Neuroscience and Disease
MemBRAIN: neuronal surface biology
Intracellular Trafficking
Neuronal Polarity
Cell-Surface Proteins
Protein-Protein Interactions
Brain Disease & Ageing
Intracellular Trafficking
Neuronal Polarity
Cell-Surface Proteins
Protein-Protein Interactions
Brain Disease & Ageing
Neuronal communication, mediated by synaptic contacts within complex neural networks, is responsible for all our actions and behaviors, including movements, learning, the formation or evocation of memories, and even sleep. For synapses to form and function properly, neurons need to have molecules at the cell surface, such as cell-adhesion molecules. These proteins facilitate the formation of synapses at the appropriate time of development between certain types of neurons, for instance. Thus, the molecular and cellular mechanisms ensuring the transport and presence of these molecules on the neuronal surface are essential for the formation and functioning of the nervous system. When changes occur in these mechanisms that result in alterations in the distribution or function of these proteins, deficiencies in neuronal communication arise, which manifest as neurological changes observed in brain diseases and during aging.
In the MemBRAIN laboratory, we study the molecular and cellular mechanisms that control the distribution of cell-surface proteins in neurons (localization and abundance). Additionally, we also investigate cell-surface proteins with unknown function in the brain. We address these questions during the development of the nervous system, under pathological conditions such as tauopathies, and also during aging.
To accomplish this, we use research models such as primary rodent neuronal cultures, human neuronal cultures, rodent brain slices, viral vectors, and genetic and disease models in rodents. Our main techniques include live-cell imaging in neurons, proteomics, electrophysiology, various biochemical assays, as well as cutting-edge approaches in cellular and molecular biology, such as CRISPR-Cas9 for gene editing.
This approach will not only allow us to understand the essential mechanisms underlying the formation and function of the nervous system but also to identify new therapeutic targets and strategies to mitigate the neurological changes that arise in brain diseases and aging.
Information about journal articles, updated at 14-05-2024, from platform CIÊNCIAVITAE.
SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function
Luís F. Ribeiro; Ben Verpoort; Julie Nys; Kristel M. Vennekens; Keimpe D. Wierda; Joris de Wit, 2019. PLOS Biology. e3000466 - e3000466. 10. 17. 2019. https://doi.org/10.1371/journal.pbio.3000466 . 10.1371/journal.pbio.3000466 . PLOS Biology
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
Savas, Jeffrey N.; Ribeiro, Luís F.; Wierda, Keimpe D.; Wright, Rebecca; DeNardo-Wilke, Laura A.; Rice, Heather C.; Chamma, Ingrid; et al, 2015. Neuron. 764 - 780. 4. 87. 2015. http://dx.doi.org/10.1016/j.neuron.2015.08.007 . 10.1016/j.neuron.2015.08.007 . Neuron
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation
Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, 2021. Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . published Science Signaling
Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus
Ribeiro, L. F.; Catarino, T.; Santos, S. D.; Benoist, M.; van Leeuwen, J. F.; Esteban, J. A.; Carvalho, A. L., 2013. Proceedings of the National Academy of Sciences. E149 - E158. 1. 111. 2013. http://dx.doi.org/10.1073/pnas.1313798111 . 10.1073/pnas.1313798111 . published Proceedings of the National Academy of Sciences
Nuclear import of the DSCAM -cytoplasmic domain drives signaling capable of inhibiting synapse formation
Sachse, Sonja M; Lievens, Sam; Ribeiro, Luís F; Dascenco, Dan; Masschaele, Delphine; Horré, Katrien; Misbaer, Anke; et al, 2019. The EMBO Journal. 6. 38. 2019. http://dx.doi.org/10.15252/embj.201899669 . 10.15252/embj.201899669 . The EMBO Journal
5 6 out of 6 Featured Publications
Information about journal articles, updated at 14-05-2024, from platform CIÊNCIAVITAE.
Microglial TNFa orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep
Pinto, Maria J; Cottin, Léa; Dingli, Florent; Laigle, Victor; Ribeiro, Luís F; Triller, Antoine; Henderson, Fiona; et al, 2022. The EMBO Journal. 1. 42. 2022. http://dx.doi.org/10.15252/embj.2022111485 . 10.15252/embj.2022111485 . published The EMBO Journal
Heterotypic Amyloid ß interactions facilitate amyloid assembly and modify amyloid structure
Konstantoulea, Katerina; Guerreiro, Patricia; Ramakers, Meine; Louros, Nikolaos; Aubrey, Liam D; Houben, Bert; Michiels, Emiel; et al, 2021. The EMBO Journal. 2. 41. 2021. http://dx.doi.org/10.15252/embj.2021108591 . 10.15252/embj.2021108591 . published The EMBO Journal
Ligand-independent activity of the ghrelin receptor modulates AMPA receptor trafficking and supports memory formation
Ribeiro, Luís F.; Catarino, Tatiana; Carvalho, Mário; Cortes, Luísa; Santos, Sandra D.; Opazo, Patricio O.; Ribeiro, Lyn Rosenbrier; et al, 2021. Science Signaling. 670. 14. 2021. http://dx.doi.org/10.1126/scisignal.abb1953 . 10.1126/scisignal.abb1953 . published Science Signaling
Nuclear import of the DSCAM -cytoplasmic domain drives signaling capable of inhibiting synapse formation
Sachse, Sonja M; Lievens, Sam; Ribeiro, Luís F; Dascenco, Dan; Masschaele, Delphine; Horré, Katrien; Misbaer, Anke; et al, 2019. The EMBO Journal. 6. 38. 2019. http://dx.doi.org/10.15252/embj.201899669 . 10.15252/embj.201899669 . The EMBO Journal
SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function
Luís F. Ribeiro; Ben Verpoort; Julie Nys; Kristel M. Vennekens; Keimpe D. Wierda; Joris de Wit, 2019. PLOS Biology. e3000466 - e3000466. 10. 17. 2019. https://doi.org/10.1371/journal.pbio.3000466 . 10.1371/journal.pbio.3000466 . PLOS Biology
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes
Patel, Abdulsamie M.; Wierda, Keimpe; Thorrez, Lieven; van Putten, Maaike; De Smedt, Jonathan; Ribeiro, Luis; Tricot, Tine; et al, 2019. Translational Psychiatry. 1. 9. 2019. http://dx.doi.org/10.1038/s41398-019-0535-1 . 10.1038/s41398-019-0535-1 . published Translational Psychiatry
S-Nitrosylation of Ras Mediates Nitric Oxide-Dependent Post-Injury Neurogenesis in a Seizure Model
Santos, Ana Isabel; Carreira, Bruno Pereira; Izquierdo-Álvarez, Alicia; Ramos, Elena; Lourenço, Ana Sofia; Filipa Santos, Daniela; Morte, Maria Inês; et al, 2018. Antioxidants & Redox Signaling. 15 - 30. 1. 28. 2018. http://dx.doi.org/10.1089/ars.2016.6858 . 10.1089/ars.2016.6858 . Antioxidants & Redox Signaling
A Modular Organization of LRR Protein-Mediated Synaptic Adhesion Defines Synapse Identity
Schroeder, A.; Vanderlinden, J.; Vints, K.; Ribeiro, L.F.; Vennekens, K.M.; Gounko, N.V.; Wierda, K.D.; de Wit, J., 2018. Neuron. 329 - 344.e7. 2. 99. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049055996&partnerID=MN8TOARS . 10.1016/j.neuron.2018.06.026 . published Neuron
Trafficking mechanisms of synaptogenic cell adhesion molecules
Ribeiro, L.F.; Verpoort, B.; de Wit, J., 2018. Molecular and Cellular Neuroscience. 34 - 47. 91. 2018. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045454630&partnerID=MN8TOARS . 10.1016/j.mcn.2018.04.003 . published Molecular and Cellular Neuroscience
Neuronal Polarity: MAP2 Shifts Secretory Vesicles into High Gear for Long-Haul Transport down the Axon
Ribeiro, Luís F.; de Wit, Joris, 2017. Neuron. 223 - 225. 2. 94. 2017. http://dx.doi.org/10.1016/j.neuron.2017.04.002 . 10.1016/j.neuron.2017.04.002 . Neuron
The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors
Savas, Jeffrey N.; Ribeiro, Luís F.; Wierda, Keimpe D.; Wright, Rebecca; DeNardo-Wilke, Laura A.; Rice, Heather C.; Chamma, Ingrid; et al, 2015. Neuron. 764 - 780. 4. 87. 2015. http://dx.doi.org/10.1016/j.neuron.2015.08.007 . 10.1016/j.neuron.2015.08.007 . Neuron
GABAA receptor dephosphorylation followed by internalization is coupled to neuronal death in in vitro ischemia
Mele, Miranda; Ribeiro, Luís; Inácio, Ana R.; Wieloch, Tadeusz; Duarte, Carlos B., 2014. Neurobiology of Disease. 220 - 232. 65. 2014. http://dx.doi.org/10.1016/j.nbd.2014.01.019 . 10.1016/j.nbd.2014.01.019 . published Neurobiology of Disease
Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus
Ribeiro, L. F.; Catarino, T.; Santos, S. D.; Benoist, M.; van Leeuwen, J. F.; Esteban, J. A.; Carvalho, A. L., 2013. Proceedings of the National Academy of Sciences. E149 - E158. 1. 111. 2013. http://dx.doi.org/10.1073/pnas.1313798111 . 10.1073/pnas.1313798111 . published Proceedings of the National Academy of Sciences
Regulation of synapse composition by protein acetylation: the role of acetylated cortactin
Catarino, Tatiana; Ribeiro, Luís; Santos, Sandra D.; Carvalho, Ana Luísa, 2012. Journal of Cell Science. 149 - 162. 1. 126. 2012. http://dx.doi.org/10.1242/jcs.110742 . 10.1242/jcs.110742 . published Journal of Cell Science
Contactin-associated Protein 1 (Caspr1) Regulates the Traffic and Synaptic Content of a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)-type Glutamate Receptors
Santos, Sandra D.; Iuliano, Olga; Ribeiro, Luís; Veran, Julien; Ferreira, Joana S.; Rio, Pedro; Mulle, Christophe; Duarte, Carlos B.; Carvalho, Ana Luísa, 2012. Journal of Biological Chemistry. 6868 - 6877. 9. 287. 2012. http://dx.doi.org/10.1074/jbc.m111.322909 . 10.1074/jbc.m111.322909 . published Journal of Biological Chemistry
Activity and Protein Kinase C Regulate Synaptic Accumulation of N-Methyl-d-aspartate (NMDA) Receptors Independently of GluN1 Splice Variant
Ferreira, Joana S.; Rooyakkers, Amanda; She, Kevin; Ribeiro, Luis; Carvalho, Ana Luísa; Craig, Ann Marie, 2011. Journal of Biological Chemistry. 28331 - 28342. 32. 286. 2011. http://dx.doi.org/10.1074/jbc.m111.222539 . 10.1074/jbc.m111.222539 . published Journal of Biological Chemistry
5 16 out of 16 Publications
Collaborative Pair Pilot Project Award (Cycle 2) from Chan Zuckerberg Initiative.
CP2-1-0000000126
Individual Call to Scientific Employment Stimulus - 4th Edition: Assistant Investigator
2021.03397.CEECIND
Marie Skłodowska-Curie Action Individual Fellowship
GA: 101031398
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