Papatsenko, Dmitri; Hendry, Caroline E; Clark, Neil R; et al, 2013. Cell stem cell. 205 - 18. 2. 13. 2013. 10.1016/j.stem.2013.05.024 . Cell stem cell
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
Fidalgo, Miguel; Faiola, Francesco; Pereira, Carlos-Filipe; Ding, Junjun; Saunders, Arven; Gingold, Julian; Schaniel, Christoph; et al, 2012. Proceedings of the National Academy of Sciences of the United States of America. 16202 - 16207. 40. 109. 2012. 10.1073/pnas.1208533109 . Proceedings of the National Academy of Sciences of the United States of America
Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling
Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; Carvajal-Vergara, Xonia; Mulero-Navarro, Sonia; Pereira, Carlos F.; Gingold, Julian; et al, 2012. Cell Stem Cell. 179 - 194. 2. 11. 2012. 10.1016/j.stem.2012.05.020 . Cell Stem Cell
Using heterokaryons to understand pluripotency and reprogramming
Piccolo, Francesco M.; Pereira, Carlos F.; Cantone, Irene; Brown, Karen; Tsubouchi, Tomomi; Soza-Ried, Jorge; Merkenschlager, Matthias; Fisher, Amanda G., 2011. Philosophical Transactions of the Royal Society B-Biological Sciences. 2260 - 2265. 1575. 366. 2011. 10.1098/rstb.2011.0004 . Philosophical Transactions of the Royal Society B-Biological Sciences
Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2
Kanhere, Aditi; Viiri, Keijo; Araujo, Carla C.; Rasaiyaah, Jane; Bouwman, Russell D.; Whyte, Warren A.; Pereira, C. Filipe; et al, 2010. Molecular Cell. 675 - 688. 5. 38. 2010. 10.1016/j.molcel.2010.03.019 . Molecular Cell
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Pereira, Carlos F.; Piccolo, Francesco M.; Tsubouchi, Tomomi; Sauer, Stephan; Ryan, Natalie K.; Bruno, Ludovica; Landeira, David; et al, 2010. Cell Stem Cell. 547 - 556. 6. 6. 2010. 10.1016/j.stem.2010.04.013 . Cell Stem Cell
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
Landeira, David; Sauer, Stephan; Poot, Raymond; Dvorkina, Maria; Mazzarella, Luca; Jorgensen, Helle F.; Pereira, C. Filipe; et al, 2010. Nature Cell Biology. 618 - U214. 6. 12. 2010. 10.1038/ncb2065 . Nature Cell Biology
CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Schnetz, M.P.; Handoko, L.; Akhtar-Zaidi, B.; Bartels, C.F.; Pereira, C.F.; Fisher, A.G.; Adams, D.J.; et al, 2010. PLoS genetics. 7. 6. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952538205&partnerID=MN8TOARS . PLoS genetics
Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo
Santos, Joana; Pereira, C. Filipe; Di-Gregorio, Aida; Spruce, Thomas; Alder, Olivia; Rodriguez, Tristan; Azuara, Veronique; Merkenschlager, Matthias; Fisher, Amanda G., 2010. Epigenetics & Chromatin. 3. 2010. 10.1186/1756-8935-3-1 . Epigenetics & Chromatin
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression
Savarese, Fabio; Davila, Amparo; Nechanitzky, Robert; De La Rosa-Velazquez, Inti; Pereira, Carlos F.; Engelke, Rudolf; Takahashi, Keiko; et al, 2009. Genes & Development. 2625 - 2638. 22. 23. 2009. 10.1101/gad.1815709 . Genes & Development
Heterokaryon-based reprogramming for pluripotency
Pereira, C.F.; Fisher, A.G., 2009. Current Protocols in Stem Cell Biology. SUPPL. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-65149087887&partnerID=MN8TOARS . 10.1002/9780470151808.sc04b01s9 . Current Protocols in Stem Cell Biology
Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8(+) T Cell Differentiation
Correia, Margareta P.; Cardoso, Elsa M.; Pereira, Carlos F.; Neves, Rui; Uhrberg, Markus; Arosa, Fernando A., 2009. Journal of Immunology. 6149 - 6159. 10. 182. 2009. 10.4049/jimmunol.0802470 . Journal of Immunology
Senescence impairs successful reprogramming to pluripotent stem cells
Banito, Ana; Rashid, Sheikh T.; Acosta, Juan Carlos; Li, SiDe; Pereira, Carlos F.; Geti, Imbisaat; Pinho, Sandra; et al, 2009. Genes & Development. 2134 - 2139. 18. 23. 2009. 10.1101/gad.1811609 . Genes & Development
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells
Jorgensen, Helle F.; Terry, Anna; Beretta, Chiara; Pereira, C. Filipe; Leleu, Marion; Chen, Zhou-Feng; Kelly, Claire; Merkenschlager, Matthias; Fisher, Amanda G., 2009. Development. 715 - 721. 5. 136. 2009. 10.1242/dev.028548 . Development
Heterokaryon-Based Reprogramming of Human B Lymphocytes for Pluripotency Requires Oct4 but Not Sox2
Pereira, Carlos F.; Terranova, Remi; Ryan, Natalie K.; Santos, Joana; Morris, Kelly J.; Cui, Wei; Merkenschlager, Matthias; Fisher, Amanda G., 2008. Plos Genetics. 9. 4. 2008. 10.1371/journal.pgen.1000170 . Plos Genetics
Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2
Nunes, R.J.; Castro, M.A.A.; Gonçalves, C.M.; Bamberger, M.; Pereira, C.F.; Bismuth, G.; Carmo, A.M., 2008. Journal of Immunology. 988 - 997. 2. 180. 2008. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252290000036&KeyUID=WOS:000252290000036 . 10.4049/jimmunol.180.2.988 . Journal of Immunology
Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming
Terranova, R.; Pereira, C. F.; Du Roure, C.; Merkenschlager, M.; Fisher, A. G., 2006. Journal of Cell Science. 2065 - 2072. 10. 119. 2006. 10.1242/jcs.02945 . Journal of Cell Science
Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading
Cabrita, M.; Pereira, C. F.; Rodrigues, P.; Cardoso, E. M.; Arosa, F. A., 2005. Febs Journal. 152 - 165. 1. 272. 2005. 10.1111/j.1432-1033.2004.04387.x . Febs Journal
Red blood cells as modulators of T cell growth and survival
Arosa, F. A.; Pereira, C. F.; Fonseca, A. M., 2004. Current Pharmaceutical Design. 191 - 201. 2. 10. 2004. 10.2174/1381612043453432 . Current Pharmaceutical Design
Red blood cells upregulate cytoprotective proteins and the labile iron pool in dividing human T cells despite a reduction in oxidative stress
Fonseca, A.M.; Pereira, C.F.; Porto, G.; Arosa, F.A., 2003. Free Radical Biology and Medicine. 1404 - 1416. 11. 35. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344875071&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2003.08.011 . Free Radical Biology and Medicine
Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds
Fonseca, A. M.; Pereira, C. F.; Porto, G.; Arosa, F. A.; Fonseca, A.M.; Pereira, C.F.; Arosa, F.A., 2003. Cellular Immunology. 17 - 28. 1. 224. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142169441&partnerID=MN8TOARS . 10.1016/s0008-8749(03)00170-9 . Cellular Immunology
5 65 out of 65 Publications
Reprograming cells into hemogenic and/or hematopoietic stem cell-like cells
Methods for reprogramming stem or differentiated cells into hemogenic and/or hematopoietic stem cell-like cells by expressing transcription factors in a polycistronic vector. Treatment or diagnosis of blood disorders, cancer (especially haematological tumours) or infectious diseases.
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