Innovative Therapies

Functional Proteomics in Health and Disease

Biomarkers

Translational Research

Proteomics/Metabolomics

Mass Spectrometry

Big Data


Research lines

Translational biomarkers and therapy for Hypoxic-ischemic encephalopathy (HIE)

Biomarker research for psychiatric diseases including schizophrenia, bipolar disorder, and autism spectrum disorder

Translational research for biomarkers of neurodegenerative disorders, including Parkinson's Disease and Alzheimer's Disease

Elucidation of long-term psychotropic medication mechanisms

Interactomics approaches to identify new signaling pathways

Overview

Our research group has developed advanced mass spectrometry approaches to be used in multiple biomedical questions. The approaches range from small molecule quantification, as neurotransmitters and metabolites, to proteome profiling, identification of post-translation modifications, and intact protein analysis to identify proteoforms. The questions have been mainly focused on understanding cell biology mechanisms through interactomics or proteomics screenings; identification of disease biomarkers directly from human samples or through translational research approaches; elucidation of psychotropic long-term therapy brain modulation; and identification and quantification of drugs and metabolites in health and disease.

Publications

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Information about journal articles, updated at 03-11-2024, from platform CIÊNCIAVITAE.

Pathophysiological subtypes of mild cognitive impairment due to Alzheimer’s disease identified by CSF proteomics

Moutinho, Daniela; Mendes, Vera M.; Caula, Alessandro; Madeira, Sara C.; Baldeiras, Inês; Guerreiro, Manuela; Cardoso, Sandra; et al, 2024. Translational Neurodegeneration. 1. 13. 2024. http://dx.doi.org/10.1186/s40035-024-00412-1 . 10.1186/s40035-024-00412-1 . published Translational Neurodegeneration

Pine wilt disease: what do we know from proteomics?

Joana Cardoso; MANADAS, BRUNO; Abrantes, I.M.D.O.; ROBERTSON, LEE; Susana Arcos; Maria Teresa Troya; Alfonso Navas; Fonseca, Luís, 2024. BMC Plant Pathology. 2024. https://doi.org/10.1186/s12870-024-04771-9 . published BMC Plant Pathology

A Comparative Analysis of the Venom System between Two Morphotypes of the Sea Anemone Actinia equina

Maria Alcaide; Inês Moutinho Cabral; Lara Carvalho; Vera M. Mendes; António P. Alves de Matos; Bruno Manadas; Leonor Saúde; Mariaelena D’Ambrosio; Pedro M. Costa, 2024. Animals. 2024. https://doi.org/10.3390/ani14060981 . 10.3390/ani14060981 . Animals

Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation

Joana Martins-Macedo; Bruna Araújo; Sandra I. Anjo; Tiago Silveira-Rosa; Patrícia Patrício; Nuno Dinis Alves; Joana M. Silva; et al, 2024. Molecular Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02490-z . 10.1038/s41380-024-02490-z . Molecular Psychiatry

Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture

Marote, A.; Santos, D.; Mendes-Pinheiro, B.; Serre-Miranda, C.; Anjo, S.I.; Vieira, J.; Ferreira-Antunes, F.; et al, 2023. Stem Cell Reviews and Reports. 248 - 263. 1. 19. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85138719382&partnerID=MN8TOARS . 10.1007/s12015-022-10453-6 . Stem Cell Reviews and Reports

A peptide-centric approach to analyse quantitative proteomics data- an application to prostate cancer biomarker discovery

Lima, T.; Rodrigues, J.E.; Manadas, B.; Henrique, R.; Fardilha, M.; Vitorino, R., 2023. Journal of Proteomics. 272. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142764157&partnerID=MN8TOARS . 10.1016/j.jprot.2022.104774 . Journal of Proteomics

Enrichment of hepatic glycogen and plasma glucose from H2 18 O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice

Margarida Coelho; Rohit Mahar; Getachew D. Belew; Alejandra Torres; Cristina Barosa; Fernando Cabral; Ivan Viegas; et al, 2023. NMR in Biomedicine. 2023. https://doi.org/10.1002/nbm.4837 . 10.1002/nbm.4837 . NMR in Biomedicine

Biomarkers of hypoxic–ischemic encephalopathy: a systematic review

Inês Caramelo; Margarida Coelho; Miguel Rosado; Carla M. P. Cardoso; Alexandra Dinis; Carlos B. Duarte; Mário Grãos; Bruno Manadas, 2023. World Journal of Pediatrics. 2023. https://doi.org/10.1007/s12519-023-00698-7 . 10.1007/s12519-023-00698-7 . World Journal of Pediatrics

Proteomics Reveals mRNA Regulation and the Action of Annexins in Thyroid Cancer

Margarida Coelho; João Capela; Sandra I. Anjo; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms241914542 . 10.3390/ijms241914542 . International Journal of Molecular Sciences

An Exploration of Novel Bioactives from the Venomous Marine Annelid Glycera alba

Sónia Campos; Ana P. Rodrigo; Inês Moutinho Cabral; Vera M. Mendes; Bruno Manadas; Mariaelena D’Ambrosio; Pedro M. Costa, 2023. Toxins. 2023. https://doi.org/10.3390/toxins15110655 . 10.3390/toxins15110655 . Toxins

New Insights on Sperm Function in Male Infertility of Unknown Origin: A Multimodal Approach

Rita I. Pacheco; Maria I. Cristo; Sandra Anjo; Silva, Andreia F; Maria Inês Sousa; Renata S. Tavares; Ana Paula Sousa; et al, 2023. Biomolecules. 2023. https://www.mdpi.com/2218-273X/13/10/1462 . 10.3390/biom13101462 . Biomolecules

Functional imaging and neurochemistry identify in vivo neuroprotection mechanisms counteracting excitotoxicity and neurovascular changes in the hippocampus and visual cortex of obese and type 2 diabetic animal models

Beatriz Caramelo; Tamaeh Monteiro-Alfredo; João Martins; José Sereno; João Castelhano; Bruno Manadas; Miguel Castelo-Branco; Paulo Matafome, 2023. Journal of Neurochemistry. 2023. https://doi.org/10.1111/jnc.15825 . 10.1111/jnc.15825 . Journal of Neurochemistry

Peptidomics Unveils Distinct Acetylation Patterns of Histone and Annexin A1 in Differentiated Thyroid Cancer

Margarida Coelho; João Capela; Vera M. Mendes; João Pacheco; Margarida Sá Fernandes; Isabel Amendoeira; John G. Jones; Luís Raposo; Bruno Manadas, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms25010376 . 10.3390/ijms25010376 . International Journal of Molecular Sciences

Proteomic and Metabolic Analysis of Pinus halepensis Mill. Embryonal Masses Induced under Heat Stress

Cátia Pereira; Ander Castander-Olarieta; Itziar A. Montalbán; Vera M. Mendes; Sandra Correia; Ana Pedrosa; Bruno Manadas; Paloma Moncaleán; Jorge Canhoto, 2023. International Journal of Molecular Sciences. 2023. https://doi.org/10.3390/ijms24087211 . 10.3390/ijms24087211 . International Journal of Molecular Sciences

Proteomics of sea bass skin-scales exposed to the emerging pollutant fluoxetine compared to estradiol

Pinto, P.I.; Anjos, L.; Estêvão, M.D.; Santos, S.; Santa, C.; Manadas, B.; Monsinjon, T.; Canário, A.V.M.; Power, D.M., 2022. Science of the Total Environment. 814. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122305160&partnerID=MN8TOARS . 10.1016/j.scitotenv.2021.152671 . Science of the Total Environment

Endogenous Fluorescent Proteins in the Mucus of an Intertidal Polychaeta: Clues for Biotechnology

Ana P. Rodrigo; Ana Lopes; Ricardo Pereira; Sandra I. Anjo; Bruno Manadas; Ana R. Grosso; Pedro V. Baptista; Alexandra R. Fernandes; Pedro M. Costa, 2022. Marine Drugs. 224 - 224. 4. 20. 2022. https://doi.org/10.3390/md20040224 . 10.3390/md20040224 . Marine Drugs

Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model

Inês Serrenho; Carla M. Cardoso; Mário Grãos; Alexandra Dinis; Bruno Manadas; Graça Baltazar, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms24010257 . 10.3390/ijms24010257 . International Journal of Molecular Sciences

Increased Intake of Both Caffeine and Non-Caffeine Coffee Components Is Associated with Reduced NAFLD Severity in Subjects with Type 2 Diabetes

Margarida Coelho; Rita S. Patarrão; Inês Sousa-Lima; Rogério T. Ribeiro; Maria João Meneses; Rita Andrade; Vera M. Mendes; et al, 2022. Nutrients. 2022. https://doi.org/10.3390/nu15010004 . 10.3390/nu15010004 . Nutrients

Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression

Ana Pinto; Ana Beatriz Machado; Hugo Osorio; Marta Laranjeiro Pinto; Vitorino, R.; Gonçalo C. Justino; Cátia Santa; et al, 2022. Cancers. 2022. https://www.mdpi.com/2072-6694/15/1/270 . 10.3390/cancers15010270 . Cancers

Chronic stress causes striatal disinhibition mediated by SOM-interneurons in male mice

Diana Rodrigues; Luis Jacinto; Margarida Falcão; Ana Carolina Castro; Alexandra Cruz; Cátia Santa; Bruno Manadas; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-35028-4 . 10.1038/s41467-022-35028-4 . Nature Communications

Mass Spectrometry-Based Proteomic and Metabolomic Profiling of Serum Samples for Discovery and Validation of Tuberculosis Diagnostic Biomarker Signature

Ana Filipa Fernandes; Luís Gafeira Gonçalves; Maria Bento; Sandra I. Anjo; Bruno Manadas; Clara Barroso; Miguel Villar; et al, 2022. International Journal of Molecular Sciences. 2022. https://doi.org/10.3390/ijms232213733 . 10.3390/ijms232213733 . International Journal of Molecular Sciences

Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis

Salazar, I.L.; Lourenço, A.S.T.; Manadas, B.; Baldeiras, I.; Ferreira, C.; Teixeira, A.C.; Mendes, V.M.; et al, 2022. Journal of Neuroinflammation. 1. 19. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124466899&partnerID=MN8TOARS . 10.1186/s12974-022-02404-2 . Journal of Neuroinflammation

Systematic Review and Meta-Analysis of Mass Spectrometry Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Schizophrenia

João E. Rodrigues; Ana Martinho; Catia Santa; Nuno Madeira; Manuel Coroa; Vítor Santos; Maria J. Martins; et al, 2022. International Journal of Molecular Sciences. 4917 - 4917. 9. 23. 2022. https://doi.org/10.3390/ijms23094917 . 10.3390/ijms23094917 . International Journal of Molecular Sciences

Optimization of a Protocol for Protein Extraction from Calcified Aortic Valves for Proteomics Applications: Development of a Standard Operating Procedure

Fábio Trindade; Ana F. Ferreira; Francisca Saraiva; Diana Martins; Vera M. Mendes; Carla Sousa; Cristina Gavina; et al, 2022. Proteomes. 2022. https://doi.org/10.3390/proteomes10030030 . 10.3390/proteomes10030030 . Proteomes

COVID-19 Salivary Protein Profile: Unravelling Molecular Aspects of SARS-CoV-2 Infection

Eduardo Esteves; Vera M. Mendes; Bruno Manadas; Rafaela Lopes; Liliana Bernardino; Maria José Correia; Marlene Barros; Ana Cristina Esteves; Nuno Rosa, 2022. Journal of Clinical Medicine. 2022. https://doi.org/10.3390/jcm11195571 . 10.3390/jcm11195571 . Journal of Clinical Medicine

Virulence Biomarkers of Bursaphelenchus xylophilus: A Proteomic Approach

Cardoso, J.M.S.; Anjo, S.I.; Manadas, B.; Silva, H.; Abrantes, I.; Nakamura, K.; Fonseca, L., 2022. Frontiers in Plant Science. 12. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85125060046&partnerID=MN8TOARS . 10.3389/fpls.2021.822289 . Frontiers in Plant Science

Decoding the radiomic and proteomic phenotype of epicardial adipose tissue associated with adverse left atrial remodelling and post-operative atrial fibrillation in aortic stenosis

Mancio, J.; Sousa-Nunes, F.; Martins, R.; Fragao-Marques, M.; Conceicao, G.; Pessoa-Amorim, G.; Barros, A.S.; et al, 2022. European Heart Journal Cardiovascular Imaging. 1248 - 1259. 9. 23. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136182913&partnerID=MN8TOARS . 10.1093/ehjci/jeac092 . European Heart Journal Cardiovascular Imaging

Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis via the mitochondria dependent pathway

Magalhães, M.; Domínguez-Martín, E.M.; Jorge, J.; Gonçalves, A.C.; Díaz-Lanza, A.M.; Manadas, B.; Efferth, T.; Rijo, P.; Cabral, C., 2022. Frontiers in Pharmacology. 13. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85140619586&partnerID=MN8TOARS . 10.3389/fphar.2022.1006832 . Frontiers in Pharmacology

More than a simple epithelial layer: multifunctional role of echinoderm coelomic epithelium

Guatelli, S.; Ferrario, C.; Bonasoro, F.; Anjo, S.I.; Manadas, B.; Candia Carnevali, M.D.; Varela Coelho, A.; Sugni, M., 2022. Cell and Tissue Research. 207 - 227. 2. 390. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137783059&partnerID=MN8TOARS . 10.1007/s00441-022-03678-x . Cell and Tissue Research

Effects of microplastics alone and with adsorbed benzo(a)pyrene on the gills proteome of Scrobicularia plana

Bebianno, M.J.; Mendes, V.M.; O'Donovan, S.; Carteny, C.C.; Keiter, S.; Manadas, B., 2022. Science of the Total Environment. 842. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85133432069&partnerID=MN8TOARS . 10.1016/j.scitotenv.2022.156895 . Science of the Total Environment

Modulation of signaling pathways by DJ-1: An updated overview

Neves, M.; Grãos, M.; Anjo, S.I.; Manadas, B.; Margarida Neves; Mario Graos; Sandra Anjo; MANADAS, BRUNO, 2022. Redox Biology. 51. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126516555&partnerID=MN8TOARS . 10.1016/j.redox.2022.102283 . accepted Redox Biology

Proteome dataset of sea bass (Dicentrarchus labrax) skin-scales exposed to fluoxetine and estradiol

Anjos, L.; Pinto, P.I.S.; Santos, S.; Estêvão, M.D.; Santa, C.; Manadas, B.; Canário, A.V.M.; Power, D.M., 2022. Data in Brief. 41. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122311143&partnerID=MN8TOARS . 10.1016/j.dib.2022.107971 . Data in Brief

Chronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system

Guimarães, M.R.; Anjo, S.I.; Cunha, A.M.; Esteves, M.; Sousa, N.; Almeida, A.; Manadas, B.; Leite-Almeida, H., 2021. Pain. 1722 - 1731. 6. 162. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85106543286&partnerID=MN8TOARS . 10.1097/j.pain.0000000000002192 . Pain

Chemoprevention and therapeutic role of essential oils and phenolic compounds: Modeling tumor microenvironment in glioblastoma

Magalhães, M.; Manadas, B.; Efferth, T.; Cabral, C., 2021. Pharmacological Research. 169. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105057870&partnerID=MN8TOARS . 10.1016/j.phrs.2021.105638 . Pharmacological Research

Disclosing proteins in the leaves of cork oak plants associated with the immune response to Phytophthora cinnamomi inoculation in the roots: A long-term proteomics approach

Coelho, A.C.; Pires, R.; Schutz, G.; Santa, C.; Manadas, B.; Pinto, P., 2021. PLoS ONE. 1 January. 16. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85100319358&partnerID=MN8TOARS . 10.1371/journal.pone.0245148 . PLoS ONE

Comparative Analysis of Bursaphelenchus xylophilus Secretome Under Pinus pinaster and P. pinea Stimuli

Silva, H.; Anjo, S.I.; Manadas, B.; Abrantes, I.; Fonseca, L.; Cardoso, J.M.S., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85107053724&partnerID=MN8TOARS . 10.3389/fpls.2021.668064 . Frontiers in Plant Science

Spotted Fever Group Rickettsia Trigger Species-Specific Alterations in Macrophage Proteome Signatures with Different Impacts in Host Innate Inflammatory Responses

Curto, P.; Santa, C.; Cortes, L.; Manadas, B.; Simões, I., 2021. Microbiology Spectrum. 3. 9. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123813061&partnerID=MN8TOARS . 10.1128/SPECTRUM.00814-21 . Microbiology Spectrum

Metabolic parameters as possible diagnostic predictors in first-episode psychosis: An exploratory retrospective cohort study

Sofia Ramos Ferreira; Diana Moura; Pedro Oliveira; Vítor Santos; Miguel Bajouco; Sofia Morais; Manuel Coroa; Bruno Manadas; Nuno Madeira, 2021. Early Intervention in Psychiatry. 2021. https://doi.org/10.1111/eip.13257 . 10.1111/eip.13257 . Early Intervention in Psychiatry

Proteome-Wide Analysis of Heat-Stress in Pinus radiata Somatic Embryos Reveals a Combined Response of Sugar Metabolism and Translational Regulation Mechanisms

Castander-Olarieta, A.; Pereira, C.; Montalbán, I.A.; Mendes, V.M.; Correia, S.; Suárez-Álvarez, S.; Manadas, B.; Canhoto, J.; Moncaleán, P., 2021. Frontiers in Plant Science. 12. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104978818&partnerID=MN8TOARS . 10.3389/fpls.2021.631239 . Frontiers in Plant Science

The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway

Ana F. Cruz; Mariana B. Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al, 2021. Cancers. 3052 - 3052. 12. 13. 2021. https://doi.org/10.3390/cancers13123052 . 10.3390/cancers13123052 . Cancers

Specific Antiproliferative Properties of Proteinaceous Toxin Secretions from the Marine Annelid Eulalia sp. onto Ovarian Cancer Cells

Ana P. Rodrigo; Vera M. Mendes; Bruno Manadas; Ana R. Grosso; António P. Alves de Matos; Pedro V. Baptista; Pedro M. Costa; Alexandra R. Fernandes, 2021. Marine Drugs. 2021. https://doi.org/10.3390/md19010031 . 10.3390/md19010031 . Marine Drugs

GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Nuno A. Fonseca; Ana C. Gregório; Vera M. Mendes; Rui Lopes; Teresa Abreu; Nélio Gonçalves; Bruno Manadas; et al, 2021. Nano Today. 101095 - 101095. 37. 2021. https://doi.org/10.1016/j.nantod.2021.101095 . 10.1016/j.nantod.2021.101095 . Nano Today

Hypoxia and Hypoxia-Inducible Factor-1a Regulate Endoplasmic Reticulum Stress in Nucleus Pulposus Cells: Implications of Endoplasmic Reticulum Stress for Extracellular Matrix Secretion

Novais, E.J.; Choi, H.; Madhu, V.; Suyama, K.; Anjo, S.I.; Manadas, B.; Shapiro, I.M.; Salgado, A.J.; Risbud, M.V., 2021. American Journal of Pathology. 487 - 502. 3. 191. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099523691&partnerID=MN8TOARS . 10.1016/j.ajpath.2020.11.012 . American Journal of Pathology

Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies

Inês Serrenho; Miguel Rosado; Alexandra Dinis; Carla M. Cardoso; Mário Grãos; Bruno Manadas; Graça Baltazar, 2021. International Journal of Molecular Sciences. 2021. https://doi.org/10.3390/ijms22063142 . 10.3390/ijms22063142 . International Journal of Molecular Sciences

FA-SAT ncRNA interacts with PKM2 protein: depletion of this complex induces a switch from cell proliferation to apoptosis

Ferreira, D.; Escudeiro, A.; Adega, F.; Anjo, S.I.; Manadas, B.; Chaves, R., 2020. Cellular and Molecular Life Sciences. 1371 - 1386. 7. 77. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069637568&partnerID=MN8TOARS . 10.1007/s00018-019-03234-x . Cellular and Molecular Life Sciences

A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers

Anjo, Sandra I.; dos Santos, Patrícia Valério; Rosado, Luiza; Baltazar, Graça; Baldeiras, Inês; Pires, Diana; Gomes, Andreia; et al, 2020. Translational Neurodegeneration. 1. 9. 2020. http://dx.doi.org/10.1186/s40035-020-00188-0 . 10.1186/s40035-020-00188-0 . published Translational Neurodegeneration

Comparative proteomic analysis of nodulated and non-nodulated Casuarina glauca Sieb. ex Spreng. grown under salinity conditions using sequential window acquisition of all theoretical mass spectra (SWATH-MS)

Graça, Inês; Mendes, Vera M.; Marques, Isabel; Duro, Nuno; Costa, Mário; Ramalho, José C.; Pawlowski, Katharina; et al, 2020. International Journal of Molecular Sciences. 78 - 78. 1. 21. 2020. http://hdl.handle.net/10400.5/19224 . 10.3390/ijms21010078 . International Journal of Molecular Sciences

Cofilin-1 is a mechanosensitive regulator of transcription

Domingues, Catarina; Geraldo, A Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; et al, 2020. 2020. http://hdl.handle.net/10773/30552 . 10.3389/fcell.2020.00678 .

Proteomics-based Predictive Model for the Early Detection of Metastasis and Recurrence in Head and Neck Cancer

Ribeiro, I.P.; Esteves, L.; Anjo, S.I.; Marques, F.; Barroso, L.; Manadas, B.; Carreira, I.M.; Melo, J.B., 2020. Cancer Genomics and Proteomics. 259 - 269. 3. 17. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85084169410&partnerID=MN8TOARS . 10.21873/cgp.20186 . Cancer Genomics and Proteomics

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting

Lopes, C.; Tang, Y.; Anjo, S.I.; Manadas, B.; Onofre, I.; de Almeida, L.P.; Daley, G.Q.; Schlaeger, T.M.; Rego, A.C.C., 2020. Frontiers in Cell and Developmental Biology. 8. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85092059116&partnerID=MN8TOARS . 10.3389/fcell.2020.576592 . Frontiers in Cell and Developmental Biology

Specific Nutritional Biomarker Profiles in Mild Cognitive Impairment and Subjective Cognitive Decline Are Associated With Clinical Progression: The NUDAD Project

Francisca A. de Leeuw; Wiesje M. van der Flier; Betty M. Tijms; Philip Scheltens; Vera M. Mendes; Bruno Manadas; Jörgen Bierau; et al, 2020. Journal of the American Medical Directors Association. 2020. https://doi.org/10.1016/j.jamda.2019.12.009 . 10.1016/j.jamda.2019.12.009 . Journal of the American Medical Directors Association

Epicardial adipose tissue volume and annexin A2/fetuin-A signalling are linked to coronary calcification in advanced coronary artery disease: Computed tomography and proteomic biomarkers from the EPICHEART study

Mancio, J.; Barros, A.S.; Conceicao, G.; Pessoa-Amorim, G.; Santa, C.; Bartosch, C.; Ferreira, W.; et al, 2020. Atherosclerosis. 75 - 83. 292. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075496821&partnerID=MN8TOARS . 10.1016/j.atherosclerosis.2019.11.015 . Atherosclerosis

Influence of EPICardial adipose tissue in HEART diseases (EPICHEART) study: Protocol for a translational study in coronary atherosclerosis,Influência do Tecido Adiposo Epicárdico nas Doenças Cardíacas (EPICHEART): protocolo para um estudo de translação em aterosclerose coronário

Mancio, J.; Barros, A.S.; Conceicão, G.; Santa, C.; Pessoa-Amorim, G.; Bartosch, C.; Fragao-Marques, M.; et al, 2020. Revista Portuguesa de Cardiologia. 625 - 633. 11. 39. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095788788&partnerID=MN8TOARS . 10.1016/j.repc.2020.03.017 . Revista Portuguesa de Cardiologia

Analytical methods to monitor dopamine metabolism in plasma: Moving forward with improved diagnosis and treatment of neurological disorders

Abrantes Dias, A.S.; Amaral Pinto, J.C.; Magalhães, M.; Mendes, V.M.; Manadas, B., 2020. Journal of Pharmaceutical and Biomedical Analysis. 187. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85085476273&partnerID=MN8TOARS . 10.1016/j.jpba.2020.113323 . Journal of Pharmaceutical and Biomedical Analysis

Changes in the salivary proteome of beagle dogs after weight loss

Lucena, S.; Coelho, A.V.; Muñoz-Prieto, A.; Anjo, S.I.; Manadas, B.; Capela e Silva, F.; Lamy, E.; Tvarijonaviciute, A., 2020. Domestic Animal Endocrinology. 72. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083877714&partnerID=MN8TOARS . 10.1016/j.domaniend.2020.106474 . Domestic Animal Endocrinology

The Potential of Metabolomics in the Diagnosis of Thyroid Cancer

Margarida Coelho; Luis Raposo; Brian J. Goodfellow; Luigi Atzori; John Jones; Bruno Manadas, 2020. International Journal of Molecular Sciences. 5272 - 5272. 15. 21. 2020. https://doi.org/10.3390/ijms21155272 . 10.3390/ijms21155272 . International Journal of Molecular Sciences

Proteomic Analyses Reveal New Insights on the Antimicrobial Mechanisms of Chitosan Biopolymers and Their Nanosized Particles against Escherichia coli

Laidson P. Gomes; Sandra I. Anjo; Bruno Manadas; Ana V. Coelho; Vania M. F. Paschoalin, 2019. International Journal of Molecular Sciences. 2019. https://doi.org/10.3390/ijms21010225 . 10.3390/ijms21010225 . International Journal of Molecular Sciences

Experimental data from flesh quality assessment and shelf life monitoring of high pressure processed European sea bass (Dicentrarchus labrax) fillets

Anjos, Liliana; Pinto, Patricia IS; Tsironi, Theofania; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13462 . 10.1016/j.dib.2019.104451 .

Analysis of the quantitative proteomic signature in PBMCs of first-episode psychosis patients

Santa, Cátia; Coroa, Manuel; Morais, Sofia; Bajouco, Miguel; Anjo, Sandra; Baldeiras, Ines; Madeira, Nuno; Macedo, António; MANADAS, BRUNO, 2019. Frontiers in Cellular Neuroscience. 13. 2019. http://dx.doi.org/10.3389/conf.fncel.2019.01.00005 . 10.3389/conf.fncel.2019.01.00005 . published Frontiers in Cellular Neuroscience

An atypical aspartic protease modulates lateral root development in Arabidopsis thaliana

Soares, A.; Niedermaier, S.; Faro, R.; Loos, A.; Manadas, B.; Faro, C.; Huesgen, P.F.; Cheung, A.Y.; Simões, I., 2019. Journal of Experimental Botany. 2157 - 2171. 7. 70. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068490019&partnerID=MN8TOARS . 10.1093/jxb/erz059 . Journal of Experimental Botany

Validation of an LC-MS/MS Method for the Quantification of Caffeine and Theobromine Using Non-Matched Matrix Calibration Curve

Vera M. Mendes; Margarida Coelho; Angelo R. Tomé; Rodrigo A. Cunha; Bruno Manadas, 2019. Molecules. 2019. https://doi.org/10.3390/molecules24162863 . 10.3390/molecules24162863 . Molecules

Comparative proteomic analysis of saliva from dogs with and without obesity-related metabolic dysfuntion

Sónia Lucena; Ana Varela Coelho; Sandra I. Anjo; Bruno Manadas; Vladimir Mrljak; Fernando Capela e Silva; Elsa Lamy; Asta Tvarijonaviciute, 2019. Journal of Proteomics. 65 - 72. 201. 2019. https://doi.org/10.1016/j.jprot.2019.04.010 . 10.1016/j.jprot.2019.04.010 . Journal of Proteomics

High pressure processing of European sea bass (Dicentrarchus labrax) fillets and tools for flesh quality and shelf life monitoring

Tsironi, Theofania; Anjos, Liliana; Pinto, Patricia IS; Dimopoulos, George; Santos, Soraia; Santa, Cátia; Manadas, Bruno; et al, 2019. 2019. http://hdl.handle.net/10400.1/13638 . 10.1016/j.jfoodeng.2019.05.010 .

Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a Parkinson's disease rat model

Pinheiro, Bárbara Filipa Mendes; Anjo, Sandra I.; Manadas, Bruno; da Silva, Jorge D.; Marote, Ana Maria Franco Aveiro; Behie, Leo A.; Teixeira, Fábio G.; Salgado, A. J., 2019. 2019. http://hdl.handle.net/1822/67311 . 10.3389/fbioe.2019.00294 .

Pre-analytical stability of novel cerebrospinal fluid biomarkers

Willemse, E.A.J.; Vermeiren, Y.; Garcia-Ayllon, M.-S.; Bridel, C.; De Deyn, P.P.; Engelborghs, S.; van der Flier, W.M.; et al, 2019. Clinica Chimica Acta. 204 - 211. 497. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069842833&partnerID=MN8TOARS . 10.1016/j.cca.2019.07.024 . Clinica Chimica Acta

Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment

Anjo, S.I.; Simões, I.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Talanta. 205. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069659407&partnerID=MN8TOARS . 10.1016/j.talanta.2019.120163 . Talanta

Changes in the intestinal mucosal proteome of turkeys (Meleagris gallopavo) infected with haemorrhagic enteritis virus

Marques, A.T.; Anjo, S.I.; Bhide, M.; Varela Coelho, A.; Manadas, B.; Lecchi, C.; Grilli, G.; Ceciliani, F., 2019. Veterinary Immunology and Immunopathology. 213. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067345000&partnerID=MN8TOARS . 10.1016/j.vetimm.2019.06.001 . Veterinary Immunology and Immunopathology

Meningeal ¿d T cell-derived IL-17 controls synaptic plasticity and short-term memory

Ribeiro, M.; Brigas, H.C.; Temido-Ferreira, M.; Pousinha, P.A.; Regen, T.; Santa, C.; Coelho, J.E.; et al, 2019. Science Immunology. 40. 4. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073157928&partnerID=MN8TOARS . 10.1126/sciimmunol.aay5199 . Science Immunology

oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening

Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Mário Grãos; Bruno Manadas, 2019. Redox Biology. 101130 - 101130. 2019. https://doi.org/10.1016/j.redox.2019.101130 . 10.1016/j.redox.2019.101130 . Redox Biology

Proteomics and antioxidant enzymes reveal different mechanisms of toxicity induced by ionic and nanoparticulate silver in bacteria

Barros, D.; Pradhan, A.; Mendes, V.M.; Manadas, B.; Santos, P.M.; Pascoal, C.; Cássio, F., 2019. Environmental Science: Nano. 1207 - 1218. 4. 6. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064263150&partnerID=MN8TOARS . 10.1039/c8en01067f . Environmental Science: Nano

Corrigendum to “oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening” (Redox Biology (2019) 22, (S2213231718311856), (10.1016/j.redox.2019.101130))

Anjo, S.I.; Melo, M.N.; Loureiro, L.R.; Sabala, L.; Castanheira, P.; Grãos, M.; Manadas, B., 2019. Redox Biology. 26. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067256447&partnerID=MN8TOARS . 10.1016/j.redox.2019.101257 . Redox Biology

A pathogen and a non-pathogen spotted fever group rickettsiatrigger differential proteome signatures in macrophages

Curto, P.; Santa, C.; Allen, P.; Manadas, B.; Simões, I.; Martinez, J.J., 2019. Frontiers in Cellular and Infection Microbiology. MAR. 9. 2019. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063647273&partnerID=MN8TOARS . 10.3389/fcimb.2019.00043 . Frontiers in Cellular and Infection Microbiology

A translational view of cells' secretome analysis - from untargeted proteomics to potential circulating biomarkers

Anjo, S.I.; Manadas, B., 2018. Biochimie. 37 - 49. 155. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048135989&partnerID=MN8TOARS . 10.1016/j.biochi.2018.05.007 . Biochimie

Elucidation of the dynamic nature of interactome networks: A practical tutorial

Anjo, S.I.; Martins-Marques, T.; Pereira, P.; Girão, H.; Manadas, B., 2018. Journal of Proteomics. 116 - 126. 171. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018674162&partnerID=MN8TOARS . 10.1016/j.jprot.2017.04.011 . Journal of Proteomics

Matrisome Profiling during Intervertebral Disc Development and Ageing

Caldeira, J.; Santa, C.; Osório, H.; Molinos, M.; Manadas, B.; Goncalves, R.; Barbosa, M., 2017. Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029508543&partnerID=MN8TOARS . 10.1038/s41598-017-11960-0 . Scientific Reports

Functional and structural characterization of synthetic cardosin B-derived rennet

Almeida, C.M.; Manso, J.A.; Figueiredo, A.C.; Antunes, L.; Cruz, R.; Manadas, B.; Bur, D.; et al, 2017. Applied Microbiology and Biotechnology. 6951 - 6968. 18. 101. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026776770&partnerID=MN8TOARS . 10.1007/s00253-017-8445-8 . Applied Microbiology and Biotechnology

Insights into the human brain proteome: Disclosing the biological meaning of protein networks in cerebrospinal fluid

Bastos, P.; Ferreira, R.; Manadas, B.; Moreira, P.I.; Vitorino, R., 2017. Critical Reviews in Clinical Laboratory Sciences. 185 - 204. 3. 54. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019117156&partnerID=MN8TOARS . 10.1080/10408363.2017.1299682 . Critical Reviews in Clinical Laboratory Sciences

A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid's proteome

Trindade, F.; Bastos, P.; Leite-Moreira, A.; Manadas, B.; Ferreira, R.; Soares, S.F.; Daniel-da-Silva, A.L.; Falcão-Pires, I.; Vitorino, R., 2017. Archives of Biochemistry and Biophysics. 1 - 10. 634. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030090771&partnerID=MN8TOARS . 10.1016/j.abb.2017.09.016 . Archives of Biochemistry and Biophysics

EDTA-functionalized magnetic nanoparticles: A suitable platform for the analysis of low abundance urinary proteins

Bastos, P.; Trindade, F.; Ferreira, R.; Leite-Moreira, A.; Falcão-Pires, I.; Manadas, B.; Daniel-da-Silva, A.L.; Vitorino, R., 2017. Talanta. 81 - 88. 170. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85016933823&partnerID=MN8TOARS . 10.1016/j.talanta.2017.03.087 . Talanta

A proteomic and ultrastructural characterization of Aspergillus fumigatus' conidia adaptation at different culture ages

Anjo, S.I.; Figueiredo, F.; Fernandes, R.; Manadas, B.; Oliveira, M., 2017. Journal of Proteomics. 47 - 56. 161. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85017103862&partnerID=MN8TOARS . 10.1016/j.jprot.2017.03.021 . Journal of Proteomics

SWATH-MS as a tool for biomarker discovery: From basic research to clinical applications

Anjo, S.I.; Santa, C.; Manadas, B., 2017. Proteomics. 3-4. 17. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012914613&partnerID=MN8TOARS . 10.1002/pmic.201600278 . Proteomics

Enzymatic properties, evidence for in vivo expression, and intracellular localization of shewasin D, the pepsin homolog from Shewanella denitrificans

Leal, A.R.; Cruz, R.; Bur, D.; Huesgen, P.F.; Faro, R.; Manadas, B.; Wlodawer, A.; Faro, C.; Simoes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962833456&partnerID=MN8TOARS . 10.1038/srep23869 . Scientific Reports

Protein Quality Assessment on Saliva Samples for Biobanking Purposes

Rosa, N.; Marques, J.; Esteves, E.; Fernandes, M.; Mendes, V.M.; Afonso, A.; Dias, S.; et al, 2016. Biopreservation and Biobanking. 289 - 297. 4. 14. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981350223&partnerID=MN8TOARS . 10.1089/bio.2015.0054 . Biopreservation and Biobanking

Unveiling the Differences of Secretome of Human Bone Marrow Mesenchymal Stem Cells, Adipose Tissue-Derived Stem Cells, and Human Umbilical Cord Perivascular Cells: A Proteomic Analysis

Pires, A.O.; Mendes-Pinheiro, B.; Teixeira, F.G.; Anjo, S.I.; Ribeiro-Samy, S.; Gomes, E.D.; Serra, S.C.; et al, 2016. Stem Cells and Development. 1073 - 1083. 14. 25. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978401618&partnerID=MN8TOARS . 10.1089/scd.2016.0048 . Stem Cells and Development

A reference library of peripheral blood mononuclear cells for SWATH-MS analysis

Silva, C.; Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics - Clinical Applications. 760 - 764. 7. 10. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979075975&partnerID=MN8TOARS . 10.1002/prca.201600070 . Proteomics - Clinical Applications

Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation

Teixeira, F.G.; Panchalingam, K.M.; Assunção-Silva, R.; Serra, S.C.; Mendes-Pinheiro, B.; Patrício, P.; Jung, S.; et al, 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84974718908&partnerID=MN8TOARS . 10.1038/srep27791 . Scientific Reports

Direct analysis of [6,6-<sup>2</sup>H<inf>2</inf>]glucose and [U-<sup>13</sup>C<inf>6</inf>]glucose dry blood spot enrichments by LC-MS/MS

Coelho, M.; Mendes, V.M.; Lima, I.S.; Martins, F.O.; Fernandes, A.B.; Macedo, M.P.; Jones, J.G.; Manadas, B., 2016. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 242 - 248. 1022. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963956082&partnerID=MN8TOARS . 10.1016/j.jchromb.2016.04.027 . Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Protein precipitation of diluted samples in SDS-containing buffer with acetone leads to higher protein recovery and reproducibility in comparison with TCA/acetone approach

Santa, C.; Anjo, S.I.; Manadas, B., 2016. Proteomics. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971222028&partnerID=MN8TOARS . 10.1002/pmic.201600024 . Proteomics

Bioaccessibility and changes on cylindrospermopsin concentration in edible mussels with storage and processing time

Freitas, M.; Azevedo, J.; Carvalho, A.P.; Mendes, V.M.; Manadas, B.; Campos, A.; Vasconcelos, V.; et al, 2016. Food Control. 567 - 574. 59. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934975039&partnerID=MN8TOARS . 10.1016/j.foodcont.2015.06.025 . Food Control

Bursaphelenchus xylophilus and B. mucronatus secretomes: A comparative proteomic analysis

Cardoso, J.M.S.; Anjo, S.I.; Fonseca, L.; Egas, C.; Manadas, B.; Abrantes, I., 2016. Scientific Reports. 6. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006073833&partnerID=MN8TOARS . 10.1038/srep39007 . Scientific Reports

Erratum: Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations (Biochimie (2013) 95:12 (2297-2303) DOI: 10.1016/j.biochi.2013.06.028)

Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2016. Biochimie. 336 - 336. 121. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957818600&partnerID=MN8TOARS . 10.1016/j.biochi.2015.11.025 . Biochimie

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-ß Levels in Patients with Alzheimer's Disease?

Travassos M; Santana I; Baldeiras I; Tsolaki M; Gkatzima O; Sermin G; Yener GG; et al, 2015. 2015. http://europepmc.org/abstract/med/26401784 . 10.3233/JAD-150374 .

Gap junctional protein Cx&lt;inf&gt;43&lt;/inf&gt; is involved in the communication between extracellular vesicles and mammalian cells

Soares, A.R.; Martins-Marques, T.; Ribeiro-Rodrigues, T.; Ferreira, J.V.; Catarino, S.; Pinho, M.J.; Zuzarte, M.; et al, 2015. Scientific Reports. 5. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939865125&partnerID=MN8TOARS . 10.1038/srep13243 . Scientific Reports

Do hypoxia/normoxia culturing conditions change the neuroregulatory profile of Wharton Jelly mesenchymal stem cell secretome?

Teixeira FG; Panchalingam KM; Anjo SI; Manadas B; Pereira R; Sousa N; Salgado AJ; et al, 2015. Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec. 2015. http://europepmc.org/abstract/med/26204925 . 10.1186/s13287-015-0124-z . Introduction: The use of human umbilical cord Wharton Jelly-derived mesenchymal stem cells (hWJ-MSCs) has been considered a new potential source for future safe applications in regenerative medicine. Indeed, the application of hWJ-MSCs into different animal models of disease, including those from the central nervous system, has shown remarkable therapeutic benefits mostly associated with their sec

Corrigendum: Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells.

Soares AR; Martins-Marques T; Ribeiro-Rodrigues T; Ferreira JV; Catarino S; Pinho MJ; Zuzarte M; et al, 2015. 2015. http://europepmc.org/abstract/med/26445927 . 10.1038/srep14888 .

Reduced a-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

Schneeberger, M.; Gómez-Valadés, A.G.; Altirriba, J.; Sebastián, D.; Ramírez, S.; Garcia, A.; Esteban, Y.; et al, 2015. Cell Reports. 361 - 370. 3. 12. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937518875&partnerID=MN8TOARS . 10.1016/j.celrep.2015.06.041 . Cell Reports

Effect of Global ATGL Knockout on Murine Fasting Glucose Kinetics

Coelho, M.; Nunes, P.; Mendes, V.M.; Manadas, B.; Heerschap, A.; Jones, J.G., 2015. Journal of Diabetes Research. 2015. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937692377&partnerID=MN8TOARS . 10.1155/2015/542029 . Journal of Diabetes Research

Short GeLC-SWATH: A fast and reliable quantitative approach for proteomic screenings

Anjo, S.I.; Santa, C.; Manadas, B., 2015. Proteomics. 757 - 762. 4. 15. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922847099&partnerID=MN8TOARS . 10.1002/pmic.201400221 . Proteomics

Interacting network of the gap junction protein connexin43 is modulated by ischemia and reperfusion in the heart.

Martins-Marques T; Anjo SI; Pereira P; Manadas B; Girao H; Martins-Marques, T.; Anjo, S.I.; et al, 2015. Molecular and Cellular Proteomics. 3040 - 3055. 11. 14. 2015. http://europepmc.org/abstract/med/26316108 . 10.1074/mcp.M115.052894 . Molecular and Cellular Proteomics

Ser119 phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor

Soares-Dos-Reis, R.; Pessoa, A.S.; Matos, M.R.; Falcão, M.; Mendes, V.M.; Manadas, B.; Monteiro, F.A.; Lima, D.; Reguenga, C., 2014. Biochemical Journal. 441 - 453. 3. 459. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898656809&partnerID=MN8TOARS . 10.1042/BJ20131014 . Biochemical Journal

Unveiling the effects of the secretome of mesenchymal progenitors from the umbilical cord in different neuronal cell populations

Fraga, J.S.; Silva, N.A.; Lourenço, A.S.; Gonçalves, V.; Neves, N.M.; Reis, R.L.; Rodrigues, A.J.; et al, 2013. Biochimie. 2297 - 2303. 12. 95. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887824472&partnerID=MN8TOARS . 10.1016/j.biochi.2013.06.028 . Biochimie

Comparative analysis of the exoproteomes of listeria monocytogenes strains grown at low temperatures

Cabrita, P.; Batista, S.; Machado, H.; Moes, S.; Jenö, P.; Manadas, B.; Trigo, M.J.; et al, 2013. Foodborne Pathogens and Disease. 428 - 434. 5. 10. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879104474&partnerID=MN8TOARS . 10.1089/fpd.2012.1385 . Foodborne Pathogens and Disease

Toward a standardized saliva proteome analysis methodology

Vitorino, R.; Guedes, S.; Manadas, B.; Ferreira, R.; Amado, F., 2012. Journal of Proteomics. 5140 - 5165. 17. 75. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865548707&partnerID=MN8TOARS . 10.1016/j.jprot.2012.05.045 . Journal of Proteomics

Comparative proteomic analysis of auxin-induced embryogenic and nonembryogenic tissues of the solanaceous tree c yphomandra betacea (tamarillo)

Correia, S.; Vinhas, R.; Manadas, B.; Lourenço, A.S.; Veríssimo, P.; Canhoto, J.M., 2012. Journal of Proteome Research. 1666 - 1675. 3. 11. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857806173&partnerID=MN8TOARS . 10.1021/pr200856w . Journal of Proteome Research

Partitioning the proteome: Phase separation for targeted analysis of membrane proteins in human post-mortem brain

English, J.A.; Manadas, B.; Scaife, C.; Cotter, D.R.; Dunn, M.J., 2012. PLoS ONE. 6. 7. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862702997&partnerID=MN8TOARS . 10.1371/journal.pone.0039509 . PLoS ONE

Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides

Vinhas, R.; Cortes, L.; Cardoso, I.; Mendes, V.M.; Manadas, B.; Todo-Bom, A.; Pires, E.; Veríssimo, P., 2011. Allergy: European Journal of Allergy and Clinical Immunology. 1088 - 1098. 8. 66. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960015037&partnerID=MN8TOARS . 10.1111/j.1398-9995.2011.02598.x . Allergy: European Journal of Allergy and Clinical Immunology

Analysis of glucose metabolism in farmed European sea bass (Dicentrarchus labrax L.) using deuterated water

Viegas, I.; Mendes, V.M.; Leston, S.; Jarak, I.; Carvalho, R.A.; Pardal, M.Â.; Manadas, B.; Jones, J.G., 2011. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 341 - 347. 3. 160. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052079316&partnerID=MN8TOARS . 10.1016/j.cbpa.2011.06.029 . Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology

Proteomic analysis of an interactome for long-form AMPA receptor subunits

Santos, S.D.; Manadas, B.; Duarte, C.B.; Carvalho, A.L., 2010. Journal of Proteome Research. 1670 - 1682. 4. 9. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950666645&partnerID=MN8TOARS . 10.1021/pr900766r . Journal of Proteome Research

Peptide fractionation in proteomics approaches

Manadas, B.; Mendes, V.M.; English, J.; Dunn, M.J., 2010. Expert Review of Proteomics. 655 - 663. 5. 7. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77958550083&partnerID=MN8TOARS . 10.1586/epr.10.46 . Expert Review of Proteomics

BDNF-induced changes in the expression of the translation machinery in hippocampal neurons: Protein levels and dendritic mRNA

Manadas, B.; Santos, A.R.; Szabadfi, K.; Gomes, J.R.; Garbis, S.D.; Fountoulakis, M.; Duarte, C.B., 2009. Journal of Proteome Research. 4536 - 4552. 10. 8. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349976976&partnerID=MN8TOARS . 10.1021/pr900366x . Journal of Proteome Research

Comparative analysis of OFFGel, strong cation exchange with pH gradient, and RP at high pH for first-dimensional separation of peptides from a membrane-enriched protein fraction

Manadas, B.; English, J.A.; Wynne, K.J.; Cotter, D.R.; Dunn, M.J., 2009. Proteomics. 5194 - 5198. 22. 9. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70949086044&partnerID=MN8TOARS . 10.1002/pmic.200900349 . Proteomics

Critical roles for a genetic code alteration in the evolution of the genus Candida

Silva, R.M.; Paredes, J.A.; Moura, G.R.; Manadas, B.; Lima-Costa, T.; Rocha, R.; Miranda, I.; et al, 2007. EMBO Journal. 4555 - 4565. 21. 26. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648984625&partnerID=MN8TOARS . 10.1038/sj.emboj.7601876 . EMBO Journal

Sample sonication after trichloroacetic acid precipitation increases protein recovery from cultured hippocampal neurons, and improves resolution and reproducibility in two-dimensional gel electrophoresis

Manadas, B.J.; Vougas, K.; Fountoulakis, M.; Duarte, C.B.; Manadas, Bruno J.; Vougas, Konstantinos; Fountoulakis, Michael; Duarte, Carlos B., 2006. Electrophoresis. 1825 - 1831. 9. 27. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646590654&partnerID=MN8TOARS . 10.1002/elps.200500757 . Electrophoresis

Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

Almeida, R.D.; Manadas, B.J.; Melo, C.V.; Gomes, J.R.; Mendes, C.S.; Grãos, M.M.; Carvalho, R.F.; Carvalho, A.P.; Duarte, C.B., 2005. Cell Death and Differentiation. 1329 - 1343. 10. 12. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144508812&partnerID=MN8TOARS . 10.1038/sj.cdd.4401662 . Cell Death and Differentiation

Intracellular signaling mechanisms in photodynamic therapy

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