Publications
Information about journal articles, updated at 22-12-2024, from platform CIÊNCIAVITAE.
The Importance of Kinases in Retinal Degenerative Diseases
Paulo F. Santos; António Francisco Ambrósio; Hélène Léger, Kinases and Phosphatases. 2024. https://doi.org/10.3390/kinasesphosphatases2010006 . 10.3390/kinasesphosphatases2010006 . Kinases and Phosphatases
The NDR/LATS protein kinases in neurobiology: Key regulators of cell proliferation, differentiation and migration in the ocular and central nervous system
Santos, Paulo F.; Fazendeiro, Beatriz; Luca, Francis C.; Ambrósio, António Francisco; Léger, Hélène, European Journal of Cell Biology. 2. 102. 2023. http://dx.doi.org/10.1016/j.ejcb.2023.151333 . 10.1016/j.ejcb.2023.151333 . European Journal of Cell Biology
TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic Status
Ramos Rego, Inês; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; et al, Antioxidants. 2. 12. 2023. http://dx.doi.org/10.3390/antiox12020381 . 10.3390/antiox12020381 . Antioxidants
Intraocular implants loaded with A3R agonist rescue retinal ganglion cells from ischemic damage
Boia, Raquel; Dias, Paulo A.N.; Galindo-Romero, Caridad; Ferreira, Hugo; Aires, Inês D.; Vidal-Sanz, Manuel; Agudo-Barriuso, Marta; et al, Journal of Controlled Release. 469 - 481. 343. 2022. http://dx.doi.org/10.1016/j.jconrel.2022.02.001 . 10.1016/j.jconrel.2022.02.001 . published Journal of Controlled Release
The Benefits of Flavonoids in Diabetic Retinopathy
Matos, Ana L.; Bruno, Diogo F.; Ambrósio, António F.; Santos, Paulo F., Nutrients. 10. 12. 2020. http://dx.doi.org/10.3390/nu12103169 . 10.3390/nu12103169 . Nutrients
Keep an eye on adenosine: Its role in retinal inflammation
Santiago, Ana Raquel; Madeira, Maria H.; Boia, Raquel; Aires, Inês Dinis; Rodrigues-Neves, Catarina; Santos, Paulo Fernando; Ambrósio, António Francisco, Pharmacology & Therapeutics. 2020. http://dx.doi.org/10.1016/j.pharmthera.2020.107513 . 10.1016/j.pharmthera.2020.107513 . Pharmacology & Therapeutics
Elevated Pressure Changes the Purinergic System of Microglial Cells
Rodrigues-Neves, Ana C.; Aires, Inês D.; Vindeirinho, Joana; Boia, Raquel; Madeira, Maria H.; Gonçalves, Francisco Q.; Cunha, Rodrigo A.; et al, Frontiers in Pharmacology. 9. 2018. http://dx.doi.org/10.3389/fphar.2018.00016 . 10.3389/fphar.2018.00016 . Frontiers in Pharmacology
The Adenosinergic System in Diabetic Retinopathy
Vindeirinho, J.; Santiago, A. R.; Cavadas, C.; Ambrósio, A. F.; Santos, P. F., Journal of Diabetes Research. 1 - 8. 2016. 2016. http://dx.doi.org/10.1155/2016/4270301 . 10.1155/2016/4270301 . Journal of Diabetes Research
Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression
Meireles, Manuela; Marques, Cláudia; Norberto, Sónia; Santos, Paulo; Fernandes, Iva; Mateus, Nuno; Faria, Ana; Calhau, Conceição, Behavioural Brain Research. 223 - 228. 305. 2016. http://dx.doi.org/10.1016/j.bbr.2016.03.010 . 10.1016/j.bbr.2016.03.010 . Behavioural Brain Research
Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases
Madeira, Maria H.; Boia, Raquel; Santos, Paulo F.; Ambrósio, António F.; Santiago, Ana R., Mediators of Inflammation. 1 - 15. 2015. 2015. http://dx.doi.org/10.1155/2015/673090 . 10.1155/2015/673090 . Mediators of Inflammation
Role of Microglia Adenosine A 2A Receptors in Retinal and Brain Neurodegenerative Diseases
Santiago, Ana R.; Baptista, Filipa I.; SANTOS, PAULO F.; Cristóvão, Gonçalo; Ambrósio, António F.; Cunha, Rodrigo A.; Gomes, Catarina A., Mediators of Inflammation. 1 - 13. -. 2014. 2014. 10.1155/2014/465694 . published Mediators of Inflammation
Effect of Diabetes/Hyperglycemia on the Rat Retinal Adenosinergic System
Vindeirinho, Joana; Costa, Gabriel N.; Correia, Mariana B.; Cavadas, Cláudia; SANTOS, PAULO F., PLoS ONE. e67499 - e67499. 6. 8. 2013. 10.1371/journal.pone.0067499 . published PLoS ONE
Contribution of TNF receptor 1 to retinal neural cell death induced by elevated glucose
Costa, G.N.; Vindeirinho, J.; Cavadas, C.; Ambrósio, A.F.; Santos, P.F., Molecular and Cellular Neuroscience. 113 - 123. 1. 50. 2012. 10.1016/j.mcn.2012.04.003 . published Molecular and Cellular Neuroscience
Retinal adenosinergic system is affected by dibetes/hyperglucemia
PF Santos, Diabetologia. 1 - 542. S1. 54. 2011. http://dx.doi.org/10.1007/s00125-011-2276-4 . 10.1007/s00125-011-2276-4 . Diabetologia
Diabetes induces early transient changes in the content of vesicular transporters and no major effects in neurotransmitter release in hippocampus and retina
Baptista, Filipa I.; Gaspar, Joana M.; Cristóvão, Armando; SANTOS, PAULO F.; Köfalvi, Attila; Ambrósio, António F., Brain Research. 257 - 269. -. 1383. 2011. 10.1016/j.brainres.2011.01.071 . published Brain Research
High glucose enhances intracellular Ca2+ responses triggered by purinergic stimulation in retinal neurons and microglia
Pereira, Tiago de Oliveira Simões; da Costa, Gabriel Nascimento Ferreira; Santiago, Ana Raquel Sarabando; Ambrósio, António Francisco; dos Santos, Paulo Fernando Martins, Brain Research. 129 - 138. -. 1316. 2010. 10.1016/j.brainres.2009.12.034 . published Brain Research
High glucose changes extracellular adenosine triphosphate levels in rat retinal cultures
Costa, G.; Pereira, T.; Neto, A.M.; Cristóvão, A.J.; Ambrósio, A.F.; Santos, P.F., Journal of Neuroscience Research. 1375 - 1380. 6. 87. 2009. 10.1002/jnr.21956 . published Journal of Neuroscience Research
Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
Santiago, A. R.; Gaspar, Joana M.; Baptista, Filipa I.; Cristóvão, A.J.; Santos, P.F.; Kamphuis, W.; Ambrósio, A.F.; et al, MOLECULAR VISION . 1620 - 1630. 173. 15. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949158370&partnerID=MN8TOARS . published MOLECULAR VISION
NPY in rat retina is present in neurons, in endothelial cells and also in microglial and Müller cells
¿?lvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; et al, Neurochemistry International. 757 - 763. 5. 50. 2007. 10.1016/j.neuint.2007.01.010 . published Neurochemistry International
High glucose induces caspase-independent cell death in retinal neural cells
Santiago, A.R.; Cristóvão, A.J.; Santos, P.F.; Carvalho, C.M.; Ambrósio, A.F., Neurobiology of Disease. 464 - 472. 3. 25. 2007. 10.1016/j.nbd.2006.10.023 . published Neurobiology of Disease
Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons
Araújo, I M; Carreira, B P; Pereira, T; Santos, P F; Soulet, D; Inácio, Â; Bahr, B A; et al, Cell Death and Differentiation. 1635 - 1646. 9. 14. 2007. 10.1038/sj.cdd.4402171 . published Cell Death and Differentiation
Elevated Glucose Changes the Expression of Ionotropic Glutamate Receptor Subunits and Impairs Calcium Homeostasis in Retinal Neural Cells
Santiago, A. R.; Rosa, S.; dos Santos, Paulo Fernando Martins; Cristóvão, A.; Barber, A.; Ambrósio, A.F., Investigative Ophthalmology & Visual Science. 4130 - 4137. 9. 47. 2006. 10.1167/iovs.06-0085 . published Investigative Ophthalmology & Visual Science
High glucose and diabetes increase the release of [3H]-d-aspartate in retinal cell cultures and in rat retinas
Santiago, Ana R.; Pereira, Tiago S.; Garrido, Manuel J.; Cristóvão, Armando J.; Santos, Paulo F.; Ambrósio, António F., Neurochemistry International. 453 - 458. 6-7. 48. 2006. 10.1016/j.neuint.2005.10.013 . published Neurochemistry International
Neuronal nitric oxide synthase proteolysis limits the involvement of nitric oxide in kainate-induced neurotoxicity in hippocampal neurons
Araújo, I.M.; Ambrósio, A.F.; Leal, E.C.; Santos, P.F.; Carvalho, A.P.; Carvalho, C.M.; Araújo, Inês M.; et al, Journal of Neurochemistry. 791 - 800. 3. 85. 2003. http://www.scopus.com/inward/record.url?eid=2-s2.0-17944400535&partnerID=MN8TOARS . 10.1046/j.1471-4159.2003.01731.x . published Journal of Neurochemistry
Adenosine A1 receptors inhibit Ca2+ channels coupled to the release of ACh, but not of GABA, in cultured retina cells
Santos, Paulo F; Caramelo, Olga L; Carvalho, Arsélio P; Duarte, Carlos B, Brain Research. 10 - 15. 1. 852. 2000. 10.1016/S0006-8993(99)02155-1 . published Brain Research
Characterization of ATP release from cultures enriched in cholinergic amacrine-like neurons
Santos, P.F.; Caramelo, Olga L; Carvalho, A P; Duarte, Carlos B; Caramelo, O.L.; Carvalho, A.P.; Duarte, C.B., JOURNAL OF NEUROBIOLOGY. 340 - 348. 3. 41. 1999. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033571302&partnerID=MN8TOARS . 10.1002/(SICI)1097-4695(19991115)41:3<340::AID-NEU3>3.0.CO;2-8 . published JOURNAL OF NEUROBIOLOGY
Corelease of two functionally opposite neurotransmitters by retinal amacrine cells: Experimental evidence and functional significance
Duarte, Carlos B.; Santos, Paulo F.; Carvalho, Arsélio P., Journal of Neuroscience Research. 475 - 479. 4. 58. 1999. 10.1002/(SICI)1097-4547(19991115)58:4<475::AID-JNR1>3.0.CO;2-O . published Journal of Neuroscience Research
Metabotropic glutamate receptors modulate [3H]acetylcholine release from cultured amacrine-like neurons
Caramelo, Olga L.; Santos, Paulo F.; Carvalho, Arsélio P.; Duarte, Carlos B., Journal of Neuroscience Research. 505 - 514. 4. 58. 1999. 10.1002/(SICI)1097-4547(19991115)58:4<505::AID-JNR4>3.0.CO;2-J . published Journal of Neuroscience Research
[<sup>3</sup>H]Acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A<inf>1</inf> receptor activation
Santos, P.F.; Caramelo, O.L.; Carvalho, A.P.; Duarte, C.B., NeuroReport. 3693 - 3698. 16. 9. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032538658&partnerID=MN8TOARS . NeuroReport
Modulation of [<sup>3</sup>H]acetylcholine release from cultured amacrine-like neurons by adenosine A<inf>1</inf> receptors
Santos, P.F.; Santos, M.S.; Carvalho, A.P.; Duarte, C.B., Journal of Neurochemistry. 1086 - 1094. 3. 71. 1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031595164&partnerID=MN8TOARS . Journal of Neurochemistry
Differential acetylcholine and GABA release from cultured chick retina cells
Santos, Paulo F.; Carvalho, Ana L.; Carvalho, Arsélio P.; Duarte, Carlos B., European Journal of Neuroscience. 2723 - 2730. 8. 10. 1998. 10.1046/j.1460-9568.1998.00281.x . published European Journal of Neuroscience
Glutamate in Life and Death of Retinal Amacrine Cells
Duarte, Carlos B; Ferreira, Ildete L; Santos, Paulo F; Carvalho, Ana L; Agostinho, Paula M; Carvalho, Arsélio P, General Pharmacology: The Vascular System. 289 - 295. 3. 30. 1998. 10.1016/S0306-3623(97)00360-1 . published General Pharmacology: The Vascular System
Modulation of [H-3]acetylcholine release from cultured amacrine-like neurons by adenosine A(1) receptors
Santos, P.F.; Santos, M S; Carvalho, A.P.; Duarte, C.B., JOURNAL OF NEUROCHEMISTRY. 1086 - 1094. 3. 71. 1998. published JOURNAL OF NEUROCHEMISTRY
[3H]Acetylcholine release from rat amacrine-like neurons is inhibited by adenosine A1 receptor activation
Santos, Paulo F.; Caramelo, Olga L.; Carvalho, Arsélio P.; Duarte, Carlos B., NeuroReport. 3692 - 3698. 16. 9. 1998. 10.1097/00001756-199811160-00023 . published NeuroReport
Glutamate release evoked by glutamate receptor agonists in cultured chick retina cells: Modulation by arachidonic acid
Duarte, C.B.; Santos, P.F.; S¿nchez-Prieto, J.; Carvalho, A.P., Journal of Neuroscience Research. 363 - 373. 4. 44. 1996. 10.1002/(SICI)1097-4547(19960515)44:4<363::AID-JNR8>3.0.CO;2-A . published Journal of Neuroscience Research
On-line Detection of Glutamate Release from Culture Chick Retinospheroids
DUARTE, CARLOS B.; SANTOS, PAULO F.; S¿?NCHEZ-PRIETO, J.; CARVALHO, ARSÉLIO P., Vision Research. 1867 - 1872. 13. 36. 1996. 10.1016/0042-6989(95)00309-6 . published Vision Research
[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells
Duarte, Carlos B.; Santos, Paulo F.; Carvalho, Arsélio P., Vision Research. 1091 - 1102. 8. 36. 1996. 10.1016/0042-6989(95)00208-1 . published Vision Research
Glutamate receptor agonists evoked Ca2+-dependent and Ca2+-independent release of [3H]d-Aspartate from cultured chick retina cells
Santos, Paulo F.; Duarte, Carlos B.; Carvalho, Arsélio P., Neurochemical Research. 361 - 368. 3. 21. 1996. 10.1007/BF02531653 . published Neurochemical Research
Release of [3H]GABA evoked by glutamate receptor agonists in cultured chick retina cells: effect of Ca2+
Ferreira, Ildete L.; Duarte, Carlos B.; Santos, Paulo F.; Carvalho, Caetana M.; Carvalho, Arsélio P., Brain Research. 252 - 256. 1-2. 664. 1994. 10.1016/0006-8993(94)91981-X . published Brain Research
Glutamate increases the [Ca2+]i but stimulates Ca2+-independent release of [3H]GABA in cultured chick retina cells
Duarte, Carlos B.; Ferreira, Ildete L.; Santos, Paulo F.; Oliveira, Catarina R.; Carvalho, Arsélio P., Brain Research. 130 - 138. 1. 611. 1993. 10.1016/0006-8993(93)91784-P . published Brain Research
Ca2+-dependent release of [3H]GABA in cultured chick retina cells
Duarte, C.B.; Ferreira, I.L.; Santos, P.F.; Oliveira, C.R.; Carvalho, A.P., Brain Research. 27 - 32. 1. 591. 1992. 10.1016/0006-8993(92)90974-E . published Brain Research
5 41 out of 41 Publications
All projects
Information of exclusive responsibility of the researcher 22-12-2024 , from platform CIÊNCIAVITAE.
2023/03/01 - 2024/08/31
A Cinase Ndr2: o novo jogadore na regulação da microglia na Retinopatia Diabética
2022.06170.PTDC
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31
Centro de Inovação em Biomedicina e Biotecnologia - Laboratório Associado
LA/P/0058/2020
Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2021
LA/P/0058/2020
LA/P/0058/2020
Researcher
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
2020
CiBB strategic plan UIDP/04539/2020
UIDP/04539/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia
Funders: Fundação para a Ciência e a Tecnologia
2020
CIBB Stratergic Plan UIDB/04539/2020
UIDB/04539/2020
Researcher
Centro de Inovação em Biomedicina e Biotecnologia
Funders: Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31
CNC. IBILI
UID/NEU/04539/2019
Universidade de Coimbra; Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra; Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2017 - 2018
Finerenone in diabetic retinopathy
G4I-PT-2017-4688
Principal investigator
IBILI - Instituto Biomédico de Investigação da Luz e da Imagem
Funders: Bayer AG
2017 - 2020
BrainHealth 2020 - Detecção Precoce, Neuro-modulação e Terapias Avançadas para Neuropatologias
CENTRO-01-0145-FEDER-000008
Researcher
CNC.IBILI
2016/07/01 - 2019/12/31
Biodegradable intravitreal porous implants for the extended release of A3 adenosine receptor agonist for the treatment of glaucoma
PTDC/NEU-OSD/3123/2014
Universidade de Coimbra
Funders: Fundação para a Ciência e a Tecnologia
2015 - 2018
Funding of RD Units Strategic Plan - 2013/2015 - OE
POCI-01-0145-FEDER-007440
Researcher
CNC.IBILI
2013 - 2015
New strategies to manage brain diseases
CENTRO-07-ST24-FEDER-002002
Researcher
CNC.IBILI
2013 - 2014
Projecto Estratégico - LA 1
PEst-C/SAU/LA0001/2013
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
2011/01/01 - 2012/12/31
Projecto Estratégico - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
2007/05/01 - 2010/11/30
Neuropeptídeo Y na retina: porquê E para quê
PTDC/SAU-NEU/73119/2006
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
Funders: Fundação para a Ciência e a Tecnologia
2005/03/01 - 2008/08/31
O ATP e a retinopatia diabética: papel na regulação da microglia e na morte neuronal
POCI/SAU-NEU/59003/2004
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular; Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia
Funders: Fundação para a Ciência e a Tecnologia
2004 - 2004
Effect of ATP on intracellular levels of Ca2+ and on the release of neurotransmitters by the retina cells in culture
GAI 01/04
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular
2003 - 2006
Immunological and funcional identification of pre-synaptic glutamate receptors
POCTI/FCB/46804/2002
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
2002 - 2005
Mechanisms of cellular neurodegeneration in diabetic retinopathy
POCTI/CBO/38545/2001
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
2001 - 2004
Neurotoxicity mediated by AMPA and Kainate receptors in the hipppocampus; role of nitric oxide.
POCTI/NSE/35875/99
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular
1995/01/01 - 1998/12/31
REGULAÇÃO DA |Ca2+| i E DA LIBERTAÇÃO DE ACETILCOLINA POR GLUTAMATO EM CÉLULAS DA RETINA EM CULTURA
PRAXIS XXI/BD/3764/94
Universidade de Coimbra; Universidade de Coimbra Centro de Neurociências e Biologia Celular
Funders: Fundação para a Ciência e a Tecnologia
5 20 out of 20 projects
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