José Teixeira

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks

Benfeito, Sofia; Fernandes, Carlos; Chavarria, Daniel; Barreiro, Sandra; Cagide, Fernando; Sequeira, Lisa; Teixeira, José; et al, Journal of Medicinal Chemistry. 1835 - 1851. 3. 66. 2023. http://dx.doi.org/10.1021/acs.jmedchem.2c01630 . 10.1021/acs.jmedchem.2c01630 . Journal of Medicinal Chemistry

TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status

Inês Ramos Rego; Daniela Silvério; Maria Isabel Eufrásio; Sandra Sofia Pinhanços; Bruna Lopes da Costa; José Teixeira; Hugo Fernandes; et al, Antioxidants. 2023. https://doi.org/10.3390/antiox12020381 . 10.3390/antiox12020381 . Antioxidants

Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage

Amorim, Ricardo; Cagide, Fernando; Tavares, Ludgero C.; Simões, Rui F.; Soares, Pedro; Benfeito, Sofia; Baldeiras, Inês; et al, Free Radical Biology and Medicine. 119 - 132. 179. 2022. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304 . 10.1016/j.freeradbiomed.2021.12.304 . Free Radical Biology and Medicine

Cytoskeleton alterations in non-alcoholic fatty liver disease

Pessoa, João; Teixeira, José, Metabolism. 128. 2022. http://dx.doi.org/10.1016/j.metabol.2021.155115 . 10.1016/j.metabol.2021.155115 . Metabolism

Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease

Cláudia M. Deus; José Teixeira; Nuno Raimundo; Paolo Tucci; Fernanda Borges; Luciano Saso; Paulo J. Oliveira, European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13820 . 10.1111/eci.13820 . European Journal of Clinical Investigation

Effect of a Novel Hydroxybenzoic Acid Based Mitochondria Directed Antioxidant Molecule on Bovine Sperm Function and Embryo Production

João Campos Santos; Carla Cruz Marques; Maria Conceição Baptista; Jorge Pimenta; José Carlos Santos Teixeira; Liliana Montezinho; Fernando Cagide; et al, Animals. 2022. https://www.mdpi.com/2076-2615/12/7/804 . 10.3390/ani12070804 . Animals

Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems

Amorim, Ricardo; Simões, Inês C.M.; Teixeira, José; Cagide, Fernando; Potes, Yaiza; Soares, Pedro; Carvalho, Adriana; et al, Redox Biology. 55. 2022. http://dx.doi.org/10.1016/j.redox.2022.102400 . 10.1016/j.redox.2022.102400 . Redox Biology

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Afonso, Marta B.; Islam, Tawhidul; Magusto, Julie; Amorim, Ricardo; Lenoir, Véronique; Simões, Rui F.; Teixeira, José; et al, Hepatology. 1319 - 1334. 4. 77. 2022. http://dx.doi.org/10.1002/hep.32756 . 10.1002/hep.32756 . Hepatology

Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties

Reis, Joana; Fernandes, Carlos; Salem, Hoda; Maia, Marta; Tomé, Cláudia; Benfeito, Sofia; Teixeira, José; et al, European Journal of Medicinal Chemistry. 239. 2022. http://dx.doi.org/10.1016/j.ejmech.2022.114507 . 10.1016/j.ejmech.2022.114507 . European Journal of Medicinal Chemistry

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Fernandes, Carlos; Videira, Afonso J. C.; Veloso, Caroline D.; Benfeito, Sofia; Soares, Pedro; Martins, João D.; Gonçalves, Beatriz; et al, Biomolecules. 11. 11. 2021. http://dx.doi.org/10.3390/biom11111605 . 10.3390/biom11111605 . Biomolecules

The Alterations of Mitochondrial Function during NAFLD Progression—An Independent Effect of Mitochondrial ROS Production

Simões, Inês C. M.; Amorim, Ricardo; Teixeira, José; Karkucinska-Wieckowska, Agnieszka; Carvalho, Adriana; Pereira, Susana P.; Simões, Rui F.; et al, International Journal of Molecular Sciences. 13. 22. 2021. http://dx.doi.org/10.3390/ijms22136848 . 10.3390/ijms22136848 . International Journal of Molecular Sciences

A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients

Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Teixeira, José; Simões, Rui F.; Cagide, Fernando; Benfeito, Sofia; et al, Redox Biology. 45. 2021. http://dx.doi.org/10.1016/j.redox.2021.102037 . 10.1016/j.redox.2021.102037 . Redox Biology

Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells

Amorim, Ricardo; Simões, Inês C. M.; Veloso, Caroline; Carvalho, Adriana; Simões, Rui F.; Pereira, Francisco B.; Thiel, Theresa; et al, Nutrients. 5. 13. 2021. http://dx.doi.org/10.3390/nu13051723 . 10.3390/nu13051723 . Nutrients

Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts

Teixeira, José; Basit, Farhan; Willems, Peter H.G.M.; Wagenaars, Jori A.; van de Westerlo, Els; Amorim, Ricardo; Cagide, Fernando; et al, Free Radical Biology and Medicine. 314 - 324. 163. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.023 . 10.1016/j.freeradbiomed.2020.12.023 . Free Radical Biology and Medicine

Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents

Oliveira, Catarina; Bagetta, Donatella; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Silva, Tiago; Garrido, Jorge; et al, European Journal of Medicinal Chemistry. 116 - 129. 174. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.04.026 . 10.1016/j.ejmech.2019.04.026 . published European Journal of Medicinal Chemistry

Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction

Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al, European Journal of Medicinal Chemistry. 525 - 545. 167. 2019. http://dx.doi.org/10.1016/j.ejmech.2019.01.055 . 10.1016/j.ejmech.2019.01.055 . published European Journal of Medicinal Chemistry

Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis

Belew, Getachew Debas; Silva, Joao; Rito, Joao; Tavares, Ludgero; Viegas, Ivan; Teixeira, Jose; Oliveira, Paulo J.; Macedo, Maria Paula; Jones, John G., Journal of Lipid Research. 2050 - 2056. 12. 60. 2019. http://dx.doi.org/10.1194/jlr.ra119000354 . 10.1194/jlr.ra119000354 . published Journal of Lipid Research

Sources of hepatic glycogen synthesis in mice fed with glucose or fructose as the sole dietary carbohydrate

Jarak, Ivana; Barosa, Cristina; Martins, Fatima O.; Silva, Joao C. P.; Santos, Cristiano; Belew, Getachew Debas; Rito, Joao; et al, Magnetic Resonance in Medicine. 639 - 644. 1. 81. 2018. http://dx.doi.org/10.1002/mrm.27378 . 10.1002/mrm.27378 . published Magnetic Resonance in Medicine

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors

Reis, Joana; Cagide, Fernando; Valencia, Martín Estrada; Teixeira, José; Bagetta, Donatella; Pérez, Concepción; Uriarte, Eugenio; et al, European Journal of Medicinal Chemistry. 781 - 800. 158. 2018. http://dx.doi.org/10.1016/j.ejmech.2018.07.056 . 10.1016/j.ejmech.2018.07.056 . published European Journal of Medicinal Chemistry

Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity

Ribeiro, José A.; Benfeito, Sofia; Cagide, Fernando; Teixeira, José; Oliveira, Paulo J.; Borges, Fernanda; Silva, António F.; Pereira, Carlos M., Analytical Chemistry. 7989 - 7996. 13. 90. 2018. http://dx.doi.org/10.1021/acs.analchem.8b00787 . 10.1021/acs.analchem.8b00787 . published Analytical Chemistry

Hydroxybenzoic Acid Derivatives as Dual-Target Ligands: Mitochondriotropic Antioxidants and Cholinesterase Inhibitors

Oliveira, Catarina; Cagide, Fernando; Teixeira, José; Amorim, Ricardo; Sequeira, Lisa; Mesiti, Francesco; Silva, Tiago; et al, Frontiers in Chemistry. 6. 2018. http://dx.doi.org/10.3389/fchem.2018.00126 . 10.3389/fchem.2018.00126 . published Frontiers in Chemistry

Mitochondria: Targeting mitochondrial reactive oxygen species with mitochondriotropic polyphenolic-based antioxidants

Teixeira, José; Deus, Cláudia M.; Borges, Fernanda; Oliveira, Paulo J., The International Journal of Biochemistry & Cell Biology. 98 - 103. 97. 2018. http://dx.doi.org/10.1016/j.biocel.2018.02.007 . 10.1016/j.biocel.2018.02.007 . published The International Journal of Biochemistry & Cell Biology

Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy

Carlos Fernandes; Sofia Benfeito; Ricardo Amorim; José Teixeira; Paulo J. Oliveira; Fernando Remião; Fernanda Borges, Bioconjugate Chemistry. 2018. https://doi.org/10.1021/acs.bioconjchem.8b00383 . 10.1021/acs.bioconjchem.8b00383 . published Bioconjugate Chemistry

Disruption of mitochondrial function as mechanism for anti-cancer activity of a novel mitochondriotropic menadione derivative

Teixeira, J.; Amorim, R.; Santos, K.; Soares, P.; Datta, S.; Cortopassi, G.A.; Serafim, T.L.; et al, Toxicology. 123 - 139. 393. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034013034&partnerID=MN8TOARS . 10.1016/j.tox.2017.11.014 . published Toxicology

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

Teixeira, J.; Basit, F.; Swarts, H.G.; Forkink, M.; Oliveira, P.J.; Willems, P.H.G.M.; Koopman, W.J.H., Redox Biology. 394 - 404. 15. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040366459&partnerID=MN8TOARS . 10.1016/j.redox.2017.12.018 . published Redox Biology

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

José Teixeira; Catarina Oliveira; Fernando Cagide; Ricardo Amorim; Jorge Garrido; Fernanda Borges; Paulo J. Oliveira, Journal of Enzyme Inhibition and Medicinal Chemistry. 567 - 576. 1. 33. 2018. https://doi.org/10.1080/14756366.2018.1442831 . 10.1080/14756366.2018.1442831 . published Journal of Enzyme Inhibition and Medicinal Chemistry

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Teixeira, J.; Oliveira, C.; Amorim, R.; Cagide, F.; Garrido, J.; Ribeiro, J.A.; Pereira, C.M.; et al, Scientific Reports. 1. 7. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026475854&partnerID=MN8TOARS . 10.1038/s41598-017-07272-y . published Scientific Reports

Dietary Polyphenols and Mitochondrial Function: Role in Health and Disease

Teixeira, J.; Chavarria, D.; Borges, F.; Wojtczak, L.; Wieckowski, M. R.; Karkucinska-Wieckowska, A.; Oliveira, P. J., Curr Med Chem. 2017. https://www.ncbi.nlm.nih.gov/pubmed/28554320 . 10.2174/0929867324666170529101810 . published Curr Med Chem

Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models

Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al, Journal of Medicinal Chemistry. 7084 - 7098. 16. 60. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS . 10.1021/acs.jmedchem.7b00741 . published Journal of Medicinal Chemistry

Complex I and complex III inhibition specifically increase cytosolic hydrogen peroxide levels without inducing oxidative stress in HEK293 cells

Forkink, M.; Basit, F.; Teixeira, J.; Swarts, H.G.; Koopman, W.J.H.; Willems, P.H.G.M., Redox Biology. 607 - 616. 6. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945395305&partnerID=MN8TOARS . 10.1016/j.redox.2015.09.003 . published Redox Biology

Alzheimer's disease, enzyme targets and drug discovery struggles: From natural products to drug prototypes

Silva, T.; Reis, J.; Teixeira, J.; Borges, F., Ageing Research Reviews. 116 - 145. 1. 15. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899683262&partnerID=MN8TOARS . 10.1016/j.arr.2014.03.008 . published Ageing Research Reviews

Alzheimer's disease, cholesterol, and statins: The junctions of important metabolic pathways

Silva, T.; Teixeira, J.; Remião, F.; Borges, F., Angewandte Chemie - International Edition. 1110 - 1121. 4. 52. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872382364&partnerID=MN8TOARS . 10.1002/anie.201204964 . published Angewandte Chemie - International Edition

Alzheimer's disease and antioxidant therapy: How long how far?

Teixeira, J.; Silva, T.; Andrade, P.B.; Borges, F., Current Medicinal Chemistry. 2939 - 2952. 24. 20. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880283997&partnerID=MN8TOARS . 10.2174/1871523011320240001 . published Current Medicinal Chemistry

Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids

Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F., European Journal of Medicinal Chemistry. 289 - 296. 62. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS . 10.1016/j.ejmech.2012.12.049 . published European Journal of Medicinal Chemistry

Hydroxycinnamic acid antioxidants: An electrochemical overview

Teixeira, J.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F., BioMed Research International. 2013. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881540701&partnerID=MN8TOARS . 10.1155/2013/251754 . published BioMed Research International

Antioxidant therapy: Still in search of the 'magic bullet'

Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F., Mitochondrion. 427 - 435. 5. 13. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS . 10.1016/j.mito.2012.12.002 . published Mitochondrion

Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold

Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F., Free Radical Research. 600 - 611. 5. 46. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS . 10.3109/10715762.2012.662593 . published Free Radical Research