public.student_biography

Luís Grilo studies the impact of maternal diet during pregnancy on offspring health, aging, and long-term predisposition to disease. His main focus is on the impact of developmental programming on hepatic and cardiac function, their crosstalk, and their interplay with other organs.

Affiliation

University of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Portugal

Publications

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Information about journal articles, updated at 01-12-2024, from platform CIÊNCIAVITAE.

Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Luís F. Grilo; Kip D. Zimmerman; Sobha Puppala; Jeannie Chan; Hillary F. Huber; Ge Li; Avinash Y. L. Jadhav; et al, Advanced Science. 2024. https://doi.org/10.1002/advs.202309211 . 10.1002/advs.202309211 . Advanced Science

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Grilo, L.F.; Martins, J.D.; Diniz, M.S.; Tocantins, C.; Cavallaro, C.H.; Baldeiras, I.; Cunha-Oliveira, T.; et al, Clinical Science. 1347 - 1372. 17. 137. 2023. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169502495&partnerID=MN8TOARS . 10.1042/CS20230048 . Clinical Science

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Mariana S. Diniz; Luís F. Grilo; Carolina Tocantins; Inês Falcão-Pires; Susana P. Pereira, Metabolites. 2023. https://doi.org/10.3390/metabo13070845 . 10.3390/metabo13070845 . Metabolites

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Mariana S. Diniz; Carina C. Magalhães; Carolina Tocantins; Luís F. Grilo; José Teixeira; Susana P. Pereira, Nutrients. 2023. https://doi.org/10.3390/nu15214623 . 10.3390/nu15214623 . Nutrients

Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks after exercise cessation

Carolina Tocantins; João D. Martins; Óscar M. Rodrigues; Luís F. Grilo; Mariana S. Diniz; Jelena Stevanovic-Silva; Jorge Beleza; et al, European Journal of Clinical Investigation. 2023. https://doi.org/10.1111/eci.14069 . 10.1111/eci.14069 . European Journal of Clinical Investigation

Monoamine oxidase A-dependent ROS formation modulates human cardiomyocyte differentiation through AKT and WNT activation

Di Sante, Moises; Antonucci, Salvatore; Pontarollo, Laura; Cappellaro, Ilaria; Segat, Francesca; Deshwal, Soni; Greotti, Elisa; et al, Basic Research in Cardiology. 1. 118. 2023. http://dx.doi.org/10.1007/s00395-023-00977-4 . 10.1007/s00395-023-00977-4 . Basic Research in Cardiology

The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

Mariana S. Diniz; Carolina Tocantins; Luís F. Grilo; Susana P. Pereira, Diabetology. 2022. https://doi.org/10.3390/diabetology3040044 . 10.3390/diabetology3040044 . Diabetology

The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring

Carolina Tocantins; Mariana S. Diniz; Luís F. Grilo; Susana P. Pereira, WIREs Mechanisms of Disease. 2022. https://doi.org/10.1002/wsbm.1555 . 10.1002/wsbm.1555 . WIREs Mechanisms of Disease

The Endocrine–Metabolic Axis Regulation in Offspring Exposed to Maternal Obesity—Cause or Consequence in Metabolic Disease Programming?

Luís F. Grilo; Mariana S. Diniz; Carolina Tocantins; Ana L. Areia; Susana P. Pereira, Obesities. 2022. https://doi.org/10.3390/obesities2030019 . 10.3390/obesities2030019 . Obesities

Metabolic Disease Programming: From Mitochondria to Epigenetics, Glucocorticoid Signalling and Beyond

Luís F. Grilo; Carolina Tocantins; Mariana S. Diniz; Rodrigo Mello Gomes; Paulo J. Oliveira; Paulo Matafome; Susana P. Pereira, European Journal of Clinical Investigation. 2021. https://doi.org/10.1111/eci.13625 . 10.1111/eci.13625 . European Journal of Clinical Investigation

Mitochondrial physiology

Grilo, Luís F., Bioenergetics Communications. 2020. https://www.bioenergetics-communications.org/index.php/BEC2020.1_doi10.26124bec2020-0001.v1 . 10.26124/BEC:2020-0001.V1 . Bioenergetics Communications

Development of a 96-well based assay for kinetic determination of catalase enzymatic-activity in biological samples.

Grilo, Luís F.; João D. Martins; Chiara H. Cavallaro; Peter W. Nathanielsz; Paulo J. Oliveira (E41F-4FB7-5948); Susana P. Pereira, Toxicology in vitro : an international journal published in association with BIBRA. 2020. https://doi.org/10.1016/j.tiv.2020.104996 . 10.1016/j.tiv.2020.104996 . submitted Toxicology in vitro : an international journal published in association with BIBRA

P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress

Grilo, Luís F., Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2020. http://dx.doi.org/10.1016/j.bbadis.2020.165964 . 10.1016/j.bbadis.2020.165964 . Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Mitochondrial respiratory states and rates.

Grilo, Luís F., 2019.

A Mitochondrial Approach to Cardiovascular Risk and Disease

Caroline D. Veloso; Getachew D. Belew; Luciana L. Ferreira; Luís F. Grilo; John G. Jones; Piero Portincasa; Vilma A. Sardão; Paulo J. Oliveira, Current Pharmaceutical Design. 3175 - 3194. 29. 25. 2019. https://doi.org/10.2174/1389203720666190830163735 . 10.2174/1389203720666190830163735 . Current Pharmaceutical Design

All projects

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Information of exclusive responsibility of the researcher 01-12-2024 , from platform CIÊNCIAVITAE.

2022/03 - 2022/12

CardioCLOCK: Unraveling Mechanisms of Developmental Programming-aging interactions in the heart

2022/0010

PhD Student Fellow

Funders: Fundação Luso-Americana para o Desenvolvimento

2022/03 - 2022/12

CardioCLOCK: Unraveling Mechanisms of Developmental Programming-aging interactions in the heart

21-076

PhD Student Fellow

Funders: Fulbright Portugal

2022/01 - 2023/12

BraveHEART: Improvig Nature by Addressing Bioactive Dietary Polyphenols to Mitochondria for the Protection of Cardiac Complications in Non-Alcoholic Fatty Liver Disease.

EXPL/BIA-BQM/1361/2021

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2022/07 - 2023/06

MitoBOOST v2.0 - Proof of Concept for the Use of Mitochondrial Targeted Polyphenols to Treat Non-Alcoholic Fatty Liver Disease

CENTRO-01-0145-FEDER-181226

Researcher

Funders: Autoridade de Gestão do Programa Operacional CENTRO2020

2022/06 - 2023/11

Mitochondria as potential drivers of sex-specific microglia dysfunctional remodelling and anxiety caused by prenatal stress.

EXPL/MED-NEU/1002/2021

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2020/11 - 2024/10

CardioCLOCK: Unraveling Mechanisms of Developmental Programming-aging interactions in the heart

SFRH/BD/5539/2020

PhD Student Fellow

Funders: Fundação para a Ciência e a Tecnologia

2020/07 - 2023/06

Preservation of natural and cultural heritage and scientific validation of practices with medicinal plants from Côa Valley

COA/BRB/0019/2019

Researcher

Funders: Fundação para a Ciência e a Tecnologia

2017/09 - 2020/09

EXERCISING THE FUTURE: Voluntary Exercise During Gestational Diabetes as a Means to Improve Mitochondrial Function in the Offspring

PTDC/DTP-DES/1082/2014

Other

Funders: Fundação para a Ciência e a Tecnologia

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