Quan Zhang

Loss of tetraspanin-7 expression reduces pancreatic ß-cell exocytosis Ca²⁺ sensitivity but has limited effect on systemic metabolism

McLaughlin, Kerry; Acreman, Samuel; Nawaz, Sameena; Cutteridge, Joseph; Clark, Anne; Knudsen, Jakob G.; Denwood, Geoffrey; et al, Diabetic Medicine. 12. 39. 2022. http://dx.doi.org/10.1111/dme.14984 . 10.1111/dme.14984 . Diabetic Medicine

A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic ß-cells

Yingying Ye; Mohammad Barghouth; Haiqiang Dou; Cheng Luan; Yongzhi Wang; Alexandros Karagiannopoulos; Xiaoping Jiang; et al, Nature Communications. 2022. https://doi.org/10.1038/s41467-022-31103-y . 10.1038/s41467-022-31103-y . Nature Communications

Regulation of a-cell glucagon secretion: The role of second messengers

Samuel Acreman; Quan Zhang, Chronic Diseases and Translational Medicine. 2021. https://doi.org/10.1016/j.cdtm.2021.06.001 . 10.1016/j.cdtm.2021.06.001 . Chronic Diseases and Translational Medicine

Temporal metabolic and transcriptomic characteristics crossing islets and liver reveal dynamic pathophysiology in diet-induced diabetes

Gao R; Fu Q; Jiang HM; Shen M; Zhao RL; Qian Y; He YQ; et al, iScience. 102265 - 102265. 4. 24. 2021. http://dx.doi.org/10.1016/j.isci.2021.102265 . 10.1016/j.isci.2021.102265 . iScience

d-Cells: The Neighborhood Watch in the Islet Community

Rui Gao; Tao Yang; Quan Zhang, Biology. 74 - 74. 2. 10. 2021. https://doi.org/10.3390/biology10020074 . 10.3390/biology10020074 . Biology

‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon-secreting a-cells

Quan Zhang; Haiqiang Dou; Patrik Rorsman, The Journal of Physiology. 4765 - 4780. 21. 598. 2020. https://doi.org/10.1113/JP279775 . 10.1113/JP279775 . The Journal of Physiology

“Take Me To Your Leader”: An Electrophysiological Appraisal of the Role of Hub Cells in Pancreatic Islets

Satin, Leslie S.; Zhang, Quan; Rorsman, Patrik, Diabetes. 830 - 836. 5. 69. 2020. http://dx.doi.org/10.2337/dbi19-0012 . 10.2337/dbi19-0012 . Diabetes

Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta cells

Quan Zhang; Elisa Vergari; Geoffrey Denwood; Albert Salehi; Julie Adam; Ahmed Alrifaiy; Ingrid Wernstedt Asterholm; et al, Nature Metabolism. 2020. https://doi.org/10.1038/s42255-019-0158-0 . 10.1038/s42255-019-0158-0 . Nature Metabolism

Gs/Gq signaling switch in ß cells defines incretin effectiveness in diabetes

Oduori, Okechi S.; Murao, Naoya; Shimomura, Kenju; Takahashi, Harumi; Zhang, Quan; Dou, Haiqiang; Sakai, Shihomi; et al, Journal of Clinical Investigation. 6639 - 6655. 12. 130. 2020. http://dx.doi.org/10.1172/jci140046 . 10.1172/jci140046 . Journal of Clinical Investigation

Glucose stimulates somatostatin secretion in pancreatic d-cells by cAMP-dependent intracellular Ca2+ release

Denwood, Geoffrey; Tarasov, Andrei; Salehi, Albert; Vergari, Elisa; Ramracheya, Reshma; Takahashi, Harumi; Nikolaev, Viacheslav O.; et al, The Journal of General Physiology. 1094 - 1115. 9. 151. 2019. http://dx.doi.org/10.1085/jgp.201912351 . 10.1085/jgp.201912351 . The Journal of General Physiology

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Knudsen, Jakob G.; Hamilton, Alexander; Ramracheya, Reshma; Tarasov, Andrei I.; Brereton, Melissa; Haythorne, Elizabeth; Chibalina, Margarita V.; et al, Cell Metabolism. 430 - 442.e4. 2. 29. 2019. http://dx.doi.org/10.1016/j.cmet.2018.10.003 . 10.1016/j.cmet.2018.10.003 . Cell Metabolism

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Quan Zhang; Elisa Vergari; Jakob G. Knudsen; Reshma Ramracheya; Albert Salehi; Julie Adam; Ingrid Wernstedt Asterholm; et al, Nature Communications. 1. 10. 2019. https://doi.org/10.1038/s41467-018-08193-8 . 10.1038/s41467-018-08193-8 . Nature Communications

Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+Mobilization From Acidic Stores in Pancreatic a-Cells

Hamilton, Alexander; Zhang, Quan; Salehi, Albert; Willems, Mara; Knudsen, Jakob G.; Ringgaard, Anna K.; Chapman, Caroline E.; et al, Diabetes. 1128 - 1139. 6. 67. 2018. http://dx.doi.org/10.2337/db17-1102 . 10.2337/db17-1102 . Diabetes

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca2+ channels

Ramracheya, Reshma; Chapman, Caroline; Chibalina, Margarita; Dou, Haiqiang; Miranda, Caroline; González, Alejandro; Moritoh, Yusuke; et al, Physiological Reports. 17. 6. 2018. http://dx.doi.org/10.14814/phy2.13852 . 10.14814/phy2.13852 . Physiological Reports

Biphasic voltage-dependent inactivation of human NaV 1.3, 1.6 and 1.7 Na+ channels expressed in rodent insulin-secreting cells

Mahdieh Godazgar; Quan Zhang; Margarita V. Chibalina; Patrik Rorsman, The Journal of Physiology. 1601 - 1626. 9. 596. 2018. https://doi.org/10.1113/JP275587 . 10.1113/JP275587 . The Journal of Physiology

a-cell glucokinase suppresses glucose-regulated glucagon secretion

Quan Zhang; Davide Basco; Albert Salehi; Andrei Tarasov; Wanda Dolci; Pedro Herrera; Ioannis Spiliotis; et al, Nature Communications. 1. 9. 2018. https://doi.org/10.1038/s41467-018-03034-0 . 10.1038/s41467-018-03034-0 . Nature Communications

Modulation of large dense core vesicle insulin content mediates rhythmic hormone release from pancreatic beta cells over the 24h cycle

Quinault, Aurore; Leloup, Corinne; Denwood, Geoffrey; Spiegelhalter, Coralie; Rodriguez, Marianne; Lefebvre, Philippe; Messaddeq, Nadia; et al, PLOS ONE. 3. 13. 2018. http://dx.doi.org/10.1371/journal.pone.0193882 . 10.1371/journal.pone.0193882 . PLOS ONE

Fumarate Hydratase Deletion in Pancreatic ß Cells Leads to Progressive Diabetes

Adam, Julie; Ramracheya, Reshma; Chibalina, Margarita V.; Ternette, Nicola; Hamilton, Alexander; Tarasov, Andrei I.; Zhang, Quan; et al, Cell Reports. 3135 - 3148. 13. 20. 2017. http://dx.doi.org/10.1016/j.celrep.2017.08.093 . 10.1016/j.celrep.2017.08.093 . Cell Reports

Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

Zhang, Quan; Babinsky, Valerie N; Hannan, Fadil M; Ramracheya, Reshma D; Nesbit, M Andrew; Hugill, Alison; Bentley, Liz; et al, Endocrinology. 2486 - 2502. 8. 158. 2017. http://dx.doi.org/10.1210/en.2017-00111 . 10.1210/en.2017-00111 . Endocrinology

Functional identification of islet cell types by electrophysiological fingerprinting

Briant, Linford J. B.; Zhang, Quan; Vergari, Elisa; Kellard, Joely A.; Rodriguez, Blanca; Ashcroft, Frances M.; Rorsman, Patrik, Journal of The Royal Society Interface. 128. 14. 2017. http://dx.doi.org/10.1098/rsif.2016.0999 . 10.1098/rsif.2016.0999 . Journal of The Royal Society Interface

Glucagon secretion from pancreatic a-cells

Briant, Linford; Salehi, Albert; Vergari, Elisa; Zhang, Quan; Rorsman, Patrik, Upsala Journal of Medical Sciences. 113 - 119. 2. 121. 2016. http://dx.doi.org/10.3109/03009734.2016.1156789 . 10.3109/03009734.2016.1156789 . Upsala Journal of Medical Sciences

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic ß Cells

Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C.; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; et al, Journal of Biological Chemistry. 21376 - 21392. 35. 290. 2015. http://dx.doi.org/10.1074/jbc.m115.671248 . 10.1074/jbc.m115.671248 . Journal of Biological Chemistry

Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination?

Brereton, Melissa F.; Vergari, Elisa; Zhang, Quan; Clark, Anne, Journal of Histochemistry & Cytochemistry. 575 - 591. 8. 63. 2015. http://dx.doi.org/10.1369/0022155415583535 . 10.1369/0022155415583535 . Journal of Histochemistry & Cytochemistry

ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretion

Rorsman, Patrik; Ramracheya, Reshma; Rorsman, Nils J. G.; Zhang, Quan, Diabetologia. 1749 - 1761. 9. 57. 2014. http://dx.doi.org/10.1007/s00125-014-3279-8 . 10.1007/s00125-014-3279-8 . Diabetologia

MicroRNA-7a regulates pancreatic ß cell function

Latreille, Mathieu; Hausser, Jean; Stützer, Ina; Zhang, Quan; Hastoy, Benoit; Gargani, Sofia; Kerr-Conte, Julie; et al, Journal of Clinical Investigation. 2722 - 2735. 6. 124. 2014. http://dx.doi.org/10.1172/jci73066 . 10.1172/jci73066 . Journal of Clinical Investigation

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Brereton, Melissa F.; Iberl, Michaela; Shimomura, Kenju; Zhang, Quan; Adriaenssens, Alice E.; Proks, Peter; Spiliotis, Ioannis I.; et al, Nature Communications. 1. 5. 2014. http://dx.doi.org/10.1038/ncomms5639 . 10.1038/ncomms5639 . Nature Communications

Na+current properties in islet a- and ß-cells reflect cell-specific Scn3a and Scn9a expression

Zhang, Quan; Chibalina, Margarita V.; Bengtsson, Martin; Groschner, Lukas N.; Ramracheya, Reshma; Rorsman, Nils J. G.; Leiss, Veronika; et al, The Journal of Physiology. 4677 - 4696. 21. 592. 2014. http://dx.doi.org/10.1113/jphysiol.2014.274209 . 10.1113/jphysiol.2014.274209 . The Journal of Physiology

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Zhang, Quan; Ramracheya, Reshma; Lahmann, Carolina; Tarasov, Andrei; Bengtsson, Martin; Braha, Orit; Braun, Matthias; et al, Cell Metabolism. 871 - 882. 6. 18. 2013. http://dx.doi.org/10.1016/j.cmet.2013.10.014 . 10.1016/j.cmet.2013.10.014 . Cell Metabolism

Regulation of calcium in pancreatic a- and ß-cells in health and disease

Rorsman, Patrik; Braun, Matthias; Zhang, Quan, Cell Calcium. 300 - 308. 3-4. 51. 2012. http://dx.doi.org/10.1016/j.ceca.2011.11.006 . 10.1016/j.ceca.2011.11.006 . Cell Calcium

Multivesicular exocytosis in rat pancreatic beta cells

Hoppa, M. B.; Jones, E.; Karanauskaite, J.; Ramracheya, R.; Braun, M.; Collins, S. C.; Zhang, Q.; et al, Diabetologia. 1001 - 1012. 4. 55. 2011. http://dx.doi.org/10.1007/s00125-011-2400-5 . 10.1007/s00125-011-2400-5 . Diabetologia

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?

Walker, J. N.; Ramracheya, R.; Zhang, Q.; Johnson, P. R. V.; Braun, M.; Rorsman, P., Diabetes, Obesity and Metabolism. 95 - 105. 13. 2011. http://dx.doi.org/10.1111/j.1463-1326.2011.01450.x . 10.1111/j.1463-1326.2011.01450.x . Diabetes, Obesity and Metabolism

Electrophysiology of pancreatic ß-cells in intact mouse islets of Langerhans

Rorsman, Patrik; Eliasson, Lena; Kanno, Takahiro; Zhang, Quan; Gopel, Sven, Progress in Biophysics and Molecular Biology. 224 - 235. 2. 107. 2011. http://dx.doi.org/10.1016/j.pbiomolbio.2011.06.009 . 10.1016/j.pbiomolbio.2011.06.009 . Progress in Biophysics and Molecular Biology

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

Zhang, Quan; De Marinis, Yang Z.; Salehi, Albert; Ward, Caroline E.; Abdulkader, Fernando; Bengtsson, Martin; Braha, Orit; et al, Cell Metabolism. 543 - 553. 6. 11. 2010. http://dx.doi.org/10.1016/j.cmet.2010.04.007 . 10.1016/j.cmet.2010.04.007 . Cell Metabolism

Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles

Collins, S. C.; Hoppa, M. B.; Walker, J. N.; Amisten, S.; Abdulkader, F.; Bengtsson, M.; Fearnside, J.; et al, Diabetes. 1192 - 1201. 5. 59. 2010. http://dx.doi.org/10.2337/db09-0791 . 10.2337/db09-0791 . Diabetes

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in alpha-Cells Inhibits Glucagon Secretion From Human Islets

Ramracheya, R.; Ward, C.; Shigeto, M.; Walker, J. N.; Amisten, S.; Zhang, Q.; Johnson, P. R.; Rorsman, P.; Braun, M., Diabetes. 2198 - 2208. 9. 59. 2010. http://dx.doi.org/10.2337/db09-1505 . 10.2337/db09-1505 . Diabetes

Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules

Hoppa, Michael B.; Collins, Stephan; Ramracheya, Reshma; Hodson, Leanne; Amisten, Stefan; Zhang, Quan; Johnson, Paul; et al, Cell Metabolism. 455 - 465. 6. 10. 2009. http://dx.doi.org/10.1016/j.cmet.2009.09.011 . 10.1016/j.cmet.2009.09.011 . Cell Metabolism

Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells

Braun, M.; Ramracheya, R.; Amisten, S.; Bengtsson, M.; Moritoh, Y.; Zhang, Q.; Johnson, P. R.; Rorsman, P., Diabetologia. 1566 - 1578. 8. 52. 2009. http://dx.doi.org/10.1007/s00125-009-1382-z . 10.1007/s00125-009-1382-z . Diabetologia

Synaptotagmin-7 is a principal Ca2+sensor for Ca2+-induced glucagon exocytosis in pancreas

Gustavsson, Natalia; Wei, Shun-Hui; Hoang, Dong Nhut; Lao, Ye; Zhang, Quan; Radda, George K.; Rorsman, Patrik; Südhof, Thomas C.; Han, Weiping, The Journal of Physiology. 1169 - 1178. 6. 587. 2009. http://dx.doi.org/10.1113/jphysiol.2008.168005 . 10.1113/jphysiol.2008.168005 . The Journal of Physiology

Cell coupling in mouse pancreatic ß-cells measured in intact islets of Langerhans

Zhang, Quan; Galvanovskis, Juris; Abdulkader, Fernando; Partridge, Christopher J; Göpel, Sven O; Eliasson, Lena; Rorsman, Patrik, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 3503 - 3523. 1880. 366. 2008. http://dx.doi.org/10.1098/rsta.2008.0110 . 10.1098/rsta.2008.0110 . Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

Braun, M.; Ramracheya, R.; Bengtsson, M.; Zhang, Q.; Karanauskaite, J.; Partridge, C.; Johnson, P. R.; Rorsman, P., Diabetes. 1618 - 1628. 6. 57. 2008. http://dx.doi.org/10.2337/db07-0991 . 10.2337/db07-0991 . Diabetes

R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion

Zhang, Quan; Bengtsson, Martin; Partridge, Chris; Salehi, Albert; Braun, Matthias; Cox, Roger; Eliasson, Lena; et al, Nature Cell Biology. 453 - 460. 4. 9. 2007. http://dx.doi.org/10.1038/ncb1563 . 10.1038/ncb1563 . Nature Cell Biology

Capacitance measurements of exocytosis in mouse pancreatic a-, ß- and d-cells within intact islets of Langerhans

Göpel, Sven; Zhang, Quan; Eliasson, Lena; Ma, Xiao-Song; Galvanovskis, Juris; Kanno, Takahiro; Salehi, Albert; Rorsman, Patrik, The Journal of Physiology. 711 - 726. 3. 556. 2004. http://dx.doi.org/10.1113/jphysiol.2003.059675 . 10.1113/jphysiol.2003.059675 . The Journal of Physiology