Carla Varela

An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromatase Inhibitor for Estrogen Receptor-Positive (ER+) Breast Cancer: Effects on Sensitive and Resistant Cell Lines

Amaral, Cristina; Correia-da-Silva, Georgina; Almeida, Cristina Ferreira; Valente, Maria João; Varela, Carla; Tavares-da-Silva, Elisiário; Vinggaard, Anne Marie; Teixeira, Natércia; Roleira, Fernanda M. F., Molecules. 2. 28. 2023. http://dx.doi.org/10.3390/molecules28020789 . 10.3390/molecules28020789 . published Molecules

Essential Oils from Côa Valley Lamiaceae Species: Cytotoxicity and Antiproliferative Effect on Glioblastoma Cells

Marques, Mário Pedro; Neves, Beatriz Guapo; Varela, Carla; Zuzarte, Mónica; Gonçalves, Ana Cristina; Dias, Maria Inês; Amaral, Joana S.; et al, Pharmaceutics. 2. 15. 2023. http://dx.doi.org/10.3390/pharmaceutics15020341 . 10.3390/pharmaceutics15020341 . published Pharmaceutics

Potential of Côa Valley (Portugal) Plants Extracts in Cell Model for Hepatic Lipid Toxicity

Melim, C.; Teixeira, J.; Varela, Carla; Marques, M. ; Sardão, Vilma; Oliveira, Paulo E41F-4FB7-5948 ; Cabral, C, European Journal of Clinical Investigation. 0236 - . S1. 52. 2022. http://dx.doi.org/10.1111/eci.13796 . 10.1111/eci.13796 . published European Journal of Clinical Investigation

Design, synthesis, biological activity evaluation and structure-activity relationships of new steroidal aromatase inhibitors. The case of C-ring and 7ß substituted steroids

Roleira, Fernanda M.F.; Costa, Saul C.; Gomes, Ana R.; Varela, Carla L.; Amaral, Cristina; Augusto, Tiago V.; Correia-da-Silva, Georgina; et al, Bioorganic Chemistry. 131. 2022. http://dx.doi.org/10.1016/j.bioorg.2022.106286 . 10.1016/j.bioorg.2022.106286 . published Bioorganic Chemistry

In Vitro Cardioprotective Potential of Côa Valley (Portugal) Plants Extracts Against Lipotoxic Insults

Ilina, V.; Teixeira, J.; Varela, Carla; Marques, M. ; Sardão, Vilma; Melim, C. ; Baranenko, D. ; Oliveira, P. E41F-4FB7-5948; Cabral, C, European Journal of Clinical Investigation. 0242 - . S1. 52. 2022. http://dx.doi.org/10.1111/eci.13796 . 10.1111/eci.13796 . published European Journal of Clinical Investigation

Oxymestane, a cytostatic steroid derivative of exemestane with greater antitumor activity in non-estrogen-dependent cell lines

Pires, Ana S.; Varela, Carla L.; Marques, Inês A.; Abrantes, Ana M.; Gonçalves, Cristina; Rodrigues, Tiago; Matafome, Paulo; et al, The Journal of Steroid Biochemistry and Molecular Biology. 212. 2021. http://dx.doi.org/10.1016/j.jsbmb.2021.105950 . 10.1016/j.jsbmb.2021.105950 . published The Journal of Steroid Biochemistry and Molecular Biology

Design, synthesis, and antitumor activity evaluation of steroidal oximes

Gomes, Ana R.; Pires, Ana S.; Abrantes, Ana M.; Gonçalves, Ana C.; Costa, Saul C.; Varela, Carla L.; Silva, Elisiário T.; Botelho, Maria F.; Roleira, Fernanda M.F., Bioorganic & Medicinal Chemistry. 46. 2021. http://dx.doi.org/10.1016/j.bmc.2021.116360 . 10.1016/j.bmc.2021.116360 . published Bioorganic & Medicinal Chemistry

Getting the Classroom Closer to Research Work: Undergraduate Students Prepare N-Hexylcinnamamide

Carla L. Varela; Ana M. T. D. P. V. Cabral; Isabel R. Barbosa; Saul C. Costa; Elisiário J. T. Silva; Fernanda M. F. Roleira, Journal of Chemical Education. 2020. https://doi.org/10.1021/acs.jchemed.8b00604 . 10.1021/acs.jchemed.8b00604 . Journal of Chemical Education

C-6a- vs C-7a-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure–Activity Relationships

Roleira, Fernanda M. F.; Varela, Carla; Amaral, Cristina; Costa, Saul C.; Correia-da-Silva, Georgina; Moraca, Federica; Costa, Giosuè; et al, Journal of Medicinal Chemistry. 3636 - 3657. 7. 62. 2019. http://dx.doi.org/10.1021/acs.jmedchem.9b00157 . 10.1021/acs.jmedchem.9b00157 . published Journal of Medicinal Chemistry

Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors

Augusto, Tiago V.; Amaral, Cristina; Varela, Carla L.; Bernardo, Fernanda; da Silva, Elisiário Tavares; Roleira, Fernanda F.M.; Costa, Saul; Teixeira, Natércia; Correia-da-Silva, Georgina, The Journal of Steroid Biochemistry and Molecular Biology. 195. 2019. http://dx.doi.org/10.1016/j.jsbmb.2019.105486 . 10.1016/j.jsbmb.2019.105486 . published The Journal of Steroid Biochemistry and Molecular Biology

miR-145-loaded micelleplexes as a novel therapeutic strategy to inhibit proliferation and migration of osteosarcoma cells

Magalhães, Mariana; Almeida, Mauro; Tavares-da-Silva, Elisiário; Roleira, Fernanda M.F.; Varela, Carla; Jorge, Joana; Gonçalves, Ana Cristina; et al, European Journal of Pharmaceutical Sciences. 28 - 42. 123. 2018. http://dx.doi.org/10.1016/j.ejps.2018.07.021 . 10.1016/j.ejps.2018.07.021 . published European Journal of Pharmaceutical Sciences

Characterization of polymeric nanoparticles for intravenous delivery: Focus on stability

Oliveira, C.L.; Veiga, F.; Varela, C.; Roleira, F.; Tavares, E.; Silveira, I.; Ribeiro, A.J., Colloids and Surfaces B: Biointerfaces. 326 - 333. 150. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006136637&partnerID=MN8TOARS . 10.1016/j.colsurfb.2016.10.046 . Colloids and Surfaces B: Biointerfaces

Characterization of polymeric nanoparticles for intravenous delivery: Focus on stability

Oliveira, Claudia L.; Veiga, Francisco; Varela, Carla; Roleira, Fernanda; Tavares, Elisiário; Silveira, Isabel; Ribeiro, Antonio J., Colloids and Surfaces B: Biointerfaces. 326 - 333. 150. 2017. http://dx.doi.org/10.1016/j.colsurfb.2016.10.046 . 10.1016/j.colsurfb.2016.10.046 . published Colloids and Surfaces B: Biointerfaces

New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies

Pintus, F.; Matos, M.J.; Vilar, S.; Hripcsak, G.; Varela, C.; Uriarte, E.; Santana, L.; et al, Bioorganic and Medicinal Chemistry. 1687 - 1695. 5. 25. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011876563&partnerID=MN8TOARS . 10.1016/j.bmc.2017.01.037 . Bioorganic and Medicinal Chemistry

Anti-tumor efficacy of new 7a-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells

Amaral, C.; Varela, C.L.; Maurício, J.; Sobral, A.F.; Costa, S.C.; Roleira, F.M.F.; Tavares-da-Silva, E.J.; Correia-da-Silva, G.; Teixeira, N., Journal of Steroid Biochemistry and Molecular Biology. 218 - 228. 171. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017457908&partnerID=MN8TOARS . 10.1016/j.jsbmb.2017.04.002 . Journal of Steroid Biochemistry and Molecular Biology

Progress in the development of small molecules as new human A<inf>3</inf> adenosine receptor ligands based on the 3-thiophenylcoumarin core

Matos, M.J.; Vilar, S.; Kachler, S.; Vazquez-Rodriguez, S.; Varela, C.; Delogu, G.; Hripcsak, G.; et al, MedChemComm. 845 - 852. 5. 7. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971242753&partnerID=MN8TOARS . 10.1039/c5md00573f . MedChemComm

Exploring new chemical functionalities to improve aromatase inhibition of steroids

Varela, C.L.; Amaral, C.; Correia-Da-Silva, G.; Costa, S.C.; Carvalho, R.A.; Costa, G.; Alcaro, S.; et al, Bioorganic and Medicinal Chemistry. 2823 - 2831. 12. 24. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965029205&partnerID=MN8TOARS . 10.1016/j.bmc.2016.04.056 . Bioorganic and Medicinal Chemistry

Combined dual effect of modulation of human neutrophils’ oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives

Tavares-da-Silva, E.J.; Varela, C.L.; Pires, A.S.; Encarnação, J.C.; Abrantes, A.M.; Botelho, M.F.; Carvalho, R.A.; et al, Bioorganic and Medicinal Chemistry. 3556 - 3564. 16. 24. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973461690&partnerID=MN8TOARS . 10.1016/j.bmc.2016.05.065 . Bioorganic and Medicinal Chemistry

Design and discovery of tyrosinase inhibitors based on a coumarin scaffold

Matos, M.J.; Varela, C.; Vilar, S.; Hripcsak, G.; Borges, F.; Santana, L.; Uriarte, E.; et al, RSC Advances. 94227 - 94235. 114. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946594387&partnerID=MN8TOARS . 10.1039/c5ra14465e . RSC Advances

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane

Amaral, C.; Lopes, A.; Varela, C.L.; Da Silva, E.T.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N., International Journal of Biochemistry and Cell Biology. 183 - 195. 69. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946406321&partnerID=MN8TOARS . 10.1016/j.biocel.2015.10.024 . International Journal of Biochemistry and Cell Biology

Plant derived and dietary phenolic antioxidants: Anticancer properties

Roleira, F.M.F.; Tavares-Da-Silva, E.J.; Varela, C.L.; Costa, S.C.; Silva, T.; Garrido, J.; Borges, F., Food Chemistry. 235 - 258. 183. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925860642&partnerID=MN8TOARS . 10.1016/j.foodchem.2015.03.039 . Food Chemistry

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line

Varela, C.L.; Amaral, C.; Tavares Da Silva, E.; Lopes, A.; Correia-Da-Silva, G.; Carvalho, R.A.; Costa, S.C.P.; Roleira, F.M.F.; Teixeira, N., European Journal of Medicinal Chemistry. 336 - 345. 87. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907586379&partnerID=MN8TOARS . 10.1016/j.ejmech.2014.09.074 . European Journal of Medicinal Chemistry

Insights into the synthesis of steroidal A-ring olefins

Varela, C.L.; Roleira, F.M.F.; Costa, S.C.P.; Pinto, A.S.C.T.; Martins, A.I.O.S.; Carvalho, R.A.; Teixeira, N.A.; Correia-Da-Silva, G.; Tavares-Da-Silva, E., Helvetica Chimica Acta. 39 - 46. 1. 97. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892750803&partnerID=MN8TOARS . 10.1002/hlca.201300082 . Helvetica Chimica Acta

Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: Aromatase inhibition and autophagy

Amaral, C.; Varela, C.; Azevedo, M.; Da Silva, E.T.; Roleira, F.M.F.; Chen, S.; Correia-Da-Silva, G.; Teixeira, N., Journal of Steroid Biochemistry and Molecular Biology. 51 - 59. 1. 135. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873021507&partnerID=MN8TOARS . 10.1016/j.jsbmb.2012.12.017 . Journal of Steroid Biochemistry and Molecular Biology

Design, synthesis and biochemical studies of new 7a-allylandrostanes as aromatase inhibitors

Varela, C.L.; Amaral, C.; Correia-Da-Silva, G.; Carvalho, R.A.; Teixeira, N.A.; Costa, S.C.; Roleira, F.M.F.; Tavares-Da-Silva, E.J., Steroids. 662 - 669. 7. 78. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877042832&partnerID=MN8TOARS . 10.1016/j.steroids.2013.02.016 . Steroids

Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis

Amaral, C.; Varela, C.; Borges, M.; Tavares Da Silva, E.; Roleira, F.M.F.; Correia-Da-Silva, G.; Teixeira, N., Apoptosis. 1426 - 1436. 11. 18. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886434710&partnerID=MN8TOARS . 10.1007/s10495-013-0879-6 . Apoptosis

New steroidal 17ß-carboxy derivatives present anti-5a-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line

Amaral, C.; Varela, C.; Correia-Da-Silva, G.; Tavares Da Silva, E.; Carvalho, R.A.; Costa, S.C.P.; Cunha, S.C.; et al, Biochimie. 2097 - 2106. 11. 95. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885049687&partnerID=MN8TOARS . 10.1016/j.biochi.2013.07.023 . Biochimie

6-Methyl-ideneandrost-4-ene-3,17-dione

Andrade, L.C.R.; De Almeida, M.J.M.; Fernandes Roleira, F.M.; Varela, C.L.; Tavares Da Silva, E.J., Acta Crystallographica Section E: Structure Reports Online. 4. 68. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860285797&partnerID=MN8TOARS . 10.1107/S1600536812013207 . Acta Crystallographica Section E: Structure Reports Online

New structure-activity relationships of A-and D-ring modified steroidal aromatase inhibitors: Design, synthesis, and biochemical evaluation

Varela, C.; Tavares Da Silva, E.J.; Amaral, C.; Correia Da Silva, G.; Baptista, T.; Alcaro, S.; Costa, G.; et al, Journal of Medicinal Chemistry. 3992 - 4002. 8. 55. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860267099&partnerID=MN8TOARS . 10.1021/jm300262w . Journal of Medicinal Chemistry

5a-Androst-3-en-17-one oxime

Andrade, L.C.R.; De Almeida, M.J.M.; Roleira, F.M.F.; Varela, C.L.; Da Silva, E.J.T., Acta Crystallographica Section C: Crystal Structure Communications. 9. 64. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-51049117281&partnerID=MN8TOARS . 10.1107/S0108270108023299 . Acta Crystallographica Section C: Crystal Structure Communications