Rui Manuel Silva Gomes Barbosa

Design and Evaluation of a Lactate Microbiosensor: Toward Multianalyte Monitoring of Neurometabolic Markers In Vivo in the Brain

Eliana Fernandes; Ana Ledo; Rui M. Barbosa, Molecules. 2022. https://doi.org/10.3390/molecules27020514 . 10.3390/molecules27020514 . Molecules

Highly sensitive and selective nanostructured microbiosensors for glucose and lactate simultaneous measurements in blood serum and in vivo in brain tissue

Biosensors and Bioelectronics. 113874 - 113874. 199. 2022. http://dx.doi.org/10.1016/j.bios.2021.113874 . 10.1016/j.bios.2021.113874 . Biosensors and Bioelectronics

The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration

Ledo, A.; Lourenço, C.F.; Cadenas, E.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 500 - 513. 162. 2021. http://dx.doi.org/10.1016/j.freeradbiomed.2020.11.005 . 10.1016/j.freeradbiomed.2020.11.005 . Free Radical Biology and Medicine

The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling

Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M., Neurochemical Research. 64 - 76. 1. 46. 2020. http://dx.doi.org/10.1007/s11064-020-03015-0 . 10.1007/s11064-020-03015-0 . Neurochemical Research

Enhanced selectivity and stability of ruthenium purple-modified carbon fiber microelectrodes for detection of hydrogen peroxide in brain tissue

Ledo, Ana; Fernandes, Eliana; Brett, Christopher M.A.; Barbosa, Rui M., Sensors and Actuators B: Chemical. 311. 2020. http://dx.doi.org/10.1016/j.snb.2020.127899 . 10.1016/j.snb.2020.127899 . Sensors and Actuators B: Chemical

Electrochemical Evaluation of a Multi-Site Clinical Depth Recording Electrode for Monitoring Cerebral Tissue Oxygen

Ledo, Ana; Fernandes, Eliana; Quintero, Jorge E.; Gerhardt, Greg A.; Barbosa, Rui M., Micromachines. 7. 11. 2020. http://dx.doi.org/10.3390/mi11070632 . 10.3390/mi11070632 . Micromachines

Platinized carbon fiber-based glucose microbiosensor designed for metabolic studies in brain slices

Lourenço, Cátia F.; Caetano, Miguel; Ledo, Ana; Barbosa, Rui M., Bioelectrochemistry. 130. 2019. http://dx.doi.org/10.1016/j.bioelechem.2019.06.010 . 10.1016/j.bioelechem.2019.06.010 . Bioelectrochemistry

Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays

Nuno R. Ferreira; Ana Ledo; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa, Bioelectrochemistry. 142 - 150. 121. 2018. https://doi.org/10.1016/j.bioelechem.2018.01.009 . 10.1016/j.bioelechem.2018.01.009 . Bioelectrochemistry

Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices

Cândida Dias; Cátia F. Lourenço; Rui M. Barbosa; João Laranjinha; Ana Ledo, Analytical Biochemistry. 43 - 50. 551. 2018. https://doi.org/10.1016/j.ab.2018.05.010 . 10.1016/j.ab.2018.05.010 . Analytical Biochemistry

Concurrent measurements of neurochemical and electrophysiological activity with microelectrode arrays: New perspectives for constant potential amperometry

Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa, Current Opinion in Electrochemistry. 129 - 140. 12. 2018. https://doi.org/10.1016/j.coelec.2018.05.018 . 10.1016/j.coelec.2018.05.018 . Current Opinion in Electrochemistry

Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays

Cátia F. Lourenço; Ana Ledo; Greg A. Gerhardt; João Laranjinha; Rui M. Barbosa, Scientific Reports. 2017. https://doi.org/10.1038/s41598-017-07119-6 . 10.1038/s41598-017-07119-6 . Scientific Reports

Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research

Ana Ledo; Cátia F. Lourenço; João Laranjinha; Greg A. Gerhardt; Rui M. Barbosa, Analytical Chemistry. 2017. https://doi.org/10.1021/acs.analchem.7b03452 . 10.1021/acs.analchem.7b03452 . Analytical Chemistry

Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue

Ana Ledo; Cátia F. Lourenço; João Laranjinha; Christopher M. A. Brett; Greg A. Gerhardt; Rui M. Barbosa, Analytical Chemistry. 1674 - 1683. 3. 89. 2017. https://doi.org/10.1021/acs.analchem.6b03772 . 10.1021/acs.analchem.6b03772 . Analytical Chemistry

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Egea, J.; Fabregat, I.; Frapart, Y.M.; Ghezzi, P.; Görlach, A.; Kietzmann, T.; Kubaichuk, K.; et al, Redox Biology. 94 - 162. 13. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020032301&partnerID=MN8TOARS . 10.1016/j.redox.2017.05.007 . Redox Biology

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

Nunes, C.; Almeida, L.; Barbosa, R.M.; Laranjinha, J., Food and Function. 387 - 396. 1. 8. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010953233&partnerID=MN8TOARS . 10.1039/c6fo01529h . Food and Function

Neurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration

Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 668 - 682. 108. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85018262522&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2017.04.026 . Free Radical Biology and Medicine

Neurovascular uncoupling in the triple transgenic model of Alzheimer's disease: Impaired cerebral blood flow response to neuronal-derived nitric oxide signaling

Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., Experimental Neurology. 36 - 43. 291. 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011654048&partnerID=MN8TOARS . 10.1016/j.expneurol.2017.01.013 . Experimental Neurology

Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation

Dias, C.; Lourenço, C.F.; Ferreiro, E.; Barbosa, R.M.; Laranjinha, J.; Ledo, A., Neurobiology of Aging. 84 - 95. 46. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978903965&partnerID=MN8TOARS . 10.1016/j.neurobiolaging.2016.06.012 . Neurobiology of Aging

Microelectrode array biosensor for high-resolution measurements of extracellular glucose in the brain

Lourenço, C.F.; Ledo, A.; Laranjinha, J.; Gerhardt, G.A.; Barbosa, R.M., Sensors and Actuators, B: Chemical. 298 - 307. 237. 2016. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976594136&partnerID=MN8TOARS . 10.1016/j.snb.2016.06.083 . Sensors and Actuators, B: Chemical

Neurovascular and neurometabolic derailment in aging and alzheimer's disease

Lourenço, C.F.; Ledo, A.; Dias, C.; Barbosa, R.M.; Laranjinha, J., Frontiers in Aging Neuroscience. MAY. 7. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931266835&partnerID=MN8TOARS . 10.3389/fnagi.2015.00103 . Frontiers in Aging Neuroscience

Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay

Ferreira, N.R.; Lourenço, C.F.; Barbosa, R.M.; Laranjinha, J., Brain Research Bulletin. 13 - 19. 114. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925442099&partnerID=MN8TOARS . 10.1016/j.brainresbull.2015.03.002 . Brain Research Bulletin

Dietary nitrite induces nitrosation of the gastric mucosa: The protective action of the mucus and the modulatory effect of red wine

Pereira, C.; Barbosa, R.M.; Laranjinha, J., Journal of Nutritional Biochemistry. 476 - 483. 5. 26. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928275461&partnerID=MN8TOARS . 10.1016/j.jnutbio.2014.12.004 . Journal of Nutritional Biochemistry

Simultaneous measurement of cholinergic tone and neuronal network dynamics in vivo in the rat brain using a novel choline oxidase based electrochemical biosensor

Santos, R.M.; Laranjinha, J.; Barbosa, R.M.; Sirota, A., Biosensors and Bioelectronics. 83 - 94. 69. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84923082333&partnerID=MN8TOARS . 10.1016/j.bios.2015.02.003 . Biosensors and Bioelectronics

Ethyl nitrite is produced in the human stomach from dietary nitrate and ethanol, releasing nitric oxide at physiological pH: Potential impact on gastric motility

Rocha, B.S.; Gago, B.; Barbosa, R.M.; Cavaleiro, C.; Laranjinha, J., Free Radical Biology and Medicine. 160 - 166. 82. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925061584&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2015.01.021 . Free Radical Biology and Medicine

Erratum: Evidence for a pathway that facilitates nitric oxide diffusion in the brain (Neurochem. Int. (2011) 59 (90-96) DOI: 10.1016/j.neuint.2011.05.016)

Santos, R.M.; Lourenço, C.F.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Barbosa, R.M., Neurochemistry International. 91. 2015. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951179683&partnerID=MN8TOARS . 10.1016/j.neuint.2015.11.004 . Neurochemistry International

A shortcut to wide-ranging biological actions of dietary polyphenols: Modulation of the nitrate-nitrite-nitric oxide pathway in the gut

Rocha, B.S.; Nunes, C.; Pereira, C.; Barbosa, R.M.; Laranjinha, J., Food and Function. 1646 - 1652. 8. 5. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904984090&partnerID=MN8TOARS . 10.1039/c4fo00124a . Food and Function

The pattern of glutamate-induced nitric oxide dynamics in vivo and its correlation with nNOS expression in rat hippocampus, cerebral cortex and striatum

Lourenço, C.F.; Ferreira, N.R.; Santos, R.M.; Lukacova, N.; Barbosa, R.M.; Laranjinha, J., Brain Research. 1 - 11. 1554. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84895133025&partnerID=MN8TOARS . 10.1016/j.brainres.2014.01.030 . Brain Research

Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide

Lourenço, C.F.; Santos, R.M.; Barbosa, R.M.; Cadenas, E.; Radi, R.; Laranjinha, J., Free Radical Biology and Medicine. 421 - 429. 73. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903846214&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2014.05.021 . Free Radical Biology and Medicine

Age-Associated Changes of Nitric Oxide Concentration Dynamics in the Central Nervous System of Fisher 344 Rats

Ledo, A.; Lourenço, C.F.; Caetano, M.; Barbosa, R.M.; Laranjinha, J., Cellular and Molecular Neurobiology. 33 - 44. 1. 35. 2014. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921938863&partnerID=MN8TOARS . 10.1007/s10571-014-0115-0 . Cellular and Molecular Neurobiology

Human colon adenocarcinoma HT-29 cell: Electrochemistry and nicotine stimulation

Oliveira, S.C.B.; Santarino, I.B.; Enache, T.A.; Nunes, C.; Laranjinha, J.; Barbosa, R.M.; Oliveira-Brett, A.M., Bioelectrochemistry. 30 - 38. 94. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879324150&partnerID=MN8TOARS . 10.1016/j.bioelechem.2013.05.004 . Bioelectrochemistry

Pepsin is nitrated in the rat stomach, acquiring antiulcerogenic activity: A novel interaction between dietary nitrate and gut proteins

Rocha, B.S.; Gago, B.; Barbosa, R.M.; Lundberg, J.O.; Mann, G.E.; Radi, R.; Laranjinha, J., Free Radical Biology and Medicine. 26 - 34. 58. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875974388&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2012.12.017 . Free Radical Biology and Medicine

Intestinal anti-inflammatory activity of red wine extract: Unveiling the mechanisms in colonic epithelial cells

Nunes, C.; Ferreira, E.; Freitas, V.; Almeida, L.; Barbosa, R.M.; Laranjinha, J., Food and Function. 373 - 383. 3. 4. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874505366&partnerID=MN8TOARS . 10.1039/c2fo30233k . Food and Function

Real Time In Vivo Measurement of Ascorbate in the Brain Using Carbon Nanotube-Modified Microelectrodes

Ferreira, N.R.; Santos, R.M.; Laranjinha, J.; Barbosa, R.M., Electroanalysis. 1757 - 1763. 7. 25. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880348563&partnerID=MN8TOARS . 10.1002/elan.201300053 . Electroanalysis

Self-mixing microprobe for monitoring microvascular perfusion in rat brain

Figueiras, Edite; Oliveira, Ricardo; Lourenço, Cátia F; Campos, Rita; Humeau-Heurtier, Anne; Barbosa, Rui M; Laranjinha, João; et al, Medical and Biological Engineering and Computing. 103 - 112. 1-2. 51. 2013. http://hdl.handle.net/10316/80012 . 10.1007/s11517-012-0973-x . Medical and Biological Engineering and Computing

Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain

Santos, Ricardo M.; Rodrigues, Marcelo S.; Laranjinha, João; Barbosa, Rui M.; Santos, R.M.; Rodrigues, M.S.; Laranjinha, J.; Barbosa, R.M., Biosensors and Bioelectronics. 152 - 159. 1. 44. 2013. http://hdl.handle.net/10316/26914 . 10.1016/j.bios.2013.01.015 . Biosensors and Bioelectronics

The redox interplay between nitrite and nitric oxide: From the gut to the brain

Pereira, C.; Ferreira, N.R.; Rocha, B.S.; Barbosa, R.M.; Laranjinha, J., Redox Biology. 276 - 284. 1. 1. 2013. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879005609&partnerID=MN8TOARS . 10.1016/j.redox.2013.04.004 . Redox Biology

Intragastric nitration by dietary nitrite: Implications for modulation of protein and lipid signaling

Rocha, B.S.; Gago, B.; Barbosa, R.M.; Lundberg, J.O.; Radi, R.; Laranjinha, J., Free Radical Biology and Medicine. 693 - 698. 3. 52. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856266699&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2011.11.011 . Free Radical Biology and Medicine

Flow injection analysis for nitric oxide quantification based on reduced fluoresceinamine

Simões, E.F.C.; Leitão, J.M.M.; Barbosa, R.M.; Esteves Da Silva, J.C.G., Analytical Methods. 1089 - 1097. 4. 4. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859339774&partnerID=MN8TOARS . 10.1039/c2ay05774c . Analytical Methods

Nitric oxide inactivation mechanisms in the brain: Role in bioenergetics and neurodegeneration

Santos, R.M.; Lourenço, C.F.; Ledo, A.; Barbosa, R.M.; Laranjinha, J., International Journal of Cell Biology. 2012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863706810&partnerID=MN8TOARS . 10.1155/2012/391914 . International Journal of Cell Biology

In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus

LourençO, C.F.; Santos, R.; Barbosa, R.M.; Gerhardt, G.; Cadenas, E.; Laranjinha, J., Hippocampus. 622 - 630. 6. 21. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956360575&partnerID=MN8TOARS . 10.1002/hipo.20774 . Hippocampus

Preparation, standardization and measurement of nitric oxide solutions

Rui M. Barbosa; Lopes Jesus, A. J; Ricardo M. Santos; Cassilda L. Pereira; Cátia F. Marques; Bárbara S. Rocha; Nuno R. Ferreira; Ana Ledo; João Laranjinha, Global Journal of Analytical Chemistry. 272 - 274. 2. 2011. http://www.cognizure.com/abstract.aspx?p=101637271 . published Global Journal of Analytical Chemistry

Evidence for a pathway that facilitates nitric oxide diffusion in the brain

Santos, R.M.; Loureno, C.F.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Barbosa, R.M., Neurochemistry International. 90 - 96. 1. 59. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960196903&partnerID=MN8TOARS . 10.1016/j.neuint.2011.05.016 . Neurochemistry International

Dietary nitrite in nitric oxide biology: A redox interplay with implications for pathophysiology and therapeutics

Rocha, B.S.; Gago, B.; Pereira, C.; Barbosa, R.M.; Bartesaghi, S.; Lundberg, J.O.; Radi, R.; Laranjinha, J., Current Drug Targets. 1351 - 1363. 9. 12. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959998237&partnerID=MN8TOARS . 10.2174/138945011796150334 . Current Drug Targets

Brain nitric oxide inactivation is governed by the vasculature

Santos, R.M.; Lourenço, C.F.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Antioxidants and Redox Signaling. 1011 - 1021. 6. 14. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951864475&partnerID=MN8TOARS . 10.1089/ars.2010.3297 . Antioxidants and Redox Signaling

Nitric oxide and DOPAC-induced cell death: From GSH depletion to mitochondrial energy crisis

Nunes, C.; Barbosa, R.M.; Almeida, L.; Laranjinha, J., Molecular and Cellular Neuroscience. 94 - 103. 1. 48. 2011. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960921750&partnerID=MN8TOARS . 10.1016/j.mcn.2011.06.009 . Molecular and Cellular Neuroscience

Dynamic and interacting profiles of .NO and O2 in rat hippocampal slices

Ledo, A.; Barbosa, R.; Cadenas, E.; Laranjinha, J., Free Radical Biology and Medicine. 1044 - 1050. 8. 48. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950516684&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2010.01.024 . Free Radical Biology and Medicine

Diffusion of nitric oxide through the gastric wall upon reduction of nitrite by red wine: Physiological impact

Rocha, B.S.; Gago, B.; Barbosa, R.M.; Laranjinha, J., Nitric Oxide - Biology and Chemistry. 235 - 241. 3. 22. 2010. http://www.scopus.com/inward/record.url?eid=2-s2.0-76949084897&partnerID=MN8TOARS . 10.1016/j.niox.2010.01.003 . Nitric Oxide - Biology and Chemistry

Dietary polyphenols generate nitric oxide from nitrite in the stomach and induce smooth muscle relaxation

Rocha, B.S.; Gago, B.; Barbosa, R.M.; Laranjinha, J., Toxicology. 41 - 48. 1-2. 265. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349876563&partnerID=MN8TOARS . 10.1016/j.tox.2009.09.008 . Toxicology

Stimulation of NMDA and AMPA glutamate receptors elicits distinct concentration dynamics of nitric oxide in rat hippocampal slices

Frade, J.G.; Barbosa, R.M.; Laranjinha, J., Hippocampus. 603 - 611. 7. 19. 2009. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649667029&partnerID=MN8TOARS . 10.1002/hipo.20536 . Hippocampus

LDL isolated from plasma-loaded red wine procyanidins resist lipid oxidation and tocopherol depletion

Lourenço, C.F.; Gago, B.; Barbosa, R.M.; De Freitas, V.; Laranjinha, J., Journal of Agricultural and Food Chemistry. 3798 - 3804. 10. 56. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549089760&partnerID=MN8TOARS . 10.1021/jf0733259 . Journal of Agricultural and Food Chemistry

Glutamate induces release of glutathione from cultured rat astrocytes - A possible neuroprotective mechanism?

Frade, J.; Pope, S.; Schmidt, M.; Dringen, R.; Barbosa, R.; Pocock, J.; Laranjinha, J.; Heales, S., Journal of Neurochemistry. 1144 - 1152. 4. 105. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-42549146494&partnerID=MN8TOARS . 10.1111/j.1471-4159.2008.05216.x . Journal of Neurochemistry

Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in the absence of functional K-ATP channels

Antunes, Célia M.; Rosário, Luís M.; Barbosa, Rui M.; Silva, Amélia S.; Baldeiras, Inês E.; Tomé, Ângelo R.; Santos, Rosa M.; et al, Endocrine Journal. 639 - 650. 4. 55. 2008. http://hdl.handle.net/10174/1525 . 10.1507/endocrj.K07E-131 . Endocrine Journal

A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue

Santos, R.M.; Lourenço, C.F.; Piedade, A.P.; Andrews, R.; Pomerleau, F.; Huettl, P.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M., Biosensors and Bioelectronics. 704 - 709. 4. 24. 2008. http://www.scopus.com/inward/record.url?eid=2-s2.0-53049092283&partnerID=MN8TOARS . 10.1016/j.bios.2008.06.034 . Biosensors and Bioelectronics

The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions

Gago, Bruno; Nyström, Thomas; Cavaleiro, Carlos; Rocha, Bárbara S.; Barbosa, Rui M.; Laranjinha, João; Lundberg, Jon O.; et al, Free Radical Biology and Medicine. 404 - 412. 4. 45. 2008. http://hdl.handle.net/10316/5829 . 10.1016/j.freeradbiomed.2008.04.027 . Free Radical Biology and Medicine

LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion

Lourenço, Cátia F.; Gago, Bruno; Barbosa, Rui M.; Freitas, Víctor de; Laranjinha, João, 2008. http://hdl.handle.net/10316/10603 .

Conformational Isomorphism of Organic Crystals: Racemic and Homochiral Atenolol

Castro, R. A. Esteves de; Canotilho, João; Barbosa, Rui M.; Silva, M. Ramos; Beja, A. Matos; Paixão, J. A.; Redinha, J. Simões; et al, Crystal Growth and Design. 496 - 500. 3. 7. 2007. http://hdl.handle.net/10316/10572 . 10.1021/cg0601857 . Crystal Growth and Design

Infrared spectroscopy of racemic and enantiomeric forms of atenolol

de Castro, R.A.E.; Canotilho, J.; Barbosa, R.M.; Redinha, J.S.; Castro, R. A. Esteves de; Canotilho, João; Barbosa, Rui M.; Redinha, J. Simões, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy. 1194 - 1200. 5. 67. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34347379327&partnerID=MN8TOARS . 10.1016/j.saa.2006.10.007 . Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

Red wine-dependent reduction of nitrite to nitric oxide in the stomach

Gago, B.; Lundberg, J.O.; Barbosa, R.M.; Laranjinha, J., Free Radical Biology and Medicine. 1233 - 1242. 9. 43. 2007. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548743996&partnerID=MN8TOARS . 10.1016/j.freeradbiomed.2007.06.007 . Free Radical Biology and Medicine

Regulation of nitric oxide dynamics in hippocampus by NMDA and AMPA glutamate receptors

Ledo, A.; Frade, J.G.; Barbosa, R.M.; Laranjinha, J., Current Topics in Pharmacology. 55 - 70. 2. 10. 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149182950&partnerID=MN8TOARS . Current Topics in Pharmacology

Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes

Ferreira, N.R.; Ledo, A.; Frade, J.G.; Gerhardt, G.A.; Laranjinha, J.; Barbosa, R.M.; Ferreira, Nuno R.; et al, Analytica Chimica Acta. 1 - 7. 1-2. 535. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-15744400539&partnerID=MN8TOARS . 10.1016/j.aca.2004.12.017 . Analytica Chimica Acta

Concentration Dynamics of Nitric Oxide in Rat Hippocampal Slices

Ledo, Ana; Barbosa, Rui M.; Cadenas, Enrique; Gerhardt, Greg; Laranjinha, João, 2005. http://hdl.handle.net/10316/9661 .

Mechanisms of neuroprotection by polyphenols

Frade, J.G.; Ferreira, N.R.; Barbosa, R.M.; Laranjinha, J., Current Medicinal Chemistry - Central Nervous System Agents. 307 - 318. 4. 5. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28244468104&partnerID=MN8TOARS . 10.2174/156801505774913062 . Current Medicinal Chemistry - Central Nervous System Agents

In situ sensing of DNA damage by a nitric oxide-releasing compound

Diculescu, V.C.; Barbosa, R.M.; Oliveira Brett, A.M., Analytical Letters. 2525 - 2540. 15. 38. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-30744437404&partnerID=MN8TOARS . 10.1080/00032710500369737 . Analytical Letters

Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor

Ledo, A.; Barbosa, R.M.; Gerhardt, G.A.; Cadenas, E.; Laranjinha, J.; Ledo, Ana; Barbosa, Rui M.; et al, Proceedings of the National Academy of Sciences of the United States of America. 17483 - 17488. 48. 102. 2005. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444486330&partnerID=MN8TOARS . 10.1073/pnas.0503624102 . Proceedings of the National Academy of Sciences of the United States of America

Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions

Ledo, Ana; Frade, João; Barbosa, Rui M.; Laranjinha, João; Ledo, A.; Frade, J.; Barbosa, R.M.; Laranjinha, J., Molecular Aspects of Medicine. 75 - 89. 1-2. 25. 2004. http://hdl.handle.net/10316/5770 . 10.1016/j.mam.2004.02.010 . Molecular Aspects of Medicine

Insulinotropic action of white lupine seeds (Lupinus albus L.): Effects of ion fluxes and insulin secretion from isolated pancreatic islets

Pereira, F.C.; Ouedraogo, R.; Lebrun, P.; Barbosa, R.M.; Cunha, A.P.; Santos, R.M.; Rosário, L.M., Biomedical Research. 103 - 109. 2. 22. 2001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0009494765&partnerID=MN8TOARS . Biomedical Research

Involvement of protein kinase C in cholinergic potentiation of glucose-induced 5-HT/insulin secretion

Baldeiras, Inês E.; Barbosa, Rui M.; Santos, Rosa M.; Rosário, Luís M., 2000. http://hdl.handle.net/10316/3891 .

Control of pulsatile 5-HT/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics

Barbosa, Rui M.; Silva, Amélia M.; Tomé, Angelo R.; Stamford, Jonathan A.; Santos, Rosa M.; Rosário, Luís M.; Barbosa, R.M.; et al, Journal of Physiology. 135 - 143. 1. 510. 1998. http://hdl.handle.net/10316/8367 . 10.1111/j.1469-7793.1998.135bz.x . Journal of Physiology

Erratum: Real time electrochemical detection of 5-HT/Insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization (Biochemical and Biophysical Research Communications (1996) 228 (100-104))

Barbosa, R.M.; Silva, A.M.; Tome, A.R.; Stamford, J.A.; Santos, R.M.; Rosario, L.M., Biochemical and Biophysical Research Communications. 2. 231. 1997. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030978941&partnerID=MN8TOARS . Biochemical and Biophysical Research Communications

Real time electrochemical detection of 5-HT/insulin secretion from single pancreatic islets: Effect of glucose and K+ depolarization

Barbosa, R.M.; Silva, A.M.; Tomé, A.R.; Stamford, J.A.; Santos, R.M.; Rosário, L.M., Biochemical and Biophysical Research Communications. 100 - 104. 1. 228. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030297323&partnerID=MN8TOARS . 10.1006/bbrc.1996.1622 . Biochemical and Biophysical Research Communications

Electrochemical studies of zinc in zinc-insulin solution

Barbosa, R.M.; Rosário, L.M.; Brett, C.M.A.; Oliveira Brett, A.M., Analyst. 1789 - 1793. 12. 121. 1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030453233&partnerID=MN8TOARS . 10.1039/an9962101789 . Analyst

Cell-specific purinergic receptors coupled to Ca2+ entry and Ca2+ release from internal stores in adrenal chromaffin cells: Differential sensitivity to UTP and Suramin

Castro, E.; Mateo, J.; Tomé, A.R.; Barbosa, R.M.; Miras-Portugal, M.T.; Rosário, L.M., Journal of Biological Chemistry. 5098 - 5106. 10. 270. 1995. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028912175&partnerID=MN8TOARS . Journal of Biological Chemistry

Differential modulation of pancreatic ß-cell bursting by intracellular pH in the presence and absence of a K-ATP channel blocker

Barbosa, R.M.; Salgado, A.P.; Santos, R.M.; Rosário, L.M., FEBS Letters. 9 - 13. 1-2. 332. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027436596&partnerID=MN8TOARS . 10.1016/0014-5793(93)80471-6 . FEBS Letters

Bursting electrical activity in pancreatic ß-cells: evidence that the channel underlying the burst is sensitive to Ca2+ influx through L-type Ca2+ channels

Rosário, L.M.; Barbosa, R.M.; Antunes, C.M.; Silva, A.M.; Abrunhosa, A.J.; Santos, R.M., Pflügers Archiv European Journal of Physiology. 439 - 447. 5-6. 424. 1993. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027282069&partnerID=MN8TOARS . 10.1007/BF00374906 . Pflügers Archiv European Journal of Physiology

High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic ß-cells during blockade of K(ATP) channels

Santos, R.M.; Barbosa, R.M.; Silva, A.M.; Antunes, C.M.; Rosario, L.M., Biochemical and Biophysical Research Communications. 872 - 879. 2. 187. 1992. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026611726&partnerID=MN8TOARS . 10.1016/0006-291X(92)91278-X . Biochemical and Biophysical Research Communications