Mário Grãos

Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions.

Estronca L; Francisco V; Pitrez P; Honório I; Carvalho L; Vazão H; Blersch J; et al, Nanoscale horizons. 2021. http://europepmc.org/abstract/med/33576750 . 10.1039/d0nh00550a . Nanoscale horizons

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Floriddia, Elisa M.; Lourenço, Tânia; Zhang, Shupei; van Bruggen, David; Hilscher, Markus M.; Kukanja, Petra; Gonçalves dos Santos, João P.; et al, Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-19453-x . 10.1038/s41467-020-19453-x . Nature Communications

Cofilin-1 Is a Mechanosensitive Regulator of Transcription

Domingues, Catarina; Geraldo, A. Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A.; et al, Frontiers in Cell and Developmental Biology. 8. 2020. http://dx.doi.org/10.3389/fcell.2020.00678 . 10.3389/fcell.2020.00678 . Frontiers in Cell and Developmental Biology

A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

Anjo, Sandra I.; dos Santos, Patrícia Valério; Rosado, Luiza; Baltazar, Graça; Baldeiras, Inês; Pires, Diana; Gomes, Andreia; et al, Translational Neurodegeneration. 1. 9. 2020. http://dx.doi.org/10.1186/s40035-020-00188-0 . 10.1186/s40035-020-00188-0 . Translational Neurodegeneration

oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening

Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Mário Grãos; Bruno Manadas, Redox Biology. 101130 - 101130. 2019. https://doi.org/10.1016/j.redox.2019.101130 . 10.1016/j.redox.2019.101130 . Redox Biology

Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction.

Gerardo H; Lima A; Carvalho J; Ramos JRD; Couceiro S; Travasso RDM; Pires das Neves R; Grãos M, Scientific reports. 2019. http://europepmc.org/abstract/med/31235788 . 10.1038/s41598-019-45352-3 . Scientific reports

Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment

Anjo, Sandra Isabel; Simões, Isaura; Castanheira, Pedro; Grãos, Mário; Manadas, Bruno, Talanta. 205. 2019. http://dx.doi.org/10.1016/j.talanta.2019.120163 . 10.1016/j.talanta.2019.120163 . Talanta

Modulation of oligodendrocyte differentiation by mechanotransduction

Lourenço, T.; Grãos, M., Frontiers in Cellular Neuroscience. NOV2016. 10. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007417961&partnerID=MN8TOARS . 10.3389/fncel.2016.00277 . Frontiers in Cellular Neuroscience

Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues

Lourenço, T.; Paes De Faria, J.; Bippes, C.A.; Maia, J.; Lopes-Da-Silva, J.A.; Relvas, J.B.; Graõs, M., Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958568082&partnerID=MN8TOARS . 10.1038/srep21563 . Scientific Reports

Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions

Kostic, I.; Fidalgo-Carvalho, I.; Aday, S.; Vazão, H.; Carvalheiro, T.; Grãos, M.; Duarte, A.; et al, Scientific Reports. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84946935547&partnerID=MN8TOARS . 10.1038/srep16406 . published Scientific Reports

Dose-dependent inhibition of BACE-1 by the monoterpenoid 2,3,4,4-tetramethyl-5-methylenecyclopent-2-enone in cellular and mouse models of Alzheimer's disease

Videira, R.; Castanheira, P.; Grãos, M.; Resende, R.; Salgueiro, L.; Faro, C.; Cavaleiro, C., Journal of Natural Products. 1275 - 1279. 6. 77. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903648214&partnerID=MN8TOARS . 10.1021/np400903w . Journal of Natural Products

Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage

Leite, C.; Silva, N.T.; Mendes, S.; Ribeiro, A.; De Faria, J.P.; Lourenço, T.; Santos, F.D.; et al, PLoS ONE. 10. 9. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910047126&partnerID=MN8TOARS . 10.1371/journal.pone.0111059 . PLoS ONE

Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells

Ribeiro, A.; Laranjeira, P.; Mendes, S.; Velada, I.; Leite, C.; Andrade, P.; Santos, F.; et al, Stem Cell Research and Therapy. 5. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885350762&partnerID=MN8TOARS . 10.1186/scrt336 . Stem Cell Research and Therapy

A necrodane monoterpenoid from Lavandula luisieri essential oil as a cell-permeable inhibitor of BACE-1, the ß-secretase in Alzheimer's disease

Videira, R.; Castanheira, P.; Grãos, M.; Salgueiro, L.; Faro, C.; Cavaleiro, C., Flavour and Fragrance Journal. 380 - 388. 6. 28. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885865286&partnerID=MN8TOARS . 10.1002/ffj.3156 . Flavour and Fragrance Journal

Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency

Pereira, S.L.; Grãos, M.; Rodrigues, A.S.; Anjo, S.I.; Carvalho, R.A.; Oliveira, P.J.; Arenas, E.; Ramalho-Santos, J., PLoS ONE. 12. 8. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891590984&partnerID=MN8TOARS . 10.1371/journal.pone.0082095 . PLoS ONE

The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations

Ribeiro, C.A.; Fraga, J.S.; Grãos, M.; Neves, N.M.; Reis, R.L.; Gimble, J.M.; Sousa, N.; Salgado, A.J., Stem Cell Research and Therapy. 3. 3. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861667226&partnerID=MN8TOARS . 10.1186/scrt109 . Stem Cell Research and Therapy

VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells

Maia, J.; Vazão, H.; Pedroso, D.C.S.; Jesus, C.S.H.; Brito, R.M.M.; Grãos, M.; Gil, M.H.; Ferreira, L., Biomacromolecules. 2906 - 2916. 9. 13. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866111153&partnerID=MN8TOARS . 10.1021/bm3009268 . Biomacromolecules

Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons

Gomes, J.R.; Costa, J.T.; Melo, C.V.; Felizzi, F.; Monteiro, P.; Pinto, M.J.; Inácio, A.R.; et al, Journal of Neuroscience. 4610 - 4622. 13. 32. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859013000&partnerID=MN8TOARS . 10.1523/JNEUROSCI.0374-12.2012 . Journal of Neuroscience

Proteomics-based technologies in the discovery of biomarkers for multiple sclerosis in the cerebrospinal fluid.

Lourenço AS; Baldeiras I; Grãos M; Duarte CB; Lourenço, A.S.T.; Baldeiras, I.; Grãos, M.; Duarte, C.B., Current molecular medicine. 326 - 349. 4. 11. 2011. http://europepmc.org/abstract/med/21506919 . 10.2174/156652411795677981 . Current molecular medicine

Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells

Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L., PLoS ONE. 3. 6. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS . 10.1371/journal.pone.0017771 . PLoS ONE

Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells

Grãos, M.; Simões-Wüst, A.P.; Duarte, C.B.; Brenneisen, R.; Hamburger, M.; Mennet, M.; Ramos, M.H.; et al, Phytomedicine. 980 - 986. 12. 17. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956619629&partnerID=MN8TOARS . 10.1016/j.phymed.2010.03.005 . Phytomedicine

POLAR MAPPER: A computational tool for integrated visualization of protein interaction networks and mRNA expression data

Grãos, M.; Gonçalves, J.P.; Valente, A.X.C.N., Journal of the Royal Society Interface. 881 - 896. 39. 6. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949092735&partnerID=MN8TOARS . 10.1098/rsif.2008.0407 . Journal of the Royal Society Interface

Growth-factor-dependent phosphorylation of Bim in mitosis

Grãos, M.; Almeida, A.D.; Chatterjee, S., Biochemical Journal. 185 - 194. 1. 388. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-19544385223&partnerID=MN8TOARS . 10.1042/BJ20041385 . Biochemical Journal

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

Almeida, R.D.; Manadas, B.J.; Melo, C.V.; Gomes, J.R.; Mendes, C.S.; Grãos, M.M.; Carvalho, R.F.; Carvalho, A.P.; Duarte, C.B., Cell Death and Differentiation. 1329 - 1343. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144508812&partnerID=MN8TOARS . 10.1038/sj.cdd.4401662 . Cell Death and Differentiation