Metabolism, Aging and Disease
Organelle Crosstalk in Aging and Disease
Organelle crosstalk
mitochondria
lysosomes
endoplasmic reticulum
peroxisomes
nucleus
multi-omics
aging
Organelle crosstalk
mitochondria
lysosomes
endoplasmic reticulum
peroxisomes
nucleus
multi-omics
aging
Cells work as a small machine in which the different components (organelles) are coordinated with each other, as in a car. When that coordination between organelles is lost, there is development of pathologies that affect muscles (including the heart), liver, eyes, ears, and nervous system. Our goal is to understand how cellular organelles crosstalk with each other so that we can avoid diseases caused by the loss of that coordination. We use mammalian models (mouse) and cellular (human, mouse, rat) to tackle these questions and define novel therapeutic strategies to neurodegenerative, muscular and other diseases.
Information about journal articles, updated at 12-04-2026, from platform CIÊNCIAVITAE.
VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement
Vats, Somya; Dionisio, Pedro; Lemercier, Quentin; Pineau, Raphael; Therreau, Ludivine; Lipecka, Joanna; Cholley, Béatrice; et al, 2026. Nature Communications. 2026. https://doi.org/10.1038/s41467-026-69900-4 . 10.1038/s41467-026-69900-4 . published Nature Communications
Dynamins maintain nuclear envelope homeostasis and genome stability
Aveleira, Célia; Martial, Thibaud; Carrique, Loïc; Gaspar, Rita; Caulino-Rocha, Ana; Myatt, Izaak; Wendler, Franz; et al, 2026. Nature Communications. 2026. https://doi.org/10.1038/s41467-025-68130-4 . 10.1038/s41467-025-68130-4 . Nature Communications
The mitochondriotropic antioxidants AntiOxBEN2 and AntiOxCIN4 are structurally-similar but differentially alter energy homeostasis in human skin fibroblasts
Teixeira, José; Benfeito, Sofia; Carreira, Rodrigo; Barbosa, André; Amorim, Ricardo; Tavares, Ludgero C.; Jones, John G.; et al, 2025. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2. 1866. 2025. https://doi.org/10.1016/j.bbabio.2025.149535 . 10.1016/j.bbabio.2025.149535 . Biochimica et Biophysica Acta (BBA) - Bioenergetics
Role of lipids in interorganelle communication
Neuza Domingues; Joana Pires; Ira Milosevic; Nuno Raimundo, 2025. Trends in Cell Biology. 2025. https://doi.org/10.1016/j.tcb.2024.04.008 . 10.1016/j.tcb.2024.04.008 . Trends in Cell Biology
Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling
Domingues, Neuza; Calcagni’, Alessia; Freire, Sofia; Pires, Joana; Casqueiro, Ricardo; Salazar, Ivan L; Herz, Niculin Joachim; et al, 2025. EMBO Reports. 6096 - 6120. 24. 26. 2025. https://doi.org/10.1038/s44319-025-00613-3 . 10.1038/s44319-025-00613-3 . EMBO Reports
Upregulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain
Francesco Agostini; Leonardo Pereyra; Justin Dale; King Faisal Yambire; Silvia Maglioni; Alfonso Schiavi; Natascia Ventura; Ira Milosevic; Nuno Raimundo, 2024. Journal of Biological Chemistry. 2024. https://doi.org/10.1016/j.jbc.2024.107403 . 10.1016/j.jbc.2024.107403 . Journal of Biological Chemistry
Role of lipids in inter-organelle communication
Domingues, Neuza; Joana F. Pires; Milosevic, Ira; Raimundo, Nuno, 2024. Trends in Cell Biology. 2024. in press Trends in Cell Biology
Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons
Beatriz, Margarida; Rodrigues, Ricardo J.; Vilaça, Rita; Egas, Conceição; Pinheiro, Paulo S.; Daley, George Q.; Schlaeger, Thorsten M.; et al, 2023. Theranostics. 3707 - 3724. 11. 13. 2023. https://doi.org/10.7150/thno.81981 . 10.7150/thno.81981 . Theranostics
Lack of peroxisomal catalase affects heat shock response inCaenorhabditis elegans
Marina Musa; Pedro A Dionisio; Ricardo Casqueiro; Ira Milosevic; Nuno Raimundo; Anita Krisko, 2023. Life Science Alliance. 2023. https://doi.org/10.26508/lsa.202201737 . 10.26508/lsa.202201737 . Life Science Alliance
Feeding and lipophagy: it takes guts to deliver
Nuno Raimundo, 2022. The EMBO Journal. 2022. https://doi.org/10.15252/embj.2022112180 . 10.15252/embj.2022112180 . The EMBO Journal
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I.; Schäfer, T.; Hornburg, D.; Mishra, A.; Da Silva Padilha, M.; Fernández-Mosquera, L.; Feigenbutz, D.; et al, 2022. Life Science Alliance. 3. 5. 2022. http://www.scopus.com/inward/record.url?eid=2-s2.0-85122904549&partnerID=MN8TOARS . 10.26508/lsa.202101185 . Life Science Alliance
Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans
Silvia Maglioni; Alfonso Schiavi; Marlen Melcher; Vanessa Brinkmann; Zhongrui Luo; Anna Laromaine; Nuno Raimundo; et al, 2022. Nature Communications. 2022. https://doi.org/10.1038/s41467-022-29972-4 . 10.1038/s41467-022-29972-4 . Nature Communications
Modulation of cellular redox environment as a novel therapeutic strategy for Parkinson's disease
Cláudia M. Deus; José Teixeira; Nuno Raimundo; Paolo Tucci; Fernanda Borges; Luciano Saso; Paulo J. Oliveira, 2022. European Journal of Clinical Investigation. 2022. https://doi.org/10.1111/eci.13820 . 10.1111/eci.13820 . European Journal of Clinical Investigation
A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients.
2021. Redox biology. 2021. https://europepmc.org/articles/PMC8220403 . 10.1016/j.redox.2021.102037 . Redox biology
Corrigendum to ‘A mitochondria-targeted caffeic acid derivative reverts cellular and mitochondrial defects in human skin fibroblasts from male sporadic Parkinson's disease patients’. [Redox Biology 45 (2021) 102037] (Redox Biology (2021) 45, (S2213231721001968), (10.1016/j.redox.2021.102037))
Deus, C.M.; Pereira, S.P.; Cunha-Oliveira, T.; Teixeira, J.; Simões, R.F.; Cagide, F.; Benfeito, S.; et al, 2021. Redox Biology. 47. 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85113538562&partnerID=MN8TOARS . 10.1016/j.redox.2021.102117 . Redox Biology
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al, 2021. Autophagy. 1 - 382. 1. 17. 2021. http://dx.doi.org/10.1080/15548627.2020.1797280 . 10.1080/15548627.2020.1797280 . Autophagy
ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, Garik V.; Abdelmohsen, Kotb; Andreux, Pénélope; Bagdonaite, Ieva; Barzilai, Nir; Brunak, Søren; Cabreiro, Filipe; et al, 2020. Aging. 2020. http://dx.doi.org/10.18632/aging.202454 . 10.18632/aging.202454 . Aging
ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo
Sathyanarayanan, Udhayabhaskar; Musa, Marina; Bou Dib, Peter; Raimundo, Nuno; Milosevic, Ira; Krisko, Anita, 2020. Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-19104-1 . 10.1038/s41467-020-19104-1 . Nature Communications
Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss
Zhao, Jingjing; Li, Gen; Zhao, Xuan; Lin, Xin; Gao, Yunge; Raimundo, Nuno; Li, Geng-Lin; et al, 2020. Aging. 2020. http://dx.doi.org/10.18632/aging.102977 . 10.18632/aging.102977 . Aging
Endophilin-A coordinates priming and fusion of neurosecretory vesicles via intersectin
Gowrisankaran, Sindhuja; Houy, Sébastien; del Castillo, Johanna G. Peña; Steubler, Vicky; Gelker, Monika; Kroll, Jana; Pinheiro, Paulo S.; et al, 2020. Nature Communications. 1. 11. 2020. http://dx.doi.org/10.1038/s41467-020-14993-8 . 10.1038/s41467-020-14993-8 . Nature Communications
Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration
Deus, Cláudia M.; Yambire, King Faisal; Oliveira, Paulo J.; Raimundo, Nuno, 2020. Trends in Molecular Medicine. 71 - 88. 1. 26. 2020. http://dx.doi.org/10.1016/j.molmed.2019.10.009 . 10.1016/j.molmed.2019.10.009 . published Trends in Molecular Medicine
Mitochondrial remodeling in human skin fibroblasts from sporadic male Parkinson's disease patients uncovers metabolic and mitochondrial bioenergetic defects
Deus, Cláudia M.; Pereira, Susana P.; Cunha-Oliveira, Teresa; Pereira, Francisco B.; Raimundo, Nuno; Oliveira, Paulo J., 2020. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 3. 1866. 2020. http://dx.doi.org/10.1016/j.bbadis.2019.165615 . 10.1016/j.bbadis.2019.165615 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Editorial: Autophagy and related transcription factors in liver and gut diseases
Eid, N.; Menon, M.B.; Thomes, P.; Zeng, T.; Raimundo, N.; Fernandez-Checa, J.C.; Wang, L.; et al, 2020. Frontiers in Pharmacology. 10. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079427744&partnerID=MN8TOARS . 10.3389/fphar.2019.01610 . Frontiers in Pharmacology
Author Correction: ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo (Nature Communications, (2020), 11, 1, (5226), 10.1038/s41467-020-19104-1)
Sathyanarayanan, U.; Musa, M.; Dib, P.B.; Raimundo, N.; Milosevic, I.; Krisko, A., 2020. Nature Communications. 1. 11. 2020. http://www.scopus.com/inward/record.url?eid=2-s2.0-85097586562&partnerID=MN8TOARS . 10.1038/s41467-020-20394-8 . Nature Communications
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
Yambire, King Faisal; Fernandez-Mosquera, Lorena; Steinfeld, Robert; Mühle, Christiane; Ikonen, Elina; Milosevic, Ira; Raimundo, Nuno, 2019. eLife. 8. 2019. http://dx.doi.org/10.7554/elife.39598 . 10.7554/elife.39598 . published eLife
Editorial: Mitochondrial Communication in Physiology, Disease and Aging
Raimundo, Nuno; Krisko, Anita, 2019. Frontiers in Cell and Developmental Biology. 7. 2019. http://dx.doi.org/10.3389/fcell.2019.00054 . 10.3389/fcell.2019.00054 . published Frontiers in Cell and Developmental Biology
Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
Barriocanal-Casado, Eliana; Hidalgo-Gutiérrez, Agustín; Raimundo, Nuno; González-García, Pilar; Acuña-Castroviejo, Darío; Escames, Germaine; López, Luis C., 2019. EBioMedicine. 511 - 523. 42. 2019. http://dx.doi.org/10.1016/j.ebiom.2019.03.025 . 10.1016/j.ebiom.2019.03.025 . published EBioMedicine
Mitochondrial fission requires DRP1 but not dynamins
Fonseca, Tiago Branco; Sánchez-Guerrero, Ángela; Milosevic, Ira; Raimundo, Nuno, 2019. Nature. E34 - E42. 7761. 570. 2019. http://dx.doi.org/10.1038/s41586-019-1296-y . 10.1038/s41586-019-1296-y . published Nature
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo
Yambire, King Faisal; Rostosky, Christine; Watanabe, Takashi; Pacheu-Grau, David; Torres-Odio, Sylvia; Sanchez-Guerrero, Angela; Senderovich, Ola; et al, 2019. eLife. 8. 2019. http://dx.doi.org/10.7554/elife.51031 . 10.7554/elife.51031 . published eLife
Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis
Fernandez-Mosquera, Lorena; Yambire, King Faisal; Couto, Renata; Pereyra, Leonardo; Pabis, Kamil; Ponsford, Amy H.; Diogo, Cátia V.; et al, 2019. Autophagy. 1572 - 1591. 9. 15. 2019. http://dx.doi.org/10.1080/15548627.2019.1586256 . 10.1080/15548627.2019.1586256 . published Autophagy
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
King Faisal Yambire; Lorena Fernandez-Mosquera; Robert Steinfeld; Christiane Mühle; Elina Ikonen; Ira Milosevic; Nuno Raimundo, 2019. eLife. 2019. https://doi.org/10.7554/eLife.39598 . 10.7554/eLife.39598 . eLife
Cross-organelle communication at the core of longevity
Raimundo, Nuno; Kriško, Anita, 2018. Aging. 15 - 16. 1. 10. 2018. http://dx.doi.org/10.18632/aging.101373 . 10.18632/aging.101373 . published Aging
Mitochondrial adventures at the organelle society
Cátia V. Diogo; King Faisal Yambire; Lorena Fernández Mosquera; Tiago Branco F.; Nuno Raimundo, 2018. Biochemical and Biophysical Research Communications. 87 - 93. 1. 500. 2018. https://doi.org/10.1016/j.bbrc.2017.04.124 . 10.1016/j.bbrc.2017.04.124 . published Biochemical and Biophysical Research Communications
Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation
Simão, Daniel; Silva, Marta M.; Terrasso, Ana P.; Arez, Francisca; Sousa, Marcos F.Q.; Mehrjardi, Narges Z.; Šaric, Tomo; et al, 2018. Stem Cell Reports. 552 - 564. 2. 11. 2018. http://dx.doi.org/10.1016/j.stemcr.2018.06.020 . 10.1016/j.stemcr.2018.06.020 . published Stem Cell Reports
Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling
Musa, Marina; Peric, Matea; Bou Dib, Peter; Sobocanec, Sandra; Šaric, Ana; Lovric, Anita; Rudan, Marina; et al, 2018. Aging. 2407 - 2427. 9. 10. 2018. http://dx.doi.org/10.18632/aging.101560 . 10.18632/aging.101560 . published Aging
Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis
Fernández-Mosquera, Lorena; Diogo, Cátia V.; Yambire, King Faisal; Santos, Gabriela L.; Luna Sánchez, Marta; Bénit, Paule; Rustin, Pierre; et al, 2017. Scientific Reports. 1. 7. 2017. http://dx.doi.org/10.1038/srep45076 . 10.1038/srep45076 . published Scientific Reports
TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan
Peric, Matea; Lovric, Anita; Šaric, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolic, Andrea; et al, 2017. Aging Cell. 994 - 1005. 5. 16. 2017. http://dx.doi.org/10.1111/acel.12623 . 10.1111/acel.12623 . published Aging Cell
Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan
Peric, Matea; Dib, Peter Bou; Dennerlein, Sven; Musa, Marina; Rudan, Marina; Lovric, Anita; Nikolic, Andrea; et al, 2016. Scientific Reports. 1. 6. 2016. http://dx.doi.org/10.1038/srep28751 . 10.1038/srep28751 . Scientific Reports
Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System
John D. Murdoch; Christine M. Rostosky; Sindhuja Gowrisankaran; Amandeep S. Arora; Sandra-Fausia Soukup; Ramon Vidal; Vincenzo Capece; et al, 2016. Cell Reports. 1071 - 1086. 4. 17. 2016. http://dx.doi.org/10.1016/j.celrep.2016.09.058 . 10.1016/j.celrep.2016.09.058 . published Cell Reports
Mechanisms of communication between mitochondria and lysosomes
Raimundo, Nuno; Fernández-Mosquera, Lorena; Yambire, King Faisal; Diogo, Cátia V., 2016. The International Journal of Biochemistry & Cell Biology. 345 - 349. 79. 2016. http://dx.doi.org/10.1016/j.biocel.2016.08.020 . 10.1016/j.biocel.2016.08.020 . published The International Journal of Biochemistry & Cell Biology
Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness
McKay, Sharen E.; Yan, Wayne; Nouws, Jessica; Thormann, Maximilian J.; Raimundo, Nuno; Khan, Abdul; Santos-Sacchi, Joseph; Song, Lei; Shadel, Gerald S., 2015. The American Journal of Pathology. 3132 - 3140. 12. 185. 2015. http://dx.doi.org/10.1016/j.ajpath.2015.08.014 . 10.1016/j.ajpath.2015.08.014 . published The American Journal of Pathology
Mitochondrial DNA stress primes the antiviral innate immune response
West, A. Phillip; Khoury-Hanold, William; Staron, Matthew; Tal, Michal C.; Pineda, Cristiana M.; Lang, Sabine M.; Bestwick, Megan; et al, 2015. Nature. 553 - 557. 7548. 520. 2015. http://dx.doi.org/10.1038/nature14156 . 10.1038/nature14156 . published Nature
Mitochondrial pathology: stress signals from the energy factory
Raimundo, Nuno, 2014. Trends in Molecular Medicine. 282 - 292. 5. 20. 2014. http://dx.doi.org/10.1016/j.molmed.2014.01.005 . 10.1016/j.molmed.2014.01.005 . published Trends in Molecular Medicine
Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity
Schroeder, Elizabeth A.; Raimundo, Nuno; Shadel, Gerald S., 2013. Cell Metabolism. 954 - 964. 6. 17. 2013. http://dx.doi.org/10.1016/j.cmet.2013.04.003 . 10.1016/j.cmet.2013.04.003 . published Cell Metabolism
Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness
Raimundo, Nuno; Song, Lei; Shutt, Timothy E.; McKay, Sharen E.; Cotney, Justin; Guan, Min-Xin; Gilliland, Thomas C.; et al, 2012. Cell. 716 - 726. 4. 148. 2012. http://dx.doi.org/10.1016/j.cell.2011.12.027 . 10.1016/j.cell.2011.12.027 . published Cell
Revisiting the TCA cycle: signaling to tumor formation
Raimundo, Nuno; Baysal, Bora E.; Shadel, Gerald S., 2011. Trends in Molecular Medicine. 641 - 649. 11. 17. 2011. http://dx.doi.org/10.1016/j.molmed.2011.06.001 . 10.1016/j.molmed.2011.06.001 . published Trends in Molecular Medicine
Mitochondrial myopathy induces a starvation-like response
Tyynismaa, Henna; Carroll, Christopher J.; Raimundo, Nuno; Ahola-Erkkilä, Sofia; Wenz, Tina; Ruhanen, Heini; Guse, Kilian; et al, 2010. Human Molecular Genetics. 3948 - 3958. 20. 19. 2010. http://dx.doi.org/10.1093/hmg/ddq310 . 10.1093/hmg/ddq310 . published Human Molecular Genetics
Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas
Raimundo, N; Vanharanta, S; Aaltonen, L A; Hovatta, I; Suomalainen, A, 2009. Oncogene. 1261 - 1273. 9. 28. 2009. http://dx.doi.org/10.1038/onc.2008.472 . 10.1038/onc.2008.472 . published Oncogene
A "radical" mitochondrial view of autophagy-related pathology
Raimundo, Nuno; Shadel, Gerald S., 2009. Aging. 354 - 356. 4. 1. 2009. http://dx.doi.org/10.18632/aging.100037 . 10.18632/aging.100037 . published Aging
Differential metabolic consequences of fumarate hydratase and respiratory chain defects
Raimundo, Nuno; Ahtinen, Jouni; Fumic, Ksenija; Baric, Ivo; Remes, Anne M.; Renkonen, Risto; Lapatto, Risto; Suomalainen, Anu, 2008. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 287 - 294. 5. 1782. 2008. http://dx.doi.org/10.1016/j.bbadis.2008.01.008 . 10.1016/j.bbadis.2008.01.008 . published Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action
Guarino, Maria P.; Afonso, Ricardo A.; Raimundo, Nuno; Raposo, João F.; Macedo, M. Paula, 2003. American Journal of Physiology-Gastrointestinal and Liver Physiology. G588 - G594. 4. 284. 2003. http://dx.doi.org/10.1152/ajpgi.00423.2002 . 10.1152/ajpgi.00423.2002 . published American Journal of Physiology-Gastrointestinal and Liver Physiology
5 51 out of 51 Publications
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